Patents by Inventor Haruo Matsuda
Haruo Matsuda has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8658770Abstract: [Object] To obtain an anti-integrin ?8?1 antibody which binds to integrin ?8?1 derived from mammals of different species. Also, to obtain an anti-integrin ?8?1 antibody which inhibits binding between integrin ?8?1 and its ligand. [Solution] Anti-integrin ?8?1 antibodies which bind to integrin ?8?1 derived from mammals of different species have been obtained. In addition, inhibitors, which contain an anti-integrin ?8?1 antibody, of binding between integrin ?8?1 and its ligand have been obtained.Type: GrantFiled: October 19, 2010Date of Patent: February 25, 2014Assignee: Hiroshima UniversityInventors: Haruo Matsuda, Norihisa Nishimichi, Yoshiko Tateishi, Yasuyuki Yokosaki
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Publication number: 20120237530Abstract: [Object] To obtain an anti-integrin ?8?1 antibody which binds to integrin ?8?1 derived from mammals of different species. Also, to obtain an anti-integrin ?8?1 antibody which inhibits binding between integrin ?8?1 and its ligand. [Solution] Anti-integrin ?8?1 antibodies which bind to integrin ?8?1 derived from mammals of different species have been obtained. In addition, inhibitors, which contain an anti-integrin ?8?1 antibody, of binding between integrin ?8?1 and its ligand have been obtained.Type: ApplicationFiled: October 19, 2010Publication date: September 20, 2012Applicant: HIROSHIMA UNIVERSITYInventors: Haruo Matsuda, Norihisa Nishimichi, Yoshiko Tateishi, Yasuyuki Yokosaki
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Patent number: 8198082Abstract: A chicken embryonic stem cell is established, which stably has pluripotency and an ability of being differentiated into a germ cell. For evaluating on whether or not the chicken embryonic stem cell can be applied to genetic modification technique, detection is made on a protein which serves as an indicator of the ability of being differentiated into a germ cell. This provides (i) a chicken embryonic stem cell applicable to genetic modification technique and (ii) a method for evaluation of the chicken embryonic stem cell.Type: GrantFiled: March 26, 2008Date of Patent: June 12, 2012Assignees: Hiroshima University, Hiroshima Industrial Promotion OrganizationInventors: Hiroyuki Horiuchi, Haruo Matsuda, Shuichi Furusawa, Mikiharu Nakano, Yusuke Yamashita, Masaki Nishimoto
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Publication number: 20120087926Abstract: Anti-LOX-1 antibodies having higher efficiency in action and excellent cross-reactivity are obtained. The anti-LOX-1 antibodies having higher efficiency in action and excellent cross-reactivity have been obtained, the antibodies being which specifically binds to a LOX-1 and having heavy chain CDR3 comprising one or more amino acid sequences selected from the group consisting of a) an amino acid sequence set forth in SEQ ID NO: 1, b) an amino acid sequence having 80% or more homology to the amino acid sequence a), c) an amino acid sequence having one or several amino acid deletions, substitutions, or additions in the amino acid sequence a), and d) an amino acid sequence encoded by a nucleotide sequence of a nucleic acid chain hybridizing under a stringent condition with a nucleic acid chain having a nucleotide sequence complementary to a nucleotide sequence encoding the amino acid sequence a).Type: ApplicationFiled: June 17, 2010Publication date: April 12, 2012Applicant: BASF Coatings GmbHInventors: Haruo Matsuda, Tatsuya Sawamura
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Patent number: 7867732Abstract: In one embodiment of the present application, a polypeptide capable of binding to a sugar chain is disclosed, particularly a high-mannose-type sugar chain bound to an antibody, more preferably a sugar chain bound to a chicken antibody. Also disclosed is a method for the purification of an antibody (specifically a chicken antibody) as a representative application of the polypeptide. Further disclosed is means for the purification. The polypeptide, BML-17, is a novel lectin made of 168 amino acid residues isolated from Bryopsis maxima. By using BML-17, it becomes possible to purify an antibody (e.g., a chicken antibody) readily and with high efficiency.Type: GrantFiled: February 27, 2006Date of Patent: January 11, 2011Assignee: National University of Corporation Hiroshima UniversityInventors: Kanji Hori, Haruo Matsuda
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Publication number: 20100205684Abstract: A chicken embryonic stem cell is established, which stably has pluripotency and an ability of being differentiated into a germ cell. For evaluating on whether or not the chicken embryonic stem cell can be applied to genetic modification technique, detection is made on a protein which serves as an indicator of the ability of being differentiated into a germ cell. This provides (i) a chicken embryonic stem cell applicable to genetic modification technique and (ii) a method for evaluation of the chicken embryonic stem cell.Type: ApplicationFiled: March 26, 2008Publication date: August 12, 2010Inventors: Hiroyuki Horiuchi, Haruo Matsuda, Shuichi Furusawa, Mikiharu Nakano, Yusuke Yamashita, Masaki Nishimoto
