Patents by Inventor Harvey Kasdan
Harvey Kasdan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10371640Abstract: The present invention provide compositions and methods for classifying leukocytes in a leukocyte population using fluorescence detection. The methods include contacting a leukocyte population in a sample having one or more leukocyte types with a diagnostic composition, exciting the leukocyte population with a light source; and measuring emitted light from each of the one or more leukocyte types to classify the leukocyte population.Type: GrantFiled: July 11, 2017Date of Patent: August 6, 2019Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGYInventors: Yu-Chong Tai, Wendian Shi, Harvey Kasdan
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Publication number: 20170315060Abstract: The present invention provide compositions and methods for classifying leukocytes in a leukocyte population using fluorescence detection. The methods include contacting a leukocyte population in a sample having one or more leukocyte types with a diagnostic composition, exciting the leukocyte population with a light source; and measuring emitted light from each of the one or more leukocyte types to classify the leukocyte population.Type: ApplicationFiled: July 11, 2017Publication date: November 2, 2017Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGYInventors: YU-CHONG TAI, WENDIAN SHI, HARVEY KASDAN
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Patent number: 9029158Abstract: Described herein are particular embodiments relating to a microfluidic device that may be utilized for cell sensing, counting, and/or sorting. Particular aspects relate to a microfabricated device that is capable of differentiating single cell types from dense cell populations. One particular embodiment relates a device and methods of using the same for sensing, counting, and/or sorting leukocytes from whole, undiluted blood samples.Type: GrantFiled: June 4, 2014Date of Patent: May 12, 2015Assignee: California Institute of TechnologyInventors: Yu-Chong Tai, Siyang Zheng, Jeffrey Chun-Hui Lin, Harvey Kasdan
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Publication number: 20140377742Abstract: Described herein are particular embodiments relating to a microfluidic device that may be utilized for cell sensing, counting, and/or sorting. Particular aspects relate to a microfabricated device that is capable of differentiating single cell types from dense cell populations. One particular embodiment relates a device and methods of using the same for sensing, counting, and/or sorting leukocytes from whole, undiluted blood samples.Type: ApplicationFiled: June 4, 2014Publication date: December 25, 2014Applicant: California Institute of TechnologyInventors: Yu-Chong Tai, Siyang Zheng, Jeffrey Chun-Hui Lin, Harvey Kasdan
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Patent number: 8447417Abstract: The invention is a state machine having a host controller that controls a level-1 controller, wherein the level-1 controller controls the level-2 controller. The level-2 controller controls system component controllers, which in turn control system components to execute a process segment. For example, the machine includes a host controller that selects a set of states to be executed, a level-1 controller that activates the set of states in a predetermined order, wherein each state includes commands, and a level-2 controller that controls system components according to the commands. A method of executing a process includes identifying a set of states to be executed, issuing state commands that need to be issued to execute the current state in the set of states, and activating a next state only after all expected status reports have been received for the current state.Type: GrantFiled: December 4, 2007Date of Patent: May 21, 2013Assignee: IRIS International, Inc.Inventors: Harvey Kasdan, Kenneth S. Gold, Jon Frank Tindel, Ken A. Atterholt, David Alan Fridge
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Patent number: 8354075Abstract: The present invention provides a streamline-based device and a method for using the device for continuous separation of particles including cells in biological fluids. The device includes a main microchannel and an array of side microchannels disposed on a substrate. The main microchannel has a plurality of stagnation points with a predetermined geometric design, for example, each of the stagnation points has a predetermined distance from the upstream edge of each of the side microchannels. The particles are separated and collected in the side microchannels.Type: GrantFiled: April 20, 2006Date of Patent: January 15, 2013Assignees: California Institute of Technology, IRIS International, Inc.Inventors: Yu-Chong Tai, Siyang Zheng, Harvey Kasdan
