Abstract: Transcription factors (TFs) represent a major class of therapeutic targets for the treatment of human diseases including cancer. Although the biological function and even crystal structure of many TFs have been clearly elucidated, there is still no viable approach to target the majority of TFs, thus rendering them undruggable for decades. PROTACs (PROteolysis TArgeting Chimeras) have emerged as a powerful tool for the pharmaceutical development since the effect of PROTACs largely relies on engineered protein-protein interaction to aid the degradation of targets by the ubiquitin-proteasome system (UPS). The present disclosure provides a DNA-PROTAC platform for targeted degraders of individual TFs of interest. These DNA based Transcription Factor targetting PROTACS (or “TF-PROTACS”) may provide specificity to TF degradation based on the conserved DNA-binding motifs of respective TFs.

Abstract: According to an aspect, a computer-implemented method includes accessing a profile of a user that indicates a likelihood that the user will execute each of a plurality of types of processing when training a new AI model. A runtime matrix that includes identifiers of runtime environments is accessed. The matrix also includes, for each of the runtime environments, a frequency of use of the runtime environment to train previously trained AI models using each of the plurality of types of processing. One or more of the runtime environments is selected for output to the user based at least in part on the profile of the user and the runtime matrix. Identifiers of the selected one or more of the runtime environments are output to a user interface of the user along with a suggestion to use one of the selected one or more of the runtime environments.

Abstract: Disclosed are antigen binding polypeptides and antigen binding polypeptide complexes (e.g., antibodies and antigen binding fragments thereof) having certain structural and/or functional features. Also disclosed are polynucleotides and vectors encoding such polypeptides and polypeptide complexes; host cells, pharmaceutical compositions and kits containing such polypeptides and polypeptide complexes; and methods of using such polypeptides and polypeptide complexes.

Abstract: The disclosure relates to an automatic measuring system and a method thereof for drilling fluid parameters measurement. The system includes i. mud container, configured for test drilling fluid preparation and samples collection; ii. heat jacket, configured to keep the drilling fluid in the tank warm iii. heat exchanger, configured to simulate the practical conditions; iv. plunger pump, configured to pump the test drilling fluid to the flowing test device; v. flow test device, configured to simulate the flowing states of drilling fluid in the borehole annulus and drilling string, and also measure the pressure and flow rate of drilling fluid vi. control module, configured to obtain rheological parameters and the best rheological mode of the drilling fluid in the borehole annulus and drilling string based on the pressure and flow rate.

Abstract: A video playing method and apparatus are described that implement an adaptively varied playing speed, and meet a playing setting of a user, thereby improving viewing experience of the user in a video played at an adaptively varied speed. The method includes obtaining a first playing speed and obtaining first information. The first information includes image information of a video and/or voice information of the video. The method further includes playing the video at a second playing speed that is obtained based on the first playing speed and the first information.

Abstract: The present disclosure provides a direct current (DC) transformer error detection apparatus for a pulsating harmonic signal, including a DC and pulsating harmonic current output module and an external detected input module, where the DC and pulsating harmonic current output module outputs a DC and a DC superimposed pulsating harmonic current to an internal sampling circuit and a self-calibrated standard resistor array; and the internal sampling circuit converts the input DC and the input DC superimposed pulsating harmonic current into a voltage signal, and sends the voltage signal to an analog-to-digital (AD) sampling and measurement component through a front-end conditioning circuit and a detected input channel. The DC transformer error detection apparatus can complete self-calibration for measurement of the DC and the pulsating harmonic signal on a test site.

Abstract: An optical system affixed to an electronic apparatus is provided, including a first optical module, a second optical module, and a third optical module. The first optical module is configured to adjust the moving direction of a first light from a first moving direction to a second moving direction, wherein the first moving direction is not parallel to the second moving direction. The second optical module is configured to receive the first light moving in the second moving direction. The first light reaches the third optical module via the first optical module and the second optical module in sequence. The third optical module includes a first photoelectric converter configured to transform the first light into a first image signal.

Abstract: An optical element driving mechanism includes a movable assembly, a fixed assembly, and a driving assembly. The movable assembly is configured to be connected to an optical element. The movable assembly is movable relative to the fixed assembly. The driving assembly is configured to drive the movable assembly to move relative to the fixed assembly in a range of motion. The optical element driving mechanism further includes a positioning assembly configured to position the movable assembly at a predetermined position relative to the fixed assembly when the driving assembly is not operating.

Abstract: Driving a display of an input-display device includes generating, during a first display frame, a first touch sensing waveform to be applied to a touch screen of the display, and generating, during a second display frame, a second touch sensing waveform to be applied to the touch screen. The first touch sensing waveform generates on the display a first touch-to-display noise pattern of touch-to-display noise artifacts. The second touch sensing waveform generates on the display a second touch-to-display noise pattern of touch-to-display noise artifacts. The second touch-to-display noise pattern mitigates the first touch-to-display noise pattern.

Abstract: This application relates to the field of image processing, and in particular, to a multi-lens video recording method and related devices. The method includes: performing collaborative photographing through a plurality of cameras, determining a target camera movement mode based on main subject information in images obtained through photographing and motion information of the cameras, and then fusing, based on the target camera movement mode, the images obtained through photographing by using the plurality of cameras, to implement online camera movement fusion on the plurality of video stream images.

