Patents by Inventor Haruki Takai
Haruki Takai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20070185168Abstract: For example, a piperidine derivative represented by following formula (I) (wherein, —C(?O)-Z- represents —C(?O)—CH2—, —C(?O)—C(CH3)2—, —C(?O)—NH—, —C(?O)—O—, —C(?O)—S—, —C(?O)—CH2CH2—, —C(?O)—CH?CH—, —C(?O)—CH2O—, —C(?O)—CH2S—, —C(?O)—CH2CH2CH2— or —C(?O)—NR8CH2—; R1 represents a hydrogen atom, substituted or unsubstituted lower alkyl, or the like; R2 represents a hydrogen atom or hydroxy; R3 represents a hydrogen atom, substituted or unsubstituted lower alkyl, or the like; R5 represents a hydrogen atom, hydroxy, or the like; R6 represents a hydrogen atom, hydroxy, substituted or unsubstituted lower alkyl, or the like, etc.Type: ApplicationFiled: April 7, 2005Publication date: August 9, 2007Inventors: Haruki Takai, Shunji Kunori, Shiro Shirakura, Katsumi Shinoda, Atsuko Mizutani, Koji Yamada, Shinichiro Toki, Tomoyuki Nishikawa
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Patent number: 6211227Abstract: The present invention provides tricyclic compounds which are useful for the treatment of pollakiuria and urinary incontinence and which are represented by general formula (I): (wherein R1 represents hydrogen, substituted or unsubstituted lower alkyl, etc.; X1—X2—X3 represents CR5═CR6—CR7═CR8 (wherein R5, R6, R7 and R8, which may be the same or different, each represents hydrogen, substituted or unsubstituted lower alkyl, hydroxy, substituted or unsubstituted lower alkoxy, etc.), N(O)m═CR5—CR6═CR7 (wherein R5, R6 and R7 have the same significances as defined above, and m represents 0 or 1), S—CR7═CR8 (wherein R7 and R8 have the same significances as defined above), etc.Type: GrantFiled: October 14, 1999Date of Patent: April 3, 2001Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Makoto Yoshida, Takashi Seishi, Shigeru Aono, Tsuyoshi Yamagata, Kaoru Atsuki, Toshiaki Kumazawa, Haruki Takai, Koji Suzuki, Akira Karasawa
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Patent number: 5948784Abstract: Disclosed are quinazoline derivatives represented by formula (I): wherein R.sup.1 represents hydrogen, lower alkyl, alkenyl, or aralkyl; R.sup.2, R.sup.3, R.sup.4, and R.sup.5 represent hydrogen, lower alkyl, lower alkoxy, lower alkanoyl, or the like; R.sup.6, R.sup.7, R.sup.8, and R.sup.9 represent hydrogen, lower alkyl, lower alkoxy, aralkyloxy, or the like, or any adjoining two of them are combined to form methylenedioxy or the like; R.sup.10 represents hydrogen, lower alkyl, or the like; R.sup.11 and R.sup.12 represent hydrogen, lower alkyl, cycloalkyl, phenyl, or aralkyl, or R.sup.11 and R.sup.12 are combined together with N to form a heterocyclic group; and n represents 0, 1 or 2, and pharmaceutically acceptable salts thereof. These compounds have adenosine uptake inhibitory activity and are useful for the protection of myocardium and for the prevention or treatment of renal diseases such as nephritis and diabetic nephropathy.Type: GrantFiled: June 3, 1998Date of Patent: September 7, 1999Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Shigeki Fujiwara, Yuko Okamura, Haruki Takai, Hiromi Nonaka, Takahiro Moriyama, Kozo Yao, Akira Karasawa
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Patent number: 5891902Abstract: The present invention relates to indole derivatives represented by formula (I): ##STR1## wherein R.sup.1 and R.sup.2 independently represent hydrogen, lower alkyl, hydroxy, lower alkoxy, halogen, --O--(CH.sub.2).sub.n --OR.sup.5, or ##STR2## R.sup.3 represents hydrogen, lower alkyl, or ##STR3## R.sup.4 represents hydroxy, lower alkoxy, substituted or unsubstituted aryloxy, or --NR.sup.10 R.sup.11, and X represents CO or SO.sub.2, with the proviso that when R.sup.3 is hydrogen or lower alkyl, and X is CO, R.sup.4 is --NR.sup.10 R.sup.11, or pharmaceutically acceptable salts thereof.Type: GrantFiled: July 15, 1996Date of Patent: April 6, 1999Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Daisuke Machii, Haruki Takai, Nobuo Kosaka, Hisakatsu Seo, Tomomi Sugiyama, Joji Nakamura, Hiroyuki Ishida, Katsushige Gomi, Soichiro Sato, Masako Uchii, Koji Suzuki
