Patents by Inventor Harunobu Mukaiyama
Harunobu Mukaiyama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7589126Abstract: The present invention relates to a 5-amidino-2-hydroxybenzenesulfonamide derivative represented by the general formula: wherein R1 is a hydrogen atom or an optionally substituted lower alkyl group; R2 is a di(lower alkyl)amino group, a lower alkyl group, a cycloalkyl group, an optionally substituted aryl group, an optionally substituted heterocycloalkyl group, or an optionally substituted aromatic heterocyclic group; T is an oxygen atom, a sulfur atom, a sulfonyl group etc.; Q is a hydrogen atom or an optionally substituted lower alkyl group; and Z is a hydrogen atom, a hydroxy group etc., or a pharmaceutically acceptable salt thereof, which exert a potent and selective activated blood coagulation factor X inhibitory activity and is useful as an agent for the prevention or treatment of a disease occurred associating an activated blood coagulation factor X, a pharmaceutical composition comprising the same, a pharmaceutical use thereof and an intermediate thereof.Type: GrantFiled: October 27, 2006Date of Patent: September 15, 2009Assignee: Kissei Pharmaceutical Co., Ltd.Inventors: Kosuke Okazaki, Masahiko Uchida, Harunobu Mukaiyama, Hiroaki Kobayashi, Yuichiro Kai, Hideki Takeuchi, Kenji Yokoyama, Yoshihiro Terao, Yuji Hoyano, Hiroaki Shiohara, Norihiko Kikuchi
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Patent number: 7402692Abstract: The present invention provides novel intermediates represented by general formula (I) etc. for preparing a phenoxyacetic acid derivative represented by general formula (X) or a pharmaceutically acceptable salt thereof, which has ?3-adrenoceptor stimulating activity and are useful for treating or preventing obesity, hyperglycemia, diseases caused by intestinal hypermotility, pollakiuria, urinary incontinence, depression or biliary calculus.Type: GrantFiled: October 24, 2007Date of Patent: July 22, 2008Assignee: Kissei Pharmaceutical Co., Ltd.Inventors: Nobuyuki Tanaka, Tetsuro Tamai, Harunobu Mukaiyama, Takehiro Ishikawa, Junichi Kobayashi, Satoshi Akahane, Hiromu Harada
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Patent number: 7396954Abstract: The present invention provides novel intermediates represented by general formula (I) etc. for preparing a phenoxyacetic acid derivative represented by general formula (X) or a pharmaceutically acceptable salt thereof, which has ?3-adrenoceptor stimulating activity and are useful for treating or preventing obesity, hyperglycemia, diseases caused by intestinal hypermotility, pollakiuria, urinary incontinence, depression or biliary calculus.Type: GrantFiled: October 24, 2007Date of Patent: July 8, 2008Assignee: Kissei Pharmaceutical Co., Ltd.Inventors: Nobuyuki Tanaka, Tetsuro Tamai, Harunobu Mukaiyama, Takehiro Ishikawa, Junichi Kobayashi, Satoshi Akahane, Hiromu Harada
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Patent number: 7393968Abstract: The present invention provides novel intermediates represented by general formula (I) etc. for preparing a phenoxyacetic acid derivative represented by general formula (X) or a pharmaceutically acceptable salt thereof, which has ?3-adrenoceptor stimulating activity and are useful for treating or preventing obesity, hyperglycemia, diseases caused by intestinal hypermotility, pollakiuria, urinary incontinence, depression or biliary calculus.Type: GrantFiled: October 24, 2007Date of Patent: July 1, 2008Assignee: Kissei Pharmaceutical Co., Ltd.Inventors: Nobuyuki Tanaka, Tetsuro Tamai, Harunobu Mukaiyama, Takehiro Ishikawa, Junichi Kobayashi, Satoshi Akahane, Hiromu Harada
