Patents by Inventor Hassan Pajouhesh

Hassan Pajouhesh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HETEROCYCLIC AMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS
    Publication number: 20090221603
    Abstract: Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted N-type or T-type calcium channel activity are disclosed. Specifically, a series of heterocyclic amides are disclosed of the general formula (1) where Z is N or ?CHNR2 and X is NR2, O, S, S?O or SO2. Among other definitions for R, R1, W and Y, the compounds of formula (1) are further characterized by at least one of W or Y being CR3Ar2 where Ar is an aromatic or heteroaromatic ring (for example, where W or Y is a benzhydryl moiety).
    Type: Application
    Filed: December 19, 2006
    Publication date: September 3, 2009
    Inventors: Hassan Pajouhesh, Ramesh Kaul, Yanbing Ding, Gabriel Hum, Hossein Pajouhesh
  • Diamine calcium channel blockers
    Patent number: 7511077
    Abstract: Aromatic derivatives of aliphatic diamines are effective in ameliorating conditions characterized by unwanted calcium ion channel activity, especially T-type and N-type channels. These conditions include, for example, stroke and pain.
    Type: Grant
    Filed: February 8, 2006
    Date of Patent: March 31, 2009
    Assignee: Neuromed Pharmaceuticals Ltd.
    Inventors: Hassan Pajouhesh, Hossein Pajouhesh, Yanbing Ding, Terrance P. Snutch, Francesco Belardetti
  • N-type calcium channel blockers
    Patent number: 7507760
    Abstract: The invention relates to novel 3-amino pyrrolidine derivatives, as well as methods for modulating calcium channel activity and for treating conditions associated with calcium channel function. In particular, the compounds generally contain at least one benzhydril moiety, and are useful in treating conditions which benefit from blocking calcium ion channels.
    Type: Grant
    Filed: January 22, 2004
    Date of Patent: March 24, 2009
    Assignee: Neuromed Pharmaceuticals Ltd.
    Inventors: Hassan Pajouhesh, Hossein Pajouhesh, Yanbing Ding, Terrance P. Snutch
  • BICYCLIC PYRIMIDINE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS
    Publication number: 20080280900
    Abstract: Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted T-type calcium channel activity are disclosed. Specifically, a series of compounds containing thienopyrimidine or oxoquinazoline derivatives are disclosed of the general formula (1) or formula (2) where X is a linker and Y is an aromatic moiety or N(R5)(R6).
    Type: Application
    Filed: May 9, 2008
    Publication date: November 13, 2008
    Inventors: Hassan PAJOUHESH, Hossein PAJOUHESH, Yanbing DING, Jason TAN, Mike GRIMWOOD, Francesco BELARDETTI, Ramesh KAUL
  • AMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS
    Publication number: 20080227823
    Abstract: Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted T-type calcium channel activity are disclosed. Specifically, a series of compounds containing both a diamide and aromatic functionality are disclosed of the general formula (1) where X1 and X2 are linkers.
    Type: Application
    Filed: March 4, 2008
    Publication date: September 18, 2008
    Inventors: Hassan Pajouhesh, Nagasree Chakka, Yuanxi Zhou, Francesco Belardetti
  • UREA DERIVATIVES AS CALCIUM CHANNEL BLOCKERS
    Publication number: 20080221117
    Abstract: Urea derivatives which comprise piperidine or piperazine rings and further substitution are effective in ameliorating conditions characterized by unwanted calcium ion channel activity.
    Type: Application
    Filed: May 7, 2008
    Publication date: September 11, 2008
    Inventors: Hassan PAJOUHESH, Hossein Pajouhesh, Yanbing Ding, Terrance P. Snutch
  • UREA DERIVATIVES AS CALCIUM CHANNEL BLOCKERS
    Publication number: 20080207633
    Abstract: Urea derivatives which comprise piperidine or piperazine rings and further substitution are effective in ameliorating conditions characterized by unwanted calcium ion channel activity.
    Type: Application
    Filed: April 28, 2008
    Publication date: August 28, 2008
    Inventors: Hassan Pajouhesh, Hossein Pajouhesh, Yanbing Ding, Terrance P. Snutch
  • Urea derivatives as calcium channel blockers
    Patent number: 7378420
    Abstract: Derivatives of urea that contain piperazine rings and additional substitution with aromatic groups are effective in ameliorating conditions associated with unwanted calcium ion channel activity.
    Type: Grant
    Filed: August 30, 2005
    Date of Patent: May 27, 2008
    Assignee: Neuromed Pharmaceuticals Ltd.
    Inventors: Hassan Pajouhesh, Hossein Pajouhesh, Yanbing Ding, Terrance P. Snutch
  • N-type calcium channel blockers
    Patent number: 7244758
    Abstract: Compounds that are derivatives of 3-aminomethyl-pyrrolidine generally containing at least one benzhydril moiety are useful in treating conditions which benefit from blocking calcium ion channels.
    Type: Grant
    Filed: May 28, 2004
    Date of Patent: July 17, 2007
    Assignee: Neuromed Pharmaceuticals Ltd.
    Inventors: Hassan Pajouhesh, Terrance P. Snutch, Hossein Pajouhesh, Yanbing Ding
  • Preferentially substituted calcium channel blockers
    Patent number: 7186726
    Abstract: Certain piperazine substituted compounds are described which are useful in altering calcium channel activity.
