Patents by Inventor Hartwig Mueller
Hartwig Mueller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10383876Abstract: The present invention relates:—to 2-amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo-[1,2-c]quinazolin-5-yl]pyrimidine-5-carboxamide dihydrochloride salt of formula (II): or a tautomer, solvate or hydrate thereof;—to methods of preparing said dihydrochloride salt;—to said dihydrochloride salt for the treatment and/or prophylaxis of a disease;—to the use of said dihydrochloride salt for the preparation of a medicament for the treatment and/or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, more particularly for the treatment or prophylaxis of a cancer, particularly lung cancer, in particular non-small cell lung carcinoma, colorectal cancer, melanoma, pancreatic cancer, hepatocyte carcinoma, pancreatic cancer, hepatocyte carcinoma or breast cancer;—to a pharmaceutical composition comprising said dihydrochloride salt; and—to a pharmaceutical combination comprising said dihydrochloride salt in combination with one or more further pharmaceutical agentType: GrantFiled: March 29, 2012Date of Patent: August 20, 2019Assignee: BAYER INTELLECTUAL PROPERTY GMBHInventors: Jan-Georg Peters, Hans-Christian Militzer, Hartwig Müller
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Patent number: 9636344Abstract: The present invention relates to 2-amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo-[1,2-c]quinazolin-5-yl]pyrimidine-5-carboxamide dihydrochloride salt of formula (II): or a tautomer, solvate or hydrate thereof; and to its use for the treatment of non-Hodgkin's lymphoma.Type: GrantFiled: January 7, 2016Date of Patent: May 2, 2017Assignee: Bayer Intellectual Property GmbHInventors: Jan-Georg Peters, Hans-Christian Militzer, Hartwig Müller
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Publication number: 20160193219Abstract: The present invention relates to 2-amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo-[1,2-c]quinazolin-5-yl]pyrimidine-5-carboxamide dihydrochloride salt of formula (II): or a tautomer, solvate or hydrate thereof; and to its use for the treatment of non-Hodgkin's lymphoma.Type: ApplicationFiled: January 7, 2016Publication date: July 7, 2016Inventors: Jan-Georg PETERS, Hans-Christian MILITZER, Hartwig MÜLLER
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Patent number: 8961688Abstract: Disclosed are a method and a device for plasma treating workpieces (5). Said workpiece is inserted into a chamber (7) of a treatment station (3), which can be at least partly evacuated, and is positioned within the treatment station by means of a holding element. In order to simultaneously supply at least two chambers with at least one operating means, a flow of the operating means is branched at least once so as to form at least two partial flows (55).Type: GrantFiled: May 9, 2003Date of Patent: February 24, 2015Assignee: KHS Corpoplast GmbHInventors: Michael Lizenberg, Frank Lewin, Hartwig Müller, Klaus Vogel, Gregor Arnold, Stephan Behle, Andreas Lüttringhaus-Henkel, Matthias Bicker, Jürgen Klein, Marten Walther
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Publication number: 20140072529Abstract: The present invention relates:—to 2-amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo-[1,2-c]quinazolin-5-yl]pyrimidine-5-carboxamide dihydrochloride salt of formula (II): or a tautomer, solvate or hydrate thereof;—to methods of preparing said dihydrochloride salt;—to said dihydrochloride salt for the treatment and/or prophylaxis of a disease;—to the use of said dihydrochloride salt for the preparation of a medicament for the treatment and/or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, more particularly for the treatment or prophylaxis of a cancer, particularly lung cancer, in particular non-small cell lung carcinoma, colorectal cancer, melanoma, pancreatic cancer, hepatocyte carcinoma, pancreatic cancer, hepatocyte carcinoma or breast cancer;—to a pharmaceutical composition comprising said dihydrochloride salt; and to a pharmaceutical combination comprising said dihydrochloride salt in combination with one or more further pharmaceutical agentType: ApplicationFiled: March 29, 2012Publication date: March 13, 2014Applicant: BAYER INTELLECTUAL PROPERTY GMBHInventors: Jan-Georg Peters, Hans-Christian Militzer, Hartwig Müller
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Publication number: 20130186336Abstract: A device for plasma treatment of workpieces. The workpiece is placed into a chamber of a processing station that can be at least partially evacuated. The plasma chamber is bounded by a chamber floor, a chamber cover, and a side chamber wall. The plasma chamber is coupled to a device for feeding and/or discharging process gases in a controlled manner. The plasma chamber is further disposed on a rotatable plasma wheel supported on a static base. At least one process gas channel is disposed in the region of the base, bounded at least in regions by a cover. The cover is implemented as part of the plasma wheel and includes at least one connection opening to the process gas channel. The connection opening can be coupled to an inner chamber by a connecting channel and at least one control valve.Type: ApplicationFiled: June 3, 2011Publication date: July 25, 2013Applicant: KHS CORPOPLAST GMBHInventors: Sönke Siebels, Hartwig Müller
