Abstract: The present application provides a color LED driving circuit, which comprises a set of switches and a color controller. The switch assembly has a first switch and a second switch, respectively having a first terminal, a second terminal and a control terminal. The first terminal of the first switch is configured to be coupled to a first LED load, and the first terminal of the second switch is configured to be coupled to a second LED load. The color controller comprises a first controller and a second controller. A ground terminal of the first controller is coupled to ground. The first controller is used to generate an output signal according to a PWM signal, and transmit the output signal to the second controller.

Abstract: A first set of features associated with a neural network are parameterized. A decision tree is generated from the first set of features. One or more adjustments for the neural network are received at the decision tree. A second set of features associated with the adjustments at the decision tree are parameterized. The parameterized first and second set of features are combined into a plurality of parameters. From the plurality, an adjusted neural network is generated.

Abstract: The present invention relates to a method for manipulating a tiny object, including: providing a charged particle beam; forming a non-uniform charge distribution in a fluid medium; and applying, to a tiny object, a gradient force formed by the non-uniform charge distribution. The present invention extends manipulation to a nanoscale, and can be applied to various microscopic tiny objects such as conductors, non-conductors, and living or non-living biological cells or organelles, and therefore surely promote great progress in the fields of physics, chemistry, biology and medicine.

Abstract: A dynamic characteristic analysis method of DET and RELAP5 coupling based on a universal instrumental variable method includes steps of: constructing a DET simulation model of a discrete dynamic event tree and modifying TRIP cards of an input file by adding universal instrumental TRIP variables according to state transition types of DET simulation objects, the universal instrumental TRIP variable being variable type or logical type; setting a simulation time of the RELAP5, controlling a simulation step, and analyzing an output result file of each simulation step of the RELAP5; backtracking the RELAP5 according to state transition types of DET simulation objects. The dynamic characteristic analysis method has advantages of simplifying TRIP setting process and method of DET state transition objects in an input file of the RELAP5 required for the coupling of DET and RELAP5, reducing a modeling complexity and improving a modeling efficiency.

Abstract: The present disclosure relates to compositions and methods for compositions, methods, and kits for treating cancer using chimeric antigen receptor (CAR) modified cells. Some embodiments of the present disclosure relate to an isolated nucleic acid sequence encoding CAR. The CAR may include an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain. The antigen binding domain may bind to an antigen of a non-essential organ.

Abstract: Aspects of the invention include detecting an error alert from a target computer system. In response to detecting the error alert, performance data is then retrieved from the target computer system. A gated recurrent unit (GRU) neural network is used to generate a prediction of a root cause of the error alert based on the performance data. The weights of a reset gate of the GRU neural network are adjusted based on received feedback of the prediction.

Abstract: One or more embodiments of this specification provide methods and apparatuses for transmitting messages. A method includes: determining a blockchain message from two or more message queues stored in a relay node in a blockchain relay communication network based on a message transmission policy, the message transmission policy being configured to transmit blockchain messages in the blockchain relay communication network based upon a priority identifier representing a priority of a blockchain message to be transmitted in the blockchain relay communication network; obtaining identifier from the blockchain message, and determining one or more target blockchain nodes in the blockchain relay communication network corresponding to the identifier; determining a target relay node connected to the one or more target blockchain nodes in the blockchain relay communication network; and transmitting the blockchain message to the one or more target blockchain nodes through the target relay node.

Abstract: A chimeric antigen receptor, includes an extracellular domain, a transmembrane domain, and an intracellular domain, which are connected in sequence, where the extracellular domain includes an antigen recognition region and a hinge region, and one end of the intracellular domain which is connected to the transmembrane domain is connected to a CD3? intracellular region. The chimeric antigen receptor can further improve the treatment effect of B-cell leukemia lymphoma, and reduce inflammatory cytokines generated from macrophage mononuclear cell activation by down-regulating cytokines, so that cytokine storm can be prevented in an early stage, and the risk of neurotoxicity can be reduced. The treatment effect of mesothelin high-expression solid tumors is further improved in mesothelin-positive tumor treatment, and the prevention of cytokine storm and the reduced risk of neurotoxicity can be realized at an early stage.

Abstract: The present invention provides a pharmaceutical composition for treating myocardial ischemia, comprising Salvia Miltiorrhiza medicinal material 250-700 parts by weight, Radix Notoginseng medicinal material 50-150 parts by weight, Borneolum Syntheticum 3-9 parts by weight, and ranolazine 25-100 parts by weight. According to a further aspect of the present invention, there is provided a use of a pharmaceutical composition for preparation of a medicine for prevention and/or treatment of myocardial ischemia.

Abstract: An array substrate and a liquid crystal display panel thereof. The array substrate includes a substrate having a plurality of pixel regions arranged in an array. Each of the pixel regions (120a) includes: a first electrode, a second electrode, an insulation protrusion, and a reflection electrode. An electric field is fit to form between the second electrode and the first electrode, and an electric field is also fit to form between the reflection electrode and the second electrode. The second electrode includes a slit electrode, which includes a plurality of slit portions and a plurality of electrode portions each arranged between adjacent slit portions. The electrode portion at least includes a first strip-shaped portion and a second strip-shaped portion. An extension direction of the first strip-shaped portion intersects with that of the second strip-shaped portion, and the first strip and second strip-shaped portions of each electrode portion are connected at a corresponding bending portion.

