Abstract: A method of targeting cancer tissue in a subject includes administering to the subject a plurality of functionalized Tymovirus virus or virus-like particles loaded with or conjugated to an imaging agent, a therapeutic agent or a targeting agent.

Abstract: Disclosed are a tricyclic boronic acid derivative, and a preparation method therefor and an application thereof. Specifically, discloses are a compound represented by formula (I), an optical isomer and pharmaceutically acceptable salt thereof, and an application of the compound as a ?-lactamase inhibitor and an application of a composition as an antibacterial drug.

Abstract: A nanoparticle for diagnostic, therapeutic, and/or theranostic applications includes a rod-shaped plant virus like particle (VLP), one or more gadolinium T1 contrast agents conjugated to an interior surface of the VLP, and a layer of polydopamine (PDA) coated over a portion of the exterior surface of the VLP.

Abstract: A method of targeting cancer tissue in a subject includes administering to the subject a plurality of functionalized Tymovirus virus or virus-like particles loaded with or conjugated to an imaging agent, a therapeutic agent or a targeting agent.

Abstract: A method of targeting cancer tissue in a subject includes administering to the subject a plurality of functionalized Tymovirus virus or virus-like particles loaded with or conjugated to an imaging agent, a therapeutic agent or a targeting agent.

Abstract: An apparatus and methods for timing mismatch in a power amplifier includes a segmented PA with two-path timing mismatch calibration to improve ACLR performance over different signal transitions, process, voltage and temperature (PVT) variations and device aging; a fast and efficient algorithm for measuring and calibrating the delay of two paths (signal path and control path); a signal magnitude variation detection circuit, such as flash ADC, with improved comparator's performance for RF signal processing and minimum delay. A method for choosing the threshold voltage of the magnitude variation detection circuit, according to status of the signals and orthogonal frequency-division multiplexing (OFDM) related standards; other critical blocks.

Abstract: A method of targeting cancer tissue in a subject includes administering to the subject a plurality of functionalized Tymovirus virus or virus-like particles loaded with or conjugated to an imaging agent, a therapeutic agent or a targeting agent.

Abstract: A voltage regulator includes a load detection controller for detecting whether an output capacitor is present at an output of the voltage regulator; a digital controller for selecting a functional state of the voltage regulator based on a signal from the load detection controller; a first feedback loop for regulation when the output capacitor is not present; a second feedback loop for regulation when the capacitance output capacitor is present; and a first pass transistor shared by the load detection controller, the first feedback loop, and the second feedback loop, wherein the first pass transistor is configured to work with the first or second feedback loop selected for regulation based on the functional state of the voltage regulator.

Abstract: A silicon based (e.g., SiGe, CMOS, or BiCMOS) transmitter includes an algorithm that strategically segment and pre-distort the input signal according to its power; a reconfigurable power amplifier (PA) having a plurality of PA sections, wherein the plurality of PA sections comprise discrete weighted transistor arrays that are digitally turned OFF or ON according to a magnitude of an input signal; an impedance matching network equipped with a common-mode feedback (CMFB) mechanism configured to reduce common-mode glitches at an output of the PA due to ON/OFF manipulations of the PA segments; and a 1:N transformer, which comprises a capacitive matching engine and a power detector, disposed between the impedance matching network and the reconfigurable linear PA.

Abstract: A low-dropout (LDO) voltage regulator includes an adaptive bias source for generating a bulk-bias signal to a pass device in the LDO voltage regulator, wherein the adaptive bias source generates the bulk-bias signal based on a signal obtained at an output of the LDO voltage regulator. The signal includes a current signal, which is proportional to a current at the output of the LDO voltage regulator, and/or a feedback signal from a feedback path connected between the adaptive bias source and the output of the LDO voltage regulator for sensing negative and/or positive spikes.

Abstract: The present invention relates to an aflatoxin-detection device. The aflatoxin-detection device includes a flow path for a test solution and a plurality of nanocompo site strips disposed within the flow path. Each nanocomposite strip of the plurality of nanocomposite strips is arranged in a spaced parallel relationship with a successive nanocomposite strip of the plurality of nanocomposite strips. The plurality of nanocomposite strips exhibit high affinity for aflatoxin. Absorption of aflatoxin induces fluorescence of the plurality of nanocomposite strips. Responsive to a fluorescence intensity of each nanocomposite strip of the plurality of nanocomposite strips, a concentration of aflatoxin in the test solution is determined.