Patents by Inventor Harvey L. Kasdan
Harvey L. Kasdan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11946848Abstract: For analyzing a sample containing particles of at least two categories, such as a sample containing blood cells, a particle counter subject to a detection limit is coupled with an analyzer capable of discerning particle number ratios, such as a visual analyzer, and a processor. A first category of particles can be present beyond detection range limits while a second category of particles is present within respective detection range limits. The concentration of the second category of particles is determined by the particle counter. A ratio of counts of the first category to the second category is determined on the analyzer. The concentration of particles in the first category is calculated on the processor based on the ratio and the count or concentration of particles in the second category.Type: GrantFiled: November 9, 2022Date of Patent: April 2, 2024Assignee: Iris International, Inc.Inventors: Thomas H. Adams, Bart J. Wanders, John Roche, Harvey L. Kasdan
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Publication number: 20230243731Abstract: For analyzing a sample containing particles of at least two categories, such as a sample containing blood cells, a particle counter subject to a detection limit is coupled with an analyzer capable of discerning particle number ratios, such as a visual analyzer, and a processor. A first category of particles can be present beyond detection range limits while a second category of particles is present within respective detection range limits. The concentration of the second category of particles is determined by the particle counter. A ratio of counts of the first category to the second category is determined on the analyzer. The concentration of particles in the first category is calculated on the processor based on the ratio and the count or concentration of particles in the second category.Type: ApplicationFiled: April 11, 2023Publication date: August 3, 2023Inventors: Thomas H. Adams, Bart J. Wanders, John Roche, Harvey L. Kasdan
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Publication number: 20230152203Abstract: For analyzing a sample containing particles of at least two categories, such as a sample containing blood cells, a particle counter subject to a detection limit is coupled with an analyzer capable of discerning particle number ratios, such as a visual analyzer, and a processor. A first category of particles can be present beyond detection range limits while a second category of particles is present within respective detection range limits. The concentration of the second category of particles is determined by the particle counter. A ratio of counts of the first category to the second category is determined on the analyzer. The concentration of particles in the first category is calculated on the processor based on the ratio and the count or concentration of particles in the second category.Type: ApplicationFiled: November 9, 2022Publication date: May 18, 2023Inventors: Thomas H. Adams, Bart J. Wanders, John Roche, Harvey L. Kasdan
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Patent number: 11525766Abstract: For analyzing a sample containing particles of at least two categories, such as a sample containing blood cells, a particle counter subject to a detection limit is coupled with an analyzer capable of discerning particle number ratios, such as a visual analyzer, and a processor. A first category of particles can be present beyond detection range limits while a second category of particles is present within respective detection range limits. The concentration of the second category of particles is determined by the particle counter. A ratio of counts of the first category to the second category is determined on the analyzer. The concentration of particles in the first category is calculated on the processor based on the ratio and the count or concentration of particles in the second category.Type: GrantFiled: August 6, 2019Date of Patent: December 13, 2022Assignee: Iris International, Inc.Inventors: Thomas H. Adams, Bart J. Wanders, John Roche, Harvey L. Kasdan
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Publication number: 20200033249Abstract: For analyzing a sample containing particles of at least two categories, such as a sample containing blood cells, a particle counter subject to a detection limit is coupled with an analyzer capable of discerning particle number ratios, such as a visual analyzer, and a processor. A first category of particles can be present beyond detection range limits while a second category of particles is present within respective detection range limits. The concentration of the second category of particles is determined by the particle counter. A ratio of counts of the first category to the second category is determined on the analyzer. The concentration of particles in the first category is calculated on the processor based on the ratio and the count or concentration of particles in the second category.Type: ApplicationFiled: August 6, 2019Publication date: January 30, 2020Inventors: Thomas H. Adams, Bart J. Wanders, John Roche, Harvey L. Kasdan
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Patent number: 10429292Abstract: For analyzing a sample containing particles of at least two categories, such as a sample containing blood cells, a particle counter subject to a detection limit is coupled with an analyzer capable of discerning particle number ratios, such as a visual analyzer, and a processor. A first category of particles can be present beyond detection range limits while a second category of particles is present within respective detection range limits. The concentration of the second category of particles is determined by the particle counter. A ratio of counts of the first category to the second category is determined on the analyzer. The concentration of particles in the first category is calculated on the processor based on the ratio and the count or concentration of particles in the second category.Type: GrantFiled: March 17, 2014Date of Patent: October 1, 2019Assignee: Iris International, Inc.Inventors: Thomas H. Adams, Bart J. Wanders, John Roche, Harvey L. Kasdan
