Abstract: A lubrication-condition detector detects a lubricant shortage of a target portion that repeats a predetermined operation at a predetermined cycle. The lubrication-condition detector includes: a physical-quantity measuring unit for continuously measuring a physical quantity related to the target portion; and a computer for determining a presence of a lubricant shortage based on the physical quantity. The computer includes: a cycle extractor for extracting a cycle datum per an operational cycle from continuous data including the physical quantity and its measuring time; a representative-value calculator for calculating a representative value for each of plural cycle data; and determining unit for determining a presence of a lubricant shortage based on the plural representative values.

Abstract: A lubrication-condition detector detects a lubricant shortage of a target portion that repeats a predetermined operation at a predetermined cycle. The lubrication-condition detector includes: a physical-quantity measuring unit for continuously measuring a physical quantity related to the target portion; and a computer for determining a presence of a lubricant shortage based on the physical quantity. The computer includes: a cycle extractor for extracting a cycle datum per an operational cycle from continuous data including the physical quantity and its measuring time; a representative-value calculator for calculating a representative value for each of plural cycle data; and determining unit for determining a presence of a lubricant shortage based on the plural representative values.

Abstract: A lubrication-condition detector detects a lubricant shortage of a target portion that repeats a predetermined operation at a predetermined cycle. The lubrication-condition detector includes: a physical-quantity measuring unit for continuously measuring a physical quantity related to the target portion; and a computer for determining a presence of a lubricant shortage based on the physical quantity. The computer includes: a cycle extractor for extracting a cycle datum per an operational cycle from continuous data including the physical quantity and its measuring time; a representative-value calculator for calculating a representative value for each of plural cycle data; and determining unit for determining a presence of a lubricant shortage based on the plural representative values.

Abstract: A lubrication-condition detector detects a lubricant shortage of a target portion that repeats a predetermined operation at a predetermined cycle. The lubrication-condition detector includes: a physical-quantity measuring unit for continuously measuring a physical quantity related to the target portion; and a computer for determining a presence of a lubricant shortage based on the physical quantity. The computer includes: a cycle extractor for extracting a cycle datum per an operational cycle from continuous data including the physical quantity and its measuring time; a representative-value calculator for calculating a representative value for each of plural cycle data; and determining unit for determining a presence of a lubricant shortage based on the plural representative values.

Abstract: A die drive unit has a cylinder mechanism which hydraulically drives a piston member and an additional drive mechanism which drives the piston member by means of a drive source other than a hydraulic one. A first oil chamber is formed on one side of the piston member. A second oil chamber and a third oil chamber are formed on the other side of the piston member. The first oil chamber and the second oil chamber are connected to each other by an oil passage. The piston pressure receiving area of the first oil chamber is equal to the sum of those of the second and third oil chambers.

Abstract: A die drive unit has a cylinder mechanism which hydraulically drives a piston member and an additional drive mechanism which drives the piston member by means of a drive source other than a hydraulic one. A first oil chamber is formed on one side of the piston member. A second oil chamber and a third oil chamber are formed on the other side of the piston member. The first oil chamber and the second oil chamber are connected to each other by an oil passage. The piston pressure receiving area of the first oil chamber is equal to the sum of those of the second and third oil chambers.

Abstract: An indazole compound having a piperazinyl moiety in the structure thereof, which is a 5-HT.sub.4 receptor agonist which is useful in the treatment of digestive tract disorders.

Abstract: A combination of setting a correction value of an atmospheric temperature for each temporal section in response to a predicted value of a variation of the atmospheric temperature in a day and a delayed variation of a temperature of hydraulic oil due to thermal inertia and correcting a command value for a temperature regulation of the hydraulic oil at a supply source of the hydraulic oil in response to the correction value of the atmospheric temperature, performing a feed forward compensation of the temperature of the hydraulic oil with respect to the variation of the atmospheric temperature for the day as a cyclic period, permits a working body of hydraulic oil to be kept at an adequate temperature, even under working conditions subjected to significant influences of atmospheric temperature variations and thermal inertia.

