Abstract: An engineered targeting exosome comprising; a modified Lamp2b peptide, a targeting peptide or antibody; and a Fc portion of IgG2b. The targeting peptide or antibody detects a target protein within a cell and precisely delivers the exosome to cells expressing the target protein and the Fc portion of IgGb2 induces antibody-dependent cell-mediated cytotoxicity (ADCC) events in cells expressing the target protein. Also disclosed are methods of using the engineered targeting exosome to detect and/or deplete cells expressing the target protein.

Abstract: Described herein are novel anti-CD3 antibodies conjugated to folate and uses thereof treatment of diseases or conditions that would benefit from such conjugate are provided.

Abstract: Disclosed herein are nano-encapsulated compositions and systems and methods of preparing the same. The compositions may be obtained through co-axial electrospraying with pulsating voltage. The nano-encapsulated composition exhibit improved pharmacokinetic properties. Various embodiments include systems and methods that apply a constant voltage and/or a pulsating voltage at a frequency to a plate having co-axial outlets through which a core solution and capsule solution flow. In some implementations, the pulsating voltage fluctuates between a minimum pulsating voltage and a maximum pulsating voltage, wherein the minimum pulsating voltage is 0 KV or greater and the maximum pulsating voltage is greater than 0 KV and the minimum pulsating voltage. The constant voltage is greater than 0 KV, and a total maximum applied voltage to the plate is the sum of the maximum pulsating voltage and the constant voltage.

Abstract: CD206-positive M2 macrophage-targeting exosomes and methods of use thereof are provided. One embodiment provides a CD206-positive M2 macrophage-targeting exosome expressing a CD206 binding peptide and an Fc portion of IgG2b. In some embodiments, the CD206 binding peptide is encoded by a nucleic acid sequence having 95%, 99%, or 100% sequence identity to SEQ ID NO:2 and the IgG2b is encoded by a sequence having 95%, 99%, or 100% sequence identity to SEQ ID NO:6.

Abstract: Described herein are novel anti-CD3 antibodies conjugated to folate and uses thereof treatment of diseases or conditions that would benefit from such conjugate are provided.