Abstract: A compound represented by formula (I) and a preparation method thereof, and a pharmaceutically acceptable salt thereof, a metabolic precursor thereof, a metabolite thereof, an isomer thereof or a prodrug thereof; experiments show that the indole alkaloid not only promotes axon growth of peripheral sensory neurons, improves the nerve conduction velocity and anesthesia symptom of diabetic rats, but also promotes healing of foot ulcer wounds of diabetic rats, thus having good therapeutic effects on diabetic complication peripheral neuropathy and diabetic feet; they also show that the indole alkaloid also obviously reduces a degree of pulmonary fibrosis induced by bleomycin in mice, and plays a role in protecting lung tissues.

Abstract: A compound represented by formula (I) and a preparation method thereof, and a pharmaceutically acceptable salt thereof, a metabolic precursor thereof, a metabolite thereof, an isomer thereof or a prodrug thereof; experiments show that the indole alkaloid not only promotes axon growth of peripheral sensory neurons, improves the nerve conduction velocity and anesthesia symptom of diabetic rats, but also promotes healing of foot ulcer wounds of diabetic rats, thus having good therapeutic effects on diabetic complication peripheral neuropathy and diabetic feet; they als show that the indole alkaloid also obviously reduces a degree of pulmonary fibrosis induced by bleomycin in mice, and plays a role in protecting lung tissues.

Abstract: An output control circuit, a method for transmitting data, and an electronic device are disclosed. The output control circuit includes: a serial-to-parallel conversion circuit configured to obtain at least one group of parallel data through a serial-to-parallel conversion; an intermediate-stage cache circuit configured to divide the at least one group of parallel data into at least two categories of subgroup parallel data according to sequence of serial-to-parallel conversion; a latch output circuit including a plurality of latch arrays each of which receiving any category of subgroup parallel data and latching and outputting any subgroup parallel data in any category of subgroup parallel data; and a selection control circuit configured to, within an effective pulse duration of the any subgroup parallel data, control a latch array for the any subgroup parallel data in the plurality of latch arrays to latch and output the any subgroup parallel data.

Abstract: A garden tool includes a connecting rod assembly, a working head, a power source, a first rod connected to the working head, a second rod connected to the power source, and a connection structure for mechanical and electrical connection between the first and second rods. A first terminal is arranged on the first rod and a second terminal arranged on the second rod, the first terminal being connected to a first wire, the second terminal being connected to a second wire, the first terminal and the second terminal connectable to transmit power of the power source to the working head through the first wire and the second wire. A second base is mounted in the second rod, the second base including at least two jacks independent of each other. At least two second terminals are respectively mounted in respective jacks.

Abstract: An output control circuit, a method for transmitting data, and an electronic device are disclosed. The output control circuit includes: a serial-to-parallel conversion circuit configured to obtain at least one group of parallel data through a serial-to-parallel conversion; an intermediate-stage cache circuit configured to divide the at least one group of parallel data into at least two categories of subgroup parallel data according to sequence of serial-to-parallel conversion; a latch output circuit including a plurality of latch arrays each of which receiving any category of subgroup parallel data and latching and outputting any subgroup parallel data in any category of subgroup parallel data; and a selection control circuit configured to, within an effective pulse duration of the any subgroup parallel data, control a latch array for the any subgroup parallel data in the plurality of latch arrays to latch and output the any subgroup parallel data.

Abstract: A level shifter includes a power supply rail conversion block, an RS latch and a digital detection block. The power supply rail conversion block comprises a first NLDMOS transistor, a second NLDMOS transistor, a first PLDMOS transistor, a second PLDMOS transistor, a first PMOS transistor, a second PMOS transistor, a first NMOS transistor, a second NMOS transistor, and a first inverter. A gate of the first NLDMOS transistor is connected to an input of the first inverter, a drain of the first NLDMOS transistor is connected to a drain of the first PLDMOS transistor; a source of the first NLDMOS transistor and a source of the second NLDMOS are connected to a referenced ground of an LV power supply rail. The digital detection block comprises a second inverter, a third inverter, a first delay chain, a second delay chain, a first NAND gate and a second NAND gate.

Abstract: A garden tool includes a connecting rod assembly, a working head, a power source, a first rod connected to the working head, a second rod connected to the power source, and a connection structure for mechanical and electrical connection between the first and second rods. A first terminal is arranged on the first rod and a second terminal arranged on the second rod, the first terminal being connected to a first wire, the second terminal being connected to a second wire, the first terminal and the second terminal connectable to transmit power of the power source to the working head through the first wire and the second wire. A second base is mounted in the second rod, the second base including at least two jacks independent of each other. At least two second terminals are respectively mounted in respective jacks.

Abstract: Disclosed is a method for preparing 7-halo-2-oxoheptylate, an intermediate of cilastatin. The main steps are as follows: A. Addition reaction, in which 6-halo-hexanal is reacted with a cyanide to obtain 7-halo-?-hydroxyl-heptonitrile; B. Hydrolysis reaction, in which 7-halo-?-hydroxyl-heptonitrile is converted to 7-halo-?-hydroxyl-heptylic acid; C. Esterification reaction, in which 7-halo-?-hydroxyl-heptylic acid is converted to 7-halo-?-hydroxyl-heptylate; and D. Oxidation reaction, in which 7-halo-?-hydroxyl-heptylate is converted to 7-halo-2-oxoheptylate. 7-halo-?-hydroxyl-heptylic acid or ester thereof, which is a new intermediate for synthesizing 7-halo-2-oxoheptylate or cilastatin, and a method for synthesizing cilastatin are also disclosed. The methods of the invention are suitable for commercial production because of their simple process and mild reaction condition.

Abstract: Disclosed is a method for preparing 7-halo-2-oxoheptylate, an intermediate of cilastatin. The main steps are as follows: A. Addition reaction, in which 6-halo-hexanal is reacted with a cyanide to obtain 7-halo-?-hydroxyl-heptonitrile; B. Hydrolysis reaction, in which 7-halo-?-hydroxyl-heptonitrile is converted to 7-halo-?-hydroxyl-heptylic acid; C. Esterification reaction, in which 7-halo-?-hydroxyl-heptylic acid is converted to 7-halo-?-hydroxyl-heptylate; and D. Oxidation reaction, in which 7-halo-?-hydroxyl-heptylate is converted to 7-halo-2-oxoheptylate. 7-halo-?-hydroxyl-heptylic acid or ester thereof, which is a new intermediate for synthesizing 7-halo-2-oxoheptylate or cilastatin, and a method for synthesizing cilastatin are also disclosed. The methods of the invention are suitable for commercial production because of their simple process and mild reaction condition.