Patents by Inventor Hassan Issafras

Hassan Issafras has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTI-GPC3 ANTIBODIES, MULTISPECIFIC ANTIBODIES AND METHODS OF USE
    Publication number: 20240043558
    Abstract: Provided are antibodies and antibody derivatives that bind to GPC3 and methods of using the same. The antibody or antibody derivative comprises a single domain antibody that binds to GPC3. The antibody derivative is a multispecific antibody that binds to GPC3 and an additional antigen, e.g., 4-1BB.
    Type: Application
    Filed: October 20, 2023
    Publication date: February 8, 2024
    Inventors: Hassan ISSAFRAS, Wenfeng XU, Wei-Dong JIANG, Heungnam KIM
  • ANTI-GPC3 ANTIBODIES AND METHODS OF USE
    Publication number: 20240043559
    Abstract: Provided are antibodies and antibody derivatives that bind to GPC3 and methods of using the same. The antibody or antibody derivative comprises a single domain antibody that binds to GPC3.
    Type: Application
    Filed: October 20, 2023
    Publication date: February 8, 2024
    Inventors: Hassan ISSAFRAS, Wenfeng XU, Wei-Dong JIANG, Heungnam KIM
  • Parathyroid hormone receptor 1 (PTH1R) antibodies and uses thereof
    Patent number: 11787876
    Abstract: The present disclosure relates, in general, human antibodies against human parathyroid hormone receptor 1 (PTH1R) and methods of use of such antibodies in the treatment of cancer, Humoral Hypercalcemia of Malignancy (HHM), or Primary Hyperparathyroidism (PHPT) and Secondary Hyperparathyroidism (SHPT) and cachexia.
    Type: Grant
    Filed: November 26, 2019
    Date of Patent: October 17, 2023
    Assignee: XOMA (US) LLC
    Inventors: Raphael D. Levy, Hassan Issafras, Agnes Choppin Holmes, Kirk W. Johnson, Amer M. Mirza, Daniel H. Bedinger, Rachel A. Hunt, Toshihiko Takeuchi, Kiranjit Kaur Ahluwalia, Robyn Cotter
  • ANTIBODIES THAT BIND INTERLEUKIN-2 AND USES THEREOF
    Publication number: 20210188969
    Abstract: The present disclosure relates, in general, to human antibodies against human interleukin 2 (IL-2) and methods of use of such antibodies for modulating IL-2 activity and use in the treatment of conditions such as cancer, autoimmune disease, or infection.
    Type: Application
    Filed: December 4, 2020
    Publication date: June 24, 2021
    Inventors: Marina Roell, Mark Rubinstein, Hassan Issafras, Llewelyn Lao, Ou Li, Daniel H. Bedinger, Kristin Camfield Lind, Agnes Choppin Holmes, Toshihiko Takeuchi, Lauren Schwimmer, Hoa Giang, Amer M. Mirza, Kirk W. Johnson
  • Antibodies that bind interleukin-2 and uses thereof
    Patent number: 10858428
    Abstract: The present disclosure relates, in general, to human antibodies against human interleukin 2 (IL-2) and methods of use of such antibodies for modulating IL-2 activity and use in the treatment of conditions such as cancer, autoimmune disease, or infection.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: December 8, 2020
    Assignees: XOMA (US) LLC, MUSC FOUNDATION FOR RESEARCH DEVELOPMENT
    Inventors: Marina Roell, Mark Rubinstein, Hassan Issafras, Llewelyn Lao, Ou Li, Daniel H. Bedinger, Kristin Camfield Lind, Agnes Choppin Holmes, Toshihiko Takeuchi, Lauren Schwimmer, Hoa Giang, Amer M. Mirza, Kirk W. Johnson
  • Parathyroid Hormone Receptor 1 (PTH1R) Antibodies and Uses Thereof
    Publication number: 20200317817
    Abstract: The present disclosure relates, in general, human antibodies against human parathyroid hormone receptor 1 (PTH1R) and methods of use of such antibodies in the treatment of cancer, Humoral Hypercalcemia of Malignancy (HHM), or Primary Hyperparathyroidism (PHPT) and Secondary Hyperparathyroidism (SHPT) and cachexia.
