Patents by Inventor Haydee Geronimo Perez
Haydee Geronimo Perez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220259300Abstract: Vaccine composition containing a mutant of the human Interleukin-15 (IL-15). The use of said mutant polypeptide of human IL-15 to manufacture a medicament for the active immunotherapy of diseases associated with IL-15 overexpression, including some autoimmune diseases and hematological malignancies. Administration to an individual that needs it of a therapeutically effective amount of the vaccine, that comprises the mutant polypeptide of the human IL-15 of the invention, constitutes a method for the therapy of IL-15 over-expressing related diseases.Type: ApplicationFiled: November 22, 2021Publication date: August 18, 2022Inventors: Yunier RODRIGUEZ ALVAREZ, Yanelys MORERA DÍAZ, Haydee GERONIMO PEREZ
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Publication number: 20200181254Abstract: Vaccine composition containing a mutant of the human Interleukin-15 (IL-15). The use of said mutant polypeptide of human IL-15 to manufacture a medicament for the active immunotherapy of diseases associated with IL-15 overexpression, including some autoimmune diseases and hematological malignancies. Administration to an individual that needs it of a therapeutically effective amount of the vaccine, that comprises the mutant polypeptide of the human IL-15 of the invention, constitutes a method for the therapy of IL-15 over-expressing related diseases.Type: ApplicationFiled: December 20, 2017Publication date: June 11, 2020Inventors: Yunier RODRIGUEZ ALVAREZ, Yanelys MORERA DÍAZ, Haydee GERONIMO PEREZ
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Patent number: 8431524Abstract: The present invention is related to the field of molecular immunology, particularly to a peptide derived from the sequence of interleukine-15 (IL-15), wherein said peptide was optimized to inhibit the biological activity of this molecule. In the present invention, it is shown that this peptide inhibits IL-15-induced T cell proliferation, Tumor Necrosis Factor ? (TNF?) induction and the expression of IL-8 and IL-6 by the IL-15 receptor ? subunit (IL-15R?), all these effects mediated by the binding of the peptide to the IL-15R?. The invention is also related to the use of the peptide to treat pathologies where the abnormal expression of IL-15 or IL-15R? is related to the course of the disease, such as rheumatoid arthritis (RA) and prostate cancer.Type: GrantFiled: September 30, 2009Date of Patent: April 30, 2013Assignee: Centro de Ingenieria Genetica y BiotecnologiaInventors: Alicia Santos Savio, Osvaldo Reyes Acosta, Haydee Geronimo Perez, Hilda Elisa Garay Perez, Yunier Rodriguez Alvarez, Gerardo Enríque Guillen Nieto
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Publication number: 20110251140Abstract: The present invention is related to the field of molecular immunology, particularly to a peptide derived from the sequence of interleukine-15 (IL-15), wherein said peptide was optimized to inhibit the biological activity of this molecule. In the present invention, it is shown that this peptide inhibits IL-15-induced T cell proliferation, Tumor Necrosis Factor ? (TNF?) induction and the expression of IL-8 and IL-6 by the IL-15 receptor a subunit (IL-15R?), all these effects mediated by the binding of the peptide to the IL-15R?. The invention is also related to the use of the peptide to treat pathologies where the abnormal expression of IL-15 or IL-15R? is related to the course of the disease, such as rheumatoid arthritis (RA) and prostate cancer.Type: ApplicationFiled: September 30, 2009Publication date: October 13, 2011Inventors: Alicia Santos Savio, Osvaldo Reyes Acosta, Haydee Geronimo Perez, Hilda Elisa Garay Perez, Yunier Rodriguez Alvarez, Gerardo Enrique Guillen Nieto
