Patents by Inventor Hazel J. Dyke

Hazel J. Dyke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tricyclic sulphonamide compounds and methods of making and using same
    Patent number: 9868717
    Abstract: The invention provides tricyclic compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Grant
    Filed: November 5, 2013
    Date of Patent: January 16, 2018
    Assignee: Zafgen, Inc.
    Inventors: Thomas D. Pallin, Susan M. Cramp, Hazel J. Dyke, Robert Zahler
  • PARTIALLY SATURATED TRICYCLIC COMPOUNDS AND METHODS OF MAKING AND USING SAME
    Publication number: 20180002307
    Abstract: The invention provides tricyclic compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Application
    Filed: February 15, 2017
    Publication date: January 4, 2018
    Inventors: Susan M. Cramp, Hazel J. Dyke, Thomas D. Pallin, Robert Zahler
  • Tricyclic compounds and methods of making and using same
    Patent number: 9839623
    Abstract: The invention provides tricyclic compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Grant
    Filed: January 7, 2016
    Date of Patent: December 12, 2017
    Assignee: Zafgen, Inc.
    Inventors: David Clark, Susan M. Cramp, Hazel J. Dyke, Thomas D. Pallin, Robert Zahler
  • Partially saturated tricyclic compounds and methods of making and using same
    Patent number: 9617237
    Abstract: The invention provides tricyclic compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Grant
    Filed: February 3, 2016
    Date of Patent: April 11, 2017
    Assignee: Zafgen, Inc.
    Inventors: Susan M. Cramp, Hazel J. Dyke, Thomas D. Pallin, Robert Zahler
  • PARTIALLY SATURATED TRICYCLIC COMPOUNDS AND METHODS OF MAKING AND USING SAME
    Publication number: 20170001973
    Abstract: The invention provides tricyclic compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Application
    Filed: February 3, 2016
    Publication date: January 5, 2017
    Inventors: Susan M. Cramp, Hazel J. Dyke, Thomas D. Pallin, Robert Zahler
  • TRICYCLIC COMPOUNDS AND METHODS OF MAKING AND USING SAME
    Publication number: 20160354338
    Abstract: The invention provides tricyclic compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Application
    Filed: January 7, 2016
    Publication date: December 8, 2016
    Inventors: David Clark, Susan M. Cramp, Hazel J. Dyke, Thomas D. Pallin, Robert Zahler
  • TRICYCLIC PYRAZOLE SULPHONAMIDE COMPOUNDS AND METHODS OF MAKING AND USING SAME
    Publication number: 20160324865
    Abstract: The invention provides tricyclic sulfonamide compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Application
    Filed: December 14, 2015
    Publication date: November 10, 2016
    Inventors: Susan M. Cramp, Hazel J. Dyke, Thomas D. Pallin, Robert Zahler
  • Tricyclic sulfone compounds and methods of making and using same
    Patent number: 9440943
    Abstract: The invention provides tricyclic sulfone compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Grant
    Filed: January 17, 2013
    Date of Patent: September 13, 2016
    Assignee: Zafgen, Inc.
    Inventors: Thomas D. Pallin, Hazel J. Dyke, Susan M. Cramp, Robert Zahler
  • Tricyclic sulfonamide compounds and methods of making and using same
    Patent number: 9359369
    Abstract: The invention provides tricyclic sulfonamide compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Grant
    Filed: January 17, 2013
    Date of Patent: June 7, 2016
    Assignee: Zafgen, Inc.
    Inventors: Thomas D. Pallin, Hazel J. Dyke, Susan M. Cramp, Robert Zahler
  • TRICYCLIC SULPHONAMIDE COMPOUNDS AND METHODS OF MAKING AND USING SAME
    Publication number: 20160083362
    Abstract: The invention provides tricyclic compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Application
    Filed: November 5, 2013
    Publication date: March 24, 2016
    Inventors: Thomas D. PALLIN, Susan M. CRAMP, Hazel J. DYKE, Robert ZAHLER
  • SULPHONE COMPOUNDS AND METHODS OF MAKING AND USING SAME
    Publication number: 20160051531
    Abstract: The invention provides sulphone compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various sulphone compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Application
    Filed: March 24, 2015
    Publication date: February 25, 2016
    Inventors: Hazel J. Dyke, Susan M. Cramp, Thomas D. Pallin, Janusz J. Kulagowski, John G. Montana, Robert Zahler
  • Sulphone compounds and methods of making and using same
    Patent number: 9067905
    Abstract: The invention provides sulphone compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various sulphone compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Grant
    Filed: April 23, 2012
    Date of Patent: June 30, 2015
    Assignee: Zafgen, Inc.
    Inventors: Hazel J. Dyke, Susan M. Cramp, Thomas D. Pallin, Janusz J. Kulagowski, John G. Montana, Robert Zahler
  • TRICYCLIC SULFONE COMPOUNDS AND METHODS OF MAKING AND USING SAME
    Publication number: 20150119456
    Abstract: The invention provides tricyclic sulfone compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Application
    Filed: January 17, 2013
    Publication date: April 30, 2015
    Inventors: Thomas D. Pallin, Hazel J. Dyke, Susan M. Cramp, Robert Zahler
  • TRICYCLIC SULFONAMIDE COMPOUNDS AND METHODS OF MAKING AND USING SAME
    Publication number: 20140378462
    Abstract: The invention provides tricyclic sulfonamide compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Application
    Filed: January 17, 2013
    Publication date: December 25, 2014
    Applicant: ZAFGEN, INC.
    Inventors: Thomas D. Pallin, Hazel J. Dyke, Susan M. Cramp, Robert Zahler
  • Sulphone Compounds and Methods of Making and Using Same
    Publication number: 20130053364
    Abstract: The invention provides sulphone compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various sulphone compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Application
    Filed: April 23, 2012
    Publication date: February 28, 2013
    Inventors: Hazel J. Dyke, Susan M. Cramp, Thomas D. Pallin, Janusz J. Kulagowski, John G. Montana, Robert Zahler
  • 2,6-substituted-4-monosubstitutedamino-pyrimidine as prostaglandin D2 receptor antagonists
    Patent number: 8193183
    Abstract: The present invention is directed to a compound of Formula (I) wherein Cy1, Cy2, L1, L2, and R1 are as defined herein, a pharmaceutical composition comprising a pharmaceutically effective amount of one or more compounds according to Formula (I) in admixture with a pharmaceutically acceptable carrier, and a method of treating a patient suffering from a PGD2-mediated disorder including, but not limited to, allergic disease (such as allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy), systemic mastocytosis, disorders accompanied by systemic mast cell activation, anaphylaxis shock, bronchoconstriction, bronchitis, urticaria, eczema, diseases accompanied by itch (such as atopic dermatitis and urticaria), diseases (such as cataract, retinal detachment, inflammation, infection and sleeping disorders) which is generated secondarily as a result of behavior accompanied by itch (such as scratching and beating), inflammation, chronic obstructive pulmonary diseases, ischem
    Type: Grant
    Filed: April 16, 2007
    Date of Patent: June 5, 2012
    Assignee: Aventis Pharmaceuticals Inc.
    Inventors: Sungtaek Lim, Keith John Harris, David Stefany, Charles J. Gardner, Bin Cao, Ray Boffey, Timothy A. Gillespy, Joacy C. Aguiar, Hazel J. Dyke, Elsa A. Dechaux