Patents by Inventor Haruo Koike

Haruo Koike has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7223882
    Abstract: A process for a preparation of Compound (V), a pharmaceutically acceptable salt or a solvate thereof, said process comprising the steps represented by the following formula: wherein R1 and R2 are each independently C1–C8 alkyl.
    Type: Grant
    Filed: March 18, 2003
    Date of Patent: May 29, 2007
    Assignee: Shionogi & Co., Ltd.
    Inventors: Haruo Koike, Katsuo Oda, Yutaka Nishino, Makoto Kakinuma
  • Patent number: 7189857
    Abstract: A method for producing a compound represented by the general formula (I-A) or the general formula (I-B), comprising the following step: wherein R1 is an optionally substituted lower alkyl, and the like; R2 is a lower alkyl or an optionally substituted aralkyl, and the like; R3 is a lower alkyl, characterized in that a compound represented by the general formula (II-A) or the general formula (II-B) is treated with thionyl chloride.
    Type: Grant
    Filed: November 25, 2003
    Date of Patent: March 13, 2007
    Assignee: Shionogi & Co., Ltd.
    Inventors: Makoto Kobayashi, Haruo Koike, Masahiko Nagai
  • Publication number: 20050143596
    Abstract: A process for a preparation of Compound (V), a pharmaceutically acceptable salt or a solvate thereof, said process comprising the steps represented by the following formula: wherein R1 and R2 are each independently C1-C8 alkyl
    Type: Application
    Filed: March 18, 2003
    Publication date: June 30, 2005
    Applicant: Shionogi & Co. Ltd.
    Inventors: Haruo Koike, Katsuo Oda, Yutaka Nishino, Makoto Kakinuma
  • Patent number: 6875874
    Abstract: A method for producing a compound represented by the general formula (I-A) or the general formula (I-B), comprising the following step: wherein R1 is an optionally substituted lower alkyl, and the like; R2 is a lower alkyl or an optionally substituted aralkyl, and the like; R3 is a lower alkyl, characterized in that a compound represented by the general formula (II-A) or the general formula (II-B) is treated with thionyl chloride.
    Type: Grant
    Filed: November 25, 2003
    Date of Patent: April 5, 2005
    Assignee: Shionogi & Co., Ltd.
    Inventors: Makoto Kobayashi, Haruo Koike, Masahiko Nagai
  • Patent number: 6844437
    Abstract: The invention concerns a process for the manufacture of tert-butyl (E)-(6-[2-4-(4-flourophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]vinyl)-(4R,6S)-2,2-dimethyl[1,3]-dioxan-4-yl)acetate, the novel starting material used in said process and the use of the process in the manufacture of a pharmaceutical.
    Type: Grant
    Filed: February 15, 2000
    Date of Patent: January 18, 2005
    Assignees: Astrazeneca AB, Shionogi & Co. Ltd.
    Inventors: Nigel P Taylor, Loius J Diorazio, Haruo Koike, Mikio Kabaki
  • Patent number: 6784171
    Abstract: The invention concerns a process for the manufacture of tert-butyl (E)-(6-[2-4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]vinyl)-(4R, 6S)-2,2-dimethyl(1,3-dioxan-4-yl) acetate, the novel starting material used in said process and the use of the process in the manufacture of a pharmaceutical.
    Type: Grant
    Filed: July 2, 2003
    Date of Patent: August 31, 2004
    Assignee: AstraZeneca
    Inventors: Nigel P Taylor, Loius J Diorazio, Haruo Koike, Mikio Kabaki
  • Patent number: 6747157
    Abstract: A method for producing a compound represented by the general formula (I-A) or the general formula (I-B), comprising the following step: wherein R1 is an optionally substituted lower alkyl, and the like; R2 is a lower alkyl or an optionally substituted aralkyl, and the like; R3 is a lower alkyl, characterized in that a compound represented by the general formula (II-A) or the general formula (II-B) is treated with thionyl chloride.
    Type: Grant
    Filed: August 27, 2002
    Date of Patent: June 8, 2004
    Assignee: Shionogi & Co., Ltd.
    Inventors: Makoto Kobayashi, Haruo Koike, Masahiko Nagai
  • Publication number: 20040106820
    Abstract: A method for producing a compound represented by the general formula (I-A) or the general formula (I-B), comprising the following step: 1
    Type: Application
    Filed: November 25, 2003
    Publication date: June 3, 2004
    Inventors: Makoto Kobayashi, Haruo Koike, Masahiko Nagai
  • Publication number: 20040077876
    Abstract: A method for producing a compound represented by the general formula (I-A) or the general formula (I-B), comprising the following step: 1
    Type: Application
    Filed: November 25, 2003
    Publication date: April 22, 2004
    Applicant: Shionogi & Co., Ltd.