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Publication number: 20080045740Abstract: The present invention provides novel intermediates represented by general formula (I) etc. for preparing a phenoxyacetic acid derivative represented by general formula (X) or a pharmaceutically acceptable salt thereof, which has ?3-adrenoceptor stimulating activity and are useful for treating or preventing obesity, hyperglycemia, diseases caused by intestinal hypermotility, pollakiuria, urinary incontinence, depression or biliary calculus. The present invention also provides a process for preparing said intermediates and a method of using said intermediates.Type: ApplicationFiled: October 24, 2007Publication date: February 21, 2008Applicant: KISSEI PHARMACEUTICAL CO., LTD.Inventors: Nobuyuki TANAKA, Tetsuro Tamai, Harunobu Mukaiyama, Takehiro Ishikawa, Junichi Kobayashi, Satoshi Akahane, Hiromu Harada
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Publication number: 20080045741Abstract: The present invention provides novel intermediates represented by general formula (I) etc. for preparing a phenoxyacetic acid derivative represented by general formula (X) or a pharmaceutically acceptable salt thereof, which has ?3-adrenoceptor stimulating activity and are useful for treating or preventing obesity, hyperglycemia, diseases caused by intestinal hypermotility, pollakiuria, urinary incontinence, depression or biliary calculus. The present invention also provides a process for preparing said intermediates and a method of using said intermediates.Type: ApplicationFiled: October 24, 2007Publication date: February 21, 2008Applicant: KISSEI PHARMACEUTICAL CO., LTD.Inventors: Nobuyuki Tanaka, Tetsuro Tamai, Harunobu Mukaiyama, Takehiro Ishikawa, Junichi Kobayashi, Satoshi Akahane, Hiromu Harada
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Publication number: 20080045739Abstract: The present invention provides novel intermediates represented by general formula (I) etc. for preparing a phenoxyacetic acid derivative represented by general formula (X) or a pharmaceutically acceptable salt thereof, which has ?3-adrenoceptor stimulating activity and are useful for treating or preventing obesity, hyperglycemia, diseases caused by intestinal hypermotility, pollakiuria, urinary incontinence, depression or biliary calculus. The present invention also provides a process for preparing said intermediates and a method of using said intermediates.Type: ApplicationFiled: October 24, 2007Publication date: February 21, 2008Applicant: KISSEI PHARMACEUTICAL CO., LTDInventors: Nobuyuki Tanaka, Tetsuro Tamai, Harunobu Mukaiyama, Takehiro Ishikawa, Junichi Kobayashi, Satoshi Akahane, Hiromu Harada
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Patent number: 7329771Abstract: The present invention provides novel intermediates represented by general formula (I) etc. for preparing a phenoxyacetic acid derivative represented by general formula (X) or a pharmaceutically acceptable salt thereof, which has ?3-adrenoceptor stimulating activity and are useful for treating or preventing obesity, hyperglycemia, diseases caused by intestinal hypermotility, pollakiuria, urinary incontinence, depression or biliary calculus. The present invention also provides a process for preparing said intermediates and a method of using said intermediates.Type: GrantFiled: September 5, 2002Date of Patent: February 12, 2008Assignee: Kissei Pharmaceuticals Co., Ltd.Inventors: Nobuyuki Tanaka, Tetsuro Tamai, Harunobu Mukaiyama, Takehiro Ishikawa, Junichi Kobayashi, Satoshi Akahane, Hiromu Harada
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Patent number: 7256215Abstract: The present invention provides a novel crystalline form of n-butyl[4-[2-[2-hydroxy-5-(N-hydroxycarbamimidoyl) benzenesulfonylamino]ethyl]-2?-methanesulfonyl-3-yloxy] acetate hydrochloride, pharmaceutical compositions containing the same and their uses, which exhibits excellent inhibitory activities against activated blood coagulation factor X, and is useful for the treatment or prevention of a tromboembolic disease.Type: GrantFiled: March 4, 2003Date of Patent: August 14, 2007Assignee: Kissei Pharmaceutical Co., Ltd.Inventors: Harunobu Mukaiyama, Yuichiro Kai, Hideki Takeuchi, Kenji Yokoyama, Yoshihiro Terao, Satoshi Akahane
