Patents by Inventor Harumi Uenoyama
Harumi Uenoyama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6887430Abstract: A total reflection cell has a total reflection prism on at least one surface thereof. A mixed solution containing a gold colloid labelled antibody which is adsorbed on a gold colloid is stored in the total reflection cell, and a sample solution containing an antigen causing antigen-antibody reaction with the antibody is added thereto for forming a gold colloid labelled immune complex. A measuring beam is introduced into the total reflection prism from an incident optical system at an angle ? of incidence causing total reflection and an outgoing beam from the total reflection prism is received by a measuring optical system, thereby measuring absorption by the gold colloid labelled immune complex and carrying out qualification and determination of the antigen.Type: GrantFiled: March 12, 1999Date of Patent: May 3, 2005Assignee: Kyoto Dai-Ichi Kagaku Co., Ltd.Inventors: Xiaoming Dou, Yoshinori Yamaguchi, Harumi Uenoyama
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Patent number: 6612986Abstract: A dispersed-type testing/measuring system provides for example a simplified terminal unit to be installed at a patient's home. The dispersed-type testing/measuring system has a central controlling unit 20 and a plurality of terminal units 30 each accessible to the central controlling unit via a communication line 15. Each terminal unit 30 includes a crude data collecting portion 40, and a data transmitting means 45 for sending the data collected by the crude data collecting portion 40 to the central controlling unit 20. The central controlling unit 20 includes a measurement data calculating means 210 for generating measurement data by making calculation on the crude data sent from each terminal unit 30.Type: GrantFiled: March 7, 2001Date of Patent: September 2, 2003Assignee: Kyoto Daiichi Kagaku Co., Ltd.Inventors: Shigeru Doi, Harumi Uenoyama, Yoshinori Yamaguchi
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Publication number: 20010009972Abstract: A dispersed-type testing/measuring system provides for example a simplified terminal unit to be installed at a patient's home.Type: ApplicationFiled: March 7, 2001Publication date: July 26, 2001Applicant: KYOTO DAIICHI KAGAKU CO., LTD.Inventors: Shigeru Doi, Harumi Uenoyama, Yoshinori Yamaguchi
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Patent number: 6221009Abstract: A dispersed-type testing/measuring system provides for example a simplified terminal unit to be installed at a patient's home. The dispersed-type testing/measuring system has a central controlling unit (20) and a plurality of terminal units 30 each accessible to the central controlling unit via a communication line (15). Each terminal unit (30) includes a crude data collecting portion (40), and a data transmitting means 45 for sending the data collected by the crude data collecting portion 40 to the central controlling unit (20). The central controlling unit 20 includes a measurement data calculating means (210) for generating measurement data by making calculation on the crude data sent from each terminal unit (30).Type: GrantFiled: March 9, 1999Date of Patent: April 24, 2001Assignee: Kyoto Daiichi Kagaku Co., Ltd.Inventors: Shigeru Doi, Harumi Uenoyama, Yoshinori Yamaguchi
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Patent number: 6147749Abstract: To project measuring light with good reproducibility onto the measuring part of a measured object so that measurement conditions can always be constant. An optical measuring apparatus is equipped with a spectroscopic analyzer that detects the spectral intensity of the reflected light of measuring light projected onto a human hand. Spectroscopic analyzer moves in the direction" of the X-axis, Y axis, and Z axis, and around the Z axis by a moving mechanism. During the registration of the measuring part of the human hand, a CCD camera takes a picture of the human hand, and the operator selects a part having a feature from the pattern of the taken image. During the spectrometry, the CCD camera again takes a picture of the human hand. The optical measuring apparatus then detects the registered feature part on the currently taken image, moves spectroscopic analyzer by moving mechanism, and projects measuring light onto the registered feature part.Type: GrantFiled: April 29, 1997Date of Patent: November 14, 2000Assignees: Kyoto Daiichi Kagaku Co., LTD, Kurashiki Boseki Kabushiki KaishaInventors: Hiroko Kubo, Yoshio Mitsumura, Harumi Uenoyama, Kexin Xu
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Patent number: 6125292Abstract: A sensor includes an analyzing part and a passage having two ends. One end of the passage is connected to the analyzing part. The other end of the passage is closed before use so that the inside of the passage and the analyzing part is sealed to prevent a contact with the outside. When the sensor is to be used, the other end of the passage is opened so as to provide an inlet for a sample.Type: GrantFiled: December 7, 1998Date of Patent: September 26, 2000Assignee: Kyoto Daiichi Kagaku Co., Ltd.Inventors: Harumi Uenoyama, Kohei Ishida