    Inventors: Makoto Kobayashi, Haruo Koike, Masahiko Nagai
  • Publication number: 20040049036
    Abstract: The invention concerns a process for the manufacture of tert-butyl (E)-(6-[2-4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]vinyl}-(4R, 6S)-2,2-dimethyl[1,3-dioxan-4-yl) acetate, the novel starting material used in said process and the use of the process in the manufacture of a pharmaceutical.
    Type: Application
    Filed: July 2, 2003
    Publication date: March 11, 2004
    Applicants: ASTRAZENECA AB, SHIONOGI & CO., LTD.
    Inventors: Nigel P. Taylor, Louis Diorazio, Haruo Koike, Mikio Kabaki
  • Patent number: 6541641
    Abstract: A method for producing a compound represented by the general formula (I-A) or the general formula (I-B), comprising the following step: wherein R1 is an optionally substituted lower alkyl, and the like; R2 is a lower alkyl or an optionally substituted aralkyl, and the like: R3 is a lower alkyl, characterized in that a compound represented by the general formula (II-A) or the general formula (II-B) is treated with thionyl chloride.
    Type: Grant
    Filed: June 19, 2002
    Date of Patent: April 1, 2003
    Assignee: Shionogi & Co., Ltd.
    Inventors: Makoto Kobayashi, Haruo Koike, Masahiko Nagai
  • Publication number: 20030055264
    Abstract: A method for producing a compound represented by the general formula (I-A) or the general formula (I-B), comprising the following step: 1
    Type: Application
    Filed: August 27, 2002
    Publication date: March 20, 2003
    Applicant: Shionogi & Co., Ltd.
    Inventors: Makoto Kobayashi, Haruo Koike, Masahiko Nagai
  • Patent number: 6015921
    Abstract: A method for preparing carbamoylmethylurea derivatives of the formula (I): ##STR1## characterized by reacting a compound of the formula (II): ##STR2## with a compound of the formula (III): ##STR3##
    Type: Grant
    Filed: February 3, 1998
    Date of Patent: January 18, 2000
    Assignee: Shionogi & Co., Ltd.
    Inventors: Haruo Koike, Yasufumi Ueda, Koji Matsuda, Mikio Kabaki
  • Patent number: 5260440
    Abstract: The compounds of the present invention inhibit the HMG-CoA reductase, and subsequently suppress the biosynthesis of cholesterol. And they are useful in the treatment of hypercholesterolemia, hyperlipoproteinemia, and atherosclerosis.
    Type: Grant
    Filed: June 12, 1992
    Date of Patent: November 9, 1993
    Assignee: Shionogi Seiyaku Kabushiki Kaisha
    Inventors: Kentaro Hirai, Teruyuki Ishiba, Haruo Koike, Masamichi Watanabe
  • Patent number: 5128366
    Abstract: The compounds of the present invention inhibit HMG-CoA reductase, and subsequently suppress the synthesis of cholesterol. And they are useful in the treatment of hypercholesterolemia, hyperlipoproteinemia, and atherosclerosis. The compounds have the formula ##STR1## wherein R.sup.1, R.sup.2, and R.sup.3 each is independently hydrogen, optionally substituted lower alkyl, or optionally substituted aryl; R.sup.4 is lower alkyl, aralkyl, aryl, or heteroaryl, each of which is optionally substituted; X is vinylene or ethylene; Y is ##STR2## where R.sup.5 is hydrogen, lower alkyl, aryl, aralkyl, or a cation capable of forming a non-toxic pharmaceutically acceptable salt.
    Type: Grant
    Filed: May 30, 1991
    Date of Patent: July 7, 1992
    Assignee: Shinogi & Co., Ltd.
    Inventors: Kentaro Hirai, Teruyuki Ishiba, Haruo Koike, Masamichi Watanabe
  • Patent number: 4629795
    Abstract: An improved process for preparing a vinyl imidazole derivative (I) and a new method of production of a monoimidazole derivative (II) are provided: ##STR1## wherein R.sup.1 is halogen; and R.sup.2, X, and Y are each is hydrogen or halogen.The vinyl imidazole derivatives (I) are useful as antimycotic agents for humans and animals or agricultural fungicides, and the monoimidazole derivatives (II) can be utilized as intermediates for preparing them.
    Type: Grant
    Filed: May 2, 1985
    Date of Patent: December 16, 1986
    Assignee: Shionogi & Co., Ltd.
    Inventors: Yoshinori Hamada, Shoji Shinomoto, Isamu Yamada, Haruo Koike
  • Patent number: RE37314
    Abstract: The compounds of the present invention inhibit the HMG-CoA reductase, and subsequently suppress the biosynthesis of cholesterol. And they are useful in the treatment of hypercholesterolemia, hyperlipoproteinemia, and atherosclerosis.
    Type: Grant
    Filed: August 27, 1998
    Date of Patent: August 7, 2001
    Assignee: Shionogi Seiyaku Kabushiki Kaisha
    Inventors: Kentaro Hirai, Teruyuki Ishiba, Haruo Koike, Masamichi Watanabe