Abstract: The present invention relates to a gold complex having a compound of formula (I) as anticancer or chemotherapeutic agent. The present invention also relates to method of preparation of such complexes, pharmaceutical compositions containing such complexes and further extends to a method of treating or diagnosing a subject/patient suffering from cancer using such complexes.

Abstract: The present invention relates to a NDG-Mn3O4 nanocomposite comprising a nitrogen doped graphene (NDG) and Mn3O4 nanoparticles. The NDG-Mn3O4 nanocomposite is useful in bimodal performance including photodynamic therapy (PDT) and magnetic resonance imaging (MRI). The NDG-Mn3O4 nanocomposites of the present invention caused significant cell death under laser irradiation, while control and Mn3O4 nanoparticles showed negligible cell death.

Abstract: The present disclosure pertains to a 3D scaffold for cell growth and proliferation. In particular, the present disclosure provides a method of producing an artificial 3D scaffold to support stem cell growth and later their differentiation, by converting biodegradable amphiphilic copolymers (star polymer) into nanowire scaffolds, through a molecular self-assembly process. The invention also relates to the use of said scaffold for cell culture and/or transplantation.

Abstract: The present disclosure relates generally to anti-cancer pharmaceuticals. More specifically, the disclosure is directed to gold complexes of Formula I with anti-cancer properties. The disclosure also provides a pharmaceutical composition comprising the complexes, a process of synthesizing the complexes and a method of treating cancer. The complexes of the present disclosure have a multi-target approach to cancer therapeutics by inducing cell apoptosis, cytotoxicity, mitochondrial membrane potential depolarization and increasing reactive oxygen species in cancer cells.

Abstract: The present disclosure provides HRG-Mn3O4 hybrid nanoparticles. The HRG-Mn3O4 hybrid nanoparticles do not pose any cytotoxicity at normal physiological conditions and therefore they are nontoxic and biocompatible at physiological conditions. The HRG-Mn3O4 hybrid nanoparticles under exposure of laser light cause massive cellular damage indicating their potential use for photodynamic therapy of cancer. The HRG-Mn3O4 hybrid nanoparticles enhance the magnetic resonance signals from cancer cells and exhibit excellent MRI contrast property for tumor imaging and are therefore useful contrast agent.

Abstract: Indexing gene expression data for comparing gene signatures includes assigning one of a plurality of fold change-based grading scores to each of a number of genes in a probe gene signature. The fold change-based grading scores reflect relative expression of one of the number of genes in the probe gene signature. Each of the number of genes in the probe gene signature assigned a particular grading score is weighted by the particular grading score. A ratio of each weighted number of genes in the probe gene signature assigned a particular grading score to a total number of genes in the probe gene signature is determined. Then, ratios of each weighted number of genes in the probe gene signature assigned each particular grading score to the total number of genes in the probe gene signature are summed to generate an index of gene expression.

Abstract: Systems and methods for molecular fingerprinting to identify Inbreeding and Outbreeding Depression Factors (IODFs) in an animal are described. In one aspect, the systems and methods receive inputs such as information pertaining to a set of loci, allele quantity and size, genotype, and/or so on. The systems and methods calculate, based on at least a subset of inputs and a set of microsatellite markers, an IODF. The systems and methods evaluate the calculated IODF to determine if the animal is a suitable/good candidate for a breeding program.