Abstract: An improved process for the manufacture of Clopidogrel starting from 2-(2-thienyl)ethylamine, which eliminates the isolation of an unstable intermediate like 2-(2-thienyl)ethyl formimine by subjecting it to a one pot cyclization to get 4,5,6,7-tetrahydrothieno (3,2-c) pyridine of Formula II and further reacting with halo-compound of formula III (where X is Cl or Br) at 20 to 90° C. temperature characterized in a solvent like water and/or dichloroethane in presence of organic or inorganic bases is disclosed herein. This inventions also discloses Crystalline Form I of (+)-(S)-clopidogrel hydrogen sulphate and its preparation thereof.

Abstract: An improved process for the manufacture of Clopidogrel starting from 2-(2-thienyl) ethylamine, which eliminates the isolation of an unstable intermediate like 2-(2-thienyl) ethyl formimine by subjecting it to a one pot cyclization to get 4, 5, 6, 7-tetrahydrothieno (3,2-c) pyridine of Formula II and further reacting with halo-compound of Formula III (where X is Cl or Br) at 20 to 90° C. temperature characterized in a solvent like water and/or dichloroethane in presence of organic or inorganic bases is disclosed herein. This invention further discloses a process for resolution of racemic Clopidogrel into its optical antipodes and converting the dextroclopidogrel base into its known polymorphs namely ‘Form I’ or ‘Form II’ in solvents selected from methyl propyl ketone, methyl isopropyl ketone, diethyl ketone or their mixture thereof, mixture of ethyl acetate and methyl propyl ketone, mixture of ethyl acetate and methyl isopropyl ketone, or mixture of ethyl acetate and diethyl ketone or ethyl acetate.

Abstract: A process for the resolution of isomeric tramadol mixtures comprising: providing a purification stock comprising both cis and trans tramadol; contacting the purification stock with an acid under conditions effective to form an acid salt of the cis and trans tramadol in the purification stock; and separating the cis tramadol acid salt from the trans tramadol to obtain a purified cis tramadol acid salt; and optionally converting the cis tramadol acid salt to cis tramadol or to a pharmaceutically active salt thereof.

Abstract: An improved process for the manufacture of Clopidogrel starting from 2-(2-thienyl) ethylamine, which eliminates the isolation of an unstable intermediate like 2-(2-thienyl) ethyl formimine by subjecting it to a one pot cyclization to get 4, 5, 6, 7-tetrahydrothieno (3,2-c) pyridine of Formula II and further reacting with halo-compound of Formula III (where X is Cl or Br) at 20 to 90° C. temperature characterized in a solvent like water and/or dichloroethane in presence of organic or inorganic bases is disclosed herein. This invention further discloses a process for resolution of racemic Clopidogrel into its optical antipodes and converting the dextroclopidogrel base into its known polymorphs namely ‘Form I’ or ‘Form II’ in solvents selected from methyl propyl ketone, methyl isopropyl ketone, diethyl ketone or their mixture thereof, mixture of ethyl acetate and methyl propyl ketone, mixture of ethyl acetate and methyl isopropyl ketone, or mixture of ethyl acetate and diethyl ketone or ethyl acetate.

Abstract: A system is provided for use on large vehicles of the type wherein the vehicle frame is supported on vehicle axle assemblies through air bags, and each air bag has a lower end coupled to the lower end of an arm such as a swing arm whose upper end is pivotally mounted on the frame. The height of the air bag is sensed by a pair of tilt sensors, sensing tilt of its location with respect to gravity, and the difference in tilt indicates air bag height. The output of the tilt sensors may be filtered, and a motion detector allows rapid filling or dumping of air bags independent of filtering of tilt sensor signals. Control of the vehicle air suspension can also be based upon inputs from one or more air bag pressure sensors.

Abstract: A system is provided for use on large vehicles of the type wherein the vehicle frame (12) is supported on vehicle axle assemblies (14, 20, 22) through air bags (26, 30, 32), and each air bag has a lower end coupled to the lower end of an arm such as a swing arm (112) whose upper end is pivotally mounted on the frame. The height of the air bag is sensed by a pair of tilt sensors (50, 52), one on a tilt arm such as the swing arm (112), that has one end pivotally connected to the vehicle frame and an opposite end at least pivotally connected to the vehicle axle assembly. The other sensor senses tilt of the vehicle frame about an axis parallel to the axes of pivoting of the tilt arm. Each tilt sensor senses tilt of its location with respect to gravity, and the difference in tilt indicates air bag height.

Abstract: A system for manufacturing wire harness assemblies is provided. Each wire harness includes a shielded cable having a plurality of insulated conductors therein, with each conductor being terminated at its respective opposed ends and with the terminated ends being mounted in connector housings. The system includes a plurality of pallets that are movable along a conveyor to work stations at which various assembly steps are carried out. A first station is provided for mounting the cables to the pallet, such that the wires at the opposed ends are mounted in fixtures. A second station may selectively deposit drop wires into fixtures on the pallets. A third station trims and strips the ends of the wires and aligns the drop wires with the cable wires. A fourth station sequentially crimps terminals to the ends of the wires, with the pallet being indexable between successive crimps.

Abstract: A method is disclosed for terminating a coaxial connector to a coaxial cable. The coaxial connector has an elongated signal pin surrounded in part by an insulating jacket and an elongated shield member surrounding the insulating jacket while the coaxial cable has a signal wire surrounded by an inner insulating member, ground means surrounding the insulating jacket and an outer insulating sheath surrounding the ground means. The method includes providing an elongated conductive shield member having a front portion and a rear portion. The front portion of the shield member is secured onto the insulating jacket surrounding the signal pin whereby a portion of the signal pin is positioned within the rear portion. The ground means is electrically and mechanically bonded to the rear portion of the shield member. The signal wire is then electrically and mechanically bonded to an exposed portion of the signal pin within the rear portion of the shield member while the signal pin is held by the shield member.

