Patents by Inventor Harvey Lodish

Harvey Lodish has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nucleic acid loaded extracellular vesicles
    Patent number: 11970718
    Abstract: An extracellular vesicle loaded with a nucleic acid cargo and method for preparing the loaded vesicle is disclosed.
    Type: Grant
    Filed: January 12, 2021
    Date of Patent: April 30, 2024
    Assignee: Carmine Therapeutics Pte. Ltd.
    Inventors: Harvey Lodish, Ronne Yeo, Waqas Muhammad Usman, Tenzin Gocha
  • METHODS AND COMPOSITIONS FOR TREATING A PREMATURE STOP CODON-MEDIATED DISORDER
    Publication number: 20240050594
    Abstract: Modified tRNAs can be used to express in a mammalian cell a functional gene product encoded by a gene containing a premature stop codon and/or to treat a disease mediated by a premature stop codon.
    Type: Application
    Filed: April 3, 2023
    Publication date: February 15, 2024
    Inventors: Jeffery M. Coller, Thomas Sweet, Harvey Lodish
  • Methods and compositions for treating a premature stop codon-mediated disorder
    Patent number: 11617802
    Abstract: Modified tRNAs can be used to express in a mammalian cell a functional gene product encoded by a gene containing a premature stop codon and/or to treat a disease mediated by a premature stop codon.
    Type: Grant
    Filed: January 16, 2021
    Date of Patent: April 4, 2023
    Assignees: CASE WESTERN RESERVE UNIVERSITY, WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH
    Inventors: Jeffery M. Coller, Thomas Sweet, Harvey Lodish
  • NUCLEIC ACID LOADED RED BLOOD CELL EXTRACELLULAR VESICLES
    Publication number: 20230050813
    Abstract: A red blood cell extracellular vesicle (RBCEV) loaded with a nucleic acid cargo; method for preparing the loaded vesicle; and the therapeutic use of the vesicle thereof are disclosed. The nucleic acid cargoes may be DNA or RNA, single stranded or double stranded, as well as linear or circular.
    Type: Application
    Filed: January 12, 2021
    Publication date: February 16, 2023
    Inventors: Tenzin Gocha, Harvey Lodish, Waqas Muhammad Usman, Ronne Wee Yeh Yeo
  • Efficient generation of human red blood cells via enriching peripheral blood erythroid progenitors
    Patent number: 11371019
    Abstract: A population of early-stage burst-forming unit-eryhtoid (BFU-E) cells characterized by low expression of the Type III Transforming Growth Factor ? Receptor (TGFRPIII) and uses thereof for producing red blood cells in vitro, genotoxicity analysis of chemicals, drug sensitivity assessment, and drug development. Also described herein are methods for producing the population of early-stage BFU-E cells and methods for producing red blood cells.
    Type: Grant
    Filed: March 3, 2017
    Date of Patent: June 28, 2022
    Assignee: Whitehead Institute for Biomedical Research
    Inventors: Harvey Lodish, Xiaofei Gao, Hsiang-Ying Lee
  • METHODS AND COMPOSITIONS FOR INCREASING PROTEIN EXPRESSION AND/OR TREATING A HAPLOINSUFFICIENCY DISORDER
    Publication number: 20220073933
    Abstract: A tRNA that hybridizes to a non-optimal codon can be used to increase expression in a mammalian cell of a gene product encoded by a gene containing the non-optimal codon or to treat a haploinsufficiency disorder in a subject having a haploinsufficient gene containing the non-optimal codon.
    Type: Application
    Filed: September 26, 2019
    Publication date: March 10, 2022
    Inventors: Jeffery M. Coller, Thomas Sweet, Harvey Lodish
  • In vitro production of red blood cells with sortaggable proteins
    Patent number: 11266695
    Abstract: Methods for the in vitro production of enucleated red blood cells and the enucleated red blood cells thus prepared are provided. Such enucleated red blood cells may express a sortaggable surface protein, which allows for surface modification in the presence of a sortase. Also described herein are surface modified enucleated red blood cells, e.g., conjugated with an agent of interest such as a peptide, a detectable label, or a chemotherapeutic agent, and uses thereof in delivering the agent to a subject.
    Type: Grant
    Filed: March 23, 2018
    Date of Patent: March 8, 2022
    Assignee: Whitehead Institute for Biomedical Research
    Inventors: Harvey Lodish, Hidde L. Ploegh, Hsiang-Ying Sherry Lee, Jiahai Shi, Lenka Hoffman, Novalia Pishesha
  • METHODS AND COMPOSITIONS FOR TREATING A PREMATURE STOP CODON-MEDIATED DISORDER
    Publication number: 20210299279
    Abstract: Modified tRNAs can be used to express in a mammalian cell a functional gene product encoded by a gene containing a premature stop codon and/or to treat a disease mediated by a premature stop codon.
