Patents by Inventor Haruyuki Oshima

Haruyuki Oshima has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pure culture of Pantoea agglomerans ferm BP-3511
    Patent number: 5494819
    Abstract: A pure culture of Pantoea agglomerans having all of the characteristics of FERM BP-3511 is disclosed. The characteristics include morphology, growth, physiological, carbon utilization sources and various enzymatic tests, as well as the required production of a lipopolysaccharide and all of these characteristics have been identified for the culture of P. agglomerans. In addition the lipopolysaccharide has a dominant molecular weight of 6,500.+-.2,500 as determined by SDS-PAGE method, 2.+-.phosphorus, 5.+-.hexosamines and 2.+-.1 2-keto-3-deoxyoctonate per molecular weight of 5,000. The specific enzymatic tests involve such enzymes as lysin decarboxylase, arginine dihydroxylase, phenylalanine deaminase and ornithine decarboxylase. Further, a test for utilization of malonate by the culture is disclosed.
    Type: Grant
    Filed: April 12, 1994
    Date of Patent: February 27, 1996
    Assignees: Gen-Ichiro Soma, Den'Ichi Mizuno
    Inventors: Gen-Ichiro Soma, Kiyoshi Yoshimura, Daisuke Tsukioka, Den'Ichi Mizuno, Haruyuki Oshima
  • Method for the treatment of narcotic withdrawal symptoms in animals using lipopolysaccharides
    Patent number: 5413993
    Abstract: Antiwithdrawal agents and veterinary antiwithdrawal agents are disclosed which contain lipopolysaccharide (LPS) representatives which have the following physical properties:LPS1 Dominant molecular weight: 5,000.+-.1,000 as determined by SDS-PAGR method______________________________________ Phosphorus number: 2 .+-. 1/5,000 (m.w.) Hexosamine number: 9 .+-. 1/5,000 (m.w.) KDO number: 2 .+-. 1/5,000 (m.w.); ______________________________________LPS2 Dominant molecular weight: 6,500.+-.2,500 as determined by SDS-PAGR method ______________________________________ Phosphorus number: 1 to 2/5,000 (m.w.) Hexosamine number: 7 .+-. 1/5,000 (m.w.) KDO number: 1 to 2/5,000 (m.w.); and ______________________________________LPS3 Dominant molecular weight:6,500.+-.2,500 as determined by SDS-PAGE method ______________________________________ Phosphorus number: 2 .+-. 1/5,000 (m.w.) Hexosamine number: 5 .+-. 1/5,000 (m.w.) KDO number: 2 .+-. 1/5,000 (m.w.
    Type: Grant
    Filed: August 20, 1992
    Date of Patent: May 9, 1995
    Assignees: Gen-Ichiro Soma, Den'Ichi Mizuno
    Inventors: Gen-Ichiro Soma, Kiyoshi Yoshimura, Daisuke Tsukioka, Den'Ichi Mizuno, Haruyuki Oshima
  • Method for the stimulation of the immune system of an animal by use of limulus test-positive plant glycolipid
    Patent number: 5382430
    Abstract: A limulus test-positive plant glycolipid having the following properties: molecular weight: 8000 .+-.1000 by SDS electrophoresis, number of phosphorous not less than 1/mol; number of hexosamine 6 .+-.2/mol; number of fatty acids 6 .+-.2/mol is effective in the stimulation of osteogenesis, oviposition and shell strength improvement in animals. The glycolipid may be administered as a composition comprising an effective amount of the glycolipid in admixture with a pharmaceutically or veterinarily acceptable carrier, such that when administered to an animal, the immune system of the animal is favorably stimulated.
    Type: Grant
    Filed: December 14, 1992
    Date of Patent: January 17, 1995
    Assignees: Chiba Flour Milling Co., Ltd., Den'ichi Mizuno, Gen-Ichiro Soma
    Inventors: Gen-Ichiro Soma, Jun Yoshimura, Daisuke Tsukioka, Den'ichi Mizuno, Haruyuki Oshima
  • Lipopolysaccharide-producing bacteria, lipopolysaccharides, and lipopolysaccharide-containing, medicines and veterinary medicines
    Patent number: 5346891
    Abstract: Novel LPS having the following physical properties, novel bacilli providing those LPS, and novel immunity stimulators, anagesics, and antiwithdrawal agents, and novel veterinary immunity stimulators, analgesics, and antiwithdrawal agents containing LPS selected from the group consisting of those LPSs and mixtures thereof.LPS1 Dominant molecular weight: 5,000.+-.1,000 as determined by______________________________________ SDS-PAGE method ______________________________________ Phosphorus number: 2 .+-. 1/5,000 (m.w.) Hexosamine number: 9 .+-. 1/5,000 (m.w.) KDO number: 2 .+-. 1/5,000 (m.w.) ______________________________________LPS2 Dominant molecular weight: 6,500.+-.2,500 as determined by ______________________________________ SDS-PAGE method ______________________________________ Phosphorus number: 1 to 2/5,000 (m.w.) Hexosamine number: 7 .+-. 1/5,000 (m.w.) KDO number: 1 to 2/5,000 (m.w.) ______________________________________ LPS3 Dominant molecular weight: 6,500.+-.
    Type: Grant
    Filed: August 20, 1991
    Date of Patent: September 13, 1994
    Assignees: Gen-Ichiro Soma, Den'ichi Mizuno
    Inventors: Gen-Ichiro Soma, Kiyoshi Yoshimura, Daisuke Tsukioka, Den'ichi Mizuno, Haruyuki Oshima
  • LPS-containing analgesics and veterinary analgesics
    Patent number: 5281583
    Abstract: An analgesic composition comprising an effective amount of at least one member of LPS whose macrophage activation ED.sub.50 is 0.
    Type: Grant
    Filed: August 22, 1991
    Date of Patent: January 25, 1994
    Assignees: Den'Ichi Mizuno, Gen-Ichiro Soma
    Inventors: Gen-Ichiro Soma, Kiyoshi Yoshimura, Daisuke Tsukioka, Den'Ichi Mizuno, Haruyuki Oshima
  • Limulus test-positive plant glycolipid and method of stimulating the immunity system of an animal
    Patent number: 5236709
    Abstract: A limulus test-positive plant glycolipid having the following properties:molecular weight: 8000.+-.1000 (SDS electrophoresis)number of phosphorus: not less than 1/mol.number of hexosamine: 6.+-.2/mol.number of fatty acid: 6.+-.2/mol is effective in the stimulation of osteogenesis, oviposition and shell strength improvement in animals. The glycolipid may be administered as a composition comprising an effective amount of said glycolipid in admixture with a pharmaceutically or veterinarily acceptable carrier, such that when administered to an animal, the immune system of said animal is favorably stimulated.
    Type: Grant
    Filed: February 6, 1990
    Date of Patent: August 17, 1993
    Assignees: Chiba Flour Milling Co., Ltd., Den'Ichi Mizuno, Gen-Ichiro Soma
    Inventors: Gen-Ichiro Soma, Jun Yoshimura, Daisuke Tsukioka, Den'Ichi Mizuno, Haruyuki Oshima