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Patent number: 8007776Abstract: Vaccine composition containing IL-15 for active immunization to treatment diseases related to over-expression of this cytokine. The technical aim pursued in this invention is to inhibit IL-15 activity through development of a therapeutic vaccine which elicits IL-15 neutralizing antibodies in the immunized host. IL-15 can be presented in this vaccine composition either alone or coupled to a carrier such as the P64k protein with a vaccine adjuvant such as Aluminum hydroxide. Besides, this invention is related to the use of this vaccine for treatment of Rheumatoid arthritis and other IL-15 over-expressing related diseases, and leukemia, where this cytokine acts as a growth factor.Type: GrantFiled: October 8, 2003Date of Patent: August 30, 2011Assignee: Centro de Ingenieria Genetica y BiotecnologiaInventors: Alicia Santos Savio, Ricardo Silva Rodriguez, Yanelis Morera Diaz, Armando Alexei Rodriquez Alfonso, Jose Rafael Martinez Castillo, Haydee Geronimo Perez, Alejandro Moro Soria, Silvio Ernesto Perea Rodriguez
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Patent number: 7799760Abstract: The invention relates to the use of Epidermal Growth Factor (EGF) in a preferably-injectable pharmaceutical composition which is administered by means of infiltration into and around chronic cutaneous ischaemic lesions in order to prevent diabetic foot amputation. Said composition can be administered to recently-created surgical surfaces damaged by the effect of acute reperfusion with oxygenated blood following prolonged ischaemia, thereby preventing further surgical procedures and favoring the preservation of the extremity. The aforementioned composition can be used to improve (i) the cell microenvironment, thereby increasing the reparative and defensive capacity and viability of the is tissues and (ii) the cicatrization of cutaneous ischaemic lesions, thereby stimulating cell proliferation. The invention is suitable for use in human, veterinary and experimental medicine, specifically in vascular angiology and surgery, dermatology, burn treatment and reconstructive surgery and geriatric medicine.Type: GrantFiled: August 22, 2008Date of Patent: September 21, 2010Assignee: Centro de Ingenieria Genetica y BiotecnologiaInventors: Jorge Berlanga Acosta, Jose I. Fernandez Montequin, Calixto Valdes Perez, Neobalis Franco Perez, Ingrid Rojas Constantin, Hector Santana Milian, Larissa Chacon Corvea, Gerardo E. Guillen Nieto, Luis Herrera Martinez, Leonardo Canan-Haden Frias, Haydee Geronimo Perez, Jorge Sotolongo Pena
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Patent number: 7736638Abstract: Current invention is related to the molecular pharmacology branch particularly to a peptide belonging to the Interleukin-15 sequence (IL-15) which is able to inhibit IL-15 biological activity, analogues or mimetic of such peptides. In the current invention it is shown that the peptide inhibits both IL-15-induced T cells proliferation upon binding to the IL15 receptor a subunit (IL15R?) and TNF?-mediated apoptosis. Besides, this invention is related to the use of this peptide in the treatment of several pathologies where aberrant IL-15 or IL-15R? expression is associated to the disease progression.Type: GrantFiled: September 16, 2005Date of Patent: June 15, 2010Assignee: Centro de Ingenieria Genetica y BiotecnologiaInventors: Alicia Santos Savio, Ania Cabrales Rico, Osvaldo Reyes Acosta, Haydee Geronimo Perez, Celia Aurora Arrieta Aguero, Silvio Ernesto Perea Rodriguez
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Publication number: 20090136511Abstract: Current invention is related to the molecular pharmacology branch particularly to a peptide belonging to the Interleukin-15 sequence (IL-15) which is able to inhibit IL-15 biological activity, analogues or mimetic of such peptides. In the current invention it is shown that the peptide inhibits both IL-15-induced T cells proliferation upon binding to the IL15 receptor ? subunit (IL15R?) and TNF?-mediated apoptosis. Besides, this invention is related to the use of this peptide in the treatment of several pathologies where aberrant IL-15 or IL-15R? expression is associated to the disease progression.Type: ApplicationFiled: September 16, 2005Publication date: May 28, 2009Applicant: CENTRO DE INGENIERIA GENETICA Y BIOTECNOLOGIAInventors: Alicia Santos Savio, Ania Cabrales Rico, Osvaldo Reyes Acosta, Haydee Geronimo Perez, Celia Aurora Arrieta Aguero, Silvio Ernesto Perea Rodriguez