Abstract: Driving a display of an input-display device includes generating, during a first display frame, a first touch sensing waveform to be applied to a touch screen of the display, and generating, during a second display frame, a second touch sensing waveform to be applied to the touch screen. The first touch sensing waveform generates on the display a first touch-to-display noise pattern of touch-to-display noise artifacts. The second touch sensing waveform generates on the display a second touch-to-display noise pattern of touch-to-display noise artifacts. The second touch-to-display noise pattern mitigates the first touch-to-display noise pattern.

Abstract: A controller of a touch display device is configured to perform steps of: transmitting a main uplink signal to an input device, the main uplink signal indicating an amount of a plurality of downlink signals transmitted in a frame; transmitting a first sub-uplink signal to the input device, the first sub-uplink signal notifying the input device of a time length of a first downlink signal among the plurality of downlink signals; transmitting a second sub-uplink signal to the input device, the second sub-uplink signal notifying the input device of a time length of a second downlink signal among the plurality of downlink signals; and receiving the plurality of downlink signals from the input device.

Abstract: The present disclosure relates to systems and methods for image processing. The system may obtain low-frequency component of a first image. For each element of the first image, the system may adjust a luminance of the element in response to determining that the luminance of the element is less than a predetermined luminance threshold. The system may determine a first luminance weight map corresponding to the first image based on the adjusted luminance of each element of the first image. The system may obtain low-frequency component of a second image and determine a second luminance weight map corresponding to the second image based on a luminance of each element of the second image. The system may further determine a fused image based on the low-frequency component of the first image, the first luminance weight map, the low-frequency component of the second image, and the second luminance weight map.

Abstract: The present disclosure generally relates in certain embodiments to a magnetic imaging kit for biochemical sensing, e.g., for detection of analytes, via magnetic imaging techniques. For instance, in one set of embodiments, the kit comprises a collection of magnetic imaging agents (e.g. superparamagnetic iron oxide nanoparticles) and linker species (e.g. a catechol, phosphothreonine, and/or derivative thereof) with a molecular weight of less than or equal to 1000 Da, or less than or equal to 500 Da. The magnetic imaging agents may sense the presence of an analyte via aggregation or disaggregation of the two or more magnetic imaging agents. In addition, certain aspects are directed to a method of exposing two or more magnetic imaging agents to a region on or in a subject and imaging the region to determine the analyte.

Abstract: A user permission allocation method includes acquiring currently collected facial feature information of a user; determining a difference degree of the current facial feature information of the user according to the acquired facial feature information of the user and facial feature information included in stored standard sample information; and allocating a user permission to the user according to the determined difference degree. Compared with a manner of using a fixed face threshold, a difference degree of current facial feature information of the user is determined, and when a user permission is allocated to the user, an external factor that affects the collected facial feature information is used as a reference factor.

Abstract: A multimedia file transmission method, which relates to the fields of data transmission and image processing, includes acquiring network information; determining a transmission version of a multimedia file according to the network information, where different transmission versions are corresponding to different multimedia file quality; and transmitting the multimedia file according to the transmission version. The network information is automatically acquired, and the transmission version of the multimedia file is automatically determined according to the network information, which not only saves an operation of manually selecting, by a user, a transmission version and reduces operation complexity, but also improves appropriateness of determining a transmission version.

Abstract: Embodiments disclose a vehicle-mounted device upgrade method and a related device. The method may be applied to an intelligent vehicle, the intelligent vehicle includes a vehicle-mounted control device, and the method may include: receiving, by the vehicle-mounted control device, a first partial key sent by the communications device; restoring, by the vehicle-mounted control device, a first key by using the first partial key and a second partial key that is stored on the vehicle-mounted control device; and performing, by the vehicle-mounted control device, secure processing on a first upgrade file by using the first key, to obtain the securely processed first upgrade file, where the secure processing includes generating first message authentication code (MAC), and the securely processed first upgrade file includes the first upgrade file and the first MAC. According to this application, the vehicle-mounted device can be securely and efficiently upgraded.

Abstract: A method of using an active pen to wake a computer device from a power-saving mode is provided. The computer device includes a detecting apparatus, a processor, and a touch screen display panel. When the computer device is in a power-saving mode, the detecting apparatus continuously detects presence of the active pen within an effective detecting range with respect to the touch screen display panel. The detecting apparatus transmits a wakeup signal to the processor to wake the computer device when the detection circuit detects that the active pen is within the effective detecting range.

Abstract: A method of preparing a coated nanoparticle can include decomposing a compound to produce a nanoparticle, oxidizing the nanoparticle to produce an oxidized nanoparticle, and coating the oxidized nanoparticle with a zwitterionic ligand to produce the coated nanoparticle. The coated nanoparticle or the nanoparticle can be used in magnetic resonance imaging.

Abstract: A touch display panel and a manufacturing method thereof are provided. The touch display panel includes a substrate, a conductor, a first pressure sensing electrode and a second pressure sensing electrode. The conductor is stacked under the substrate, and the conductor is not connected to a bias. The first pressure sensing electrode is disposed on the substrate and disposed above the conductor. A compression zone exists between the first pressure sensing electrode and the conductor, so as to form a first pressure sensing capacitor. The second pressure sensing electrode is disposed on the substrate and disposed above the conductor. The compression zone exists between the second pressure sensing electrode and the conductor, so as to form a second pressure sensing capacitor connected in series with the first pressure sensing capacitor.