    Type: Application
    Filed: November 26, 2019
    Publication date: October 8, 2020
    Inventors: Raphael D. Levy, Hassan Issafras, Agnes Choppin Holmes, Kirk W. Johnson, Amer M. Mirza, Daniel H. Bedinger, Rachel A. Hunt, Toshikiko Takeuchi, Kiranjit Kaur Ahluwalia, Robyn Cotter
  • Parathyroid hormone receptor 1 (PTH1R) antibodies and uses thereof
    Patent number: 10519250
    Abstract: The present disclosure relates, in general, human antibodies against human parathyroid hormone receptor 1 (PTH1R) and methods of use of such antibodies in the treatment of cancer, Humoral Hypercalcemia of Malignancy (HHM), or Primary Hyperparathyroidism (PHPT) and Secondary Hyperparathyroidism (SHPT) and cachexia.
    Type: Grant
    Filed: August 1, 2017
    Date of Patent: December 31, 2019
    Assignee: XOMA (US) LLC
    Inventors: Raphael D. Levy, Hassan Issafras, Agnes Choppin Holmes, Kirk W. Johnson, Amer M. Mirza, Daniel H. Bedinger, Rachel A. Hunt, Toshihiko Takeuchi, Kiranjit Kaur Ahluwalia, Robyn Cotter
  • Antibody fragments against the insulin receptor and uses thereof to treat hypoglycemia
    Patent number: 10253101
    Abstract: The present disclosure relates, in general, to methods of treating or preventing hypoglycemia using a negative modulator antibody fragment that binds to the insulin receptor and modulates the action of insulin at the insulin receptor.
    Type: Grant
    Filed: August 5, 2016
    Date of Patent: April 9, 2019
    Assignee: XOMA (US) LLC
    Inventors: Paul Rubin, Toshihiko Takeuchi, Hassan Issafras, Kiranjit Ahluwalia, John Corbin, Ira Goldfine, Kirk Johnson, Ou Li, Daniel Bedinger
  • Antibody Fragments Against the Insulin Receptor and Uses Thereof to Treat Hypoglycemia
    Publication number: 20180251562
    Abstract: The present disclosure relates, in general, to methods of treating or preventing hypoglycemia using a negative modulator antibody fragment that binds to the insulin receptor and modulates the action of insulin at the insulin receptor.
    Type: Application
    Filed: February 15, 2018
    Publication date: September 6, 2018
    Inventors: Paul Rubin, Toshihiko Takeuchi, Hassan Issafras, Kiranjit Ahluwalia, John Corbin, lra Goldfine, Kirk Johnson, Ou Li, Daniel Bedinger
  • Antibodies That Bind Interleukin-2 and Uses Thereof
    Publication number: 20180094053
    Abstract: The present disclosure relates, in general, to human antibodies against human interleukin 2 (IL-2) and methods of use of such antibodies for modulating IL-2 activity and use in the treatment of conditions such as cancer, autoimmune disease, or infection.
    Type: Application
    Filed: September 28, 2017
    Publication date: April 5, 2018
    Inventors: Marina Roell, Mark Rubinstein, Hassan Issafras, Llewelyn Lao, Ou Li, Daniel H. Bedinger, Kristin Camfield Lind, Agnes Choppin Holmes, Toshihiko Takeuchi, Lauren Schwimmer, Hoa Giang, Amer M. Mirza, Kirk W. Johnson
  • Parathyroid Hormone Receptor 1 (PTH1R) Antibodies and Uses Thereof
    Publication number: 20180030154
    Abstract: The present disclosure relates, in general, human antibodies against human parathyroid hormone receptor 1 (PTH1R) and methods of use of such antibodies in the treatment of cancer, Humoral Hypercalcemia of Malignancy (HHM), or Primary Hyperparathyroidism (PHPT) and Secondary Hyperparathyroidism (SHPT) and cachexia.
    Type: Application
    Filed: August 1, 2017
    Publication date: February 1, 2018
    Inventors: Raphael D. Levy, Hassan Issafras, Agnes Choppin Holmes, Kirk W. Johnson, Amer M. Mirza, Daniel H. Bedinger, Rachel A. Hunt, Toshihiko Takeuchi, Kiranjit Kaur Ahluwalia, Robyn Cotter
  • Antibody Fragments Against the Insulin Receptor and Uses Thereof to Treat Hypoglycemia
    Publication number: 20170037135
    Abstract: The present disclosure relates, in general, to methods of treating or preventing hypoglycemia using a negative modulator antibody fragment that binds to the insulin receptor and modulates the action of insulin at the insulin receptor.
    Type: Application
    Filed: August 5, 2016
    Publication date: February 9, 2017
    Inventors: Paul Rubin, Toshihiko Takeuchi, Hassan Issafras, Kiranjit Ahluwalia, John Corbin, Ira Goldfine, Kirk Johnson, Ou Li, Daniel Bedinger