Patents by Inventor Hartwig Schroder
Hartwig Schroder has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20160194676Abstract: The present invention relates to genetically modified microorganisms capable of producing beta-glucans, characterized in that the genetically modified microorganism overexpresses (i) a polynucleotide encoding a polypeptide having 1,3-?-D-glucan synthase-activity, and/or (ii) a polypeptide having 1,3-?-D-glucan synthase-activity, compared to a corresponding non-modified control microorganism of the same strain. The present invention also relates to the use of a polynucleotide encoding a polypeptide having 1,3-?-D-glucan synthase-activity or the use of such a polypeptide for producing ?-glucans. Furthermore, the present invention relates to methods for producing ?-glucans comprising the introduction of a promoter upstream of a polynucleotide encoding a polypeptide having 1,3-?-D-glucan synthase-activity thereby increasing the expression of the polynucleotide, or a polynucleotide encoding a polypeptide having 1,3-?-D-glucan synthase-activity into a microorganism being able to synthesize ?-glucans.Type: ApplicationFiled: March 18, 2016Publication date: July 7, 2016Inventors: Beata Brockmann, Andrea Herold, Oskar Zelder, Stefan Haefner, Christian Fleck, Hartwig Schröder, Mari Granström, Julia Kristiane Schmidt
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Patent number: 9322041Abstract: The present invention relates to genetically modified microorganisms capable of producing beta-glucans, characterized in that the genetically modified microorganism overexpresses (i) a polynucleotide encoding a polypeptide having 1,3-?-D-glucan synthase-activity, and/or (ii) a polypeptide having 1,3-?-D-glucan synthase-activity, compared to a corresponding non-modified control microorganism of the same strain. The present invention also relates to the use of a polynucleotide encoding a polypeptide having 1,3-?-D-glucan synthase-activity or the use of such a polypeptide for producing ?-glucans. Furthermore, the present invention relates to methods for producing ?-glucans comprising the introduction of a promoter upstream of a polynucleotide encoding a polypeptide having 1,3-?-D-glucan synthase-activity thereby increasing the expression of the polynucleotide, or a polynucleotide encoding a polypeptide having 1,3-?-D-glucan synthase-activity into a microorganism being able to synthesize ?-glucans.Type: GrantFiled: July 3, 2013Date of Patent: April 26, 2016Assignees: BASF SE, Wintershall Holding GmbHInventors: Beata Brockmann, Andrea Herold, Oskar Zelder, Stefan Haefner, Christian Fleck, Hartwig Schröder, Mari Granström, Julia Kristiane Schmidt
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Publication number: 20150197776Abstract: The present invention relates to bacterial strains, capable of utilizing glycerol as a carbon source for the fermentative production of succinic acid, wherein said strains are genetically modified so that they comprise a deregulation of their endogenous pyruvate-formate-lyase enzyme activity, as well as to methods of producing organic acids, in particular succinic acid, by making use of such microorganism. The present invention also relates to the downstream processing of the produced organic acids by cation exchange chromatography.Type: ApplicationFiled: April 1, 2015Publication date: July 16, 2015Applicant: BASF SEInventors: Hartwig Schröder, Stefan Haefner, Gregory Von Abendroth, Rajan Hollmann, Aline Raddatz, Hansgeorg Ernst, Hans Gurski
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Publication number: 20150152453Abstract: The present invention relates to genetically modified microorganisms capable of producing beta-glucans, characterized in that said genetically modified microorganism overexpresses (i) a polynucleotide encoding a polypeptide having 1,3-?-D-glucan synthase-activity, and/or (ii) a polypeptide having 1,3-?-D-glucan synthase-activity, compared to a corresponding non-modified control microorganism of the same strain. The present invention also relates to the use of a polynucleotide encoding a polypeptide having 1,3-?-D-glucan synthase-activity or the use of such a polypeptide for producing ?-glucans. Furthermore, the present invention relates to methods for producing ?-glucans comprising the introduction of a promoter upstream of a polynucleotide encoding a polypeptide having 1,3-?-D-glucan synthase-activity thereby increasing the expression of said polynucleotide, or a polynucleotide encoding a polypeptide having 1,3-?-D-glucan synthase-activity into a microorganism being able to synthesize ?-glucans.Type: ApplicationFiled: July 3, 2013Publication date: June 4, 2015Inventors: Beata Brockmann, Andrea Herold, Oskar Zelder, Stefan Haefner, Christian Fleck, Hartwig Schröder, Mari Granström, Julia Kristine Schmidt