    Type: Application
    Filed: January 16, 2021
    Publication date: September 30, 2021
    Inventors: Jeffery M. Coller, Thomas Sweet, Harvey Lodish
  • NUCLEIC ACID LOADED EXTRACELLULAR VESICLES
    Publication number: 20210214217
    Abstract: An extracellular vesicle loaded with a nucleic acid cargo and method for preparing the loaded vesicle is disclosed.
    Type: Application
    Filed: January 12, 2021
    Publication date: July 15, 2021
    Applicant: Carmine Therapeutics Pte. Ltd.
    Inventors: Harvey Lodish, Ronne Yeo, Waqas Muhammad Usman, Tenzin Gocha
  • PRODUCTION OF ENUCLEATED RED BLOOD CELLS AND USES THEREOF
    Publication number: 20200206269
    Abstract: Multi-step methods for the in vitro production of enucleated red blood cells and the enucleated red blood cells thus prepared are provided. Such enucleated red blood cells may express fusion proteins comprising an antigen binding protein which allows the red blood cell to bind a toxin or an antigen of a pathogen. Also described herein are methods for neutralizing a toxin or pathogen in a subject by administering enucleated red blood cells that express any of the fusion proteins provided herein.
    Type: Application
    Filed: August 22, 2018
    Publication date: July 2, 2020
    Applicants: Whitehead Institute for Biomedical Research, Trustees of Tufts College
    Inventors: Harvey Lodish, Nai-Jia Huang, Novalia Pishesha, Hidde L. Ploegh, Charles Shoemaker
  • METHODS AND COMPOSITIONS FOR TREATING A PREMATURE STOP CODON-MEDIATED DISORDER
    Publication number: 20200101174
    Abstract: Modified tRNAs can be used to express in a mammalian cell a functional gene product encoded by a gene containing a premature stop codon and/or to treat a disease mediated by a premature stop codon.
    Type: Application
    Filed: October 28, 2019
    Publication date: April 2, 2020
    Inventors: Jeffery M. Coller, Thomas Sweet, Harvey Lodish
  • IN VITRO PRODUCTION OF RED BLOOD CELLS WITH PROTEINS COMPRISING SORTASE RECOGNITION MOTIFS
    Publication number: 20200069736
    Abstract: Methods for the in vitro production of enucleated red blood cells and the enucleated red blood cells thus prepared are provided. Such enucleated red blood cells may express a sortaggable surface protein, which allows for surface modification in the presence of a sortase. Also described herein are surface modified enucleated red blood cells, e.g., conjugated with an agent of interest such as a peptide, a detectable label, or a chemotherapeutic agent, and uses thereof in delivering the agent to a subject.
    Type: Application
    Filed: September 16, 2019
    Publication date: March 5, 2020
    Applicant: Whitehead Institute for Biomedical Research
    Inventors: Harvey Lodish, Hidde L. Ploegh, Hsiang-Ying Lee, Jiahai Shi, Lenka Hoffman, Novalia Pishesha
  • In vitro production of red blood cells with proteins comprising sortase recognition motifs
    Patent number: 10471099
    Abstract: Methods for the in vitro production of enucleated red blood cells and the enucleated red blood cells thus prepared are provided. Such enucleated red blood cells may express a sortaggable surface protein, which allows for surface modification in the presence of a sortase. Also described herein are surface modified enucleated red blood cells, e.g., conjugated with an agent of interest such as a peptide, a detectable label, or a chemotherapeutic agent, and uses thereof in delivering the agent to a subject.
    Type: Grant
    Filed: May 9, 2014
    Date of Patent: November 12, 2019
    Assignee: Whitehead Institute for Biomedical Research
    Inventors: Harvey Lodish, Hidde L. Ploegh, Hsiang-Ying Lee, Jiahai Shi, Lenka Hoffman, Novalia Pishesha
  • EFFICIENT GENERATION OF HUMAN RED BLOOD CELL VIA ENRICHING PERIPHERAL BLOOD ERYTHROID PROGENITORS
    Publication number: 20190093080
    Abstract: A population of early-stage burst-forming unit-eryhtoid (BFU-E) cells characterized by low expression of the Type III Transforming Growth Factor ? Receptor (TGFRPIII) and uses thereof for producing red blood cells in vitro, genotoxicity analysis of chemicals, drug sensitivity assessment, and drug development. Also described herein are methods for producing the population of early-stage BFU-E cells and methods for producing red blood cells.