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Patent number: 5726325Abstract: The present invention relates to tricyclic compounds represented by general formula (I) which are useful as therapeutic agents for urinary incontinence: ##STR1## wherein R.sup.1 represents hydrogen and the like; --X.sup.1 --X.sup.2 --X.sup.3 -- represents --CR.sup.2 .dbd.CR.sup.3 --CR.sup.4 .dbd.CR.sup.5 -- (wherein R.sup.2, R.sup.3, R.sup.4, and R.sup.5 represent hydrogen and the like) and the like; and Y represents --CH.sub.2 O-- and the like.Type: GrantFiled: June 6, 1997Date of Patent: March 10, 1998Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Makoto Yoshida, Shin-ichi Sasaki, Shigeru Aono, Shigeki Fujiwara, Haruki Takai, Tsuyoshi Yamagata, Ken Nagashima, Akira Karasawa
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Patent number: 5698560Abstract: The present invention relates to imidazoquinazoline derivatives represented by formula (I): ##STR1## wherein R.sup.1 represents hydrogen, substituted or unsubstituted lower alkyl, cycloalkyl, lower alkenyl, substituted or unsubstituted aralkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroarylalkyl, or substituted or unsubstituted heteroaryl, R.sup.2 and R.sup.3 represent independently hydrogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted aralkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroarylalkyl, or substituted or unsubstituted heteroaryl, or R.sup.2 and R.sup.3 are combined to represent a heterocyclic group containing a nitrogen atom, R.sup.4 represents hydrogen or substituted or unsubstituted lower alkyl, X represents O or S, Y represents a single bond or O, n represents 0, 1, 2, or 3, and pharmaceutically acceptable salts thereof.Type: GrantFiled: October 23, 1996Date of Patent: December 16, 1997Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Yasuo Onoda, Shin-ichi Sasaki, Daisuke Machii, Haruki Takai, Tetsuji Ohno, Koji Yamada, Michio Ichimura, Hiroshi Kase
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Patent number: 5661147Abstract: The present invention relates to imidazoquinazoline derivatives represented by the general formula (I): ##STR1## or pharmacologically acceptable salts thereof. The compounds of the present invention have strong and selective cGMP-specific PDE inhibitory activity and are useful for treating or ameliorating cardiovascular diseases such as thrombosis, angina pectoris, hypertension, arterial sclerosis and the like, as well as asthma and the like.Type: GrantFiled: April 26, 1995Date of Patent: August 26, 1997Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Daisuke Machii, Kenji Matsuno, Iwao Kinoshita, Yuji Nomoto, Haruki Takai, Tetsuji Ohno, Ken Nagashima, Tomoko Ishikawa, Koji Yamada, Michio Ichimura, Hiroshi Kase
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Patent number: 5658917Abstract: The present invention relates to an adenosine uptake inhibitor and an agent for the myocardium protection or the prevention or treatment of inflammatory edema, comprising a 1,2,3,4-tetrahydro-2,4-dioxoquinazoline derivative represented by formula (I): ##STR1## wherein R.sup.1 represents hydrogen, substituted or unsubstituted lower alkyl, alkenyl, or substituted or unsubstituted aralkyl; R.sup.2, R.sup.3, R.sup.4, and R.sup.5 independently represent hydrogen, halogen, amino, mono- or di(lower alkyl)amino, lower alkanoylamino, nitro, cyano, substituted or unsubstituted lower alkyl, hydroxy, lower alkoxy, lower alkylthio, carboxy, lower alkoxycarbonyl, lower