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Patent number: 5942754Abstract: A sample solution is stored in a total reflection cell, and a measuring beam is introduced from an incident optical system to be totally reflected, for measuring a total reflection absorption spectrum. Hydrogen peroxide contained in the sample solution is determined on the basis of absorbance at the position of any absorption peak of the spectrum which is present at 1200 to 1500 cm.sup.-1 or 2600 to 3000 cm.sup.-1. Hydrogen peroxide contained in an aqueous solution can be simply quantitatively analyzed through optical analysis.Type: GrantFiled: November 27, 1995Date of Patent: August 24, 1999Assignee: Kyoto Dai Ichi Kagaku Co., Ltd.Inventors: Yoshinori Yamaguchi, Masayuki Yagi, Dou Xiaoming, Emi Ashibe, Harumi Uenoyama
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Patent number: 5891029Abstract: To secure a highly accurate measurement value of biological information with minimized variation by positioning a target part of a living body with good reproducibility and by positioning the target part of the living body easily with high reproducibility without pressing blood vessels in the living body. The concentration of a particular component in the living body is measured by the use of a transmitted or reflected spectrum obtained by projecting light onto the target part of the living body. A biological information measuring template 2 includes a shape memory medium 6 having a contact surface which, when the target part is pressed to the contact surface, undergoes change according to the shape of the target part, to thereby store the shape. The target part 1 of the living body is arranged at a store portion of the shape memory medium and is illuminated by light.Type: GrantFiled: February 7, 1997Date of Patent: April 6, 1999Assignees: Kyoto Daiichi Kagaku Co., Ltd., Kurashiki Boseki Kabushiki KaishaInventors: Koji Matsuoka, Yoshio Mitsumura, Harumi Uenoyama, Kexin Xu
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Patent number: 5870188Abstract: An excitation beam from a laser is passed through a bandpass filter, and applied to a sample by a collimator lens. An optical adjusting part comprising a camera lens and a converging lens is provided for receiving scattered light from the sample, so that the camera lens receives the scattered light and converts the same to a parallel beam. The converging lens has chromatic aberration, and receives and converges the parallel beam from the camera lens. An inlet slit of a spectroscope is provided as an inlet port on a converging position by the converging lens. This inlet slit is a circular hole having a diameter of about 200 .mu.m. The inlet slit is arranged on a position for converging anti-Stokes-Raman scattered light through the chromatic aberration of the converging lens.Type: GrantFiled: September 19, 1996Date of Patent: February 9, 1999Assignee: Kyoto Dei-ichi, Kagaku Co. Ltd.Inventors: Yukihiro Ozaki, Yoshinori Yamaguchi, Xiaoming Dou, Harumi Uenoyama
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Patent number: 5856117Abstract: This invention provides a method for measuring the concentration of urinary trypsin inhibitors which is excellent in precision and reproducibility, whose operation is simple, and in which a possibility of damaging a plastic cell is eliminated. The method for measuring the concentration of urinary trypsin inhibitors comprises mixing an urine sample, a protease solution containing trypsin, and a buffer solution, adding a substrate solution to the mixture to cause the enzyme reaction, and measuring the activity of the enzyme, wherein the buffer solution is prepared so that it contains at least 0.15 .mu.mol calcium per 1 .mu.g of the trypsin but no more than 100 .mu.Type: GrantFiled: June 20, 1997Date of Patent: January 5, 1999Assignee: Kyoto Daiichi Kagaku Co., Ltd.Inventors: Harumi Uenoyama, Kyouichi Ohshiro, Atsuko Nanbu, Satoshi Fukunaga
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Patent number: 5815260Abstract: A concave urine collector is set under a front end portion of a stool body, so that urine can be collected in a bowl. Single fiber holes are set on a front end and a left side of the urine collector respectively, while condenser lenses for condensing light on the bowl side, an excitation light fiber member carrying excitation light from an excitation light source and a Raman light receiving fiber member for receiving Raman light are set in the fiber holes respectively. The excitation light fiber member is connected with the excitation light source, and the Raman light receiving fiber member communicates with a spectro-detector. A Raman signal separated into its spectral components detected by the spectro-detector is data-processed by a data processing part, and outputted from a data output part as a measurement result.Type: GrantFiled: October 17, 1996Date of Patent: September 29, 1998Assignee: Kyoto Dai-ichi Kagaku Co., Ltd.Inventors: Xiaoming Dou, Harumi Uenoyama, Yung Xiang Wang, Koji Matsuoka
