Patents by Inventor Harvey B. Buck
Harvey B. Buck has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20160011140Abstract: Methods are disclosed for measuring an analyte concentration in a fluidic sample. Such methods further allow one to provide an error code or correct and/or compensate for interferents such as an antioxidant before providing an analyte concentration. The measurement methods utilize information obtained from test sequences having at least one DC block, such as a slow-ramped bi-polar waveform, where a closed circuit condition is maintained during the DC block. The methods use information relating to status of a redox mediator feature during the electrochemical analysis to provide an antioxidant failsafe if the antioxidant is interfering with the analyte concentration. Also disclosed are devices, apparatuses and systems incorporating the various measurement methods.Type: ApplicationFiled: September 11, 2015Publication date: January 14, 2016Applicant: ROCHE DIABETES CARE, INC.Inventors: Harvey B. Buck, JR., Scott E. Carpenter, Zheng Zheng Pan
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Publication number: 20150356264Abstract: A medical system is disclosed, which can be useable in particular for monitoring and/or controlling at least one bodily function of a user. The medical system comprises a control device and at least one medical user element embodied separately from the control device. The medical user element and the control device are designed to exchange data wirelessly. The medical system is designed to enable an automatic assignment step, wherein an exchange of personal data between the medical user element and the control device is enabled by the automatic assignment step. The medical system is furthermore designed to automatically initiate the automatic assignment step by means of an assignment coupling between the medical user element and the control device. The medical system is furthermore designed to enable a separation of the assignment coupling for medical operation of the medical system after the assignment step.Type: ApplicationFiled: August 7, 2015Publication date: December 10, 2015Inventors: Nicole BERNINI, Harvey B. BUCK, JR., Andreas EBERHART, Sybille FROECH, Otto GAA, Michael MARQUANT, Juergen RASCH-MENGES, Bernd ROESICKE, Joerg SCHERER
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Patent number: 9101306Abstract: A medical system is disclosed, which can be useable in particular for monitoring and/or controlling at least one bodily function of a user. The medical system comprises a control device and at least one medical user element embodied separately from the control device. The medical user element and the control device are designed to exchange data wirelessly. The medical system is designed to enable an automatic assignment step, wherein an exchange of personal data between the medical user element and the control device is enabled by the automatic assignment step. The medical system is furthermore designed to automatically initiate the automatic assignment step by means of an assignment coupling between the medical user element and the control device. The medical system is furthermore designed to enable a separation of the assignment coupling for medical operation of the medical system after the assignment step.Type: GrantFiled: September 22, 2011Date of Patent: August 11, 2015Assignees: Roche Diagnostics Operations, Inc., Roche Diagnostics International AGInventors: Nicole Bernini, Harvey B. Buck, Jr., Andreas Eberhart, Sybille Froech, Otto Gaa, Michael Marquant, Juergen Rasch-Menges, Bernd Roesicke, Joerg Scherer
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Patent number: 8586373Abstract: The present disclosure relates to various methods for measuring the amount of an analyte present in a biological fluid using an electrochemical testing process. Various embodiments are disclosed, including the use of AC test signals and the performance of tests having a Total Test Time within about 3.0 seconds or less, and/or having a clinically low Total System Error.Type: GrantFiled: October 24, 2012Date of Patent: November 19, 2013Assignee: Roche Diagnostics Operations, Inc.Inventors: Eric R. Diebold, Terry A. Beaty, Harvey B. Buck, Jr.
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Patent number: 8420404Abstract: The present disclosure relates to various methods for measuring the amount of an analyte present in a biological fluid using an electrochemical testing process. Various embodiments are disclosed, including the use of AC test signals and the performance of tests having a Total Test Time within about 3.0 seconds or less, and/or having a clinically low Total System Error.Type: GrantFiled: October 24, 2012Date of Patent: April 16, 2013Assignee: Roche Diagnostics Operations, Inc.Inventors: Eric R. Diebold, Terry A. Beaty, Harvey B. Buck, Jr.
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Publication number: 20130048512Abstract: The present disclosure relates to various methods for measuring the amount of an analyte present in a biological fluid using an electrochemical testing process. Various embodiments are disclosed, including the use of AC test signals and the performance of tests having a Total Test Time within about 3.0 seconds or less, and/or having a clinically low Total System Error.Type: ApplicationFiled: October 24, 2012Publication date: February 28, 2013Inventors: Eric R. Diebold, Terry A. Beaty, Harvey B. Buck, JR.
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Patent number: 8298828Abstract: The present disclosure relates to various methods for measuring the amount of an analyte present in a biological fluid using an electrochemical testing process. Various embodiments are disclosed, including the use of AC test signals and the performance of tests having a Total Test Time within about 3.0 seconds or less, and/or having a clinically low Total System Error.Type: GrantFiled: March 13, 2012Date of Patent: October 30, 2012Assignee: Roche Diagnostics Operations, Inc.Inventors: Eric R. Diebold, Terry A. Beaty, Harvey B. Buck, Jr.