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Publication number: 20110184537Abstract: The invention is a state machine having a host controller that controls a level-1 controller, wherein the level-1 controller controls the level-2 controller. The level-2 controller controls system component controllers, which in turn control system components to execute a process segment. For example, the machine includes a host controller that selects a set of states to be executed, a level-1 controller that activates the set of states in a predetermined order, wherein each state includes commands, and a level-2 controller that controls system components according to the commands. A method of executing a process includes identifying a set of states to be executed, issuing state commands that need to be issued to execute the current state in the set of states, and activating a next state only after all expected status reports have been received for the current state.Type: ApplicationFiled: April 5, 2011Publication date: July 28, 2011Inventors: Harvey Kasdan, Kenneth S. Gold, Jon Frank Tindel, Ken A. Atterholt, David Alan Fridge
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Publication number: 20090042241Abstract: Described herein are particular embodiments relating to a microfluidic device that may be utilized for cell sensing, counting, and/or sorting. Particular aspects relate to a microfabricated device that is capable of differentiating single cell types from dense cell populations. One particular embodiment relates a device and methods of using the same for sensing, counting, and/or sorting leukocytes from whole, undiluted blood samples.Type: ApplicationFiled: April 4, 2008Publication date: February 12, 2009Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGYInventors: Tai Yu-Chong, Siyang Zheng, Jeffrey Chun-Hui Lin, Harvey Kasdan
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Publication number: 20080140224Abstract: The invention is a state machine having a host controller that controls a level-1 controller, wherein the level-1 controller controls the level-2 controller. The level-2 controller controls system component controllers, which in turn control system components to execute a process segment. For example, the machine includes a host controller that selects a set of states to be executed, a level-1 controller that activates the set of states in a predetermined order, wherein each state includes commands, and a level-2 controller that controls system components according to the commands. A method of executing a process includes identifying a set of states to be executed, issuing state commands that need to be issued to execute the current state in the set of states, and activating a next state only after all expected status reports have been received for the current state.Type: ApplicationFiled: December 4, 2007Publication date: June 12, 2008Inventors: Harvey Kasdan, Kenneth S. Gold, Jon Frank Tindel, Ken A. Atterholt, David Alan Fridge
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Patent number: 7319907Abstract: The invention is a state machine having a host controller that controls a level-i controller, wherein the level-1 controller controls the level-2 controller. The level-2 controller controls system component controllers, which in turn control system components to execute a process segment. For example, the machine includes a host controller that selects a set of states to be executed, a level-1 controller that activates the set of states in a predetermined order, wherein each state includes commands, and a level-2 controller that controls system components according to the commands. A method of executing a process includes identifying a set of states to be executed, issuing state commands that need to be issued to execute the current state in the set of states, and activating a next state only after all expected status reports have been received for the current state.Type: GrantFiled: November 18, 2003Date of Patent: January 15, 2008Assignee: International Remote Imaging Systems, Inc.Inventors: Harvey Kasdan, Kenneth S. Gold, Jon Frank Tindel, Ken A. Atterholt, David Alan Fridge
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Publication number: 20060220787Abstract: A method and apparatus for detecting and tracking an object within a defined area, and determining its position, status, movement and identity therein, includes interrogating the defined area to communicate with an information device associated with an object and transmit information received to a master controller unit, which determines the object's presence, position, status, movement and identity within the defined area. It is emphasized that this abstract is provided to comply with the rules requiring an abstract which will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or the meaning of the claims.Type: ApplicationFiled: March 1, 2006Publication date: October 5, 2006Inventors: Richard Turner, Harvey Kasdan
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Publication number: 20050200453Abstract: A method and apparatus for detecting and tracking an object with a defined area, and determining its position, status movement and identity therein, includes interrogating the defined area to communicate with an information device on object and transmit received to a master controller unit, which determines the object's presence, position, movement and identity with the defined area. It is emphasized that this abstract is provided to comply with the rules requiring an abstract which will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or the meaning of the claims.Type: ApplicationFiled: January 21, 2005Publication date: September 15, 2005Inventors: Richard Turner, Harvey Kasdan
