Patents by Inventor Hazel Dyke

Hazel Dyke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20080269239
    Abstract: The present invention relates to novel pyrimidine compounds, for the modulation of the histamine H4 receptor and the treatment or prevention of conditions mediated by the histamine H4 receptor. The invention also relates to the preparation of such compounds.
    Type: Application
    Filed: November 11, 2005
    Publication date: October 30, 2008
    Applicant: Argenta Discovery Ltd.
    Inventors: Neil Harris, Christopher Higgs, Stephen Wren, Hazel Dyke, Steven Price, Sue Cramp
  • Publication number: 20080261946
    Abstract: The present invention relates to novel pyrimidine compounds, for the modulation of the histamine H4 receptor and the treatment or prevention of conditions mediated by the histamine H4 receptor. The invention also relates to the preparation of such compounds.
    Type: Application
    Filed: September 20, 2006
    Publication date: October 23, 2008
    Applicant: CELLZOME (UK) LTD.
    Inventors: Hazel Dyke, Steven Price, Sue Cramp
  • Publication number: 20080085886
    Abstract: The invention relates to azabenzofuranyl compounds of Formula I with anti-cancer and/or anti-inflammatory activity and more specifically to azabenzofuranyl compounds which inhibit MEK kinase activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth or treating a hyperproliferative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.
    Type: Application
    Filed: August 20, 2007
    Publication date: April 10, 2008
    Inventors: Pascal Savy, Stephen Price, Hazel Dyke, John Montana, Karen Williams, Mark Stanley, Liang Bao
  • Publication number: 20080081821
    Abstract: The invention relates to azabenzothiophenyl compounds of Formula I with anti-cancer and/or anti-inflammatory activity and more specifically to azabenzothiophenyl compounds which inhibit MEK kinase activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth or treating a hyperproliferative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.
    Type: Application
    Filed: August 20, 2007
    Publication date: April 3, 2008
    Inventors: Pascal Savy, Stephen Price, Hazel Dyke, John Montana, Karen Williams, Mark Stanley, Liang Bao
  • Publication number: 20080004282
    Abstract: The present invention relates to compositions and methods to modulate the activity of gated ion channels.
    Type: Application
    Filed: April 10, 2007
    Publication date: January 3, 2008
    Applicant: PainCeptor Pharma Corporation
    Inventors: Rahul Vohra, Zhonghong Gan, Chang-Qing Wei, Stephen Price, Hazel Dyke, Elsa Dechaux
  • Publication number: 20080004306
    Abstract: The present invention relates to compositions and methods to modulate the activity of gated ion channels.
    Type: Application
    Filed: April 10, 2007
    Publication date: January 3, 2008
    Applicant: PainCeptor Pharma Corporation
    Inventors: Rahul Vohra, Zhonghong Gan, Hazel Dyke, Stephen Price
  • Publication number: 20070249648
    Abstract: The invention provides compounds of general formula. wherein A, B, W, X, Y, Z, D, E, R1 and n are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
    Type: Application
    Filed: October 21, 2004
    Publication date: October 25, 2007
    Inventors: HÃ¥kan Bladh, Stephen Connolly, Hazel Dyke, Annea Lisius, Stephen Price, Igor Shamovsky, Marco Van Den Heuvel
  • Publication number: 20070244131
    Abstract: The present invention is directed to a compound of Formula (I) wherein Cy1, Cy2, L1, L2, and R1 are as defined herein, a pharmaceutical composition comprising a pharmaceutically effective amount of one or more compounds according to Formula (I) in admixture with a pharmaceutically acceptable carrier, and a method of treating a patient suffering from a PGD2-mediated disorder including, but not limited to, allergic disease (such as allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy), systemic mastocytosis, disorders accompanied by systemic mast cell activation, anaphylaxis shock, bronchoconstriction, bronchitis, urticaria, eczema, diseases accompanied by itch (such as atopic dermatitis and urticaria), diseases (such as cataract, retinal detachment, inflammation, infection and sleeping disorders) which is generated secondarily as a result of behavior accompanied by itch (such as scratching and beating), inflammation, chronic obstructive pulmonary diseases, ische
    Type: Application
    Filed: April 16, 2007
    Publication date: October 18, 2007
    Applicant: AVENTIS PHARMACEUTICALS INC.
    Inventors: Sungtaek Lim, Keith Harris, David Stefany, Charles Gardner, Bin Cao, Ray Boffey, Timothy Gillespy, Joacy Aguiar, Hazel Dyke, Elsa Dechaux
  • Publication number: 20060276507
    Abstract: A class of piperidine and related heterocyclic derivatives, C-substituted by a substituted aryl or heteroaryl moiety, and N-substituted by an ethylsulfonyl group which in turn is substituted at the 2-position by a hydroxamic acid moiety and also by a range of alternative substituents, being potent inhibitors of CD23 shedding, are useful in the treatment and/or prevention of allergic, inflammatory and neoplastic diseases.
    Type: Application
    Filed: June 18, 2004
    Publication date: December 7, 2006
    Applicant: Celltech R&D Limited
    Inventors: David Owen, Robert Watson, Daniel Allen, Andrew Sharpe, Hazel Dyke
  • Publication number: 20060241118
    Abstract: A class of piperazine and related heterocyclic derivatives, substituted at the 4-position by a substituted aryl or heteroaryl moiety, and at the 1-position by an ethylsulfonyl group which in turn is substituted at the 2-position by a hydroxamic acid moiety and also by a range of alternative substituents, being potent inhibitors of CD23 shedding, are useful in the treatment and/or prevention of allergic, inflammatory and neoplastic diseases.
    Type: Application
    Filed: June 18, 2004
    Publication date: October 26, 2006
    Applicant: Celltech R&D Limited
    Inventors: David Owen, Robert Watson, Daniel Allen, Andrew Sharpe, Hazel Dyke
  • Publication number: 20060122234
    Abstract: A compound of formula (I): which can be used in the treatment of diseases associated with histone deacetylase enzymatic activity.
    Type: Application
    Filed: July 24, 2003
    Publication date: June 8, 2006
    Inventors: Janet Archer, Walter Bordogna, Richard Bull, David Clark, Hazel Dyke, Matthew Gill, Neil Harris, Marco Van Den Heuvel, Stephen Price