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Patent number: 9757729Abstract: Described herein are particular embodiments relating to a microfluidic device that may be utilized for cell sensing, counting, and/or sorting. Particular aspects relate to a microfabricated device that is capable of differentiating single cell types from dense cell populations. One particular embodiment relates a device and methods of using the same for sensing, counting, and/or sorting leukocytes from whole, undiluted blood samples.Type: GrantFiled: November 18, 2016Date of Patent: September 12, 2017Assignee: California Institute of TechnologyInventors: Yu-Chong Tai, Siyang Zheng, Jeffrey Chun-Hui Lin, Harvey L. Kasdan
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Publication number: 20170136463Abstract: Described herein are particular embodiments relating to a microfluidic device that may be utilized for cell sensing, counting, and/or sorting. Particular aspects relate to a microfabricated device that is capable of differentiating single cell types from dense cell populations. One particular embodiment relates a device and methods of using the same for sensing, counting, and/or sorting leukocytes from whole, undiluted blood samples.Type: ApplicationFiled: November 18, 2016Publication date: May 18, 2017Applicant: California Institute of TechnologyInventors: Yu-Chong Tai, Siyang Zheng, Jeffrey Chun-Hui Lin, Harvey L. Kasdan
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Patent number: 9535059Abstract: Described herein are particular embodiments relating to a microfluidic device that may be utilized for cell sensing, counting, and/or sorting. Particular aspects relate to a microfabricated device that is capable of differentiating single cell types from dense cell populations. One particular embodiment relates a device and methods of using the same for sensing, counting, and/or sorting leukocytes from whole, undiluted blood samples.Type: GrantFiled: November 3, 2015Date of Patent: January 3, 2017Assignee: California Institute of TechnologyInventors: Yu-Chong Tai, Siyang Zheng, Jeffrey Chun-Hui Lin, Harvey L. Kasdan
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Publication number: 20160131640Abstract: Described herein are particular embodiments relating to a microfluidic device that may be utilized for cell sensing, counting, and/or sorting. Particular aspects relate to a microfabricated device that is capable of differentiating single cell types from dense cell populations. One particular embodiment relates a device and methods of using the same for sensing, counting, and/or sorting leukocytes from whole, undiluted blood samples.Type: ApplicationFiled: November 3, 2015Publication date: May 12, 2016Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGYInventors: Yu-Chong Tai, Siyang Zheng, Jeffrey Chun-Hui Lin, Harvey L. Kasdan
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Patent number: 9234884Abstract: Described herein are particular embodiments relating to a microfluidic device that may be utilized for cell sensing, counting, and/or sorting. Particular aspects relate to a microfabricated device that is capable of differentiating single cell types from dense cell populations. One particular embodiment relates a device and methods of using the same for sensing, counting, and/or sorting leukocytes from whole, undiluted blood samples.Type: GrantFiled: April 13, 2015Date of Patent: January 12, 2016Assignee: California Institute of TechnologyInventors: Yu-Chong Tai, Siyang Zheng, Jeffrey Chun-Hui Lin, Harvey L. Kasdan
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Publication number: 20150309011Abstract: Described herein are particular embodiments relating to a microfluidic device that may be utilized for cell sensing, counting, and/or sorting. Particular aspects relate to a microfabricated device that is capable of differentiating single cell types from dense cell populations. One particular embodiment relates a device and methods of using the same for sensing, counting, and/or sorting leukocytes from whole, undiluted blood samples.Type: ApplicationFiled: April 13, 2015Publication date: October 29, 2015Applicant: California Institute of TechnologyInventors: Yu-Chong Tai, Siyang Zheng, Jeffrey Chun-Hui Lin, Harvey L. Kasdan
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Publication number: 20140273076Abstract: For analyzing a sample containing particles of at least two categories, such as a sample containing blood cells, a particle counter subject to a detection limit is coupled with an analyzer capable of discerning particle number ratios, such as a visual analyzer, and a processor. A first category of particles can be present beyond detection range limits while a second category of particles is present within respective detection range limits. The concentration of the second category of particles is determined by the particle counter. A ratio of counts of the first category to the second category is determined on the analyzer. The concentration of particles in the first category is calculated on the processor based on the ratio and the count or concentration of particles in the second category.Type: ApplicationFiled: March 17, 2014Publication date: September 18, 2014Applicant: IRIS International, Inc.Inventors: Thomas H. Adams, Bart J. Wanders, John Roche, Harvey L. Kasdan
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Publication number: 20100176918Abstract: A method and apparatus for detecting and tracking an object within a defined area, and determining its position, status, movement and identity therein, includes interrogating the defined area to communicate with an information device associated with an object and transmit information received to a master controller unit, which determines the object's presence, position, status, movement and identity within the defined area. It is emphasized that this abstract is provided to comply with the rules requiring an abstract which will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or the meaning of the claims.Type: ApplicationFiled: February 18, 2010Publication date: July 15, 2010Inventors: Richard H. Turner, Harvey L. Kasdan
