Patents by Inventor Harvey Brandwein
Harvey Brandwein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9931378Abstract: A method of treating human papillomavirus (HPV), by administering a therapeutically effective amount of a primary cell-derived biologic to a patient infected with HPV, and inducing an immune response to HPV. A method of overcoming HPV-induced immune suppression of Langerhans cells (LC), by administering a therapeutically effective amount of a primary cell-derived biologic to a patient infected with HPV, and activating LC. A method of increasing LC migration towards lymph nodes, by administering a therapeutically effective amount of a primary cell-derived biologic to a patient infected with HPV, activating LC, and inducing LC migration towards lymph nodes. A method of generating immunity against HPV, by administering an effective amount of a primary cell derived biologic to a patient infected with HPV, generating immunity against HPV, and preventing new lesions from developing.Type: GrantFiled: April 13, 2016Date of Patent: April 3, 2018Assignee: IRX Therapeutics, Inc.Inventors: James E. Egan, Martin Kast, Harvey Brandwein
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Publication number: 20160303198Abstract: A method of treating human papillomavirus (HPV), by administering a therapeutically effective amount of a primary cell-derived biologic to a patient infected with HPV, and inducing an immune response to HPV. A method of overcoming HPV-induced immune suppression of Langerhans cells (LC), by administering a therapeutically effective amount of a primary cell-derived biologic to a patient infected with HPV, and activating LC. A method of increasing LC migration towards lymph nodes, by administering a therapeutically effective amount of a primary cell-derived biologic to a patient infected with HPV, activating LC, and inducing LC migration towards lymph nodes. A method of generating immunity against HPV, by administering an effective amount of a primary cell derived biologic to a patient infected with HPV, generating immunity against HPV, and preventing new lesions from developing.Type: ApplicationFiled: April 13, 2016Publication date: October 20, 2016Applicant: IRX Therapeutics, Inc.Inventors: James E. Egan, Martin Kast, Harvey Brandwein
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Patent number: 9333238Abstract: A method of treating human papillomavirus (HPV), by administering a therapeutically effective amount of a primary cell-derived biologic to a patient infected with HPV, and inducing an immune response to HPV. A method of overcoming HPV-induced immune suppression of Langerhans cells (LC), by administering a therapeutically effective amount of a primary cell-derived biologic to a patient infected with HPV, and activating LC. A method of increasing LC migration towards lymph nodes, by administering a therapeutically effective amount of a primary cell-derived biologic to a patient infected with HPV, activating LC, and inducing LC migration towards lymph nodes. A method of generating immunity against HPV, by administering an effective amount of a primary cell derived biologic to a patient infected with HPV, generating immunity against HPV, and preventing new lesions from developing.Type: GrantFiled: December 8, 2010Date of Patent: May 10, 2016Assignee: IRX Therapeutics, Inc.Inventors: James E. Egan, Martin Kast, Harvey Brandwein
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Patent number: 8591956Abstract: A method of increasing immunological effect in a patient by administering an effective amount of a primary cell derived biologic to the patient, inducing immune production, blocking immune destruction, and increasing immunological effect in the patient. Methods of treating an immune target, treating a tumor, immune prophylaxis, and preventing tumor escape.Type: GrantFiled: August 8, 2011Date of Patent: November 26, 2013Assignee: IRX Therapeutics, Inc.Inventors: John W. Hadden, Theresa L. Whiteside-Nimick, James E. Egan, Kathy L. Signorelli-Petrat, Harvey Brandwein
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Publication number: 20120244117Abstract: A method of treating human papillomavirus (HPV), by administering a therapeutically effective amount of a primary cell-derived biologic to a patient infected with HPV, and inducing an immune response to HPV. A method of overcoming HPV-induced immune suppression of Langerhans cells (LC), by administering a therapeutically effective amount of a primary cell-derived biologic to a patient infected with HPV, and activating LC. A method of increasing LC migration towards lymph nodes, by administering a therapeutically effective amount of a primary cell-derived biologic to a patient infected with HPV, activating LC, and inducing LC migration towards lymph nodes. A method of generating immunity against HPV, by administering an effective amount of a primary cell derived biologic to a patient infected with HPV, generating immunity against HPV, and preventing new lesions from developing.Type: ApplicationFiled: December 8, 2010Publication date: September 27, 2012Applicant: IRX Therapeutics, IncInventors: James E. Egan, Martin Kast, Diane Da Silva, Harvey Brandwein
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Publication number: 20120141512Abstract: A method of increasing immunological effect in a patient by administering an effective amount of a primary cell derived biologic to the patient, inducing immune production, blocking immune destruction, and increasing immunological effect in the patient. Methods of treating an immune target, treating a tumor, immune prophylaxis, and preventing tumor escape.Type: ApplicationFiled: August 8, 2011Publication date: June 7, 2012Inventors: John W. Hadden, Theresa L. Whiteside, Margareta Czytowska, James E. Egan, Kathy L. Signorelli, Harvey Brandwein