Abstract: In the exemplary embodiment of the invention, the miniature coaxial contact terminates a coaxial cable which includes a signal wire, an insulating jacket surrounding the signal wire, ground means surrounding the insulating jacket and an outer insulating sheath surrounding the ground means. The contact includes a signal pin having a contact end for mating with an appropriate receptacle contact and a terminating end having a coined portion for termination to the signal wire. Insulator means is provided about at least a portion of the signal pin. A grounding shield tube is provided about the insulator means. The tube has an inner surface for termination to the ground means of the cable.

Abstract: A system for manufacturing wire harness assemblies is provided. Each wire harness includes a shielded cable having a plurality of insulated conductors therein, with each conductor being terminated at its respective opposed ends and with the terminated ends being mounted in connector housings. The system includes a plurality of pallets that are movable along a conveyor to work stations at which various assembly steps are carried out. A first station is provided for mounting the cables to the pallet, such that the wires at the opposed ends are mounted in fixtures. A second station may selectively deposit drop wires into fixtures on the pallets. A third station trims and strips the ends of the wires and aligns the drop wires with the cable wires. A fourth station sequentially crimps terminals to the ends of the wires, with the pallet being indexable between successive crimps.

Abstract: A modular application tooling machine includes a base unit with a delivery station for electrical connectors, a intermittently operated connector feed drive system and a continuously operated work station drive system. Feed track modules define a connector feed track along which connectors are fed by pusher modules driven by the feed drive system. Work station modules powered on demand by the work station drive system carry out cycles of operation to perform operations on connectors in the feed track. One work station module terminates conductors into insulation displacement terminals of the electrical connectors and another work station module breaks off a carrier strip connected to the terminals.

Abstract: A termination machine for inserting wires into insulation displacement slots of terminals of an electrical connector. During each termination stroke, a connector locating member moves together with the termination blade to precisely position the connector for termination. A wire locator moves together with the termination blade and moves the wire into a guide slot in a template over the connector. When the blade, the wire and the connector are in precise alignment, the termination blade completes the termination stroke. A feed slide and pawl system moves the connector in steps equal to the terminal centerline spacing, and the feed stroke is selectively adjusted to skip voids where terminals are not to be terminated.

Abstract: A termination machine for inserting wires into insulation displacement slots of terminals of an electrical connector. During each termination stroke, a connector locating member moves together with the termination blade to precisely position the connector for termination. A wire locator moves together with the termination blade and moves the wire into a guide slot in a template over the connector. When the blade, the wire and the connector are in precise alignment, the termination blade completes the termination stroke. A feed slide and pawl system moves the connector in steps equal to the terminal centerline spacing, and the feed stroke is selectively adjusted to skip voids where terminals are not to be terminated.

Abstract: A reusable injection catheter for use with a medication delivery system comprises a flexible conduit having a fluid path therethrough, a first cannula at the distal end of the conduit for insertion into the patient, a connector housing at the proximal end of the conduit having a passageway therethrough, and a second cannula extending from the housing and in fluid communication therewith. An embodiment of the present invention includes a resilient sleeve covering the second cannula to prevent fluid passage therethrough. This sleeve is adapted to be pierced by the second cannula upon the application of force to the sleeve, thus allowing fluid flow through the second cannula, and further adapted to return to its initial position upon termination of the force.

Abstract: A disposable reservoir cassette for use with a roller pump delivery system comprises a flexible reservoir tube, an air-permeable, liquid-impermeable element engaging one end of the reservoir tube, a pierceable delivery septum engaging the other end of the reservoir tube and a rigid housing containing the reservoir tube. The housing includes a backstop which supports the tube in a circular path while allowing access to the septum. The housing is adapted to be secured to the roller pump such that the circular path of the tube is adjacent to the path of a pump roller wherein motion of the pump roller compresses the reservoir tube sufficiently to drive any fluid contained therein in the direction of the delivery septum.

Abstract: There is disclosed a method for protecting thermolabile goods from degradation or destruction from high temperatures by surrounding the goods with a compound having a melting point about 3.degree. to about 5.degree. C. lower than the thermosensitive temperature of the goods and a heat capacity sufficient to protect the goods when the temperature of the environment exceeds the temperature of the goods. A representative compound is sodium sulfate decahydrate also known as Glauber's salt. In a preferred embodiment, the compound prior to use is melted, absorbed in a bibulous material, and then sealed in a plastic bag. In still another preferred embodiment, the method surrounds the compound with a layer of outer insulation which is adjacent to the outside container, which is made of cardboard, paper, and/or wood.

Abstract: A new and useful container is disclosed for storing "sharps", e.g., surgical needles or blades, comprising: (a) base means formed of a reusable and sterilizable material containing a source of magnetism; (b) collecting means for surgical needles or blades, said collecting means shaped to provide an interlocking fit with said base means; and (c) cover means with said collecting means to form an enclosure, said cover means capable of tight-fitting engagement with and placement over said collecting means to prevent said surgical needles or blades from escaping from said enclosure when said cover means is in tight-fitting engagement with said collecting means, said collecting means and said cover means attached to each other by hinge means, said collecting means being provided with locking means to lock said cover means with said collecting means when said cover means is in tight fitting engagement with said collecting means.