Abstract: To provide a new structure-dispersed composite in which a substance poorly soluble in a medium is dispersed as micronized particles, a core-shell structure is dispersed in the medium, wherein said core-shell structure contains microparticles therein, and consists of a core comp rising a core compound that is poorly soluble in said medium and a liquid shell comprising a shell compound that is poorly soluble in said medium, and the mean diameter of said core-shell structure is 10 ?m or less.

Abstract: The subject matter of the present invention is to provide a new particulate material dispersion composite in which a material poorly soluble in water is micronized and dispersed. For the above purpose, a particulate material dispersion composite is produced in the present invention, wherein a particulate material containing a specific material which is poorly soluble in water, a polymer and a lipid is dispersed in water, the mean diameter of said particulate material is 1 ?m or less, and the ratio of the combined weight of said polymer and said lipid to the weight of said specific material is 1.5 or larger.

Abstract: The present invention provides crystals of 6-[4-(4-pyridylamino)phenyl]-4,5-dihydro-3(2H)-pyridazinone hydrochloride trihydrate useful as a medicament for therapeutic treatment of cardiac failure, and the like; and a pharmaceutical composition comprising said crystals as an active ingredient. The crystal of the present invention has characteristic absorption peaks (2? degrees) at 12.9 (±0.2°) and 19.0 (±0.2°), for example, in powder X-ray diffractometry.

Abstract: A method of producing fine particle-like materials formed by a crystallization method, which producing method is capable of producing the fine particles with a narrow particle size distribution and also capable of inhibiting aggregation of the fine particles without using any dispersant; and the fine particle-like materials, are provided. The present method of producing the fine particles by crystallization comprises preparing a solution containing the material to be finely divided, and bringing this solution into contact with a substrate having the microprojections provided on its surface at a density of not less than 100 projections/cm2 to cause precipitation of the fine particles. The fine particles produced by the above method are those of physiological active materials containing no dispersant.

Abstract: There is provided a process for producing fine particles of an organic compound by a continuous-type poor solvent precipitation method which is capable of rapidly and uniformly dispersing an organic compound-containing solution in a large amount of a poor solvent, thereby more readily producing fine particles of the organic compound having a volume-average particle size of not more than 1 ?m. In the process for producing fine particles of an organic compound, the poor solvent in which the organic compound is hardly soluble, is continuously mixed with the organic compound-containing solution prepared by dissolving the organic compound in a good solvent which is miscible with the poor solvent and in which the organic compound is readily soluble, while irradiating an ultrasonic wave thereto.

Abstract: A process for the production of fullerenes by which a high-purity fullerene can be separated at high productivity from a mixture comprising a fullerene, a polycyclic aromatic hydrocarbon component, and a carbonaceous polymeric component and which comprises the step (A) of preparing a mixture comprising a fullerene, a polycyclic aromatic hydrocarbon component, and a carbonaceous polymeric component, the step (B) of separating this mixture into a polycyclic aromatic hydrocarbon component and a mixture of a fullerene and a carbonaceous polymeric component, and the step (C) of separating this mixture into a fullerene and a carbonaceous polymeric component.

Abstract: The present invention provides crystals of 6-[4-(4-pyridylamino)phenyl]-4,5-dihydro-3(2H)-pyridazinone hydrochloride trihydrate useful as a medicament for therapeutic treatment of cardiac failure, and the like; and a pharmaceutical composition comprising said crystals as an active ingredient.

Abstract: A method of separating 2,6-dimethylnaphthalene from a feed material containing a mixture of dimethylnaphthalene isomers comprises the steps of:adsorption separation using an adsorbent of a zeolite Y containing alkali metal or zinc and a desorbent of an organic solvent mainly composed of paraxylene and/or orthoxylene to obtain a solution consisting of the desorbent and the feed material containing 2,6-dimethylnaphthalene at a concentration of at least 60 wt % on the feed material other than desorbent; andcrystallization of the solution having a concentration of the desorbent at 30 to 90 wt % to obtain 2,6-dimehtylnaphthalene of high purity in a crystalline form.