Abstract: An indazole compound having the formula (I): wherein:R.sub.1 is hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 alkenyl or C.sub.3 -C.sub.6 cycloalkyl;Q is carbonyl, thiocarbonyl or methylene; andR.sub.2 is a group of the formula (II) or (IV); ##STR1## wherein R.sub.1 is C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 alkenyl or benzyl, of which a phenyl group thereof is optionally mono- or di-substituted by the same or different halogen or methoxy; m is 0 to 2; n and o is 1 or 2. The compound exhibits 5-HT.sub.4 receptor agonist activity.

Abstract: Novel diaminomethylidene derivatives represented by formula (I) ##STR1## wherein R.sup.1 is a hydrogen atom, a C.sub.1 -C.sub.6 alkyl group, a C.sub.3 -C.sub.6 cycloalkyl group and others, R.sup.2 is a group of the following formula ##STR2## and others, R.sup.3 is a hydrogen atom, a C.sub.1 -C.sub.6 alkyl group and others, X is O, S, CHNO.sub.2, C(COOR.sup.4).sub.2, C(COOR.sup.4)CN or C(CN).sub.2) or pharmacologically acceptable salts thereof.The above-mentioned compounds are useful as a gastrointestinal prokinetic agent to be used for the treatment of digestive tract diseases.

Abstract: Pyrimidine derivatives useful as a gastrointestinal prokinetic agent, represented by formula ##STR1## wherein X is O or NR.sup.5, Y is O, S or NR.sup.5 wherein R.sup.5 is a hydrogen atom, a C.sub.1 -C.sub.6 alkyl group or the like;R.sup.1 and R.sup.2 may be the same or different and each is a hydrogen atom, a C.sub.1 -C.sub.6 alkyl group or the like;R.sup.3 is CN, or COOR.sup.6 wherein R.sup.6 is a C.sub.1 -C.sub.6 alkyl group, a C.sub.3 -C.sub.6 cycloalkyl group, an aryl group or the like;R.sup.4 is --SR.sup.7 or --NR.sup.8 R.sup.9 wherein R.sup.7 is a C.sub.1 -C.sub.6 alkyl group;R.sup.8 is a C.sub.1 -C.sub.6 alkyl group or the like;R.sup.9 is a hydrogen atom, a C.sub.1 -C.sub.6 alkyl group or the like, or R.sup.8 and R.sup.9 may represent, together with the nitrogen atom to which they are attached, an N-substituted piperazine ring of formula (X) ##STR2## wherein R.sup.10 represents a C.sub.1 -C.sub.6 alkyl group or the like or a pharmacologically acceptable salt thereof.

Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof are selective agonists for 5-HT.sub.4 receptors. ##STR1## wherein Ak is a C.sub.3 -C.sub.6 alkyl group, and R is a C.sub.2 -C.sub.6 alkyl group, a C.sub.3 -C.sub.6 alkenyl group, a C.sub.3 -C.sub.6 alkynyl group, a C.sub.3 -C.sub.7 cycloalkyl group or a C.sub.3 -C.sub.6 cycloalkylmethyl group.

Abstract: Diazabicyclo derivatives of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein R is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, alkoxyalkyl, oxoalkyl, alkoxycarbonylalkyl, alkoxycarbonyl, acyl, dialkylaminoalkyl, hydroxyalkyl, haloalkyl, cyanoalkyl, heterocycloalkyl, aryl, heteroarylalkyl or arylalkyl, the aryl group and the aryl moiety being optionally substituted by alkoxy, nitro, alkyl, amino or halo;R.sup.2 is hydrogen or alkyl;R.sup.3 and R.sup.4 may be the same or different and each is hydrogen, alkyl, alkenyl, acyl, alkoxyalkyl or arylalkyl wherein the aryl moiety is optionally substituted by alkoxy, nitro, alkyl, amino or halo;with the proviso that when R.sup.2 is hydrogen and both R.sup.3 and R.sup.4 are methyl, R.sup.1 does not represent hydrogen, alkyl, unsubstituted benzyl or dimethylaminoethyl; having 5-HT.sub.3 receptor antagonist activity.

