Patents by Inventor He-Ping Han

He-Ping Han has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for inhibiting hexokinase
    Patent number: 5891717
    Abstract: Disclosed are compositions and methods for inhibiting hexokinase enzymes in mammalian cells. Specifically provided are proteins that stimulate the production of trehalose-6-phosphate and their respective genes; hexokinase-specific ribozymes and genes encoding such constructs; and agents that competitively reduce hexokinase activity, e.g., by displacing hexokinase from mitochondria, and their respective genes. The latter group of agents includes inactive hexokinases and fragments thereof that retain mitochondrial binding functions and hexokinase-glucokinase chimeras that further substitute glucokinase activity for hexokinase activity. Mammalian cells including such hexokinase inhibitors, methods of making such cells and various in vitro and in vivo methods of using cells with reduced hexokinase activity are also described herein.
    Type: Grant
    Filed: January 19, 1996
    Date of Patent: April 6, 1999
    Assignees: Betagene, Inc., Board of Regents, The University of Texas System
    Inventors: Christopher B. Newgard, He-Ping Han, Thomas C. Becker, John E. Wilson
  • Hexokinase inhibitors
    Patent number: 5854067
    Abstract: Disclosed are compositions and methods for inhibiting hexokinase enzymes in mammalian cells. Specifically provided are proteins that stimulate the production of trehalose-6-phosphate and their respective genes; hexokinase-specific ribozymes and genes encoding such constructs; and agents that competitively reduce hexokinase activity, e.g., by displacing hexokinase from mitochondria, and their respective genes. The latter group of agents includes inactive hexokinases and fragments thereof that retain mitochondrial binding functions and hexokinase-glucokinase chimeras that further substitute glucokinase activity for hexokinase activity. Mammalian cells including such hexokinase inhibitors, methods of making such cells and various in vitro and in vivo methods of using cells with reduced hexokinase activity are also described herein.
    Type: Grant
    Filed: January 19, 1996
    Date of Patent: December 29, 1998
    Assignees: Board of Regents, The University of texas System, Betagene, Inc.
    Inventors: Christopher B. Newgard, He-Ping Han, Karl D. Normington