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Patent number: 7692530Abstract: A method and apparatus for detecting and tracking an object within a defined area, and determining its position, status, movement and identity therein, includes interrogating the defined area to communicate with an information device associated with an object and transmit information received to a master controller unit, which determines the object's presence, position, status, movement and identity within the defined area. It is emphasized that this abstract is provided to comply with the rules requiring an abstract which will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or the meaning of the claims.Type: GrantFiled: March 1, 2006Date of Patent: April 6, 2010Inventors: Richard H. Turner, Harvey L. Kasdan
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Patent number: 7671718Abstract: A method and apparatus for detecting and tracking an object with a defined area, and determining its position, status movement and identity therein, includes interrogating the defined area to communicate with an information device on object and transmit received to a master controller unit, which determines the object's presence, position, movement and identity with the defined area.Type: GrantFiled: January 21, 2005Date of Patent: March 2, 2010Inventors: Richard H. Turner, Harvey L. Kasdan
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Patent number: 7324694Abstract: Most automatic particle classification methods produce errors. The invention provides a method for improving the accuracy of particle classification while shortening the amount of manual review time required from the operator. The method uses class weights, which are statistically-derived correction factors that accounts for frequency of classification errors. A first class weight and a second class weight are assigned to the first class and the second class, respectively. The number of particles in each of the first and the second classes is multiplied by the first class weight and the second class weight, respectively, to generate a corrected number of particles in each of the classes. If particles are reclassified, the class weights are recalculated in response to the reclassification. The method is usable with a complete classification where all the particles in a sample are classified, or a selective classification of a subset of the particles in the sample.Type: GrantFiled: May 21, 2004Date of Patent: January 29, 2008Assignee: International Remote Imaging Systems, Inc.Inventors: Eric Chapoulaud, Harvey L. Kasdan
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Patent number: 7236623Abstract: A method and apparatus for classifying a plurality of elements in images, where electronic images of a field of view containing elements are formed. Each of the elements has a plurality of features. A first subgroup of the plurality of features from the images of the plurality of elements are extracted and processed to segregate the plurality of elements into first and second groups. A classification class only for each of the elements in the first group is determined by selecting and processing a second subgroup of the extracted features to determine a physical characteristic of the element, and by selecting and processing a third subgroup of the extracted features in response to the determined physical characteristic to determine a classification class of the element. The second group of elements bypasses the determination of classification class.Type: GrantFiled: November 18, 2003Date of Patent: June 26, 2007Assignee: International Remote Imaging Systems, Inc.Inventors: Eric Chapoulaud, Harvey L. Kasdan, Kenneth R. Castlemen, Kenneth N. Good
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Patent number: 6947586Abstract: A multi-neural net imaging apparatus and method for classification of image elements, such as biological particles. The multi-net structure utilizes subgroups of particle features to partition the decision space by an attribute or physical characteristic of the particle and/or by individual and group particle classification that includes an unknown category. Preprocessing and post processing enables heuristic information to be included as part of the decision making process. Preprocessing classifies particles as artifacts based on certain physical characteristics. Post processing enables the use of contextual information either available from other sources or gleaned from the actual decision making process to further process the probability factors and enhance the decisions.Type: GrantFiled: April 24, 2001Date of Patent: September 20, 2005Assignee: International Remote Imaging Systems, Inc.Inventors: Harvey L. Kasdan, Michael R. Ashe, Minn Chung
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Publication number: 20040126008Abstract: A method and apparatus for classifying a plurality of elements in images, where electronic images of a field of view containing elements are formed. Each of the elements has a plurality of features. A first subgroup of the plurality of features from the images of the plurality of elements are extracted and processed to segregate the plurality of elements into first and second groups. A classification class only for each of the elements in the first group is determined by selecting and processing a second subgroup of the extracted features to determine a physical characteristic of the element, and by selecting and processing a third subgroup of the extracted features in response to the determined physical characteristic to determine a classification class of the element. The second group of elements bypasses the determination of classification class.Type: ApplicationFiled: November 18, 2003Publication date: July 1, 2004Inventors: Eric Chapoulaud, Harvey L. Kasdan, Kenneth R. Castleman, Kenneth N. Good