Abstract: Azabicyclo derivatives of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein A is a group of formula (a), (b) or (c): ##STR2## wherein R.sub.1 is hydrogen, C.sub.1 -C.sub.10 alkyl, aralkyl or di(C.sub.1 -C.sub.4) alkylamino(C.sub.1 -C.sub.6)alkyl;R.sub.2, R.sub.3 and R.sub.4 may be the same or different and each is hydrogen, amino, halogen, C.sub.1 -C.sub.4 alkoxy or phthalimide;X is O or NH;R is C.sub.1 -C.sub.4 alkyl; andY is NR, O or S;having 5-HT.sub.3 receptor antagonist activity.

Abstract: Disclosed are compounds of formula (I) ##STR1## in which A is ##STR2## The compounds are selective antagonists of 5HT at 5-HT.sub.3 receptors and useful in the treatment of psychotic disorders, neurotic diseases, gastric stasis symptoms, gastrointestinal disorders, nausea and vomiting.

Abstract: A method for the treatment of cerebrovascular contraction in mammals involving administration of a pharmaceutical composition containing as an effective ingredient a p-guanidinobenzoic acid derivative represented by the formula ##STR1## wherein R denotes a group represented by the formula ##STR2## or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

Abstract: Azabicyclo derivatives of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein A is a group of formula (a), (b) or (c): ##STR2## wherein R.sub.1 is hydrogen, C.sub.1 -C.sub.10 alkyl, aralkyl or di(C.sub.1 -C.sub.4) alkylamino(C.sub.1 -C.sub.6)alkyl;R.sub.2, R.sub.3 and R.sub.4 may be the same or different and each is hydrogen, amino, halogen, C.sub.1 -C.sub.4 alkoxy or phthalimide; X is O or NH;R is C.sub.1 -C.sub.4 alkyl; andY is NR, O or S;having 5-HT.sub.3 receptor antagonist activity.

Abstract: Disclosed are compounds of formula I ##STR1## wherein R.sub.1 is a hydrogen atom, a C.sub.1 -C.sub.6 alkyl group, benzyl or an indolyl carbonyl group, R.sub.2 is a saturated or unsaturated 5- or 8-membered heterocyclic group containing as a hetero atom one or more nitrogen atoms, the heterocyclic group is optionally substituted at an N or C atom by a C.sub.1 -C.sub.6 alkyl or aralkyl group, n is an integer of 1 to 5 and one or more hydrogen atoms, in an alkylene chain --(CH.sub.2).sub.n -- are optionally substituted by a C.sub.1 -C.sub.6 alkyl, phenyl and/or hydroxyl group, physiologically acceptable salts and quaternary ammonium salts thereof. The compounds are selective antagonists of 5-HT.sub.3 receptors and are useful in the treatment of psychotic disorders, neurotic diseases, gastric stasis symptoms, gastrointestinal disorders, nausea and vomiting.

Abstract: A process of preparing l-biopterin is disclosed which comprises the steps of:Subjecting to selective Grignard reaction D-ribose having the hydroxyl groups in the 2- and 3-positions protected by an acetal group to give 6-deoxy-3,4-O-alkylidene allitol;subjecting the 1- and 2-positions of said allitol to oxidative cleavage to form 5-deoxy-2,3-O-alkylidene-L-ribose followed by deacetalization to give 5-deoxy-L-ribose;reacting 5-deoxy-L-ribose with a hydrazine compound to form a 5-deoxy-L-ribose hydrazone compound; andsubjecting said hydrazone compound to condensation reaction with an acid addition salt of 4-hydroxy-2,5,6-triaminopyrimidine followed by oxidation.

Abstract: An apparatus for separating a balloon from a catheter member of a balloon is capable of melting and breaking a heat-meltable connecting member through which the balloon is connected to the catheter body by causing an electric current to flow between at least a pair of electrodes arranged on or in the vicinity of the connecting member. The apparatus has impedance measuring means for measuring the impedance of an electrode circuit including a pair of electrodes and lead lines connected to the electrodes, and judging means for comparing the measured value of the impedance with a predetermined reference range and capable of producing an abnormal signal when the measured value of the impedance does not fall within the predetermined reference range.