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Publication number: 20110023781Abstract: The device serves for the plasma treatment of workpieces. The workpiece is placed in the chamber of a treatment station which can at least partially be evacuated. The plasma chamber is defined by a chamber bottom, a chamber cover, as well as a lateral chamber wall, and has a positionable gas lance. The gas lance is constructed at least partially of a dielectric.Type: ApplicationFiled: August 14, 2008Publication date: February 3, 2011Inventors: Sönke Siebels, Sebastian Kytzia, Hartwig Müller, Felix Tietz
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Publication number: 20110015248Abstract: The present invention relates to substituted heterocycles, processes for their preparation, and their use in medicaments, especially for the treatment of inflammatory disease, i.e. asthma, or cancer.Type: ApplicationFiled: January 8, 2009Publication date: January 20, 2011Applicant: INTERMED DISCOVERY GMBHInventors: Marc STADLER, Stephan Seip, Hartwig Müller, Anke Mayer-Bartschmid, Michael-Alexander Brüning, Jordi Benet-Buchholz, Hiroko Togame, Reiko Dodo, Peter Reinemer, Kevin Bacon, Kinji Fuchikami, Satoko Matsukawa, Klaus Urbahns
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Patent number: 7699933Abstract: The invention relates to a method and a device which are used for the plasma treatment of work pieces. Said work piece is inserted into an at least partially evacuatable chamber of a treatment station (3) and the work piece is positioned inside the treatment station of retaining elements. At least one operating agent is at least partially impinged upon by a transporting device (44) which is displaced together with the treatment station on a closed and rotating transport path.Type: GrantFiled: May 9, 2003Date of Patent: April 20, 2010Assignee: KHS Corpoplast GmbH & Co. KGInventors: Michael Lizenberg, Frank Lewis, Hartwig Müller, Klaus Vogel, Gregor Arnold, Stephan Behle, Andreas Lüttringhaus-Henkel, Matthias Bicker, Jürgen Klein
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Patent number: 7438317Abstract: A rollover protection device includes a cassette housing which guides an extendable rollover bar. The cassette housing includes guidances for the rollover bar. The rollover bar is a single shell or multi-shell form part made of fibre reinforced plastic and has shell edge regions which at least partially extend parallel to the extension direction. The cassette housing is a hollow profile made from high strength material and is closed around the rollover bar and the guidance. The guidance is a plastic form part engaging at a shell edge region, is secured within the hollow profile and protrudes from the hollow profile at least downwards.Type: GrantFiled: February 10, 2004Date of Patent: October 21, 2008Assignee: ISE Innomotive Systems Europe GmbHInventors: Stephan Röhner, Hartwig Müller
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Patent number: 7175199Abstract: A vehicle body (F) for a passenger car convertible, which has an integrated crosswise partition panel (T) behind the seat anchors (S), on which two retractable roll bars (B) are arranged next to one another, and which vehicle body includes on the back side of the partition panel (T) that is turned away from the seat anchors, exclusively in the upper area of the partition panel, a module carrier (M), which reinforces the partition panel, and which is oriented crosswise to the longitudinal direction of the vehicle, and which extends across the width of the interior of the vehicle body, and which is mounted on the partition panel, which positions the two roll bars (B) on the back side of the partition panel, so that the module carrier and the partition panel together form bar guides (G), whereby the module carrier (M), with the two roll bars (B), is one pre-mounted modular unit (E).Type: GrantFiled: June 8, 2001Date of Patent: February 13, 2007Assignees: Blechformwerke Bernsbach AG, ISE Innomotive Systems Europe GmbHInventor: Hartwig Müller
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Publication number: 20060229353Abstract: The present invention relates to substituted heterocycles, processes for their preparation, and their use in medicaments, especially for the treatment of inflammatory disease, i.e. asthma, or cancer.Type: ApplicationFiled: February 6, 2004Publication date: October 12, 2006Inventors: Marc Stadler, Stephan Seip, Hartwig Müller, Anke Mayer-Bartschmid, Michael-Alexander Brüning, Jordi Benet-Buchholz, Hiroko Togame, Reiko Dodo, Peter Reinemer, Kevin Bacon, Kinji Fuchikami, Satoko Matsukawa, Klaus Urbahns
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Patent number: 7037099Abstract: The device serves for the blow molding of containers that comprise a thermoplastic material, wherein the device has at least one blowing station with at least one blow mold. The blow mold is formed from at least two blow mold segments that are supported by supports, wherein the blow mold has a base extension. The base extension is arranged in such a way that it is capable of being positioned in the direction of a longitudinal axis of the blow mold, and is supported by a base plate. The base plate connects the base extension to a positioning device. The base plate is additionally connected to the base extension by a profiled coupling section, wherein this profiled coupling section is formed from a coupling element, which is connected to the base plate, along with a counter element that is connected to the base extension. The profiled coupling section is capable of being actuated via a manual lever.Type: GrantFiled: July 6, 2001Date of Patent: May 2, 2006Assignee: SIG Corpoplast GmbH & Co. KGInventors: Michael Linke, Hartwig Mueller, Martin Gerhards, Michael Litzenberg