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Patent number: 7993660Abstract: A method of increasing immunological effect in a patient by administering an effective amount of a primary cell derived biologic to the patient, inducing immune production, blocking immune destruction, and increasing immunological effect in the patient. Methods of treating an immune target, treating a tumor, immune prophylaxis, and preventing tumor escape.Type: GrantFiled: November 26, 2008Date of Patent: August 9, 2011Assignee: IRx Therapeutics, Inc.Inventors: John W. Hadden, Theresa L. Whiteside, Margareta Czystowska, James E. Egan, Kathy L. Signorelli, Harvey Brandwein
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Publication number: 20090155291Abstract: A method of increasing immunological effect in a patient by administering an effective amount of a primary cell derived biologic to the patient, inducing immune production, blocking immune destruction, and increasing immunological effect in the patient. Methods of treating an immune target, treating a tumor, immune prophylaxis, and preventing tumor escape.Type: ApplicationFiled: November 26, 2008Publication date: June 18, 2009Inventors: John W. Hadden, Theresa L. Whiteside, Margareta Czystowska, James E. Egan, Kathy L. Signorelli, Harvey Brandwein
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Publication number: 20030134417Abstract: The present invention provides methods of harvesting rare cells from blood products and/or obtaining products of the rare cells. The method includes contacting a blood product containing rare cells with a porous medium, and selectively retaining rare cells of interest on the porous medium. The porous medium can be contacted with an elution fluid wherein a population of the rare cells is eluted from the porous medium. Rare cells selectively retained on the porous medium can be cultured on the porous medium, and products of the rare cells can be obtained.Type: ApplicationFiled: February 11, 2003Publication date: July 17, 2003Applicant: Pall CorporationInventors: Harvey Brandwein, Samuel O. Coker
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Patent number: 6544751Abstract: The present invention provides methods of harvesting rare cells from blood products and/or obtaining products of the rare cells. The method includes contacting a blood product containing rare cells with a porous medium, and selectively retaining rare cells of interest on the porous medium. The porous medium can be contacted with an elution fluid wherein a population of the rare cells is eluted from the porous medium. Rare cells selectively retained on the porous medium can be cultured on the porous medium, and products of the rare cells can be obtained.Type: GrantFiled: September 30, 1999Date of Patent: April 8, 2003Assignee: Pall CorporationInventors: Harvey Brandwein, Samuel Coker
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Patent number: 5266219Abstract: A device for separating plasma from blood is provided comprising a synthetic polymeric fibrous structure having a CWST in excess of 65 dynes/cm, the structure having a first region for receiving a blood sample and a second region for accumulating plasma.Type: GrantFiled: August 15, 1991Date of Patent: November 30, 1993Assignee: Pall CorporationInventors: David B. Pall, Thomas C. Gsell, Vlado I. Matkovich, Harvey Brandwein
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Patent number: 4606855Abstract: A method of determining the concentration of an antigen in a sample solution comprising(a) coating an antigen-protein conjugate onto a solid matrix,(b) conjugating an enzyme to an antibody specific for said antigen,(c) to a known quantity of a solution containing the antibody-enzyme conjugate of (b) adding a specified quantity of a sample containing an unknown amount of the antigen whose content is to be determined,(d) contacting the coated solid matrix of (a) with the solution (c) and incubate so as to effect binding between the antibody and antigen, some of the antigen being that from the sample and some being that on the solid matrix,(e) removing the solid matrix from the solution and washing,(f) immersing the solid matrix in a solution containing a known amount of an enzyme-substrate which is acted upon by the enzyme so as to effect reaction between the enzyme and enzyme-substrate to produce a product, and then separating the solid matrix form the solution of enzyme-substrate, and(g) then measuring the soType: GrantFiled: July 22, 1983Date of Patent: August 19, 1986Assignee: Mex Research Associates c/o Leon ReimerInventors: Alice Deutsch, Harvey Brandwein, Herbert Platt, Dianne M. Hunter, Andrew Dubitsky, Susan M. Durham
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Patent number: 4477576Abstract: A method of determining the concentration of an antigen in a sample solution comprising(a) coating an antigen-protein conjugate onto a solid matrix,(b) conjugating an enzyme to an antibody specific for said antigen,(c) to a known quantity of a solution containing the antibody-enzyme conjugate of (b) adding a specified quantity of a sample containing an unknown amount of the antigen whose content is to be determined,(d) contacting the coated solid matrix of (a) with the solution (c) and incubate so as to effect binding between the antibody and antigen, some of the antigen being that from the sample and some being that on the solid matrix,(e) removing the solid matrix from the solution and washing,(f) immersing the solid matrix in a solution containing a known amount of an enzyme-substrate which is acted upon by the enzyme so as to effect reaction between the enzyme and enzyme-substrate to produce a product, and then separating the solid matrix from the solution of enzyme-substrate, and(g) then measuring the soType: GrantFiled: July 26, 1982Date of Patent: October 16, 1984Assignee: Mex Research AssociatesInventors: Alice Deutsch, Harvey Brandwein, Herbert Platt, Dianne M. Hunter, Andrew Dubitsky, Susan M. Durham