Abstract: A mask structure includes a screen mask having a penetrating portion with a predetermined pattern. The screen mask includes a mesh portion having an opening formed in a grid pattern, and a mask portion having the penetrating portion and being fixed to the mesh portion so as to face the substrate. The mask portion includes a core portion that retains the shape of the mask portion, and a seal portion made of an elastic material softer than the material of the core portion and contacting the substrate.

Abstract: It is determined whether an imaginary component at a predetermined frequency of an alternating current impedance is equal to or more than a preliminarily set film-formable value or not. The metallic coating is formed in a state where the substrate is pressed by the solid electrolyte membrane when the imaginary component is equal to or more than the film-formable value in the determining. The metallic coating is formed in a state where the pressing of the substrate by the solid electrolyte membrane is released to separate the solid electrolyte membrane from the substrate, the solid electrolyte membrane is re-tensioned with a constant tensile force, and subsequently, the substrate is pressed by the re-tensioned solid electrolyte membrane when the imaginary component is smaller than the film-formable value in the determining.

Abstract: Provided is a method for producing platelets, in which damage to platelets is suppressed compared with a method in which platelets are separated using a filter from a megakaryocyte culture, and then the platelets are concentrated using a hollow fiber membrane and are further washed using the hollow fiber membrane, and purified platelets can be produced in a shorter period of time compared with the time that is taken to perform the above-described method so as to reduce damage to platelets. The method for producing purified platelets of the present invention includes a concentrating step of concentrating a megakaryocyte culture, and a centrifuging step of centrifuging platelets from an obtained concentrate.

Abstract: An endoscope treatment instrument having a sheath, a rotation axis extending in a width direction orthogonal to a longitudinal direction of the sheath, a plate formed with a first opening through which the rotation axis passes and a second opening having a width different from the width of the first opening, a forceps piece rotatably supported about the first opening and the rotation axis passing through the second opening, and a wire connected to a proximal end portion of the plate.

Abstract: A cell suspension treatment apparatus has a circulation circuit and a filling liquid supply source that supplies a filling liquid to the circulation circuit. The circulation circuit includes a hollow fiber membrane filter, a reservoir, a pump that is provided on a downstream side of the reservoir and on an upstream side of the hollow fiber membrane filter, and a valve that is provided on the downstream side of the reservoir and on an upstream side of the pump. The filling liquid supply source is connected to a portion of the circulation circuit between the first valve and the pump. After the concentrated cell suspension is stored in the reservoir, in a state where the valve is closed and the pump is driven, the filling liquid supply source starts supplying the filling liquid to the circulation circuit to push the cell suspension, which remains in a portion of the circulation circuit from the pump to the inlet port of the reservoir, to flow toward the reservoir by the filling liquid.

Abstract: The present invention provides a method for producing platelets that can improve at least one of the ability of megakaryocyte to produce platelets and the bioactivity of platelets produced even in high-density culture, for example. The method for producing platelets of the present invention includes a platelet producing step of producing platelets from megakaryocytes, wherein the platelet producing step is performed in the presence of at least one of glycine and cysteine.

Abstract: Provided is a high-frequency treatment tool including: a sheath; an electrode member being advancable and retractable in the sheath; a distal end member disposed at a distal end of the sheath, wherein the electrode member includes a columnar portion; an electrode distal end portion provided at a distal end of the columnar portion and radially extending in an outward direction; and a stopper portion disposed at a proximal end side of the columnar portion, the stopper portion having the shape of a solid of revolution about a center axis of the electrode member, the distal end member has a tapered inner surface narrowing toward the distal end, a recessed portion is formed in a portion of the stopper portion, the electrode distal end portion has a small-diameter portion recessed in a radial direction, and the channel and the small-diameter portion are located at the same position in the circumferential direction.

Abstract: The present invention provides a method for producing platelets, and the method comprises a step of culturing megakaryocytes in a culture solution in a culture vessel, wherein the culture solution is stirred with a stirrer in the culture step.

Abstract: The present invention provides a method for producing platelets, including the step of culturing megakaryocyte cells in a culture solution in a culture vessel, wherein in the culturing step, the culture solution is stirred by a stirring blade moving reciprocally.

Abstract: The present invention provides a method for producing platelets, and the method comprises a step of culturing megakaryocytes in a culture solution in a culture vessel, wherein the culture solution is stirred with a stirrer in the culture step.

Abstract: Provided is a high-frequency treatment tool including: a sheath; an electrode member being advancable and retractable in the sheath; a distal end member disposed at a distal end of the sheath, wherein the electrode member includes a columnar portion; an electrode distal end portion provided at a distal end of the columnar portion and radially extending in an outward direction; and a stopper portion disposed at a proximal end side of the columnar portion, the stopper portion having the shape of a solid of revolution about a center axis of the electrode member, the distal end member has a tapered inner surface narrowing toward the distal end, a recessed portion is formed in a portion of the stopper portion, the electrode distal end portion has a small-diameter portion recessed in a radial direction, and the channel and the small-diameter portion are located at the same position in the circumferential direction.