Patents by Inventor Hartwig Schröder

Hartwig Schröder has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11685759
    Abstract: The present invention relates to a method for obtaining crystalline 2?-fucosyllactose from a 2?-FL raw material, which contains 2?-FL as a main constituent and at least 0.
    Type: Grant
    Filed: October 17, 2019
    Date of Patent: June 27, 2023
    Assignee: BASF SE
    Inventors: Michael Puhl, Sebastian Wloch, Peter Oedman, Anne-Catrin Letzel, Hartwig Schroeder, Jacek Malisz, Daniel Seibert-Ludwig, Emiel Jan Kappert, Chung Huan Wong, Michael Barros Gross, Martin Viertelhaus
  • Publication number: 20230042456
    Abstract: Increasing space-time-yield, carbon-conversion-efficiency and carbon substrate flexibility in the production of fine chemicals The inventors of the current invention have found a surprising positive effect of increased cAMP levels and/or manipulating the PTS system on the space-time-yield, carbon-conversion-efficiency and carbon substrate flexibility of fine chemical production of a host organism. This was achieved by de-regulating adenylate cyclase cyaa by deleting the C-terminal regulatory region leading to increased cAMP levels or deleting the Crr protein activity (carbohydrate repression resistance) which regulates the carbohydrate utilization system. Both lead to increased 2-fucosyllactoe and 6-sialyllactose production (human milk oligosaccharides) and increase carbohydrate usage.
    Type: Application
    Filed: December 16, 2020
    Publication date: February 9, 2023
    Inventors: Hartwig SCHROEDER, Anne-Catrin HAILER, Birgit HOFF, Oskar ZELDER, Peter OEDMAN, Georg Benjamin WANDREY, Christian DIETZSCH, Mukesh KUMAR, Dominik SATORY, Matthew David BLANKSCHIEN, Jens Klaus PLASSMEIER
  • Patent number: 11279955
    Abstract: Described herein is a process of producing an organic compound, the process including: I) cultivating a genetically modified microorganism in a culture medium including sucrose as an assimilable carbon source to allow the genetically modified microorganism to produce the organic compound, and II) recovering the organic compound from the fermentation broth obtained in process step I) The genetically modified microorganism includes A) at least one genetic modification that leads to an increased activity of the enzyme encoded by the rbsK-gene, compared to the original microorganism that has not been genetically modified, and the original microorganism belongs to the family Pasteurellaceae. Also described herein are a genetically modified microorganism and the use thereof for the fermentative production of an organic compound from sucrose as an assimilable carbon source.
    Type: Grant
    Filed: May 18, 2018
    Date of Patent: March 22, 2022
    Assignee: BASF SE
    Inventors: Hartwig Schroeder, Stefan Haefner, Oskar Zelder, Christoph Wittmann, Anna Christine Schroer, Birgit Hoff, Nico Boehmer
  • Patent number: 10731188
    Abstract: The present invention relates to a recombinant nucleic acid molecule, a recombinant microorganism, to a method for producing alanine and to the use of the recombinant nucleic acid molecule or the recombinant microorganism for the fermentative production of alanine.
    Type: Grant
    Filed: December 28, 2018
    Date of Patent: August 4, 2020
    Assignee: BASF SE
    Inventors: Hartwig Schröder, Holger Hartmann, Qingzhao Wang, Shakir Siraj Ratani, Zheyuan Guo, Markus Pompejus
  • Publication number: 20200181653
    Abstract: Described herein is a process of producing an organic compound, the process including: I) cultivating a genetically modified microorganism in a culture medium including sucrose as an assimilable carbon source to allow the genetically modified microorganism to produce the organic compound, and II) recovering the organic compound from the fermentation broth obtained in process step I) The genetically modified microorganism includes A) at least one genetic modification that leads to an increased activity of the enzyme encoded by the rbsK-gene, compared to the original microorganism that has not been genetically modified, and the original microorganism belongs to the family Pasteurellaceae. Also described herein are a genetically modified microorganism and the use thereof for the fermentative production of an organic compound from sucrose as an assimilable carbon source.
    Type: Application
    Filed: May 18, 2018
    Publication date: June 11, 2020
    Inventors: Hartwig Schroeder, Stefan Haefner, Oskar Zelder, Christoph Wittmann, Anna Christine Schroer, Birgit Hoff, Nico Boehmer
  • Patent number: 10519474
    Abstract: Recombinant microorganism for improved production of fine chemicals The present invention relates to a recombinant nucleic acid molecule, a recombinant micro-organism, to a method for producing alanine and to the use of the recombinant nucleic acid molecule or the recombinant microorganism for the fermentative production of alanine.
