Patents by Inventor Hayao Nakanishi

Hayao Nakanishi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10641689
    Abstract: A device for preparing a glass slide specimen of cells has: a filter that has recesses, which capture target cells that are at least one of circulating tumor cells within blood or rare tumor cells within a body fluid, and pores that are formed in the recesses and that pass non-target cells therethrough; a glass slide that is superposed onto a surface of the filter, at a side at which the target cells are captured, and onto which the target cells are transferred; a cover member that is placed on a surface of the filter at a side opposite from the glass slide, and that seals in a buffer solution for immersing the target cells at interiors of the recesses; and a container into which the glass slide is immersed and in which is stored a preservation liquid that preserves the target cells that have been transferred onto the glass slide.
    Type: Grant
    Filed: June 16, 2017
    Date of Patent: May 5, 2020
    Assignee: OPTNICS PRECISION CO., LTD.
    Inventors: Seichin Kinuta, Yoshiyuki Ichinosawa, Hayao Nakanishi, Seiji Ito
  • Publication number: 20190120735
    Abstract: A device for preparing a glass slide specimen of cells has: a filter that has recesses, which capture target cells that are at least one of circulating tumor cells within blood or rare tumor cells within a body fluid, and pores that are formed in the recesses and that pass non-target cells therethrough; a glass slide that is superposed onto a surface of the filter, at a side at which the target cells are captured, and onto which the target cells are transferred; a cover member that is placed on a surface of the filter at a side opposite from the glass slide, and that seals in a buffer solution for immersing the target cells at interiors of the recesses; and a container into which the glass slide is immersed and in which is stored a preservation liquid that preserves the target cells that have been transferred onto the glass slide.
    Type: Application
    Filed: June 16, 2017
    Publication date: April 25, 2019
    Inventors: Seichin KINUTA, Yoshiyuki ICHINOSAWA, Hayao NAKANISHI, Seiji ITO
  • Patent number: 10247733
    Abstract: It is intended to find a highly specific epithelial ovarian cancer marker and to provide an antibody capable of specifically recognizing and detecting the marker or a fragment of the antibody. The present invention provides an anti-?1,6-N-acetylglucosaminyltransferase 5B antibody for diagnosis of epithelial ovarian cancer, i.e., an antibody for detection of a glycosyltransferase ?1,6-N-acetylglucosaminyltransferase 5B as an epithelial ovarian cancer marker. The antibody recognizes, as an epitope, a part of a polypeptide of the enzyme consisting of the amino acid sequence represented by SEQ ID NO: 1.
    Type: Grant
    Filed: July 26, 2012
    Date of Patent: April 2, 2019
    Assignee: National Institute of Advanced Industrial Science and Technology
    Inventors: Maki Sogabe, Tomomi Kubota, Akira Togayachi, Yuzuru Ikehara, Hisashi Narimatsu, Hiromichi Sawaki, Hayao Nakanishi, Toru Nakanishi
  • Patent number: 10022659
    Abstract: A device for isolating periphery circulating tumor cells or rare cells includes a metal filter having depressions that can capture periphery circulating tumor cells or rare cells that are in a body fluid, and pores that are formed at the depressions and that can pass therethrough body fluid cells other than periphery circulating tumor cells or rare cells.
    Type: Grant
    Filed: July 23, 2014
    Date of Patent: July 17, 2018
    Assignees: AICHI PREFECTURE, OPTNICS PRECISION CO., LTD.
    Inventors: Hayao Nakanishi, Seiji Ito, Seichin Kinuta, Yoshiyuki Ichinosawa, Akiko Yusa, Hiroyuki Honda, Mina Okochi
  • Patent number: 9968932
    Abstract: Provided is a microchannel chip, for microparticle separation, which can continuously separate microparticles, from a solution in which microparticles of different particle diameter are mixed, without needing to use an antibody or similar, and without causing clogging. Also provided are a microparticle separation method and a system for microparticle separation using the chip. Microparticles can be captured by using the microchannel chip for microparticle separation, the microchannel chip being characterised by being provided with a plurality of main channels and capture portions that are wider than the main channels and at least one of which is provided to each main channel.
    Type: Grant
    Filed: October 15, 2013
    Date of Patent: May 15, 2018
    Assignee: National University Corporation Nagoya University
    Inventors: Fumihito Arai, Taisuke Masuda, Miyako Niimi, Haruki Douke, Hayao Nakanishi, Seiji Ito
  • Patent number: 9816996
    Abstract: The present invention provides an antibody capable of specifically recognizing and detecting the highly specific cancer marker with respect to the epithelial ovarian cancer, or a fragment of the antibody. The present invention provides an anti-?1,3-N-acetylglucosaminyltransferase 3 antibody for diagnosis of epithelial ovarian cancer, i.e., an antibody for detection of a glycosyltransferase ?1,3-N-acetylglucosaminyltransferase 3 as an epithelial ovarian cancer marker. The antibody recognizes, as an epitope, a part of a polypeptide of the enzyme consisting of the amino acid sequence represented by SEQ ID NO: 1.
    Type: Grant
    Filed: July 26, 2012
    Date of Patent: November 14, 2017
    Assignee: National Institute of Advanced Industrial Science and Technology
    Inventors: Maki Sogabe, Tomomi Kubota, Akira Togayachi, Yuzuru Ikehara, Hisashi Narimatsu, Hiromichi Sawaki, Hayao Nakanishi, Toru Nakanishi
  • Publication number: 20160136552
    Abstract: A device for isolating periphery circulating tumor cells or rare cells includes a metal filter having depressions that can capture periphery circulating tumor cells or rare cells that are in a body fluid, and pores that are formed at the depressions and that can pass therethrough body fluid cells other than periphery circulating tumor cells or rare cells.