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Patent number: 7217832Abstract: The present invention relates to a 5-amidino-2-hydroxybenzenesulfonamide derivative represented by the general formula: wherein R1 is a hydrogen atom or an optionally substituted lower alkyl group; R2 is a di(lower alkyl)amino group, a lower alkyl group, a cycloalkyl group, an optionally substituted aryl group, an optionally substituted heterocycloalkyl group, or an optionally substituted aromatic heterocyclic group; T is an oxygen atom, a sulfur atom, a sulfonyl group etc.; Q is a hydrogen atom or an optionally substituted lower alkyl group; and Z is a hydrogen atom, a hydroxy group etc., or a pharmaceutically acceptable salt thereof, which exert a potent and selective activated blood coagulation factor X inhibitory activity and is useful as an agent for the prevention or treatment of a disease occurred associating an activated blood coagulation factor X, a pharmaceutical composition comprising the same, a pharmaceutical use thereof and an intermediate thereof.Type: GrantFiled: February 23, 2006Date of Patent: May 15, 2007Assignee: Kissei Pharmaceutical Co., Ltd.Inventors: Kosuke Okazaki, Masahiko Uchida, Harunobu Mukaiyama, Hiroaki Kobayashi, Yuichiro Kai, Hideki Takeuchi, Kenji Yokoyama, Yoshihiro Terao, Yuji Hoyano, Hiroaki Shiohara, Norihiko Kikuchi
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Publication number: 20070105829Abstract: The present invention relates to a 5-amidino-2-hydroxybenzenesulfonamide derivative represented by the general formula: wherein R1 is a hydrogen atom or an optionally substituted lower alkyl group; R2 is a di(lower alkyl)amino group, a lower alkyl group, a cycloalkyl group, an optionally substituted aryl group, an optionally substituted heterocycloalkyl group, or an optionally substituted aromatic heterocyclic group; T is an oxygen atom, a sulfur atom, a sulfonyl group etc.; Q is a hydrogen atom or an optionally substituted lower alkyl group; and Z is a hydrogen atom, a hydroxy group etc., or a pharmaceutically acceptable salt thereof, which exert a potent and selective activated blood coagulation factor X inhibitory activity and is useful as an agent for the prevention or treatment of a disease occurred associating an activated blood coagulation factor X, a pharmaceutical composition comprising the same, a pharmaceutical use thereof and an intermediate thereof.Type: ApplicationFiled: October 27, 2006Publication date: May 10, 2007Inventors: Kosuke OKAZAKI, Masahiko Uchida, Harunobu Mukaiyama, Hiroaki Kobayashi, Yuichiro Kai, Hideki Takeuchi, Kenji Yokoyama, Yoshihiro Terao, Yuji Hoyano, Hiroaki Shiohara, Norihiko Kikuchi
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Patent number: 7208524Abstract: The present invention relates to a 5-amidino-2-hydroxybenzenesulfonamide derivative represented by the general formula: wherein R1 is a hydrogen atom or an optionally substituted lower alkyl group; R2 is a di(lower alkyl)amino group, a lower alkyl group, a cycloalkyl group, an optionally substituted aryl group, an optionally substituted heterocycloalkyl group, or an optionally substituted aromatic heterocyclic group; T is an oxygen atom, a sulfur atom, a sulfonyl group etc.; Q is a hydrogen atom or an optionally substituted lower alkyl group; and Z is a hydrogen atom, a hydroxy group etc., or a pharmaceutically acceptable salt thereof, which exert a potent and selective activated blood coagulation factor X inhibitory activity and is useful as an agent for the prevention or treatment of a disease occurred associating an activated blood coagulation factor X, a pharmaceutical composition comprising the same, a pharmaceutical use thereof and an intermediate thereof.Type: GrantFiled: October 2, 2001Date of Patent: April 24, 2007Assignee: Kissei Pharmaceutical Co., Ltd.Inventors: Kosuke Okazaki, Masahiko Uchida, Harunobu Mukaiyama, Hiroaki Kobayashi, Yuichiro Kai, Hideki Takeuchi, Kenji Yokoyama, Yoshihiro Terao, Yuji Hoyano, Hiroaki Shiohara, Norihiko Kikuchi