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Publication number: 20080312139Abstract: The invention relates to the use of Epidermal Growth Factor (EGF) in a preferably-Injectable pharmaceutical composition which is administered by means of infiltration into and around chronic cutaneous ischaemic lesions in order to prevent diabetic foot amputation. Said composition can be administered to recently-created surgical surfaces damaged by the effect of acute reperfusion with oxygenated blood following prolonged ischaemia, thereby preventing further surgical procedures and favouring the preservation of the extremity. The aforementioned composition can be used to improve (i) the cell microenvironment, thereby increasing the reparative and defensive capacity and viability of the is tissues and (ii) the cicatrisation of cutaneous ischaemic lesions, thereby stimulating cell proliferation. The invention is suitable for use in human, veterinary and experimental medicine, specifically in vascular angiology and surgery, dermatology, burn treatment and reconstructive surgery and geriatric medicine.Type: ApplicationFiled: August 22, 2008Publication date: December 18, 2008Applicant: CENTRO DE INGENIERIA GENETICA Y BIOTECNOLOGIAInventors: Jorge Berlanga Acosta, Jose I. Fernandez Montequin, Calixto Valdes Perez, Neobalis Franco Perez, Ingrid Rojas Constantin, Hector Santana Milian, Larissa Chacon Corvea, Gerardo E. Guillen Nieto, Luis Herrera Martinez, Leonardo Canan-Haden Frias, Haydee Geronimo Perez, Jorge Sotolongo Pena
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Patent number: 7465704Abstract: The invention relates to the use of Epidermal Growth Factor (EGF) in a preferably-injectable pharmaceutical composition which is administered by means of infiltration into and around chronic cutaneous ischaemic lesions in order to prevent diabetic foot amputation. Said composition can be administered to recently-created surgical surfaces damaged by the effect of acute reperfusion with oxygenated blood following prolonged ischaemia, thereby preventing further surgical procedures and favouring the preservation of the extremity. The aforementioned composition can be used to improve (i) the cell microenvironment, thereby increasing the reparative and defensive capacity and viability of the is tissues and (ii) the cicatrisation of cutaneous ischaemic lesions, thereby stimulating cell proliferation. The invention is suitable for use in human, veterinary and experimental medicine, specifically in vascular angiology and surgery, dermatology, burn treatment and reconstructive surgery and geriatric medicine.Type: GrantFiled: December 4, 2002Date of Patent: December 16, 2008Assignee: Centro de Ingeniera Genetica y BiotecnologiaInventors: Jorge Berlanga Acosta, José I Fernández Montequin, Calixto Valdés Pérez, Neobalis Franco Pérez, Ingrid Rojas Constantin, Héctor Santana Milián, Larissa Chacón Corvea, Gerardo E. Guillén Nieto, Luis Herrera Martínez, Leonardo Canan-Haden Frías, Haydee Gerónimo Pérez, Jorge Sotolongo Pena
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Publication number: 20050107294Abstract: The invention relates to the use of Epidermal Growth Factor (EGF) in a preferably-injectable pharmaceutical composition which is administered by means of infiltration into and around chronic cutaneous ischaemic lesions in order to prevent diabetic foot amputation. Said composition can be administered to recently-created surgical surfaces damaged by the effect of acute reperfusion with oxygenated blood following prolonged ischaemia, thereby preventing further surgical procedures and favouring the preservation of the extremity. The aforementioned composition can be used to improve (i) the cell microenvironment, thereby increasing the reparative and defensive capacity and viability of the is tissues and (ii) the cicatrisation of cutaneous ischaemic lesions, thereby stimulating cell proliferation. The invention is suitable for use in human, veterinary and experimental medicine, specifically in vascular angiology and surgery, dermatology, burn treatment and reconstructive surgery and geriatric medicine.Type: ApplicationFiled: December 4, 2002Publication date: May 19, 2005Inventors: Jorge Acosta, Jose Fernandez Montequin, Calixto Valdes Perez, Neobalis Perez, Ingrid Constantin, Hector Milian, Larissa Corvea, Gerardo Guillen Nieto, Luis Martinez, Leonardo Canan-Haden Frias, Haydee Geronimo Perez, Jorge Sotolongo Pena