    Type: Application
    Filed: July 23, 2014
    Publication date: May 19, 2016
    Inventors: Hayao NAKANISHI, Seiji ITO, Seichin KINUTA, Yoshiyuki ICHINOSAWA, Akiko YUSA, Hiroyuki HONDA, Mina OKOCHI
  • Publication number: 20150293104
    Abstract: An object of the present invention is to develop and provide an epithelial ovarian cancer diagnosis marker with which epithelial ovarian cancer can be detected inexpensively, conveniently, and low invasively with high accuracy, and a method for determining the presence or absence of epithelial ovarian cancer using the marker. The present invention provides a glycoprotein having a glycan-linked asparagine residue at a particular site of the glycoprotein secreted from an epithelial ovarian cancer cell, or a fragment thereof having the glycan as an epithelial ovarian cancer diagnosis marker. The present invention also provides a method for determining the presence or absence of epithelial ovarian cancer using the glycoprotein.
    Type: Application
    Filed: July 12, 2012
    Publication date: October 15, 2015
    Applicant: National Institute of Advanced Industrial Science and Technology
    Inventors: Hirofumi Nozaki, Takashi Ohkura, Atsushi Kuno, Maki Sogabe, Tomomi Kubota, Hiroyuki Kaji, Akira Togayachi, Yuzuru Ikehara, Hisashi Narimatsu, Hayao Nakanishi, Toru Nakanishi
  • Publication number: 20150246353
    Abstract: Provided is a microchannel chip, for microparticle separation, which can continuously separate microparticles, from a solution in which microparticles of different particle diameter are mixed, without needing to use an antibody or similar, and without causing clogging. Also provided are a microparticle separation method and a system for microparticle separation using the chip. Microparticles can be captured by using the microchannel chip for microparticle separation, the microchannel chip being characterised by being provided with a plurality of main channels and capture portions that are wider than the main channels and at least one of which is provided to each main channel.
    Type: Application
    Filed: October 15, 2013
    Publication date: September 3, 2015
    Applicant: NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY
    Inventors: Fumihito Arai, Taisuke Masuda, Miyako Niimi, Haruki Douke, Hayao Nakanishi, Seiji Ito
  • Publication number: 20140295455
    Abstract: The present invention provides an antibody capable of specifically recognizing and detecting the highly specific cancer marker with respect to the epithelial ovarian cancer, or a fragment of the antibody. The present invention provides an anti-?1,3-N-acetylglucosaminyltransferase 3 antibody for diagnosis of epithelial ovarian cancer, i.e., an antibody for detection of a glycosyltransferase ?1,3-N-acetylglucosaminyltransferase 3 as an epithelial ovarian cancer marker. The antibody recognizes, as an epitope, a part of a polypeptide of the enzyme consisting of the amino acid sequence represented by SEQ ID NO: 1.
    Type: Application
    Filed: July 26, 2012
    Publication date: October 2, 2014
    Applicant: National Institute of Advanced Industrial Science and Technology
    Inventors: Maki Sogabe, Tomomi Kubota, Akira Togayachi, Yuzuru Ikehara, Hisashi Narimatsu, Hiromichi Sawaki, Hayao Nakanishi, Toru Nakanishi
  • Publication number: 20140242607
    Abstract: It is intended to find a highly specific epithelial ovarian cancer marker and to provide an antibody capable of specifically recognizing and detecting the marker or a fragment of the antibody. The present invention provides an anti-?1,6-N-acetylglucosaminyltransferase 5B antibody for diagnosis of epithelial ovarian cancer, i.e., an antibody for detection of a glycosyltransferase ?1,6-N-acetylglucosaminyltransferase 5B as an epithelial ovarian cancer marker. The antibody recognizes, as an epitope, a part of a polypeptide of the enzyme consisting of the amino acid sequence represented by SEQ ID NO: 1.
    Type: Application
    Filed: July 26, 2012
    Publication date: August 28, 2014
    Applicant: National Institute of Advanced Industrial Science and Technology
    Inventors: Maki Sogabe, Tomomi Kubota, Akira Togayachi, Yuzuru Ikehara, Hisashi Narimatsu, Hiromichi Sawaki, Hayao Nakanishi, Toru Nakanishi
  • Patent number: 8093284
    Abstract: A process for producing an aqueous solution of doripenem while decomposition of doripenem by heat is suppressed is found out. It was found out that decomposition of doripenem by heat can be suppressed by continuous heating an aqueous suspension of doripenem, and it was found out that an aqueous solution of doripenem can be produced.
    Type: Grant
    Filed: May 25, 2006
    Date of Patent: January 10, 2012
    Assignee: Shionogi & Co., Ltd.
    Inventor: Hayao Nakanishi
  • Publication number: 20090264493
    Abstract: A process for producing an aqueous solution of doripenem while decomposition of doripenem by heat is suppressed is found out. It was found out that decomposition of doripenem by heat can be suppressed by continuous heating an aqueous suspension of doripenem, and it was found out that an aqueous solution of doripenem can be produced.
    Type: Application
    Filed: May 25, 2006
    Publication date: October 22, 2009
    Inventor: Hayao Nakanishi
  • Publication number: 20080020029
    Abstract: The object of the present invention is to provide a drug delivery composition which allows efficient accumulation of an administered substance such as an anti-cancer drug and the like in a target site. The present invention provides a drug delivery liposome composition for delivering a substance to be administered to a target site, which comprises an oligosaccharide coated liposome and a substance to be administered.
    Type: Application
    Filed: March 17, 2005
    Publication date: January 24, 2008
    Applicants: TOKAI UNIVERSITY EDUCATIONAL SYSTEM, AICHI PREFECTURE
    Inventors: Naoya Kojima, Yoshitaka Shimizu, Yuzuru Ikehara, Hayao Nakanishi