Abstract: A system and methods for co-registering multi-channel images of a tissue micro array, comprising the steps of, providing a biological material on a substrate; applying one or more molecular probes, adapted to provide fluorescent molecular markers, to the biological material; obtaining a first digital image of the biological material and the fluorescent molecular markers; applying a morphological stain to the biological material; obtaining a second digital image of the biological material, computing information common to the first and second images; and co-registering the second image with the first image based on one or more registration metrics.

Abstract: A system for analyzing tissue samples, that generally comprises, a storage device for at least temporarily storing one or more images of one or more cells, wherein the images comprise a plurality of channels; and a processor that is adapted to determine the extent to which a biomarker may have translocated from at least one subcellular region to another subcellular region; and then to generate a score corresponding to the extent of translocation.

Abstract: Methods and systems for segmenting images, wherein the image pixels are categorized into a plurality of subsets using one or more indexes, then a log-likelihood function of one or more of the indexes is determined, and one or more maps are generated based on the determination of the log-likelihood function of one or more of the indexes.

Abstract: Method and systems for removing any inherent autofluorescence associated with a biological material, comprising: acquiring a first reference image of the biological material; acquiring a first set of one or more images of the biological material using one or more filters corresponding to one or more information dyes; applying the one or more additional dyes to the biological material and then acquiring a second set of one or more images comprising a separate image of the biological material with each of the filters corresponding to the information dyes and a second reference image of the biological material; coregistering the first and second reference images; and then removing any inherent autofluorescence exhibited in the informational images acquired.

Abstract: An imaging and interventional system and methods are provided. The system comprises an imaging device for acquiring volumetric image data for an anatomical region of interest, a catheter for acquiring electrophysiological (EP) measurements of the anatomical region of interest, the catheter having at least one tracking coil for detecting signals indicative of a position of the catheter, and, a processor coupled to the catheter for receiving the EP measurements and signals indicative of the position of the catheter. The position of the catheter and EP measurements are combined and superimposed on a resultant image. The method comprises acquiring volumetric image data for an anatomical region of interest, acquiring position data for a catheter inserted in the region of interest, obtaining electrophysiological (EP) measurements for the region of interest and combining the image data, position data and EP measurements into a resultant image for use in the interventional procedure.

Abstract: Method and systems for removing any inherent autofluorescence associated with a biological material, comprising: acquiring a first reference image of the biological material; acquiring a first set of one or more images of the biological material using one or more filters corresponding to one or more information dyes; applying the one or more additional dyes to the biological material and then acquiring a second set of one or more images comprising a separate image of the biological material with each of the filters corresponding to the information dyes and a second reference image of the biological material; coregistering the first and second reference images; and then removing any inherent autofluorescence exhibited in the informational images acquired.

Abstract: A coil array for use in magnetic resonance imaging (MRI) is provided and comprises a plurality of low loss coil elements and at least one non-conducting substrate adapted to position the plurality of low loss coil elements in a fixed position thereon. Further, a coil array assembly for use in a magnetic resonance imaging (MRI) scanner is provided. The coil array assembly comprises a pair of coil arrays, wherein each coil array comprises: a plurality of low loss coil elements and at least one non-conducting substrate adapted to position the plurality of low loss coil elements in a fixed position thereon. Further, the pair of coil arrays are coupled to the MRI scanner for receiving imaging signals in a region of interest excited within the pair of coil arrays. Further, the coil array is adapted for use in breast imaging.

Abstract: A system for analyzing tissue samples, that generally comprises, a storage device for at least temporarily storing one or more images of one or more cells, wherein the images comprise a plurality of channels; and a processor that is adapted to determine the extent to which a biomarker may have translocated from at least one subcellular region to another subcellular region; and then to generate a score corresponding to the extent of translocation.

Abstract: A system for analyzing tissue samples, comprising: a storage device for at least temporarily storing one or more images of one or more cells, wherein at least one of the images is indicative of one or more channels comprising a receptor tyrosine kinase (RTK); and a processing device that determines an extent to which one or more of the RTKs may have translocated from at least one subcellular region to another subcellular region of one or more of the cells; and generates a score based at least in part on the RTK translocation.

Abstract: Methods and systems for segmenting images, wherein the image pixels are categorized into a plurality of subsets using one or more indexes, then a log-likelihood function of one or more of the indexes is determined, and one or more maps are generated based on the determination of the log-likelihood function of one or more of the indexes.

Abstract: A system and methods for co-registering multi-channel images of a tissue micro array, comprising the steps of, providing a biological material on a substrate; applying one or more molecular probes, adapted to provide fluorescent molecular markers, to the biological material; obtaining a first digital image of the biological material and the fluorescent molecular markers; applying a morphological stain to the biological material; obtaining a second digital image of the biological material, computing information common to the first and second images; and co-registering the second image with the first image based on one or more registration metrics.