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Publication number: 20060205812Abstract: The present invention relates to a 5-amidino-2-hydroxybenzenesulfonamide derivative represented by the general formula: wherein R1 is a hydrogen atom or an optionally substituted lower alkyl group; R2 is a di(lower alkyl)amino group, a lower alkyl group, a cycloalkyl group, an optionally substituted aryl group, an optionally substituted heterocycloalkyl group, or an optionally substituted aromatic heterocyclic group; T is an oxygen atom, a sulfur atom, a sulfonyl group etc.; Q is a hydrogen atom or an optionally substituted lower alkyl group; and Z is a hydrogen atom, a hydroxy group etc., or a pharmaceutically acceptable salt thereof, which exert a potent and selective activated blood coagulation factor X inhibitory activity and is useful as an agent for the prevention or treatment of a disease occurred associating an activated blood coagulation factor X, a pharmaceutical composition comprising the same, a pharmaceutical use thereof and an intermediate thereof.Type: ApplicationFiled: February 23, 2006Publication date: September 14, 2006Inventors: Kosuke Okazaki, Masahiko Uchida, Harunobu Mukaiyama, Hiroaki Kobayashi, Yuichiro Kai, Hideki Takeuchi, Kenji Yokoyama, Yoshihiro Terao, Yuji Hoyano, Hiroaki Shiohara, Norihiko Kikuchi
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Publication number: 20060135605Abstract: The present invention provides novel intermediates represented by general formula (I) etc. for preparing a phenoxyacetic acid derivative represented by general formula (X) or a pharmaceutically acceptable salt thereof, which has ?3-adrenoceptor stimulating activity and are useful for treating or preventing obesity, hyperglycemia, diseases caused by intestinal hypermotility, pollakiuria, urinary incontinence, depression or biliary calculus. The present invention also provides a process for preparing said intermediates and a method of using said intermediates.Type: ApplicationFiled: September 5, 2002Publication date: June 22, 2006Inventors: Nobuyuki Tanaka, Tetsuro Tamai, Harunobu Mukaiyama, Takehiro Ishikawa, Junichi Kobayashi, Satoshi Akahane, Hiromu Harada
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Publication number: 20060116361Abstract: The present invention relates to a 5-amidino-2-hydroxybenzenesulfonamide derivative represented by the general formula: wherein R1 is a hydrogen atom or an optionally substituted lower alkyl group; R2 is a di(lower alkyl)amino group, a lower alkyl group, a cycloalkyl group, an optionally substituted aryl group, an optionally substituted heterocycloalkyl group, or an optionally substituted aromatic heterocyclic group; T is an oxygen atom, a sulfur atom, a sulfonyl group etc.; Q is a hydrogen atom or an optionally substituted lower alkyl group; and Z is a hydrogen atom, a hydroxy group etc., or a pharmaceutically acceptable salt thereof, which exert a potent and selective activated blood coagulation factor X inhibitory activity and is useful as an agent for the prevention or treatment of a disease occurred associating an activated blood coagulation factor X, a pharmaceutical composition comprising the same, a pharmaceutical use thereof and an intermediate thereof.Type: ApplicationFiled: October 2, 2001Publication date: June 1, 2006Inventors: Kosuke Okazaki, Masahiko Uchida, Harunobu Mukaiyama, Hiroaki Kobayashi, Yuichiro Kai, Hideki Takeuchi, Kenji Yokoyama, Yoshihiro Terao, Yuji Hoyano, Hiroaki Shiohara, Norihiko Kikuchi
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Publication number: 20050143457Abstract: The present invention provides a novel crystalline form of n-butyl[4-[2-[2-hydroxy-5-(N-hydroxycarbamimidoyl) benzenesulfonylamino]ethyl]-2?-methanesulfonyl-3-yloxy] acetate hydrochloride, pharmaceutical compositions containing the same and their uses, which exhibits excellent inhibitory activities against activated blood coagulation factor X, and is useful for the treatment or prevention of a tromboembolic disease.Type: ApplicationFiled: March 4, 2003Publication date: June 30, 2005Inventors: Harunobu Mukaiyama, Yuichiro Kai, Hideki Takeuchi, Kenji Yokoyama, Yoshihiro Terao, Satoshi Akahane
