Patents by Inventor Haruko Hirashima

Haruko Hirashima has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystals of isopropyl ester of N-(2,6-dichlorobenzoyl)-4-[6-(methylamino)methyl-1-methyl-2,4-dioxo-1,4-dihydroquinazoline-3(2H)-yl]-l-phenylalanine hydrochloride, production method thereof and use thereof
    Patent number: 8268844
    Abstract: Crystals of isopropyl ester of N-(2,6-dichlorobenzoyl)-4-[6-(methylamino)methyl-1-methyl-2,4-dioxo-1,4-dihydroquinazoline-3(2H)-yl]-L-phenylalanine hydrochloride: are useful as ?4 integrin inhibitors.
    Type: Grant
    Filed: September 20, 2010
    Date of Patent: September 18, 2012
    Assignee: Ajinomoto Co., Inc.
    Inventors: Koichi Fujita, Shinichiro Takahashi, Tatsuya Okuzumi, Tatsuhiro Yamada, Kotaro Okado, Noriyasu Kataoka, Haruko Hirashima, Hideyuki Yamaguchi
  • Aniline derivatives
    Patent number: 7879863
    Abstract: The present invention provides a novel compound having a kininogenase-inhibitory action and its pharmaceutical use. The compounds are represented by the formulas (A), (B), (C), (E) and (H): wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: September 29, 2006
    Date of Patent: February 1, 2011
    Assignee: Ajinomoto Co., Inc.
    Inventors: Munetaka Tokumasu, Masayuki Sugiki, Haruko Hirashima, Hideki Matsumoto, Toshihiko Yoshimura, Yasuko Nogi, Mitsuo Takahashi, Manabu Kitazawa, Akiko Oonuki, Naoyuki Fukuchi, Yoichiro Shima
  • CRYSTALS OF ISOPROPYL ESTER OF N-(2,6-DICHLOROBENZOYL)-4-[6-(METHYLAMINO)METHYL -1-METHYL-2,4-DIOXO-1,4-DIHYDROQUINAZOLINE-3(2H)-YL]-L- PHENYLALANINE HYDROCHLORIDE, PRODUCTION METHOD THEREOF AND USE THEREOF
    Publication number: 20110009434
    Abstract: Crystals of isopropyl ester of N-(2,6-dichlorobenzoyl)-4-[6-(methylamino)methyl-1-methyl-2,4-dioxo-1,4-dihydroquinazoline-3(2H)-yl]-L-phenylalanine hydrochloride are useful as ?4 integrin inhibitors.
    Type: Application
    Filed: September 20, 2010
    Publication date: January 13, 2011
    Applicant: AJINOMOTO CO., INC.
    Inventors: Koichi FUJITA, Shinichiro Takahashi, Tatsuya Okuzumi, Tatsuhiro Yamada, Kotaro Okado, Noriyasu Kataoka, Haruko Hirashima, Hideyuki Yamaguchi
  • Crystals of isopropyl ester of N-(2,6-dichlorobenzoyl)-4-[6-(methylamino)methyl-1-methyl-2,4-dioxo-1,4-dihydroquinazoline-3(2H)-yl]-L-phenylalanine hydrochloride, production method thereof and use thereof
    Patent number: 7842700
    Abstract: Crystals of isopropyl ester of N-(2,6-dichlorobenzoyl)-4-[6-(methylamino)methyl-1-methyl-2,4-dioxo-1,4-dihydroquinazoline-3(2H)-yl]-L-phenylalanine hydrochloride are useful as ?4 integrin inhibitors.
    Type: Grant
    Filed: December 21, 2007
    Date of Patent: November 30, 2010
    Assignee: Ajinomoto Co., Inc.
    Inventors: Koichi Fujita, Shinichiro Takahashi, Tatsuya Okuzumi, Tatsuhiro Yamada, Kotaro Okado, Noriyasu Kataoka, Haruko Hirashima, Hideyuki Yamaguchi
  • POLY(AMINO ACID) COMPOUND HAVING INHIBITORY ACTIVITY ON ABSORPTION OF PHOSPHORUS AND PHOSPHORUS ABSORPTION INHIBITOR
    Publication number: 20100093973
    Abstract: Herein disclosed is a water-soluble compound represented by the following general formula (I) or a salt thereof. The compound is a novel water-soluble compound having an inhibitory effect on the absorption of phosphorus in vivo. where the structural variables are defined herein.
    Type: Application
    Filed: August 27, 2009
    Publication date: April 15, 2010
    Applicant: AJINOMOTO CO., INC.
    Inventors: Tadakiyo Nakagawa, Hironobu Tsugeno, Naomi Matsutani, Masayuki Sugiki, Haruko Hirashima, Tatsuya Okuzumi, Tatsuya Kasahara, Wataru Miyanaga, Takashi Yamamoto, Masatsugu Noguchi, Kayo Matsumoto, Hideyuki Tanaka, Tomoyuki Konda
  • CRYSTALS OF PHENYLALANINE DERIVATIVES, PRODUCTION METHOD THEREOF AND USE THEREOF
    Publication number: 20080108637
    Abstract: The present invention discloses crystals of phenylalanine derivatives which have a specific structural formula, and particularly crystals which are easy to be used; crystals excellent in preservation stability, humidity resistance or solubility; and crystals which can be manufactured on the industrial scale. The present invention also discloses the production method thereof and use thereof, and particularly the use thereof as an active ingredient of pharmaceutical compositions.
    Type: Application
    Filed: December 21, 2007
    Publication date: May 8, 2008
    Applicant: AJINOMOTO CO., INC.
    Inventors: Koichi FUJITA, Shinichiro Takahashi, Tatsuya Okuzumi, Tatsuhiro Yamada, Kotaro Okado, Noriyasu Kataoka, Haruko Hirashima, Hideyuki Yamaguchi
  • ANILINE DERIVATIVES
    Publication number: 20070066586
    Abstract: The present invention provides a novel compound having a kininogenase-inhibitory action and its pharmaceutical use. The compounds are represented by the formulas (A), (B), (C), (E) and (H): wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: September 29, 2006
    Publication date: March 22, 2007
    Inventors: Munetaka Tokumasu, Masayuki Sugiki, Haruko Hirashima, Hideki Matsumoto, Toshihiko Yoshimura, Yasuko Nogi, Mitsuo Takahashi, Manabu Kitazawa, Akiko Oonuki, Naoyuki Fukuchi, Yoichiro Shima