Abstract: There are many trimmer models with 2 main parts, the static comb blade and the side moving cutter blade driven by electric motor/vibrator. These blades differ in many ways, shapes, sizes . . . which require fine adjustments and tenth of millimeter clearance at the end of the blades. Some models come with an adjuster that fits its model only with a fixed clearance that cannot be modified and does not fit other models. The proposed inventions are universal trimmer blades adjusters that fit most trimmer blades models and the clearance can be varied to meet the users' requirements. First invention design has one moving part with non-linear smooth adjustments and second invention design has two moving parts with linear fine adjustments.

Abstract: There are many trimmer models with 2 main parts, the static comb blade and the side moving cutter blade driven by electric motor/vibrator. These blades differ in many ways, shapes, sizes . . . which require fine adjustments and tenth of millimeter clearance at the end of the blades. Some models come with an adjuster that fits its model only with a fixed clearance that cannot be modified and does not fit other models. The proposed inventions are universal trimmer blades adjusters that fit most trimmer blades models and the clearance can be varied to meet the users' requirements. First invention design has one moving part with non-linear smooth adjustments and second invention design has two moving parts with linear fine adjustments.

Abstract: The present invention relates to prolonged release pharmaceutical dosage forms comprising hydromorphone or a pharmaceutically acceptable salt thereof and naloxone or a pharmaceutically acceptable salt thereof for use in the treatment of pain.

Abstract: The present invention relates to an improvement to the treatment of needles for safe disposal. The device comprises a support member having at least one recess. Each said at least one recess is configured to receive a needle contained in a corresponding plastic needle cap. The device further comprises a heating element configured to heat the support member, such that the plastic material of the needle cap softens and flows to encapsulate the corresponding needle. Each said at least one recess has dimensions such that, after heating, the needle is fully encapsulated by the plastic material of the corresponding needle cap. A corresponding method is disclosed.

Abstract: The present invention relates to prolonged release pharmaceutical dosage forms, the manufacture thereof as well as their use for administration to human beings.

Abstract: Opioid controlled release formulation resistant to alcohol extraction of the opioid.

Abstract: The present invention pertains to oral immediate release pharmaceutical compositions suitable for treating patients suffering from pain comprising oxycodone and naloxone or their pharmaceutically acceptable salts.

Abstract: The present invention relates to prolonged release pharmaceutical dosage forms comprising hydromorphone or a pharmaceutically acceptable salt thereof and naloxone or a pharmaceutically acceptable salt thereof for use in the treatment of pain.

Abstract: The present invention relates to prolonged release pharmaceutical dosage forms, the manufacture thereof as well as their use for administration to human being.

Abstract: The present invention pertains to oral immediate release pharmaceutical compositions suitable for treating patients suffering from pain comprising oxycodone and naloxone or their pharmaceutically acceptable salts.

Abstract: The present invention provides a dosage form, particularly a tamper resistant dosage form, comprising: melt-extruded particulates comprising a drug; and a matrix; wherein said melt-extruded particulates are present as a discontinuous phase in said matrix.

Abstract: The present invention relates to prolonged release pharmaceutical dosage forms comprising hydromorphone or a pharmaceutically acceptable salt thereof and naloxone or a pharmaceutically acceptable salt thereof for use in the treatment of pain.

Abstract: The present invention relates to prolonged release pharmaceutical dosage forms, the manufacture thereof as well as their use for administration to human beings.

Abstract: The invention relates to a process for preparing a controlled release pharmaceutical extrudate using a melt extruder, wherein the melt extruder comprises a die-head supporting a die-plate in which orifices are located, and a cutter adjacent to the die-head, and wherein the cutter cuts the extruded mix as it emerges under pressure and still molten or softened from the orifices of the die-plate.

Abstract: Opioid controlled release formulation resistant to alcohol extraction of the opioid.

Abstract: The present invention relates to prolonged release pharmaceutical dosage forms comprising hydromorphone or a pharmaceutically acceptable salt thereof and naloxone or a pharmaceutically acceptable salt thereof for use in the treatment of pain.

Abstract: The present invention pertains to oral immediate release pharmaceutical compositions suitable for treating patients suffering from pain comprising oxycodone and naloxone or their pharmaceutically acceptable salts.

Abstract: The present invention pertains to oral immediate release pharmaceutical compositions suitable for treating patients suffering from pain comprising oxycodone and naloxone or their pharmaceutically acceptable salts.

Abstract: Extrusion of a mix containing a pharmaceutically active agent can be achieved using a plasticizing excipient in an amount sufficient to act as plasticizer and also act as lubricant, thereby avoiding the need for inclusion of a lubricant. The invention provides multiparticulates with controlled release properties, substantially free of lubricant. The present invention is preferably directed to extruded multiparticulates containing an opioid such as oxycodone, an ammonium methacrylate copolymer such as Eudragit® RSPO, a plasticizing excipient such as preferably stearyl alcohol and a water permeability modifier such as preferably Eudragit® RLPO. The obtained multiparticulates show a release rate profile which is pH-independent.

Abstract: A neutral poly(ethyl acrylate, methyl methacrylate) copolymer is employed as a carrier in the manufacture of pharmaceutical formulations containing an active ingredient. The formulations are preferably made by melt extrusion, and can have rubbery characteristics and can exhibit tamper resistance.