Abstract: Embodiments relate to compositions and methods for treating solid tumors. For example, the compositions comprise modified cells comprising an isolated polynucleotide comprising a polynucleotide encoding a nuclear factor of activated T cells (NFAT) promoter operatively associated with a polynucleotide encoding FLT3L.

Abstract: This specification provides a message transmission methods and apparatuses. One method includes: receiving a digital certificate sent by each blockchain node of a plurality of blockchain nodes in a blockchain relay communication network, wherein the digital certificate comprises identity information of each blockchain node of the plurality of blockchain nodes and a network identifier of a blockchain network of the blockchain relay communication network that comprises a corresponding blockchain node of the plurality of blockchain nodes; verifying that a digital signature of the digital certificate is authentic based on a public key of a certification authority (CA) issuing the digital certificate; and recording a mapping relationship between the identity information of each blockchain node of the plurality of blockchain nodes and the network identifier.

Abstract: A dual-beam feed network includes a first power dividing circuit, a second power dividing circuit, and a third power dividing circuit. The first power dividing circuit is configured to convert a beam signal of a first channel into a plurality of first signals, input one first signal into a third power dividing circuit, and respectively input each remaining first signal to a corresponding antenna radiation unit. The second power dividing circuit is configured to convert a beam signal of a second channel into a plurality of second signals, input one second signal into the third power dividing circuit, and respectively input each remaining second signal to a corresponding antenna radiation unit. The third power dividing circuit is configured to couple and input the received first signal and the received second signal to a shared antenna radiation unit.

Abstract: The present invention relates to an application of a traditional Chinese medicine composition and formulation thereof in the preparation of medicaments for preventing and/or treating novel coronavirus pneumonia.

Abstract: The present disclosure provides a metal oxide semiconductor device and a method for manufacturing the same. The metal oxide semiconductor device includes a semiconductor substrate, a patterned field oxide layer, first JFET implantation regions and second JFET implantation regions. Active regions and gate regions are formed on an upper surface of the semiconductor substrate, each active region is surrounded by two or more of the gate regions, and the gate regions form a grid and some gate regions overlap to form gate intersections. The first JFET implantation regions are formed by implanting ions underneath the gate intersections of the upper surface of the semiconductor substrate. Orthogonal projections of the first JFET implantation regions and the field oxide layer onto the substrate don't overlap. The second JFET implantation regions are formed by implanting ions into the upper surface of the semiconductor substrate and located underneath the gate regions that are not gate intersections.

Abstract: A VDMOS device and a fabrication method thereof are provided. The device includes unit cells which jointly form a cellular structure. The cellular structure includes spaced-apart source regions and surrounding gate regions. Some gate regions overlap to form gate intersections comprising separation regions; the others form non-intersecting gate regions. Each unit cell has a JFET region corresponding in position to one non-intersecting gate region and a JFET shielding region corresponding in position to one gate intersection. The difference in doping concentrations of different types of dopants in the JFET shielding region surpasses difference in doping concentrations in the JFET regions and therefore depletion layers disposed along diagonals of the gate intersections expand and merge more easily, thereby increasing breakdown voltage along the diagonals. Therefore, the device exhibits enhanced voltage tolerance and stability.

Abstract: A system and method for executing input/output (I/O) tasks for clients in a distributed computing system. One or more I/O requests made by a client are received. The operation instructions for the request data in the I/O requests are separated from the request data. A data representation called data label (or label) is created for executing operation instructions of the I/O requests. A data label corresponds to each of the I/O request and includes a unique identifier, information to the source and/or destination for the request data, and an operation instruction separated from the request data. The data label is pushed into a distributed label queue and is dispatched to an individual worker node according to a scheduling policy. The worker node executes the I/O tasks by executing the dispatched data label. The system and method can execute I/O tasks independently and decoupled from the client applications.

Abstract: The present disclosure relates to a method for manufacturing a trench-gate MOSFET. In the method, a first trench is formed in a first region and a second trench is formed in a second region in an epitaxial layer. A first well is formed in a bottom surface of the first trench in the first region, and a body region is formed in the epitaxial layer in the second region, simultaneously in one ion implantation process with one mask being used. Thus, the method reduces a number of masks and simplifies ion implantation processes, thereby reducing manufacturing cost.

Abstract: Systems and methods for simulating subterranean regions having multi-scale, complex fracture geometries. Non-intrusive embedded discrete fracture modeling formulations are applied in conjunction with commercial or in-house simulators to efficiently and accurately model subsurface characteristics including temperature profiles in regions having complex hydraulic fractures, complex natural fractures, or a combination of both.

Abstract: An array base plate and a fabricating method thereof, a display panel and a displaying device. The array base plate includes a substrate, the substrate is divided into a displaying region and a non-displaying region that surrounds the displaying region, and the non-displaying region includes a chip binding region; the array base plate further includes a target film layer provided on the substrate, and the target film layer extends to the non-displaying region; and the target film layer has a depression structure on a side that faces the chip binding region, and a position of the depression structure corresponds to a position of the chip binding region, whereby an orthographic projection of an alignment film in the array base plate on the substrate does not have a coinciding area with the chip binding region.