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Patent number: 7771714Abstract: The present invention is to provide a chicken LIF gene. Based on this genetic information, LIF protein derived from the chicken can be stably supplied and it solves the problems of the creation of transgenic chickens in the past. In addition, the present invention provides not only transgenic chickens for testing purposes but also supplies the first practical transgenic stock animals. The present invention relates to leukemia inhibitory factor (LIF) shown in sequence No. 2, and the gene that encodes thereof shown in sequence No. 1, and a manufacturing method of chicken LIF. In addition, the present invention pertains to a differential preventer of the chicken differentiable cell, and a method of chicken differential prevention and a culturing method for the chicken differentiable cell using thereof, and a medium comprising thereof.Type: GrantFiled: July 17, 2007Date of Patent: August 10, 2010Assignee: Hiroshima UniversityInventors: Haruo Matsuda, Shuichi Furusawa, Hiroyuki Horiuchi
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Publication number: 20100159615Abstract: An object of the present invention is to provide an immunological detection method using an avian antibody, comprising suppressing a non-specific reaction caused by using an avian antibody. According to the present invention, there is provided an immunological detection method comprising detecting a target substance in a sample from a mammal using an avian antibody, characterized in that a non-specific reaction induced by the use of the avian antibody is suppressed.Type: ApplicationFiled: December 27, 2007Publication date: June 24, 2010Inventors: Haruo Matsuda, Fujiko Kanezawa, Hiroyuki Kubo, Norihisa Nishimichi, Masayoshi Aosasa
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Patent number: 7691589Abstract: The present invention is to provide a chicken LIF gene. Based on this genetic information, LIF protein derived from the chicken can be stably supplied and it solves the problems of the creation of transgenic chickens in the past. In addition, the present invention provides not only transgenic chickens for testing purposes but also supplies the first practical transgenic stock animals. The present invention relates to leukemia inhibitory factor (LIF) shown in sequence No. 2, and the gene that encodes thereof shown in sequence No. 1, and a manufacturing method of chicken LIF. In addition, the present invention pertains to a differential preventer of the chicken differentiable cell, and a method of chicken differential prevention and a culturing method for the chicken differentiable cell using thereof, and a medium comprising thereof.Type: GrantFiled: July 17, 2007Date of Patent: April 6, 2010Assignee: Hiroshima UniversityInventors: Haruo Matsuda, Shuichi Furusawa, Hiroyuki Horiuchi
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Patent number: 7619080Abstract: The present invention is to provide a chicken LIF gene. Based on this genetic information, LIF protein derived from the chicken can be stably supplied and it solves the problems of the creation of transgenic chickens in the past. In addition, the present invention provides not only transgenic chickens for testing purposes but also supplies the first practical transgenic stock animals. The present invention relates to leukemia inhibitory factor (LIF) shown in sequence No. 2, and the gene that encodes thereof shown in sequence No. 1, and a manufacturing method of chicken LIF. In addition, the present invention pertains to a differential preventer of the chicken differentiable cell, and a method of chicken differential prevention and a culturing method for the chicken differentiable cell using thereof, and a medium comprising thereof.Type: GrantFiled: July 17, 2007Date of Patent: November 17, 2009Assignee: Hiroshima UniversityInventors: Haruo Matsuda, Shuichi Furusawa, Hiroyuki Horiuchi
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Publication number: 20090035818Abstract: In one embodiment of the present application, a polypeptide capable of binding to a sugar chain is disclosed, particularly a high-mannose-type sugar chain bound to an antibody, more preferably a sugar chain bound to a chicken antibody. Also disclosed is a method for the purification of an antibody (specifically a chicken antibody) as a representative application of the polypeptide. Further disclosed is means for the purification. The polypeptide, BML-17, is a novel lectin made of 168 amino acid residues isolated from Bryopsis maxima. By using BML-17, it becomes possible to purify an antibody (e.g., a chicken antibody) readily and with high efficiency.Type: ApplicationFiled: February 27, 2006Publication date: February 5, 2009Inventors: Kanji Hori, Haruo Matsuda