    Type: Application
    Filed: March 3, 2017
    Publication date: March 28, 2019
    Applicant: Whitehead Institute for Biomedical Reseach
    Inventors: Harvey Lodish, Xiaofei Gao, Hsiang-Ying Lee
  • IN VITRO PRODUCTION OF RED BLOOD CELLS WITH SORTAGGABLE PROTEINS
    Publication number: 20180280440
    Abstract: Methods for the in vitro production of enucleated red blood cells and the enucleated red blood cells thus prepared are provided. Such enucleated red blood cells may express a sortaggable surface protein, which allows for surface modification in the presence of a sortase. Also described herein are surface modified enucleated red blood cells, e.g., conjugated with an agent of interest such as a peptide, a detectable label, or a chemotherapeutic agent, and uses thereof in delivering the agent to a subject.
    Type: Application
    Filed: March 23, 2018
    Publication date: October 4, 2018
    Applicant: Whitehead Institute for Biomedical Research
    Inventors: Harvey Lodish, Hidde L. Ploegh, Hsiang-Ying Sherry Lee, Jiahai Shi, Lenka Hoffman, Novalia Pishesha
  • IN VITRO PRODUCTION OF RED BLOOD CELLS WITH SORTAGGABLE PROTEINS
    Publication number: 20160082046
    Abstract: Methods for the in vitro production of enucleated red blood cells and the enucleated red blood cells thus prepared are provided. Such enucleated red blood cells may express a sortaggable surface protein, which allows for surface modification in the presence of a sortase. Also described herein are surface modified enucleated red blood cells, e.g., conjugated with an agent of interest such as a peptide, a detectable label, or a chemotherapeutic agent, and uses thereof in delivering the agent to a subject.
    Type: Application
    Filed: May 9, 2014
    Publication date: March 24, 2016
    Applicant: Whitehead Institute for Biomedical Research
    Inventors: Harvey Lodish, Hidde L. Ploegh, Hsiang-Ying Lee, Jiahai Shi, Lenka Kundrat, Novalia Pishesha
  • Ex Vivo Expansion of Human Hematopoietic Stem Cells
    Publication number: 20140308747
    Abstract: Methods and kits for expanding the number of hematopoietic stem cells are provided. The methods comprise incubating cells in medium comprising isolated IGFBP-2 and an angiopoietin-like protein (Angptl). Expanded HSCs are provided as well as culture media and kits for the expansion of human HSCs in a defined medium. Methods of administering expanded human HSCs to and individual are provided as well as methods of treating an individual by administering certain growth factors and cytokines.
    Type: Application
    Filed: November 12, 2013
    Publication date: October 16, 2014
    Applicant: Whitehead Institute for Biomedical Research
    Inventors: ChengCheng Zhang, Harvey Lodish
  • Cultured Hematopoietic Stem Cells and Method for Expansion and Analysis Thereof
    Publication number: 20140234266
    Abstract: Hematopoietic stem cells and methods for ex vivo expansion of hematopoietic stem cells are provided. The methods comprise culturing the cells in a media containing an effective amount insulin-like growth factor (IGF), fibroblast growth factor (FGF), thrombopoietin (TPO), and stem cell factor (SCF), under conditions sufficient for expansion of said cells. Methods for identifying expanded hematopoeitic stem cells and kits for ex vivo expansion of hematopoietic stem cells are also provided.
    Type: Application
    Filed: November 26, 2013
    Publication date: August 21, 2014
    Applicant: Whitehead Institute for Biomedical Research
    Inventors: ChengCheng Zhang, Harvey Lodish
  • METHODS AND PRODUCTS FOR EXPRESSION OF MICRO RNAs
    Publication number: 20140187613
    Abstract: The invention relates to microRNAs, methods of producing microRNAs and methods for using microRNAs.
    Type: Application
    Filed: November 18, 2013
    Publication date: July 3, 2014
    Applicant: Whitehead Institute for Biomedical Research
    Inventors: Chang-Zheng Chen, David P. Bartel, Harvey Lodish
  • Cultured hematopoietic stem cells and method for expansion and analysis thereof
    Patent number: 8617885
    Abstract: Hematopoietic stem cells and methods for ex vivo expansion of hematopoietic stem cells are provided. The methods comprise culturing the cells in a media containing an effective amount insulin-like growth factor(IGF), fibroblast growth factor (FGF), thrombopoietin (TPO), and stem cell factor (SCF), under conditions sufficient for expansion of said cells. Methods for identifying expanded hematopoeitc stem cells and kits for ex vivo expansion of hematopoietic stem cells are also provided.
    Type: Grant
    Filed: July 6, 2010
    Date of Patent: December 31, 2013
    Assignee: Whitehead Institute for Biomedical Research
    Inventors: Chengcheng Zhang, Harvey Lodish