Abstract: A neural network is trained for estimating patient hemodynamic data using a plurality of extravascular imaging data sets and a plurality of intravascular imaging data sets that are each co-registered to a corresponding extravascular imaging data set. A plurality of hemodynamic data sets are provided, each hemodynamic data set co-registered with the corresponding extravascular imaging data set. The neural network learns what hemodynamic data to expect for a given intravascular imaging data set. An intravascular imaging event is subsequently performed in which an intravascular imaging element is translated within a blood vessel of the patient to produce one or more intravascular images. The neural network uses its training to predict hemodynamic values corresponding to the one or more intravascular images from the intravascular imaging event, and the one or more intravascular images are outputted in combination with the predicted hemodynamic values.