    Type: Grant
    Filed: September 3, 2003
    Date of Patent: March 6, 2007
    Assignee: Neuromed Pharmaceuticals Ltd.
    Inventors: Terrance P. Snutch, Gerald W. Zamponi, Hassan Pajouhesh, Hossein Pajouhesh, Francesco Belardetti
  • Diamine calcium channel blockers
    Publication number: 20060235050
    Abstract: Aromatic derivatives of aliphatic diamines are effective in ameliorating conditions characterized by unwanted calcium ion channel activity, especially T-type and N-type channels. These conditions include, for example, stroke and pain.
    Type: Application
    Filed: February 8, 2006
    Publication date: October 19, 2006
    Applicant: Nueromed Technologies, Inc.
    Inventors: Hassan Pajouhesh, Hossein Pajouhesh, Yanbing Ding, Terrance Snutch, Francesco Belardetti
  • Calcium channel blockers comprising two benzhydril moieties
    Publication number: 20060084660
    Abstract: Certain piperazine compounds are described which are useful in altering calcium channel activity.
    Type: Application
    Filed: August 29, 2005
    Publication date: April 20, 2006
    Inventors: Terrance Snutch, Gerald Zamponi, Hassan Pajouhesh, Hossein Pajouhesh, Francesco Belardetti
  • Urea derivatives as calcium channel blockers
    Publication number: 20060063775
    Abstract: Urea derivatives which comprise piperidine or piperazine rings and further substitution are effective in ameliorating conditions characterized by unwanted calcium ion channel activity.
    Type: Application
    Filed: August 30, 2005
    Publication date: March 23, 2006
    Inventors: Hassan Pajouhesh, Hossein Pajouhesh, Yanbing Ding, Terrance Snutch
  • Diarylamine derivatives as calcium channel blockers
    Publication number: 20050227999
    Abstract: Compounds which are derivatives of diarylamine substituted piperazine and amino-piperidine are useful in treating conditions mediated by calcium ion channel activity.
    Type: Application
    Filed: August 27, 2004
    Publication date: October 13, 2005
    Inventors: Hassan Pajouhesh, Hossein Pajouhesh, Yanbing Ding, Terrance Snutch
  • Calcium channel blockers comprising two benzhydril moieties
    Patent number: 6951862
    Abstract: Certain piperazine substituted compounds are described which are useful in altering calcium channel activity.
    Type: Grant
    Filed: April 8, 2003
    Date of Patent: October 4, 2005
    Assignee: Neuromed Technologies, Inc.
    Inventors: Terrance P. Snutch, Gerald W. Zamponi, Hassan Pajouhesh, Hossein Pajouhesh, Francesco Belardetti
  • Calcium channel blockers comprising two benzhydril moieties
    Patent number: 6949554
    Abstract: Certain piperazine substituted compounds are described which are useful in altering calcium channel activity.
    Type: Grant
    Filed: December 23, 2003
    Date of Patent: September 27, 2005
    Assignee: NeuroMed Technologies Inc.
    Inventors: Terrance P. Snutch, Gerald W. Zamponi, Hassan Pajouhesh, Hossein Pajouhesh, Francesco Belardetti
  • Calcium channel inhibitors comprising benzhydril spaced from piperazine
    Patent number: 6943168
    Abstract: Certain piperazine substituted compounds are described which are useful in altering calcium channel activity.
    Type: Grant
    Filed: April 8, 2003
    Date of Patent: September 13, 2005
    Assignee: NeuroMED Technologies Inc.
    Inventors: Terrance P. Snutch, Gerald W. Zamponi, Hassan Pajouhesh, Hossein Pajouhesh, Francesco Belardetti
  • N-type calcium channel blockers
    Publication number: 20050165065
    Abstract: The invention relates to novel 3-amino pyrrolidine derivatives, as well as methods for modulating calcium channel activity and for treating conditions associated with calcium channel function. In particular, the compounds generally contain at least one benzhydril moiety, and are useful in treating conditions which benefit from blocking calcium ion channels.
    Type: Application
    Filed: January 22, 2004
    Publication date: July 28, 2005
    Inventors: Hassan Pajouhesh, Hossein Pajouhesh, Yanbing Ding, Terrance Snutch
  • N-type calcium channel blockers
    Publication number: 20050014748
    Abstract: Compounds that are derivatives of 3-aminomethyl-pyrrolidine generally containing at least one benzhydril moiety are useful in treating conditions which benefit from blocking calcium ion channels.
    Type: Application
    Filed: May 28, 2004
    Publication date: January 20, 2005
    Inventors: Hassan Pajouhesh, Terrance Snutch, Hossein Pajouhesh, Yanbing Ding
  • Calcium channel inhibitors comprising benzhydril spaced from piperazine
    Publication number: 20040266784
    Abstract: Certain piperazine substituted compounds are described which are useful in altering calcium channel activity.
    Type: Application
    Filed: April 9, 2004
    Publication date: December 30, 2004
    Inventors: Terrance P. Snutch, Gerald W. Zamponi, Hassan Pajouhesh, Francesco Belardetti, Hossein Pajouhesh