Patents by Inventor Hasan Uludag

Hasan Uludag has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • POLMERIC TRANSFECTION REAGENTS TO DELIVER NUCLEIC ACIDS FOR HOST CELL MODIFICATION
    Publication number: 20240301138
    Abstract: Effective polymeric transfection reagents for delivery of nucleic acids and their complexes to modify host cells, particularly hematopoietic cells including myeloid and lymphoid cells, pharmaceutical compositions comprising same, and methods of preparing and using same are provided. An effective compound comprises a low molecular weight polymer and aliphatic lipid-thioester or lipid-ester groups. A nanoparticle comprises the compound complexed with a nucleic acid and/or an additive. A composition or pharmaceutical composition comprises the nanoparticle and a pharmaceutically acceptable carrier. A method of treating, preventing, or ameliorating a disease in a subject comprises administering to the subject an effective amount of the nanoparticle or the composition or pharmaceutical composition.
    Type: Application
    Filed: January 14, 2022
    Publication date: September 12, 2024
    Applicant: RJH BIOSCIENCES INC.
    Inventors: Remant Badahur KC, Amarnath Praphakar RAJENDRAN, Hasan ULUDAG
  • Transfection reagents for delivery of nucleic acids
    Patent number: 11964057
    Abstract: Polymeric transfection reagents for delivery of nucleic acids to cells, pharmaceutical compositions comprising same, and methods of preparing and using same are provided. A compound comprises polyethylenimine, a lipid selected from cholesterol, lauric acid, palmitic acid, or stearic acid, and optionally, a histidine. A nanoparticle comprises the compound complexed to a nucleic acid. A composition or pharmaceutical composition comprises the nanoparticle and a pharmaceutically acceptable carrier, anti-fouling agent, targeting ligand, or combinations thereof. A method of treating, preventing, or ameliorating a disease in a subject comprises administering to the subject an effective amount of the nanoparticle or the composition or pharmaceutical composition.
    Type: Grant
    Filed: June 18, 2018
    Date of Patent: April 23, 2024
    Assignee: RJH BIOSCIENCES INC.
    Inventors: Hasan Uludag, Remant Badahur Kc, Juliana Valencia-Serna
  • TRANSFECTION REAGENTS FOR DELIVERY OF NUCLEIC ACIDS
    Publication number: 20210154149
    Abstract: Polymeric transfection reagents for delivery of nucleic acids to cells, pharmaceutical compositions comprising same, and methods of preparing and using same are provided. A compound comprises polyethylenimine, a lipid selected from cholesterol, lauric acid, palmitic acid, or stearic acid, and optionally, a histidine. A nanoparticle comprises the compound complexed to a nucleic acid. A composition or pharmaceutical composition comprises the nanoparticle and a pharmaceutically acceptable carrier, anti-fouling agent, targeting ligand, or combinations thereof. A method of treating, preventing, or ameliorating a disease in a subject comprises administering to the subject an effective amount of the nanoparticle or the composition or pharmaceutical composition.
    Type: Application
    Filed: June 18, 2018
    Publication date: May 27, 2021
    Applicant: RJH BIOSCIENCES INC.
    Inventors: Hasan ULUDAG, Remant Badahur KC, Juliana VALENCIA-SERNA
  • POLYAMINE-CONTAINING POLYMERS AND METHODS OF SYNTHESIS AND USE
    Publication number: 20130102079
    Abstract: The present invention relates to polyamine-containing polymers and methods of their synthesis and use. The polymer may be hydroxyethylcellulose, dextran, poly(vinyl alcohol) or poly(methyl acrylate).
    Type: Application
    Filed: December 21, 2012
    Publication date: April 25, 2013
    Applicant: Alberta Innovates - Technology Futures
    Inventors: Robert W. Jost, Hasan Uludag, Mehmet Yaman Boluk
  • POLYAMINE-CONTAINING POLYMERS AND METHODS OF SYNTHESIS AND USE
    Publication number: 20130102730
    Abstract: The present invention relates to polyamine-containing polymers and methods of their synthesis and use. The polymer may be hydroxyethylcellulose, dextran, poly(vinyl alcohol) or poly(methyl acrylate).
    Type: Application
    Filed: December 21, 2012
    Publication date: April 25, 2013
    Applicant: Alberta Innovates - Technology Futures
    Inventors: Robert W. Jost, Hasan Uludag, Mehmet Yaman Boluk
  • POLYAMINE-CONTAINING POLYMERS AND METHODS OF SYNTHESIS AND USE
    Publication number: 20110251265
    Abstract: The present invention relates to polyamine-containing polymers and methods of their synthesis and use. The polymer may be hydroxyethylcellulose, dextran, poly(vinyl alcohol) or poly(methyl acrylate).
    Type: Application
    Filed: April 1, 2011
    Publication date: October 13, 2011
    Inventors: Hasan Uludag, Robert W. Jost, Mehmet Yaman Boluk
  • Thermoreversible polymers for delivery and retention of osteoinductive proteins
    Publication number: 20020015734
    Abstract: A temperature-sensitive polymer formulation for delivery of osteoinductive proteins is disclosed. The formulation comprises a pharmaceutically acceptable admixture of a temperature sensitive polymer and an osteoinductive protein. The formulations of the present invention enhance the retention of the osteoinductive protein at the site of administration.
    Type: Application
    Filed: March 22, 2001
    Publication date: February 7, 2002
    Applicant: Genetics Institute, Inc.
    Inventors: Hasan Uludag, Tiejun Gao, John Wozney