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Publication number: 20090029458Abstract: The present invention is to provide a chicken LIF gene. Based on this genetic information, LIF protein derived from the chicken can be stably supplied and it solves the problems of the creation of transgenic chickens in the past. In addition, the present invention provides not only transgenic chickens for testing purposes but also supplies the first practical transgenic stock animals. The present invention relates to leukemia inhibitory factor (LIF) shown in sequence No. 2, and the gene that encodes thereof shown in sequence No. 1, and a manufacturing method of chicken LIF. In addition, the present invention pertains to a differential preventer of the chicken differentiable cell, and a method of chicken differential prevention and a culturing method for the chicken differentiable cell using thereof, and a medium comprising thereof.Type: ApplicationFiled: July 17, 2007Publication date: January 29, 2009Inventors: Haruo Matsuda, Shuichi Furusawa, Hiroyuki Horiuchi
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Publication number: 20080311654Abstract: The present invention is to provide a chicken LIF gene. Based on this genetic information, LIF protein derived from the chicken can be stably supplied and it solves the problems of the creation of transgenic chickens in the past. In addition, the present invention provides not only transgenic chickens for testing purposes but also supplies the first practical transgenic stock animals. The present invention relates to leukemia inhibitory factor (LIF) shown in sequence No. 2, and the gene that encodes thereof shown in sequence No. 1, and a manufacturing method of chicken LIF. In addition, the present invention pertains to a differential preventer of the chicken differentiable cell, and a method of chicken differential prevention and a culturing method for the chicken differentiable cell using thereof, and a medium comprising thereof.Type: ApplicationFiled: July 17, 2007Publication date: December 18, 2008Inventors: Haruo Matsuda, Shuichi Furusawa, Hiroyuki Horiuchi
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Publication number: 20080312426Abstract: The present invention is to provide a chicken LIF gene. Based on this genetic information, LIF protein derived from the chicken can be stably supplied and it solves the problems of the creation of transgenic chickens in the past. In addition, the present invention provides not only transgenic chickens for testing purposes but also supplies the first practical transgenic stock animals. The present invention relates to leukemia inhibitory factor (LIF) shown in sequence No. 2, and the gene that encodes thereof shown in sequence No. 1, and a manufacturing method of chicken LIF. In addition, the present invention pertains to a differential preventer of the chicken differentiable cell, and a method of chicken differential prevention and a culturing method for the chicken differentiable cell using thereof, and a medium comprising thereof.Type: ApplicationFiled: July 17, 2007Publication date: December 18, 2008Inventors: Haruo Matsuda, Shuichi Furusawa, Hiroyuki Horiuchi
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Publication number: 20070207499Abstract: The present invention provides a method for measuring a particular protein in a sample containing at least one protein, wherein the sample is reacted with a reagent cleaving a peptide bond of the particular protein to generate a soluble peptide fragment which is determined by a certain primary structure; and contacted with a reagent reacting specifically with the particular soluble peptide fragment, thereby detecting the presence of the particular soluble peptide fragment.Type: ApplicationFiled: September 6, 2006Publication date: September 6, 2007Applicants: Sharp Kabushiki Kaisha, TEIKYO UNIVERSITYInventors: Katsuyoshi Takahashi, Kiyohito Shimura, Haruo Matsuda, Masayoshi Aosasa
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Patent number: 7250275Abstract: The present invention is to provide a chicken LIF gene. Based on this genetic information, LIF protein derived from the chicken can be stably supplied and it solves the problems of the creation of transgenic chickens in the past. In addition, the present invention provides not only transgenic chickens for testing purposes but also supplies the first practical transgenic stock animals. The present invention relates to leukemia inhibitory factor (LIF) shown in sequence No. 2, and the gene that encodes thereof shown in sequence No. 1, and a manufacturing method of chicken LIF. In addition, the present invention pertains to a differential preventer of the chicken differentiable cell, and a method of chicken differential prevention and a culturing method for the chicken differentiable cell using thereof, and a medium comprising thereof.Type: GrantFiled: April 11, 2005Date of Patent: July 31, 2007Assignee: Hiroshima UniversityInventors: Haruo Matsuda, Shuichi Furusawa, Hiroyuki Horiuchi