alkanoyl, aralkyloxy, or lower alkanoyloxy; R.sup.6, R.sup.7, R.sup.8, and R.sup.9 independently represent hydrogen, hydroxy, substituted or unsubstituted lower alkoxy, or aralkyloxy, or any adjoining two of them are combined to form methylenedioxy; R.sup.10 represents hydrogen or lower alkyl; and Y and Z independently represent N or C--R.sup.11 (wherein R.Type: GrantFiled: April 28, 1995Date of Patent: August 19, 1997Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Shigeki Fujiwara, Daisuke Machii, Haruki Takai, Hiromi Nonaka, Hiroshi Kase, Kozo Yao, Michiyo Kawakage, Hideaki Kusaka, Akira Karasawa
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Patent number: 5648353Abstract: The present invention relates to an adenosine uptake inhibitor and an agent for the myocardium protection or the prevention or treatment of inflammatory edema, comprising a 1,2,3,4-tetrahydro-2,4-dioxoquinazoline derivative represented by formula (I): ##STR1## wherein R.sup.1 represents hydrogen, substituted or unsubstituted lower alkyl, alkenyl, or substituted or unsubstituted aralkyl; R.sup.2, R.sup.3, R.sup.4, and R.sup.5 independently represent hydrogen, halogen, amino, mono- or di(lower alkyl)amino, lower alkanoylamino, nitro, cyano, substituted or unsubstituted lower alkyl, hydroxy, lower alkoxy, lower alkylthio, carboxy, lower alkoxycarbonyl, lower alkanoyl, aralkyloxy, or lower alkanoyloxy; R.sup.6, R.sup.7, R.sup.8, and R.sup.9 independently represent hydrogen, hydroxy, substituted or unsubstituted lower alkoxy, or aralkyloxy, or any adjoining two of them are combined to form methylenedioxy; R.sup.10 represents hydrogen or lower alkyl; and Y and Z independently represent N or C--R.sup.11 (wherein R.Type: GrantFiled: May 22, 1995Date of Patent: July 15, 1997Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Shigeki Fujiwara, Daisuke Machii, Haruki Takai, Hiromi Nonaka, Hiroshi Kase, Kozo Yao, Michiyo Kawakage, Hideaki Kusaka, Akira Karasawa
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Patent number: 5624926Abstract: The present invention relates to an adenosine uptake inhibitor and an agent for the myocardium protection or the prevention or treatment of inflammatory edema, comprising a 1,2,3,4-tetrahydro-2,4-dioxoquinazoline derivative represented by formula (I): ##STR1## wherein R.sup.1 represents hydrogen, substituted or unsubstituted lower alkyl, alkenyl, or substituted or unsubstituted aralkyl; R.sup.2, R.sup.3, R.sup.4, and R.sup.5 independently represent hydrogen, halogen, amino, mono- or di(lower alkyl)amino, lower alkanoylamino, nitro, cyano, substituted or unsubstituted lower alkyl, hydroxy, lower alkoxy, lower alkylthio, carboxy, lower alkoxycarbonyl, lower alkanoyl, aralkyloxy, or lower alkanoyloxy; R.sup.6, R.sup.7, R.sup.8, and R.sup.9 independently represent hydrogen, hydroxy, substituted or unsubstituted lower alkoxy, or aralkyloxy, or any adjoining two of them are combined to form methylenedioxy; R.sup.10 represents hydrogen or lower alkyl; and Y and Z independently represent N or C--R.sup.11 (wherein R.Type: GrantFiled: October 17, 1994Date of Patent: April 29, 1997Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Shigeki Fujiwara, Daisuke Machii, Haruki Takai, Hiromi Nonaka, Hiroshi Kase, Kozo Yao, Michiyo Kawakage, Hideaki Kusaka, Akira Karasawa