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Patent number: 6988744Abstract: A rollover protection device for the passengers of a vehicle having a body and a lateral bulkhead includes a structural unit adapted to be mounted on one side of the vehicle body lateral bulkhead. The structural unit includes at least one extendible rollover bar, and a module beam being connectable in a force transmitting fashion with the lateral bulkhead and the vehicle body. The module beam extends crosswise to the longitudinal direction of the vehicle in an upper region of the lateral bulkhead, and at least one force transmission member contains the at least one rollover bar. The at least one force transmission member supports the module beam at the vehicle body bottom.Type: GrantFiled: February 20, 2003Date of Patent: January 24, 2006Assignees: Innomotive System Europe GmbH, Daimer Chrysler AGInventor: Hartwig Müller
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Publication number: 20040052892Abstract: The device serves for the blow molding of containers that comprise a thermoplastic material, wherein the device has at least one blowing station with at least one blow mold. The blow mold is formed from at least two blow mold segments that are supported by supports, wherein the blow mold has a base extension. The base extension is arranged in such a way that it is capable of being positioned in the direction of a longitudinal axis of the blow mold, and is supported by a base plate. The base plate connects the base extension to a positioning device. The base plate is additionally connected to the base extension by a profiled coupling section, wherein this profiled coupling section is formed from a coupling element, which is connected to the base plate, along with a counter element that is connected to the base extension. The profiled coupling section is capable of being actuated via a manual lever.Type: ApplicationFiled: August 27, 2003Publication date: March 18, 2004Inventors: Michael Linke, Hartwig Mueller, Martin Gerhards, Michael Litzenberg
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Patent number: 6514448Abstract: The process is used for tempering preforms made of a thermoplastic material; the preforms are to be blow molded. The preforms are provided with a temperature profile along a circumference. The temperature profile is generated by differentially heating strip-shaped regions, which extend in the direction of a longitudinal axis of the preform. A step-by-step tempering for the purpose of temporally sequential thermal conditioning of different regions of the preform is carried out with movement phases and rest phases. A carrier device is rotated by the interactions of a gear and a matching gear for initiating rotational movements. The preform is moved, motionless with regard to the rotational direction, through the tempering zone at least along a portion of the transport path before the start of the engagement of the gear with the matching gear.Type: GrantFiled: June 22, 2000Date of Patent: February 4, 2003Inventors: Klaus Vogel, Hartwig Müller, Julian Choinski, Andreas Klages, Marko Moritz
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Patent number: 6491307Abstract: An axle assembly with level control, in particular with a pneumatic suspension. Changes in level which may, if appropriate, become necessary on both vehicle sides take place incrementally and with continuous alternation between the vehicle sides, i.e. the left-hand and right-hand vehicle sides are alternately raised or lowered.Type: GrantFiled: August 3, 1999Date of Patent: December 10, 2002Assignee: DaimlerChrysler AGInventors: Uwe Charzinski, Jochen Horwath, Hartwig Mueller, Gerald Ricklefs, Friedrich Scheurer
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Patent number: 6315326Abstract: A rollbar for an open sports car which extends over the width of the vehicle, having a basic shell body which follows the rollbar shape and consists of molded two-dimensional material with longitudinal ribbings which are alternately raised toward the exterior and interior side of the rollbar. The rollbar shell is integrally formed from a pressed molding of fibrous composite plastic or metallic material and can include stiffening inserts which extend over at least part of the longitudinal extrusion of the shell. An anti-abrasion material can be integrally connected or embedded into the surface of the shell. The rollbar is light weight, optimally designed for individual types of loads and can be integrated into the car body in an esthetically appearing manner.Type: GrantFiled: July 19, 1999Date of Patent: November 13, 2001Assignees: Blechformwerke Bernsbach GmbH, ISE Innomotive Systems Europe GmbHInventors: Hartwig Müller, Robert Schweier
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Patent number: 6087929Abstract: A display device, in particular a fault display, predominantly for systems of a motor vehicle, is provided wherein, as a rule, there is a display only after an operational shut-down of a respective system occurs or when the motor vehicle is switched off.Type: GrantFiled: September 7, 1999Date of Patent: July 11, 2000Assignee: DaimlerChrysler AGInventors: Uwe Charzinski, Jochen Horwath, Hartwig Mueller, Gerald Ricklefs, Friedrich Scheurer