    Type: Grant
    Filed: June 2, 2016
    Date of Patent: December 31, 2019
    Assignee: BASF SE
    Inventors: Qingzhao Wang, Shakir Siraj Ratani, Zheyuan Guo, Hartwig Schroeder, Holger Hartmann, Markus Pompejus
  • Patent number: 10513693
    Abstract: The present invention relates to a process for producing an organic acid by fermentation, comprising the process steps: I) cultivating microorganisms in a culture medium to which are fed, as assimilable carbon sources, glycerol and a further carbonaceous compound, to allow the microorganisms to produce the organic acid, thereby obtaining a fermentation broth comprising the organic acid; II) recovering the organic acid or the salt thereof from the fermentation broth obtained in process step I); wherein, at least for a certain period of time in process step I), the consumption rate of the further carbonaceous compound (CRc.c.; in g per liter per hour) is lower than the maximum theoretical consumption rate of the further carbonaceous compound (CRc.c. max; in g per liter per hour).
    Type: Grant
    Filed: March 18, 2015
    Date of Patent: December 24, 2019
    Assignee: BASF SE
    Inventors: Esther Dantas Costa, Oskar Zelder, Hartwig Schröder, Stefan Haefner, Joanna Martyna Krawczyk, Gregory Von Abendroth, Christian Riedele, Torsten Renz
  • Patent number: 10287558
    Abstract: The present invention relates to a modified microorganism having, compared to its wild-type, a reduced activity of the enzyme that is encoded by the pykA-gene. The present invention also relates to a method for producing an organic compound and to the use of modified microorganisms.
    Type: Grant
    Filed: February 2, 2015
    Date of Patent: May 14, 2019
    Assignee: BASF SE
    Inventors: Joanna Martyna Krawczyk, Stefan Haefner, Hartwig Schröder, Esther Dantas Costa, Oskar Zelder, Gregory Von Abendroth, Christoph Wittmann, René Stellmacher, Judith Becker, Anna Lange, Benjamin J. Lyons, Thomas J. Lyons, Eudes De Crecy, Ewa Hughes
  • Patent number: 10287571
    Abstract: The present invention relates to a modified microorganism having, compared to its wildtype, —a reduced activity of an enzyme encoded by the ptsA-gene, —a reduced activity of an enzyme encoded by the ptsH-gene or —a reduced activity of an enzyme encoded by the ptsA-gene and a reduced activity of an enzyme encoded by the ptsH-gene, wherein the wildtype from which the modified microorganism has been derived belongs to the family of Pasteurellaceae. The present invention also relates to a method for producing succinic acid and to the use of modified microorganisms.
    Type: Grant
    Filed: May 7, 2015
    Date of Patent: May 14, 2019
    Assignee: BASF SE
    Inventors: Joanna Martyna Krawczyk, Stefan Haefner, Hartwig Schroeder, Oskar Zelder
  • Patent number: 10273485
    Abstract: The present invention relates to a modified microorganism having, compared to its wild-type, a reduced activity of the enzyme that is encoded by the wcaJ-gene. The present invention also relates to a method for producing an organic compound and to the use of a modified microorganism.
    Type: Grant
    Filed: February 6, 2015
    Date of Patent: April 30, 2019
    Assignee: BASF SE
    Inventors: Joanna Martyna Krawczyk, Stefan Haefner, Hartwig Schröder, Esther Dantas Costa, Oskar Zelder, Gregory Von Abendroth, Christoph Wittmann, René Stellmacher, Judith Becker
  • Publication number: 20190119710
    Abstract: The present invention relates to a recombinant nucleic acid molecule, a recombinant micro-organism, to a method for producing alanine and to the use of the recombinant nucleic acid molecule or the recombinant microorganism for the fermentative production of alanine.
    Type: Application
    Filed: December 28, 2018
    Publication date: April 25, 2019
    Inventors: Hartwig Schröder, Holger Hartmann, Qingzhao Wang, Shakir Siraj Ratani, Zheyuan Guo, Markus Pompejus
  • Patent number: 10208324
    Abstract: The present invention relates to a recombinant nucleic acid molecule, a recombinant microorganism, to a method for producing alanine and to the use of the recombinant nucleic acid molecule or the recombinant microorganism for the fermentative production of alanine.
    Type: Grant
    Filed: December 8, 2014
    Date of Patent: February 19, 2019
    Assignee: BASF SE
    Inventors: Hartwig Schröder, Holger Hartmann, Qingzhao Wang, Shakir Ratani, Zheyuan Guo, Markus Pompejus
  • Patent number: 10208323
    Abstract: The present invention relates to a recombinant nucleic acid molecule, a recombinant microorganism, to a method for producing alanine and to the use of the recombinant nucleic acid molecule or the recombinant microorganism for the fermentative production of alanine.
    Type: Grant
    Filed: June 4, 2015
    Date of Patent: February 19, 2019
    Assignee: BASF SE
    Inventors: Hartwig Schroeder, Holger Hartmann, Qingzhao Wang, Shakir Siraj Ratani, Zheyuan Guo, Markus Pompejus
  • Patent number: 10150777
    Abstract: The invention pertains to processes to produce dry biomass of pyripyropene producer organisms, processes to obtain pyripyropenes from such dry biomass, as well as to processes to produce compounds of Formula III and/or Formula IV and/or Formula V from the pyripyropenes obtained from the dry biomass. The invention does further pertain to the dry biomass itself, as well as processes using said dry biomass to obtain pyripyropenes for the production of compounds of Formula III and/or Formula IV and/or Formula V, including processes using said dry biomass to obtain pyripyropenes or compounds of Formula III and/or Formula IV and/or Formula V in order to produce pest control compositions, in particular insecticides, comprising such compounds.