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Patent number: 5605900Abstract: The present invention relates to an adenosine uptake inhibitor and an agent for the myocardium protection or the prevention or treatment of inflammatory edema, comprising a 1,2,3,4-tetrahydro-2,4-dioxoquinazoline derivative represented by formula (I): ##STR1## wherein R.sup.1 represents hydrogen, substituted or unsubstituted lower alkyl, alkenyl, or substituted or unsubstituted aralkyl; R.sup.2, R.sup.3, R.sup.4, and R.sup.5 independently represent hydrogen, halogen, amino, mono- or di(lower alkyl)amino, lower alkanoylamino, nitro, cyano, substituted or unsubstituted lower alkyl, hydroxy, lower alkoxy, lower alkylthio, carboxy, lower alkoxycarbonyl, lower alkanoyl, aralkyloxy, or lower alkanoyloxy; R.sup.6, R.sup.7, R.sup.8, and R.sup.9 independently represent hydrogen, hydroxy, substituted or unsubstituted lower alkoxy, or aralkyloxy, or any adjoining two of them are combined to form methylenedioxy; R.sup.10 represents hydrogen or lower alkyl; and Y and Z independently represent N or C-R.sup.11 (wherein R.Type: GrantFiled: April 28, 1995Date of Patent: February 25, 1997Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Shigeki Fujiwara, Daisuke Machii, Haruki Takai, Hiromi Nonaka, Hiroshi Kase, Kozo Yao, Michiyo Kawakage, Hideaki Kusaka, Akira Karasawa
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Patent number: 5523464Abstract: The present invention relates to benzenesulfonamide derivatives represented by Formula (I): ##STR1## in which R.sup.1 and R.sup.2 independently represent hydrogen or lower alkanoyl; and R.sup.3 and R.sup.4 independently represent hydrogen, lower alkyl, cycloalkyl, substituted or unsubstituted polycycloalkyl, substituted aryl, or a substituted or unsubstituted heterocyclic group, or R.sup.3 and R.sup.4 are combined together with the adjacent nitrogen atom to form a substituted or unsubstituted aliphatic heterocyclic group, or a pharmaceutically acceptable salt thereof. The derivatives are useful as therapeutic agents for osteoporosis.Type: GrantFiled: June 30, 1994Date of Patent: June 4, 1996Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Iwao Kinoshita, Haruki Takai, Nobuo Kosaka, Katsura Sugawara, Akio Ishii, Hiroyuki Ishida, Katsushige Gomi
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Patent number: 5413997Abstract: A triphenylmethane derivative represented by the following general formula: ##STR1## exhibits bone absorption inhibiting effects and is useful as a medicament for treating osteoporosis.Type: GrantFiled: January 21, 1993Date of Patent: May 9, 1995Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Iwao Kinoshita, Daisuke Machii, Yasuo Onoda, Haruki Takai, Nobuo Kosaka, Katsuichi Shuto, Katsushige Gomi, Makoto Morimoto, Akio Ishii
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Patent number: 5374634Abstract: There is provided a pyridine derivative represented by the formula (I) ##STR1## wherein each of R.sup.1 and R.sup.2 independently represents hydrogen or lower alkyl and each of R.sup.3 and R.sup.4 independently represents hydrogen, lower alkyl, alicyclic alkyl, substituted or unsubstituted polycyclic alkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heterocyclic group, or R.sup.3 and R.sup.4 are combined with nitrogen atom adjacent thereto to form a substituted or unsubstituted alicyclic heterocyclic group, or pharmaceutically acceptable salt thereof. The pyridine derivative exhibits bone resorption inhibiting effect and is useful as a medicament for treating osteoporosis.Type: GrantFiled: July 1, 1993Date of Patent: December 20, 1994Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Iwao Kinoshita, Yasuo Onoda, Haruki Takai, Nobuo Kosaka, Akio Ishii, Joji Nakamura, Hiroyuki Ishida, Katsushige Gomi
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Patent number: 5112867Abstract: A triphenylmethane derivative represented by the following general formula: ##STR1## exhibits born absorption inhibiting effects and is useful as a medicament for treating osteoporosis.Type: GrantFiled: April 27, 1990Date of Patent: May 12, 1992Assignee: Kyowa Hakko Gogyo Co., Ltd.Inventors: Iwao Kinoshita, Daisuke Machii, Yasuo Onoda, Haruki Takai, Nobuo Kasaka, Katsuichi Shuto, Katsushige Gomi, Makoto Morimoto, Akio Ishii
