Patents by Inventor Hatice Seda Kaya Okur

Hatice Seda Kaya Okur has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • High efficiency targeted in situ genome-wide profiling
    Patent number: 11885814
    Abstract: A method for detecting the binding of a chromatin-associated factor of interest to a sequence of chromatin DNA in a cell, including: contacting a permeabilized cell or nucleus with a specific binding agent that specifically recognizes the chromatin-associated factor of interest, wherein the specific binding agent is linked to a nuclease that is inactive or an activatable transposome; activating the nuclease or transposase, thereby excising the sequence of chromatin DNA bound to the chromatin-associated factor of interest; isolating the excised DNA; and determining the sequence of the excised DNA, thereby detecting binding of a chromatin-associated factor of interest to a sequence of chromatin DNA in the cell.
    Type: Grant
    Filed: January 26, 2022
    Date of Patent: January 30, 2024
    Assignee: Fred Hutchinson Cancer Center
    Inventors: Steven Henikoff, Hatice Seda Kaya Okur, Terri Dawn Bryson, Peter James Skene
  • High efficiency targeted in situ genome-wide profiling
    Patent number: 11733248
    Abstract: A method for detecting the binding of a chromatin-associated factor of interest to a sequence of chromatin DNA in a cell, including: contacting a permeabilized cell or nucleus with a specific binding agent that specifically recognizes the chromatin-associated factor of interest, wherein the specific binding agent is linked to a nuclease that is inactive or an activatable transposome; activating the nuclease or transposase, thereby excising the sequence of chromatin DNA bound to the chromatin-associated factor of interest; isolating the excised DNA; and determining the sequence of the excised DNA, thereby detecting binding of a chromatin-associated factor of interest to a sequence of chromatin DNA in the cell.
    Type: Grant
    Filed: September 25, 2018
    Date of Patent: August 22, 2023
    Assignee: Fred Hutchinson Cancer Center
    Inventors: Steven Henikoff, Hatice Seda Kaya Okur, Terri Dawn Bryson, Peter James Skene
  • HIGH EFFICIENCY TARGETED IN SITU GENOME-WIDE PROFILING
    Publication number: 20220228203
    Abstract: A method for detecting the binding of a chromatin-associated factor of interest to a sequence of chromatin DNA in a cell, including: contacting a permeabilized cell or nucleus with a specific binding agent that specifically recognizes the chromatin-associated factor of interest, wherein the specific binding agent is linked to a nuclease that is inactive or an activatable transposome; activating the nuclease or transposase, thereby excising the sequence of chromatin DNA bound to the chromatin-associated factor of interest; isolating the excised DNA; and determining the sequence of the excised DNA, thereby detecting binding of a chromatin-associated factor of interest to a sequence of chromatin DNA in the cell.
    Type: Application
    Filed: January 26, 2022
    Publication date: July 21, 2022
    Applicant: Fred Hutchinson Cancer Research Center
    Inventors: Steven Henikoff, Hatice Seda Kaya Okur, Terri Dawn Bryson, Peter James Skene
  • High Efficiency Targeted in Situ Genome-Wide Profiling
    Publication number: 20220214356
    Abstract: A method for detecting the binding of a chromatin-associated factor of interest to a sequence of chromatin DNA in a cell, including: contacting a permeabilized cell or nucleus with a specific binding agent that specifically recognizes the chromatin-associated factor of interest, wherein the specific binding agent is linked to a nuclease that is inactive or an activatable transposome; activating the nuclease or transposase, thereby excising the sequence of chromatin DNA bound to the chromatin-associated factor of interest; isolating the excised DNA; and determining the sequence of the excised DNA, thereby detecting binding of a chromatin-associated factor of interest to a sequence of chromatin DNA in the cell.
    Type: Application
    Filed: September 25, 2018
    Publication date: July 7, 2022
    Applicant: Fred Hutchinson Cancer Research Center
    Inventors: Steven Henikoff, Hatice Seda Kaya Okur, Terri Dawn Bryson, Peter James Skene