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Publication number: 20120245438Abstract: A medical system is disclosed, which can be useable in particular for monitoring and/or controlling at least one bodily function of a user. The medical system comprises a control device and at least one medical user element embodied separately from the control device. The medical user element and the control device are designed to exchange data wirelessly. The medical system is designed to enable an automatic assignment step, wherein an exchange of personal data between the medical user element and the control device is enabled by the automatic assignment step. The medical system is furthermore designed to automatically initiate the automatic assignment step by means of an assignment coupling between the medical user element and the control device. The medical system is furthermore designed to enable a separation of the assignment coupling for medical operation of the medical system after the assignment step.Type: ApplicationFiled: September 22, 2011Publication date: September 27, 2012Inventors: Nicole Bernini, Harvey B. Buck, JR., Andreas Eberhart, Sybille Froech, Otto Gaa, Michael Marquant, Juergen Rasch-Menges, Bernd Roesicke, Joerg Scherer
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Publication number: 20120209097Abstract: Sensors and methods for producing them are disclosed. A cavity is created and filled with a reagent that includes a conductive matrix, enzyme, catalyst, and binding agent, in a preferred embodiment. The cavity is substantially enclosed, leaving enough of an opening to allow the sample to enter. A portion of the material surrounding the cavity is preferably permeable to a substance useful for measuring reaction, but not to the reagent or the sample. Cavities that have the shape of a cone, conical frustum, pyramidal frustum, and right circular cylinder are given as examples. Other systems include a membrane that contains the sensor's active area and defines an internal volume of fluid, where the membrane or internal volume has a particular geometric relationship to the active area.Type: ApplicationFiled: April 26, 2012Publication date: August 16, 2012Inventors: Andre MANG, Harvey B. BUCK, Walter JERNIGAN, Michael D. Garrison
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Publication number: 20120205260Abstract: The present disclosure relates to various methods for measuring the amount of an analyte present in a biological fluid using an electrochemical testing process. Various embodiments are disclosed, including the use of AC test signals and the performance of tests having a Total Test Time within about 3.0 seconds or less, and/or having a clinically low Total System Error.Type: ApplicationFiled: March 13, 2012Publication date: August 16, 2012Inventors: Eric R. Diebold, Terry A. Beaty, Harvey B. Buck, JR.
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Patent number: 8180423Abstract: Sensors and methods for producing them are disclosed. A cavity is created and filled with a reagent that includes a conductive matrix, enzyme, catalyst, and binding agent, in a preferred embodiment. The cavity is substantially enclosed, leaving enough of an opening to allow the sample to enter. A portion of the material surrounding the cavity is preferably permeable to a substance useful for measuring reaction, but not to the reagent or the sample. Cavities that have the shape of a cone, conical frustum, pyramidal frustum, and right circular cylinder are given as examples. Other systems include a membrane that contains the sensor's active area and defines an internal volume of fluid, where the membrane or internal volume has a particular geometric relationship to the active area.Type: GrantFiled: March 29, 2006Date of Patent: May 15, 2012Assignee: Roche Diagnostics Operations, Inc.Inventors: Andre Mang, Harvey B. Buck, Jr., Michael D. Garrison, Walter Jernigan
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Patent number: 8148164Abstract: The present disclosure relates to various methods for measuring the amount of an analyte present in a biological fluid using an electrochemical testing process. Various embodiments are disclosed, including the use of AC test signals and the performance of tests having a Total Test Time within about 2.0 seconds or less, and/or having a clinically low Total System Error.Type: GrantFiled: December 30, 2009Date of Patent: April 3, 2012Assignee: Roche Diagnostics Operations, Inc.Inventors: Eric R. Diebold, Terry A. Beaty, Harvey B. Buck, Jr.
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Publication number: 20110168575Abstract: One aspect concerns a technique for detecting analyte concentrations, such as glucose concentrations, in blood or other bodily fluids. This technique utilizes an electrochemical test strip that includes a mediator system that generates a linear faradic response at relatively low applied potential differences. An alternating current excitation signal is applied to blood in the test strip. The alternating current excitation signal includes a low frequency signal and a high frequency signal that has a higher frequency than the low frequency signal. The glucose concentration is determined by measuring a low frequency response to the low frequency signal, measuring a high frequency response to the high frequency signal, estimating the glucose concentration based on the low frequency response, and correcting the glucose concentration for one or more error-causing variables based on the high frequency response.Type: ApplicationFiled: January 8, 2010Publication date: July 14, 2011Applicant: Roche Diaagnostics Operations, Inc.Inventors: Georgeta Lica, Harvey B. Buck, Henning Groll
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Patent number: 7867369Abstract: A biosensor having multiple electrical functionalities located both within and outside of the measurement zone in which a fluid sample is interrogated. Incredibly small and complex electrical patterns with high quality edges provide electrical functionalities in the biosensor and also provide the electrical wiring for the various other electrical devices provided in the inventive biosensor. In addition to a measurement zone with multiple and various electrical functionalities, biosensors of the present invention may be provided with a user interface zone, a digital device zone and/or a power generation zone. The inventive biosensors offer improved ease of use and performance, and decrease the computational burden and associated cost of the instruments that read the biosensors by adding accurate yet cost-effective functionalities to the biosensors themselves.Type: GrantFiled: June 18, 2004Date of Patent: January 11, 2011Assignee: Roche Diagnostics Operations, Inc.Inventors: Raghbir S. Bhullar, Harvey B. Buck, Jr., Brian S. Hill, Paul Douglas Walling, Terry A. Beaty, David W. Burke, Eric R. Diebold
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Publication number: 20100170807Abstract: The present disclosure relates to various methods for measuring the amount of an analyte present in a biological fluid using an electrochemical testing process. Various embodiments are disclosed, including the use of AC test signals and the performance of tests having a Total Test Time within about 2.0 seconds or less, and/or having a clinically low Total System Error.Type: ApplicationFiled: December 30, 2009Publication date: July 8, 2010Inventors: Eric R. Diebold, Terry A. Beaty, Harvey B. Buck, JR.