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Patent number: 9023632Abstract: The present invention relates to bacterial strains, capable of utilizing glycerol as a carbon source for the fermentative production of succinic acid, wherein said strains are genetically modified so that they comprise a deregulation of their endogenous pyruvate-formate-lyase enzyme activity, as well as to methods of producing organic acids, in particular succinic acid, by making use of such microorganism. The present invention also relates to the downstream processing of the produced organic acids by cation exchange chromatography.Type: GrantFiled: January 8, 2014Date of Patent: May 5, 2015Assignee: BASF SEInventors: Hartwig Schröder, Stefan Haefner, Gregory Von Abendroth, Rajan Hollmann, Aline Raddatz, Hansgeorg Ernst, Hans Gurski
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Patent number: 8883466Abstract: The present invention relates to a bacterial cell of the genus Pasteurella comprising a heterologous polypeptide having formate dehydrogenase activity. The present invention also relates to a method of manufacturing succinic acid and the use of the bacterial cell for the manufacture of succinic acid.Type: GrantFiled: December 21, 2009Date of Patent: November 11, 2014Assignee: BASF SEInventors: Edzard Scholten, Stefan Haefner, Hartwig Schröder
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Patent number: 8877466Abstract: The present invention is concerned with bacteria for the production of succinic acid. Specifically, the invention relates to a bacterial cell of the genus Pasteurella comprising a heterologous polypeptide having isocitrate lyase activity and a heterologous polypeptide having malate synthase activity. Further, the present invention contemplates a polynucleotide comprising a nucleic acid encoding a polypeptide having isocitrate lyase activity and a nucleic acid encoding a polypeptide having malate synthase activity. Finally, the present invention relates to the use of a bacterial cell of the invention for the manufacture of succinic acid.Type: GrantFiled: December 22, 2009Date of Patent: November 4, 2014Assignee: BASF SEInventors: Edzard Scholten, Stefan Haefner, Hartwig Schröder
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Publication number: 20140256005Abstract: The present invention relates to a novel method for the fermentative production of gamma-aminobutyric acid (GABA) by cultivating a recombinant microorganism expressing an enzyme having a glutamate decarboxylase activity. The present invention also relates to corresponding recombinant hosts, recombinant vectors, expression cassettes and nucleic acids suitable for preparing such hosts as well as to a method for preparing polyamides making use of GABA as obtained fermentative production.Type: ApplicationFiled: May 29, 2014Publication date: September 11, 2014Applicant: BASF SEInventors: Oskar Zelder, Weol Kyu Jeong, Corinna Klopprogge, Andrea Herold, Hartwig Schröder
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Publication number: 20140242704Abstract: The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered or caused transcription rate and/or expression rate, and methods for preparing biosynthetic products by cultivating the genetically modified microorganisms.Type: ApplicationFiled: May 8, 2014Publication date: August 28, 2014Applicant: BASF SEInventors: Oskar Zelder, Corinna Klopprogge, Burkhard Kröger, Hartwig Schröder, Stefan Haefner
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Patent number: 8771998Abstract: The present invention relates to a novel method for the fermentative production of gamma-aminobutyric acid (GABA) by cultivating a recombinant microorganism expressing an enzyme having a glutamate decarboxylase activity. The present invention also relates to corresponding recombinant hosts, recombinant vectors, expression cassettes and nucleic acids suitable for preparing such hosts as well as to a method for preparing polyamides making use of GABA as obtained fermentative production.Type: GrantFiled: February 20, 2009Date of Patent: July 8, 2014Assignee: BASF SEInventors: Oskar Zelder, Weol Kyu Jeong, Corinna Klopprogge, Andrea Herold, Hartwig Schröder
