Patents by Inventor Harvey CHE

Harvey CHE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bicyclic peptide ligands specific for OX40
    Patent number: 11613560
    Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which bind to OX40. The invention also relates to multimeric binding complexes of polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold that are functional agonists of OX40. The invention also includes drug conjugates comprising said peptides and complexes, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands, complexes and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by OX40.
    Type: Grant
    Filed: May 11, 2020
    Date of Patent: March 28, 2023
    Assignee: BicycleTx Limited
    Inventors: Tom Li Stephen, Kevin McDonnell, Nicholas Keen, Liuhong Chen, Helen Harrison, Peter U. Park, Michael Skynner, Harvey Che
  • BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR OX40
    Publication number: 20200354406
    Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which bind to OX40. The invention also relates to multimeric binding complexes of polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold that are functional agonists of OX40. The invention also includes drug conjugates comprising said peptides and complexes, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands, complexes and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by OX40.
    Type: Application
    Filed: May 11, 2020
    Publication date: November 12, 2020
    Inventors: Tom Li STEPHEN, Kevin MCDONNELL, Nicholas KEEN, Liuhong CHEN, Helen HARRISON, Peter U. PARK, Michael SKYNNER, Harvey CHE