Abstract: An imaging and interventional system and methods are provided. The system comprises an imaging device for acquiring volumetric image data for an anatomical region of interest, a catheter for acquiring electrophysiological (EP) measurements of the anatomical region of interest, the catheter having at least one tracking coil for detecting signals indicative of a position of the catheter, and, a processor coupled to the catheter for receiving the EP measurements and signals indicative of the position of the catheter. The position of the catheter and EP measurements are combined and superimposed on a resultant image. The method comprises acquiring volumetric image data for an anatomical region of interest, acquiring position data for a catheter inserted in the region of interest, obtaining electrophysiological (EP) measurements for the region of interest and combining the image data, position data and EP measurements into a resultant image for use in the interventional procedure.

Abstract: A coil array for use in magnetic resonance imaging (MRI) is provided and comprises a plurality of low loss coil elements and at least one non-conducting substrate containing adapted to position the plurality of low loss coil elements in a fixed position thereon. Further, a coil array assembly for use in a magnetic resonance imaging (MRI) scanner is provided. The coil array assembly comprises a pair of coil arrays, wherein each coil array comprises: a plurality of low loss coil elements and at least one non-conducting substrate containing adapted to position the plurality of low loss coil elements in a fixed position thereon. Further, the pair of coil arrays are coupled to the MRI scanner for receiving imaging signals in a region of interest excited within the pair of coil arrays. Further, the coil array is adapted for use in breast imaging.

Abstract: An RF coil assembly for use in a multiple receive-channel MRI system is provided. The RF coil assembly is configured as a multi-turn-element RF coil assembly to operate as a surface-coil array in cooperation with the MRI system which is configured to operate in a multiple-channel receive mode.

Abstract: An apparatus and method for segmenting three-dimensional (3D) medical images containing a region of interest is provided that identifies a first set of seed points within the region of interest and a second set of seed points outside the region of interest. A first sphere is constructed within the region of interest. Voxels contained within the medical image are classified using a spatial constrained fuzzy clustering algorithm. A plurality of second spheres is generated. Ones of the plurality of second spheres are accepted that satisfy the homogeneity function threshold as defined by the spatial constricted fuzzy clustering algorithm. A three-dimensional area is grown that defines the region of interest. The region of interest defined by the three-dimensional area is displayed.

Abstract: A method and system for segmenting three-dimensional (3D) medical images containing an object of interest are provided. The method comprises generating a plurality of successive layers of fixed radius spheres about a circumference of a sphere containing at least one seed point placed within the object of interest when a plurality of respective voxels contained within the spheres exceed a selected threshold. The generation of the layers is repeated until no further voxels contained within an outer surface of each respective layer exceed the selected threshold or a stop seed point is encountered. The layers form a segmented representation of the object of interest.

Abstract: A matrix coil for generating a variable magnetic field is provided, including a plurality of loops arranged in a series so as to have a substantially common axis and segmented into at least one arc-shaped segment, a variable current source for each of the arc-shaped segments, and a controller. The controller is configured to selectively vary an amount of current provided to each of the arc-shaped segments by the variable current sources so as to achieve a variable base field, one or more variable gradient fields, and one or more variable second order shim fields.

Abstract: The present invention provides a model and a method and apparatus for utilizing the model to simulate an imaging scenario. The model is mathematically defined by analytical basis objects and/or polygonal basis objects. Preferably, the model is a model of the human heart and thorax. Polygonal basis objects are only used to define structures in the model that experience torsion, such as certain structures in the heart that experience torsion during the cardiac cycle. The manner in which the basis objects comprising the model are transformed by scaling, translation and rotation is defined for each basis object. In the case where a basis object experiences torsion, the rotation of the basis object will change as a function of the length along the axis of the basis object about which rotation is occurring.

Abstract: The present invention provides a model and a method and apparatus for utilizing the model to simulate an imaging scenario. The model is mathematically defined by analytical basis objects and/or polygonal basis objects. Preferably, the model is a model of the human heart and thorax. Polygonal basis objects are only used to define structures in the model that experience torsion, such as certain structures in the heart that experience torsion during the cardiac cycle. The manner in which the basis objects comprising the model are transformed by scaling, translation and rotation is defined for each basis object. In the case where a basis object experiences torsion, the rotation of the basis object will change as a function of the length along the axis of the basis object about which rotation is occurring.

Abstract: A method and system for detecting iron using magnetic resonance imaging (MRI) is provided. The method comprises acquiring magnetic resonance (MR) images by a selected pulse sequence to enhance brain iron deposits using a MRI system having a substantially high magnetic field strength and characterizing regions of interest within the MR images having statistically relevant quantities of iron deposits to indicate a given disease.