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Patent number: 5772606Abstract: A urinal is provided on its forward end with a cell, which internally communicates with the urinal to outwardly project from the same. A measuring part comprises a light source part for applying a measuring beam of the visible or near infrared wavelength region to the cell which is set in a cell setting part and a light receiving part for receiving and detecting the measuring beam transmitted through the cell, and measures absorbances of uric components to be measured at wavelengths selected therefor respectively. A sensor part is adapted to detect that the cell is set in the cell setting part, so that the measuring part starts a measuring operation on the basis of a signal indicating that the sensor detects the cell. It is possible to carry out a urine test on a person who lies on bed.Type: GrantFiled: March 3, 1995Date of Patent: June 30, 1998Assignee: Kyoto Dai-Ichi Kagaku Co., Ltd.Inventors: Emi Ashibe, Takeshi Sakura, Harumi Uenoyama, Xu Kexin, Hiroko Kubo
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Patent number: 5754289Abstract: A Raman scattered light measuring apparatus comprises a near infrared semiconductor laser diode as a light source for irradiating a sample with excitation light, while a photoreceiving part for receiving Raman scattered light from the sample comprises a bandpass filter having a vibration wavenumber which is specific to a sample component to be measured as a central wavelength of its transmission region, and a detector consisting of a photodiode of Ge, InAs or InGaAs or a photomultiplier having sensitivity in a near infrared region for detecting Raman scattered light which is transmitted through the bandpass filter.Type: GrantFiled: December 27, 1996Date of Patent: May 19, 1998Assignee: Kyoto Dai-ichi Kagaku Co., Ltd.Inventors: Yukihiro Ozaki, Xiaoming Dou, Yoshinori Yamaguchi, Harumi Uenoyama
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Patent number: 5753449Abstract: An excitation beam generated from a light source is separated into a measuring beam and a reference beam by an optical path adjusting optical system including a beam splitter, so that the measuring beam is applied to a sample in a cell. Raman scattering light which is generated from the sample is detected by a spectral detector including a spectroscope through a scattering light path adjusting optical system and a wavelength selector. In a spectrum obtained by the spectral detector, a peak of Raman scattering in which wavenumber shift from the wavelength of the excitation beam is present at 800 to 920 cm.sup.-1 is employed to make quantitative measurement of hydrogen peroxide. Hydrogen peroxide contained in an aqueous solution can be simply quantitatively analyzed through optical analysis means.Type: GrantFiled: November 27, 1995Date of Patent: May 19, 1998Assignee: Kyoto Dai-ich Kagaku Co., Ltd.Inventors: Yoshinori Yamaguchi, Harumi Uenoyama, Masayuki Yagi, Dou Xiaoming
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Patent number: 5754288Abstract: As to respective expiration components to be measured, wavelengths having excellent correlations between component concentrations and Raman spectral intensity values are previously selected as measuring wavelengths which are specific to the components, an expiration specimen is irradiated with Raman excitation light, Raman spectra at the measuring wavelength which is specific to nitrogen and those at the measuring wavelengths previously selected for the components to be measured respectively are measured, Raman spectral intensity ratios of the components to the Raman spectral intensity of nitrogen are obtained, and the respective expiration components are quantitatively analyzed through a calibration curve which is previously prepared as to the Raman spectral intensity ratios of the respective components to nitrogen and concentrations.Type: GrantFiled: August 8, 1996Date of Patent: May 19, 1998Assignee: Kyoto Dai-Ichi Kagaku Co., Ltd.Inventors: Hiroshi Yamamoto, Harumi Uenoyama, Xiaoming Dou, Yung Xiang Wang, Kentaro Shimada