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Patent number: 8741623Abstract: Process for the production of cadaverine by constructing a recombinant microorganism which has a deregulated lysine decarboxylase gene and at least one deregulated gene selected from the group (i) which consists of aspartokinase, aspartatesemialdehyde dehydrogenase, dihydrodipicolinate synthase, dihydrodipicolinate reductase, tetrahydrodipicolinate succinylase, succinyl-amino-ketopimelate transaminase, succinyl-diamino-pimelate desuccinylase, diaminopimelate epimerase, diaminopimelate dehydrogenase, arginyl-tRNA synthetase, diaminopimelate decarboxylase, pyruvate carboxylase, phosphoenolpyruvate carboxylase, glucose-6-phosphate dehydrogenase, transketolase, transaldolase, 6-phosphogluconolactonase, fructose 1,6-biphosphatase, homoserine dehydrogenase, phophoenolpyruvate carboxykinase, succinyl-CoA synthetase, methylmalonyl-CoA mutase, provided that if aspartokinase is deregulated as gene (i) at least a second gene (i) other than aspartokinase has to be deregulated, and cultivating said microorganism.Type: GrantFiled: March 23, 2007Date of Patent: June 3, 2014Assignee: BASF SEInventors: Oskar Zelder, Weol Kyu Jeong, Corinna Klopprogge, Andrea Herold, Hartwig Schröder
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Patent number: 8735159Abstract: The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered or caused transcription rate and/or expression rate, and methods for preparing biosynthetic products by cultivating the genetically modified microorganisms.Type: GrantFiled: March 17, 2008Date of Patent: May 27, 2014Assignee: BASF SEInventors: Oskar Zelder, Corinna Klopprogge, Burkhard Kroger, Hartwig Schroder, Stefan Haefner
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Publication number: 20140141440Abstract: The invention pertains to/the field of production of natural products and, in particular, in the field of production of cornexistin and hydroxycornexistin. It provides polynucleotides encoding polypeptides involved in the biosynthesis of cornexistin and hydroxycornexistin as well as vectors and recombinant microorganisms comprising such polynucleotides. Also provided are methods for the production of natural products, in particular methods for the production of cornexistin and hydroxycornexistin, using such polynucleotides and polpeptides encoded therein, as well as vectors and recombinant microorganisms comprising such polynucleotides and polypeptides.Type: ApplicationFiled: November 19, 2013Publication date: May 22, 2014Applicant: BASF SEInventors: Oskar Zelder, Birgit Hoff, Hartwig Schröder, Andrea Molt, Holger Hartmann, Klaus Ditrich, Michael Breuer, Rüdiger Reingruber, Jakob Weber
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Patent number: 8728795Abstract: The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered or caused transcription rate and/or expression rate, and methods for preparing biosynthetic products by cultivating the genetically modified microorganisms.Type: GrantFiled: February 27, 2008Date of Patent: May 20, 2014Assignee: BASF SEInventors: Burkhard Kröger, Oskar Zelder, Corinna Klopprogge, Hartwig Schröder, Stefan Haefner
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Publication number: 20140127764Abstract: The present invention relates to bacterial strains, capable of utilizing glycerol as a carbon source for the fermentative production of succinic acid, wherein said strains are genetically modified so that they comprise a deregulation of their endogenous pyruvate-formate-lyase enzyme activity, as well as to methods of producing organic acids, in particular succinic acid, by making use of such microorganism. The present invention also relates to the downstream processing of the produced organic acids by cation exchange chromatography.Type: ApplicationFiled: January 8, 2014Publication date: May 8, 2014Applicant: BASF SEInventors: Hartwig Schröder, Stefan Haefner, Gregory Von Abendroth, Rajan Hollmann, Aline Raddatz, Hansgeorg Ernst, Hans Gurski