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Patent number: 6790865Abstract: The present invention provides novel 2-methylpropionic acid derivatives represented by the general formula: (wherein R1 represents a hydrogen atom, a lower alkyl group or an aralkyl group; R2 represents a hydrogen atom, a lower alkyl group or a halogen atom; A represents an oxygen atom or an imino group; the carbon atom marked with (R) represents a carbon atom in R configuration; and the carbon atom marked with (S) represents a carbon atom in S configuration) and pharmaceutically acceptable salts thereof, which have excellent &bgr;3-adrenoceptor stimulating effects and are useful as agents for the prevention or treatment of obesity, hyperglycemia, the diseases caused by intestinal hypermotility, pollakiuria, urinary incontinence, depression, or the diseases caused by biliary calculi or hypermotility of the biliary tract.Type: GrantFiled: February 5, 2003Date of Patent: September 14, 2004Assignee: Kissei Pharmaceutical Co., Ltd.Inventors: Tetsuro Tamai, Nobuyuki Tanaka, Harunobu Mukaiyama, Akihito Hirabayashi, Hideyuki Muranaka, Masaaki Sato, Masuo Akahane
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Patent number: 6696489Abstract: The present invention provides novel 2-methylpropionic acid derivatives represented by the general formula: (wherein R1 represents a hydrogen atom, a lower alkyl group or an aralkyl group; R2 represents a hydrogen atom a lower alkyl group or a halogen atom; A represents an oxygen atom or an imino group; the carbon atom marked with (R) represents a carbon atom in R configuration; and the carbon atom marked with (S) represents a carbon atom in S configuration) and pharmaceutically acceptable salts thereof, which have excellent &bgr;3-adrenoceptor stimulating effects and are useful as agents for the prevention or treatment of obesity, hyperglycemia, the diseases caused by intestinal hypermotility, pollakiuria, urinary incontinence, depression, or the diseases caused by biliary calculi or hypermotility of the biliary tract.Type: GrantFiled: October 13, 2000Date of Patent: February 24, 2004Assignee: Kissei Pharmaceutical Co., Ltd.Inventors: Tetsuro Tamai, Nobuyuki Tanaka, Harunobu Mukaiyama, Akihito Hirabayashi, Hideyuki Muranaka, Masaaki Sato, Masuo Akahane
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Publication number: 20030166719Abstract: The present invention provides novel 2-methylpropionic acid derivatives represented by the general formula: 1Type: ApplicationFiled: February 5, 2003Publication date: September 4, 2003Applicant: KISSEI PHARMACEUTICAL CO., LTD.Inventors: Tetsuro Tamai, Nobuyuki Tanaka, Harunobu Mukaiyama, Akihito Hirabayashi, Hideyuki Muranaka, Masaaki Sato, Masuo Akahane
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Patent number: 6538152Abstract: The present invention provides novel phenoxyacetic acid derivatives represented by the general formula: wherein R1 represents a hydroxy group, a lower alkoxy group, an aralkoxy group, an amino group, or a mono or di(lower alkyl)amino group; one of R2 and R3 is a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group, while the other is a hydrogen atom; R4 represents a halogen atom, a lower alkyl group, a halo(lower alkyl) group, a hydroxy group, a lower alkoxy group, an aralkoxy group, a cyano group, a nitro group, an amino group, a mono or di(lower alkyl)amino group, a carbamoyl group, a mono or di(lower alkyl)carbamoyl group or a group represented by the general formula: —NHCOR5 (wherein R5 represents a hydrogen atom or a lower alkyl group); the carbon atom marked with (R) represents a carbon atom in R configuration; and the carbon atom marked with (S) represents a carbon atom in S configuration, and pharmaceutically acceptable salts thereof, which have excellenType: GrantFiled: January 3, 2001Date of Patent: March 25, 2003Assignee: Kissei Pharmaceutical Co., Ltd.Inventors: Nobuyuki Tanaka, Tetsuro Tamai, Harunobu Mukaiyama, Akihito Hirabayashi, Hideyuki Muranaka, Masaaki Sato, Masuo Akahane