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Patent number: 5063227Abstract: Compounds of the formula ##STR1## wherein R.sub.3 is H or alkyl, Q.sub.1 and Q.sub.2 are independently hydrogen, alkyl, hydroxyl, alkoxyl, amino, mono or di alkylamino, nitro or halo or pharmaceutically acceptable salts are useful as cardiotonics.Type: GrantFiled: January 11, 1990Date of Patent: November 5, 1991Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Yuji Nomoto, Haruki Takai, Tetsuji Ohno, Kazuhiro Kubo
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Patent number: 4833674Abstract: In order to process data transmitted from a plurality of earth stations in a TDMA communications system with high speed, the data transmitted chronologically over a multiframe and written into a first memory according to first discriminating signals in a manner as to be grouped with respect to the earth stations, are then read out from the first memory according to second discriminating signals stored in a second memory irrespective of the received order. The data read out from the first memory are arranged in a manner as to be processed with ease in the subsequent unit.Type: GrantFiled: October 22, 1985Date of Patent: May 23, 1989Assignee: NEC CorporationInventors: Haruki Takai, Mikio Ujiie
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Patent number: 4797678Abstract: One of patterns representative of instants along each TDMA frame is selected as a selected pattern in response to a unique word detection pulse produced in a current frame. With the unique word detection pulse used as a write pulse, a memory memorizes the selected pattern as a memorized pattern in a memory cell accessed by one of burst identifying flags which identify time slots in the current frame, respectively. The memorized pattern is produced as a read-out pattern when accessed by the burst identifying flag which corresponds in a next succeeding frame to the above-mentioned one burst identifying flag. A calculator produces offset representing patterns. Upon coincidence of each read-out pattern and one of the offset representing patterns, a comparator produces a receive position predicting pulse predictive of a position or a unique word detection window in the next succeeding frame.Type: GrantFiled: June 13, 1985Date of Patent: January 10, 1989Assignee: NEC CorporationInventors: Akira Tsuji, Haruki Takai
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Patent number: 4712212Abstract: A terminal control device for a reference station in a TDMA satellite communication system includes means for generating a parallel acquisition window applicable to a parallel initial acquisition system and a sequential acquisition window applicable to a sequential initial acquisition system each in a TDMA frame, and selector means for selecting either one of the two different kinds of windows. The device selectively uses the two different acquisition systems and, thereby, accomplishes the advantages of both of the systems at the same time, i.e. short terminal buildup time and high TDMA frame utilization efficiency.Type: GrantFiled: January 21, 1986Date of Patent: December 8, 1987Assignee: NEC CorporationInventors: Haruki Takai, Mikio Ujiie, Hideki Nakamura
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Patent number: 4668683Abstract: Quinazoline derivatives and their pharmaceutically acceptable acid addition salts having the general formula ##STR1## wherein R.sup.1 and R.sup.2 each represents hydrogen or alkyl;R.sup.3 represents alkyl or substituted alkyl;R.sup.7 and R.sup.8 each represent alkoxy;Z is oxygen or sulfur;m is zero or 1;n is zero or an integer from 1 to 5,exhibit a cardiotonic activity with little tendency to cause tachycardia.Type: GrantFiled: March 20, 1986Date of Patent: May 26, 1987Assignee: Kyowa Hakko Kogyo K.K.Inventors: Haruki Takai, Yuji Nomoto, Tadashi Hirata, Tetsuji Ohno, Kazuhiro Kubo