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Patent number: 8673598Abstract: The present invention relates to bacterial strains, capable of utilizing glycerol as a carbon source for the fermentative production of succinic acid, wherein said strains are genetically modified so that they comprise a deregulation of their endogenous pyruvate-formate-lyase enzyme activity, as well as to methods of producing organic acids, in particular succinic acid, by making use of such microorganism. The present invention also relates to the downstream processing of the produced organic acids by cation exchange chromatography.Type: GrantFiled: February 12, 2010Date of Patent: March 18, 2014Assignee: BASF SEInventors: Hartwig Schroder, Stefan Haefner, Gregory Von Abendroth, Rajan Hollmann, Aline Raddatz, Hansgeorg Ernst, Hans Gurski
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Publication number: 20140030778Abstract: The present invention relates to a novel bacterial strain designated DD1, which has the ability to produce organic acids, in particular succinic acid (SA), which was originally isolated from bovine rumen, and is capable of utilizing glycerol as a carbon source; and variant strains derived there from retaining said capability; as well as to methods of producing organic acids, in particular succinic acid by making use of said microorganism.Type: ApplicationFiled: October 3, 2013Publication date: January 30, 2014Applicant: BASF SEInventors: EDZARD SCHOLTEN, DIRK DAGELE, STEPHAN HAEFNER, HARTWIG SCHRODER
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Publication number: 20140011243Abstract: The present invention relates to genetically modified microorganisms capable of producing beta-glucans, characterized in that said genetically modified microorganism overexpresses (i) a polynucleotide encoding a polypeptide having 1,3-?-D-glucan synthase-activity, and/or (ii) a polypeptide having 1,3-?-D-glucan synthase-activity, compared to a corresponding non-modified control microorganism of the same strain. The present invention also relates to the use of a polynucleotide encoding a polypeptide having 1,3-?-D-glucan synthase-activity or the use of such a polypeptide for producing ?-glucans. Furthermore, the present invention relates to methods for producing ?-glucans comprising the introduction of a promoter upstream of a polynucleotide encoding a polypeptide having 1,3-?-D-glucan synthase-activity thereby increasing the expression of said polynucleotide, or a polynucleotide encoding a polypeptide having 1,3-?-D-glucan synthase-activity into a microorganism being able to synthesize ?-glucans.Type: ApplicationFiled: July 3, 2013Publication date: January 9, 2014Applicants: Wintershall Holding GmbH, BASF SEInventors: Beata Brockmann, Andrea Herold, Oskar Zelder, Stefan Haefner, Christian Fleck, Hartwig Schröder, Mari Granström, Julia Kristiane Schmidt
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Patent number: 8574875Abstract: The present invention relates to a novel bacterial strain designated DD1, which has the ability to produce organic acids, in particular succinic acid (SA), which was originally isolated from bovine rumen, and is capable of utilizing glycerol as a carbon source; and variant strains derived there from retaining said capability; as well as to methods of producing organic acids, in particular succinic acid by making use of said microorganism.Type: GrantFiled: August 14, 2008Date of Patent: November 5, 2013Assignee: BASF SEInventors: Edzard Scholten, Dirk Dägele, Stephan Haefner, Hartwig Schröder
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Patent number: 8399214Abstract: The present invention features improved processes and organisms for the production of methionine. The invention demonstrates that a ?metF organism or a ?metE AmetH organism, for example, mutants of C. glutamicum or E. coli, can use a methyl capped sulfide source, e.g., dimethyl disulfide (DMDS), as a source of both sulfur and a methyl group, bypassing the need for MetH/MetE and MetF activity and the need to reduce sulfate, for the synthesis of methionine. Also described in this patent are data implicating MetY (also called MetZ) as an enzyme that incorporates a methyl capped sulfide source, e.g., DMDS, into methionine. A ?metF ?metB strain of C. glutamicum can use a methyl capped sulfide source, e.g., DMDS, as a source of both sulfide and a methyl group. Furthermore, methionine production by engineered prototrophic organisms that overproduce O-acetyl-homoserine was improved by the addition of a methyl capped sulfide source, e.g., DMDS.Type: GrantFiled: July 18, 2006Date of Patent: March 19, 2013Assignee: Evonik Degussa GmbHInventors: Oskar Zelder, Stefan Haefner, Andrea Herold, Corinna Klopprogge, Hartwig Schroder, R. Rogers Yocum, Mark K. Williams