    Type: Grant
    Filed: March 3, 2014
    Date of Patent: December 11, 2018
    Assignee: BASF SE
    Inventors: Burkhard Ernst, Manfred Ehresmann, Christopher Koradin, Andreas Pletsch, Melanie Bonnekessel, Thomas Kaeding, Karin Schein-Albrecht, Stefanie Demming, Franz Weber, Wolfgang Siegel, Hartwig Schroeder, Stephan Freyer, Peter Oedman
  • Patent number: 10047364
    Abstract: The present invention relates to a recombinant nucleic acid molecule, a recombinant microorganism, to a method for producing alanine and to the use of the recombinant nucleic acid molecule or the recombinant microorganism for the fermentative production of alanine.
    Type: Grant
    Filed: September 11, 2014
    Date of Patent: August 14, 2018
    Assignee: BASF SE
    Inventors: Hartwig Schröder, Holger Hartmann, Qingzhao Wang, Shakir Ratani, Zheyuan Guo, Markus Pompejus
  • Publication number: 20180148748
    Abstract: Recombinant microorganism for improved production of fine chemicals The present invention relates to a recombinant nucleic acid molecule, a recombinant micro-organism, to a method for producing alanine and to the use of the recombinant nucleic acid molecule or the recombinant microorganism for the fermentative production of alanine.
    Type: Application
    Filed: June 2, 2016
    Publication date: May 31, 2018
    Inventors: Qingzhao WANG, Shakir Siraj RATANI, Zheyuan GUO, Hartwig SCHROEDER, Holger HARTMANN, Markus POMPEJUS
  • Publication number: 20180105838
    Abstract: The invention relates to microbial terpene production. Known methods for microbial production of terpenes are mostly based on the direct conversion of sugars. Therefore alternative substrates, in particular alternative carbon sources, for use in microbial terpene production were desirable. The invention relates to a methylotrophic bacterium containing recombinant DNA coding for at least one polypeptide with enzymatic activity for heterologous expression in said bacterium, wherein said at least one polypeptide with enzymatic activity is selected from the group consisting an enzyme of a heterologous mevalonate pathway, a heterologous terpene synthase and optionally a heterologous synthase of a prenyl diphosphate precursor. The invention further relates in particular to a method for de novo microbial synthesis of sesquiterpenes or diterpenes from methanol and/or ethanol.
    Type: Application
    Filed: March 11, 2016
    Publication date: April 19, 2018
    Inventors: Jens SCHRADER, Markus BUCHHAUPT, Frank SONNTAG, Cora KRONER, Heike BRÜSER, Hartwig SCHRÖDER, Ralf PELZER
  • Patent number: 9932612
    Abstract: The present invention relates to bacterial strains, capable of utilizing glycerol as a carbon source for the fermentative production of succinic acid, wherein said strains are genetically modified so that they comprise a deregulation of their endogenous pyruvate-formate-lyase enzyme activity, as well as to methods of producing organic acids, in particular succinic acid, by making use of such microorganism. The present invention also relates to the downstream processing of the produced organic acids by cation exchange chromatography.
    Type: Grant
    Filed: April 1, 2015
    Date of Patent: April 3, 2018
    Assignee: BASF SE
    Inventors: Hartwig Schröder, Stefan Haefner, Gregory Von Abendroth, Rajan Hollmann, Aline Raddatz, Hansgeorg Ernst, Hans Gurski
  • Publication number: 20180030418
    Abstract: The present invention relates to a process for producing an organic acid by fermentation, comprising the process steps: I) cultivating microorganisms in a culture medium to which are fed, as assimilable carbon sources, glycerol and a further carbonaceous compound, to allow the microorganisms to produce the organic acid, thereby obtaining a fermentation broth comprising the organic acid; II) recovering the organic acid or the salt thereof from the fermentation broth obtained in process step I); wherein, at least for a certain period of time in process step I), the consumption rate of the further carbonaceous compound (CRc.c.; in g per liter per hour) is lower than the maximum theoretical consumption rate of the further carbonaceous compound (CRc.c. max; in g per liter per hour).
    Type: Application
    Filed: March 18, 2015
    Publication date: February 1, 2018
    Inventors: Esther Dantas Costa, Oskar Zelder, Hartwig Schröder, Stefan Haefner, Joanna Martyna Krawczyk, Gregory Von Abendroth, Christian Riedele, Torsten Renz
  • Patent number: 9850506
    Abstract: The present invention relates to a modified microorganism having, compared to its wild-type, a reduced activity of the enzyme that is encoded by the fruA-gene. The present invention also relates to a method for producing an organic compound and to the use of modified microorganisms.
    Type: Grant
    Filed: May 2, 2015
    Date of Patent: December 26, 2017
    Assignee: BASF SE
    Inventors: Joanna Martyna Krawczyk, Stefan Haefner, Hartwig Schröder, Esther Dantas Costa, Oskar Zelder, Gregory Von Abendroth