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Publication number: 20050033455Abstract: The invention is a state machine having a host controller that controls a level-1 controller controller, wherein the level-1 controller controls the level-2 controller. The level-2 controller controls system component controllers, which in turn control system components to execute a process segment. For example, the machine includes a host controller that selects a set of states to be executed, a level-1 controller that activates the set of states in a predetermined order, wherein each state includes commands, and a level-2 controller that controls system components according to the commands. The invention also includes a method of executing a process by identifying a set of states to be executed, issuing state commands that need to be issued to execute the current state in the set of states, and activating a next state only after all expected status reports have been received for the current state.Type: ApplicationFiled: November 18, 2003Publication date: February 10, 2005Inventors: Harvey Kasdan, Kenneth Gold, Jon Tindel, Ken Atterholt, David Fridge
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Publication number: 20050008228Abstract: Most automatic particle classification methods produce errors. The invention provides a method for improving the accuracy of particle classification while shortening the amount of manual review time required from the operator. The method uses class weights, which are statistically-derived correction factors that accounts for frequency of classification errors. A first class weight and a second class weight are assigned to the first class and the second class, respectively. The number of particles in each of the first and the second classes is multiplied by the first class weight and the second class weight, respectively, to generate a corrected number of particles in each of the classes. If particles are reclassified, the class weights are recalculated in response to the reclassification. The method is usable with a complete classification where all the particles in a sample are classified, or a selective classification of a subset of the particles in the sample.Type: ApplicationFiled: May 21, 2004Publication date: January 13, 2005Inventors: Eric Chapoulaud, Harvey Kasdan
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Patent number: 6594586Abstract: Analysis of white blood cells is carried out by first analyzing the sample using image processing to obtain a no-context estimate of each cell's content. Then, a post processing operation is carried out to refine the estimate to include information about neighboring white blood cells. The estimate is refined to take into account the identity of the neighboring cells.Type: GrantFiled: October 28, 1998Date of Patent: July 15, 2003Assignee: California Institute of TechnologyInventors: Xubo Song, Yaser Abu-Mostafa, Joseph Sill, Harvey Kasdan
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Patent number: 6590646Abstract: Particles in a fluid are counted as the fluid flows through an examination area of a particle analyzer. Parameters based upon the particle count are calculated. It is determined whether the at least one calculated parameter is within an allowable range for the parameter. Based on this determination, an indication is provided of uniformity of the fluid sample in the examination area.Type: GrantFiled: May 20, 2002Date of Patent: July 8, 2003Assignee: International Remote Imaging Systems, Inc.Inventors: Harvey Kasdan, Jaehyl Ko
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Publication number: 20030002037Abstract: Particles in a fluid are counted as the fluid flows through an examination area of a particle analyzer. Parameters based upon the particle count are calculated. It is determined whether the at least one calculated parameter is within an allowable range for the parameter. Based on this determination, an indication is provided of uniformity of the fluid sample in the examination area.Type: ApplicationFiled: May 20, 2002Publication date: January 2, 2003Inventors: Harvey Kasdan, Jaehyl Ko
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Patent number: 6424415Abstract: Particles in a fluid are counted as the fluid flows through an examination area of a particle analyzer. Parameters based upon the particle count are calculated. It is determined whether the at least one calculated parameter is within an allowable range for the parameter. Based on this determination, an indication is provided of uniformity of the fluid sample in the examination area.Type: GrantFiled: August 2, 2000Date of Patent: July 23, 2002Assignee: International Remote Imaging Systems, Inc.Inventors: Harvey Kasdan, Jaehyl Ko
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Patent number: 6184978Abstract: Particles in a fluid are counted as the fluid flows through an examination area of a particle analyzer. Parameters based upon the particle count are calculated. It is determined whether the at least one calculated parameter is within an allowable range for the parameter. Based on this determination, an indication is provided of uniformity of the fluid sample in the examination area.Type: GrantFiled: May 7, 1997Date of Patent: February 6, 2001Assignee: International Remote Imaging Systems, Inc.Inventors: Harvey Kasdan, Jaehyl Ko