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Patent number: 7751864Abstract: A method of operating an electrochemical analyte sensor having one or more electrodes may comprise applying a time-varying input signal to at least one of the one or more electrodes, monitoring a time-varying output signal produced by the sensor in response to application of the time-varying input signal, determining a complex impedance of the sensor based on the time-varying input and output signals, and determining from the complex impedance information relating to operation of the sensor.Type: GrantFiled: March 1, 2007Date of Patent: July 6, 2010Assignee: Roche Diagnostics Operations, Inc.Inventor: Harvey B. Buck, Jr.
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Patent number: 7731835Abstract: Sensors and a method for detecting an analyte are described. Sensors each have a volume of a hydrophilic medium that retains an amount of analyte proportionate to the concentration of analyte in a biological fluid, electrodes and a redox enzyme in contact with medium, and an electron transfer mediator. The fluid contacts sensors and at initially predetermined intervals intermittently applies a potential to electrode sufficient to oxidize the mediator and sensing current through electrode as a function of the duration of the applied potential. The applied mediator oxidizing applied potential is maintained for a period of time sufficient to determine the rate of change of current with time through electrode. The current flow is correlated with the current flow for known concentrations of the analyte in medium.Type: GrantFiled: January 19, 2005Date of Patent: June 8, 2010Assignee: Roche Diagnostics Operations, Inc.Inventors: Harvey B. Buck, Matthias Essenpreis
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Publication number: 20080275326Abstract: A sensor may include a substrate having a sensing portion defining a sensor thereon and a circuit mounting portion defining at least one electrically conductive pad that is electrically connected to the sensor. The sensor may be configured to produce a signal indicative of a condition of the patient. An anisotropic medium may be disposed on the circuit mounting portion and may be electrically conductive in a direction through the medium and electrically insulating in directions along the medium. An electrical circuit may be mechanically mounted to the circuit mounting portion of the first substrate via the anisotropic medium with at least one electrically conductive terminal juxtaposed over the at least one electrically conductive pad. The anisotropic medium may establish local electrical contact between the at least one electrically conductive terminal and the at least one electrically conductive pad.Type: ApplicationFiled: May 1, 2007Publication date: November 6, 2008Inventors: Joachim Kasielke, Ulrich Haueter, Ulrike Kamecke, Christian Hof, Matthew Reynolds, Timon Kasielke, Steven Gray, Harvey B. Buck, Michael Loukine, Fritz Hindelang
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Publication number: 20080214910Abstract: A method of operating an electrochemical analyte sensor having one or more electrodes may comprise applying a time-varying input signal to at least one of the one or more electrodes, monitoring a time-varying output signal produced by the sensor in response to application of the time-varying input signal, determining a complex impedance of the sensor based on the time-varying input and output signals, and determining from the complex impedance information relating to operation of the sensor.Type: ApplicationFiled: March 1, 2007Publication date: September 4, 2008Inventor: Harvey B. Buck
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Patent number: RE40198Abstract: A method and device for detection and quantification of biologically significant analytes in a liquid sample is described. The method includes contacting a volume of a liquid sample with predetermined amounts of at least a first and second redox reversible species having redox potentials differing by at least 50 millivolts. At least one of the redox reversible species comprises a liquid sample diffusible conjugate of a ligand analog of an analyte in the liquid sample and a redox reversible label. A predetermined amount of at least one specific binding partner for each analyte to be measured is combined with the sample and current flow is measured at first and second anodic and cathodic potentials and correlated with current flows for known concentrations of the respective diffusible redox reversible species. Diagnostic devices and kits, including such devices and the specified specific binding partner(s) and redox reversible species are also described.Type: GrantFiled: September 25, 2003Date of Patent: April 1, 2008Assignee: Roche Diagnostics Operations, Inc.Inventors: Harvey B. Buck, Jr., Zhi David Deng, Eric R. Diebold