Patents by Inventor Haruaki Yajima

Haruaki Yajima has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of selectively sulfating peptides
    Patent number: 5059679
    Abstract: The invention provides a method and reagent for the modification of polypeptides useful in experimental research in the area of genetic engineering starting from a polypeptide such as hCCK-33 in an unsulfated form which contains Tyr and Ser and/or Thr residues by first protecting the amino-groups in the starting polypeptide, masking the OH-groups in the Ser and/or Thr residues and selectively sulfating the OH-groups in the Tyr residues after deprotection.
    Type: Grant
    Filed: March 30, 1989
    Date of Patent: October 22, 1991
    Assignee: Shin-Etsu CHemical Co., Ltd.
    Inventors: Haruaki Yajima, Nobutaka Fujii, Shinya Kiyama
  • Reagent for removing protective groups in peptide synthesis
    Patent number: 4950418
    Abstract: Reagent for removing protective groups employed in peptide synthesis comprises a combination of hard acid and soft base. The hard acid is trialkylsilyltrifluoromethanesulphonate R.sub.3 SiO.sub.3 SCF.sub.3 and the soft base is ether. The reagent provides high efficiency of deprotection and has a low tendency to cause side reaction.
    Type: Grant
    Filed: July 25, 1989
    Date of Patent: August 21, 1990
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Haruaki Yajima, Nobutaka Fujii, Gilberto M. A. Guterres, Tatsuhiko Honguu