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Patent number: 5751418Abstract: In an optical measuring apparatus of the present invention, a spectroscopic optical system emits a measuring light beam that contains a measure light component of a measure wavelength domain where a measured object absorbs part of the light and a reference light component of a reference wavelength domain where the measured object almost completely absorbs the light, and separates the beam into beams, a photometric unit measures the light incident on an integrating sphere when a reference sample is inserted in the light path and stores the measurements in a memory and also measures the light incident on an integrating sphere when a measured object is inserted in the light path, and an arithmetic circuit calculates a light intensity ratio of the compensation light component for the measured object to the compensation light component stored in memory and then estimates background intensities during the measurement by multiplying the measurements stored in the memory by the intensity ratio.Type: GrantFiled: May 10, 1996Date of Patent: May 12, 1998Assignees: Kurashiki Boseki Kabushiki Kaisha, Kyoto Daiichi Kagaku Co., Ltd.Inventors: Eiichi Kimura, Naoki Yanai, Motonobu Shiomi, Emi Ashibe, Yutaka Yamasaki, Harumi Uenoyama
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Patent number: 5750410Abstract: A total reflection cell has a total reflection prism on at least one surface thereof. A mixed solution containing a gold colloid labelled antibody which is adsorbed on a gold colloid is stored in the total reflection cell, and a sample solution containing an antigen causing antigen-antibody reaction with the antibody is added thereto for forming a gold colloid labelled immune complex. A measuring beam is introduced into the total reflection prism from an incident optical system at an angle .theta. of incidence causing total reflection and an outgoing beam from the total reflection prism is received by a measuring optical system, thereby measuring absorption by the gold colloid labelled immune complex and carrying out qualification and determination of the antigen.Type: GrantFiled: January 26, 1996Date of Patent: May 12, 1998Assignee: Kyoto Dai-ichi Kagaku Co., Ltd.Inventors: Xiaoming Dou, Yoshinori Yamaguchi, Harumi Uenoyama
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Patent number: 5741660Abstract: As to reaction solutions in which the amount of each potassium ferricyanate, glucose oxidase and glucose substrate are set at a constant value while glucose concentrations are varied, intensity changes of peaks at a shift wavenumber of 2081 cm.sup.-1 in light scattering spectra are measured every 10 seconds, the maximum values of the intensity changes of the peaks at the respective glucose concentrations obtained, for obtaining a calibration curve from correlations between the maximum values of the reaction velocities and the glucose concentrations. The calibration curve is employed for carrying out quantitative measurement of an unknown sample.Type: GrantFiled: January 30, 1996Date of Patent: April 21, 1998Assignee: Kyoto Dai-ichi Kagaku Co., Ltd.Inventors: Xiaoming Dou, Yutaka Yamasaki, Harumi Uenoyama, Yoshinori Yamaguchi
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Patent number: 5712167Abstract: In order to quantitatively measure an Amadori compound by a simple optical method utilizing light scattering, a sample containing an Amadori compound which is stored in a cell is irradiated with excitation light from an He--Ne laser unit so that scattered light from the sample is received and separated into its spectral components for obtaining a light scattering spectrum, and a light scattering peak existing at 820 to 840 cm.sup.-1, 1655 to 1660 cm.sup.-1, 2000 to 2020 cm.sup.-1, 2080 to 2100 cm.sup.-1, 2460 to 2470 cm.sup.-1 or 2530 to 2600 cm.sup.-1 in shift wavenumber with respect to the excitation wavelength in the light scattering spectrum is detected by a detector. The saccharide concentration or the saccharification ratio of the Amadori compound is measured by a calibration curve through the peak intensity or the peak integral value of the light scattering peak.Type: GrantFiled: July 17, 1996Date of Patent: January 27, 1998Assignee: Kyoto Dai-Ichi Kagaku Co., Ltd.Inventors: Yoshinori Yamaguchi, Xiaoming Dou, Masayuki Yagi, Harumi Uenoyama
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Patent number: 5696580Abstract: A measuring beam is incident upon a triangular cell storing a liquid sample, and transmitted light thereof is received by a linear sensor so that both transmitted light intensity and a position of the beam are detected. A refractive index calculating part calculates refractive indices from the position detected by the linear sensor, while an absorbance calculating part calculates absorbance values dependent on component concentration values correcting influence by transmittance change at the triangular cell through the transmitted light intensity values and the refractive indices of the sample calculated at the refractive index calculating part. A component concentration calculating part performs a multivariate analytical operation on the basis of the absorbance values dependent on the component concentration values at a plurality of measuring wavelengths calculated at the absorbance calculating part.Type: GrantFiled: May 4, 1995Date of Patent: December 9, 1997Assignee: Kyoto Dai-Ichi Kagaku Co., Ltd.Inventors: Hiroko Kubo, Xu Kexin, Harumi Uenoyama