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Patent number: 7029664Abstract: The present invention is to provide a chicken LIF gene. Based on this genetic information, LIF protein derived from the chicken can be stably supplied and it solves the problems of the creation of transgenic chickens in the past. In addition, the present invention provides not only transgenic chickens for testing purposes but also supplies the first practical transgenic stock animals. The present invention relates to leukemia inhibitory factor (LIF) shown in sequence No. 2, and the gene that encodes thereof shown in sequence No. 1, and a manufacturing method of chicken LIF. In addition, the present invention pertains to a differential preventer of the chicken differentiable cell, and a method of chicken differential prevention and a culturing method for the chicken differentiable cell using thereof, and a medium comprising thereof.Type: GrantFiled: February 4, 2002Date of Patent: April 18, 2006Assignee: Hiroshima UniversityInventors: Haruo Matsuda, Shuichi Furusawa, Hiroyuki Horiuchi
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Publication number: 20050186626Abstract: The present invention is to provide a chicken LIF gene. Based on this genetic information, LIF protein derived from the chicken can be stably supplied and it solves the problems of the creation of transgenic chickens in the past. In addition, the present invention provides not only transgenic chickens for testing purposes but also supplies the first practical transgenic stock animals. The present invention relates to leukemia inhibitory factor (LIF) shown in sequence No. 2, and the gene that encodes thereof shown in sequence No. 1, and a manufacturing method of chicken LIF. In addition, the present invention pertains to a differential preventer of the chicken differentiable cell, and a method of chicken differential prevention and a culturing method for the chicken differentiable cell using thereof, and a medium comprising thereof.Type: ApplicationFiled: April 11, 2005Publication date: August 25, 2005Inventors: Haruo Matsuda, Shuichi Furusawa, Hiroyuki Horiuchi
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Publication number: 20030056241Abstract: The present invention is to provide a chicken LIF gene. Based on this genetic information, LIF protein derived from the chicken can be stably supplied and it solves the problems of the creation of transgenic chickens in the past. In addition, the present invention provides not only transgenic chickens for testing purposes but also supplies the first practical transgenic stock animals. The present invention relates to leukemia inhibitory factor (LIF) shown in sequence No. 2, and the gene that encodes thereof shown in sequence No. 1, and a manufacturing method of chicken LIF. In addition, the present invention pertains to a differential preventer of the chicken differentiable cell, and a method of chicken differential prevention and a culturing method for the chicken differentiable cell using thereof, and a medium comprising thereof.Type: ApplicationFiled: February 4, 2002Publication date: March 20, 2003Inventors: Haruo Matsuda, Shuichi Furusawa, Hiroyuki Horiuchi
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Patent number: 5411881Abstract: A thymidine kinase-lacking hybrid cell having an Ig-producing ability in which chicken B lymphoblast with immunized chicken spleen cell, a method of obtaining the above hybrid cell which comprises mutating chicken B lymphoblast cell, isolating a thymidine kinase-lacking cell using a culture medium containing a thymidine analog, fusing it with immunized chicken spleen cell, mutating the hybrid cell, and isolating a thymidine kinase-lacking hybrid cell using a culture medium containing a thymidine analog, a hybrid cell having an IgG-producing ability in which a chicken spleen cell immunized with an antigen is further fused with the above hybrid cell, a method of producing a chicken IgG which comprises culturing the above hybrid cell having an IgG-producing ability in a culture medium. The antibody-producing cell of the invention can produce chicken IgG stably for a long period, and thereby it opens the way for the massproduction of chicken IgG.Type: GrantFiled: May 5, 1992Date of Patent: May 2, 1995Assignee: NKK CorporationInventors: Haruo Matsuda, Shigeyuki Nishinaka, Takashi Suzuki