Abstract: Provided is an application of a sphere substance in the preparation of an intravenous injection, relating to the technical field of biomedicine. Intravenous injection of the sphere substance formed by MSC spheres or biomaterials is used as a new in-vivo delivery solution. Compared with the intravenous injection of discrete MSCs, the intravenous injection of the MSC spheres reduces the retention of the MSCs in lungs, and prolongs the-retention time and activity of the MSCs in blood and peripheral tissues, such that therapeutic effects for autoimmune diseases, inflammatory diseases, and tissues and organ injuries can be improved. In addition, the intravenous injection of biomaterial spheres is safe, can carry drugs, biologically active molecules or detection molecules, is applied to diagnosis and treatment of an animal disease model or a patient, is more effective and more durable than monomer molecules, and can also carry a variety of molecules to generate a synergistic effect.

Abstract: A device includes a virtual power line directly connected to each bitcell in a group of bitcells and a group of transistor switches connected between the virtual power line and a power supply. The device also includes a delay circuit, a first wakeup detector, and a plurality of main input-output (MIO) controllers. The delay circuit is coupled to the gate terminal of each transistor switch of the group of transistor switches. The first wakeup detector is configured to generate a first trigger signal in response to receiving a signal from the delay circuit. The plurality of main input-output (MIO) controllers is configured to be coupled to the power supply through a first group of wakeup switches and through a first group of function switches. A gate terminal of each wakeup switch in the first group of wakeup switches is configured to receive the first trigger signal.

Abstract: An image sensor (10), a camera assembly (40) and a mobile terminal (90) are disclosed. The image sensor (10) comprises panchromatic pixels and color pixels. The color pixels have the spectral response narrower than that of the panchromatic pixels, and the panchromatic pixels have the full-well capacity greater than that of the color pixels.

Abstract: Methods of scintillation, scintillation devices, and metal halide hybrids that may be used as X-ray scintillators. The metal halide hybrids may include organic metal halide hybrids, inorganic metal halide hybrids, or organic-inorganic metal halide hybrids. The metal halide hybrids may have a 0D structure. The metal halide hybrids may be in the form of one or more discrete crystals.

Abstract: An inductor having a coaxial structure is described. In one example, the structure of the single-turn inductor can include a conductor, an insulation layer, a shielding layer, and a magnetic core. An air duct can be located between the shielding layer and the magnetic core. The shielding layer and the magnetic core can both be connected to a ground. In one example, the single-turn inductor can include a single-layer termination structure formed on terminations of the shielding layer. In another example, the single-turn inductor can include a double-layer termination structure formed on terminations of the shielding layer. Displacement current in the single-turn inductor can be reduced using, for example, lumped equivalent circuit models, a semi-conductive shielding layer model, or a resistive layer and conductive shielding layer model.

Abstract: The present application provides a battery cover plate and a battery. The battery cover plate includes a cover plate body, a first seal, a second seal, and a sealing ring. The cover plate body is provided with a liquid injection hole, the first seal is attached to a hole wall of the liquid injection hole and is provided with a threaded hole extending along an axis direction of the liquid injection hole. The second seal includes a head and a connecting part, a diameter of the head is greater than a diameter of the connecting part, a first step surface is defined between the head and the connecting part, the connecting part is provided with an external thread threadedly connected to the threaded hole. The sealing ring is sleeved on the connecting part and located between the first step surface and an upper surface of the cover plate body.

Abstract: A device includes a first virtual power line coupled to a power supply through a first group of transistor switches, and a second virtual power line configured to receive the power supply through a second group of transistor switches. The device also includes a delay circuit coupled between the gate terminals of the first group of transistor switches and the gate terminals in the second group of transistor switches. The device further includes a wakeup detector and a plurality of main input-output (MIO) controllers. The wakeup detector is configured to generate a trigger signal after receiving a signal from the output of the delay circuit. The plurality of MIO controllers is coupled to the power supply through a group of wakeup switches and through a group of function switches. The gate terminals in the group of wakeup switches are configured to receive the trigger signal.

Abstract: A method and apparatus for unlocking a device or an application on the device based on gaze tracking. An image randomly selected from a set of images. Each image in the set of images includes a plurality of feature points and a sequence of feature points is pre-defined for each image. The selected image is presented to a user. A trajectory of gaze points of the user on the selected image presented to the user is determined. It is then determined whether the trajectory of gaze points of the user matches the pre-defined sequence of feature points on the selected image. The device or the application on the device is unlocked if the trajectory of gaze points of the user matches the pre-defined sequence of feature points on the selected image.

Abstract: The present disclosure provides antibody drug conjugates comprising STING modulators. Also provided are compositions comprising the antibody drug conjugates. The compounds and compositions are useful for stimulating an immune response in a subject in need thereof.

Abstract: A method and apparatus for storing autonomous driving test data and an electronic device are provided. The method may include: acquiring a task type of a test task of an autonomous vehicle; receiving message data acquired in a test of the autonomous vehicle and corresponding to the task type, and writing the message data into a data queue; creating a log file corresponding to the task type, writing the message data corresponding to the task type in the data queue into the log file, and transferring the log file and a file name of the log file to the data queue; acquiring preset disk drop scenario information corresponding to the task type; and adding, according to the preset disk drop scenario information, an unclearable mark to the log file in the data queue having data acquisition time consistent with the time of triggering disk drop storage of data.

Abstract: Disclosed are chemical entities which are compounds of formula (I): or pharmaceutically acceptable salts thereof; wherein Y, Ra, Ra?, Rb, Rc, X1, X2, X3, Rd, Z1, and Z2 have the values described herein and stereochemical configurations depicted at asterisked positions indicate absolute stereochemistry. Chemical entities according to the disclosure can be useful as inhibitors of Sumo Activating Enzyme (SAE). Further provided are pharmaceutical compositions comprising a compound of the disclosure and methods of using the compositions in the treatment of proliferative, inflammatory, cardiovascular, and neurodegenerative diseases or disorders.

Abstract: The present disclosure provides antibody drug conjugates comprising STING modulators. Also provided are compositions comprising the antibody drug conjugates. The compounds and compositions are useful for stimulating an immune response in a subject in need thereof.

Abstract: The present disclosure provides antibody drug conjugates comprising STING modulators. Also provided are compositions comprising the antibody drug conjugates. The compounds and compositions are useful for stimulating an immune response in a subject in need thereof.

Abstract: Disclosed are chemical entities which are compounds of formula (I): or pharmaceutically acceptable salts thereof; wherein Y, Ra, Ra?, Rb, Rc, X1, X2, X3, Rd, Z1, and Z2 have the values described herein and stereochemical configurations depicted at asterisked positions indicate absolute stereochemistry. Chemical entities according to the disclosure can be useful as inhibitors of Sumo Activating Enzyme (SAE). Further provided are pharmaceutical compositions comprising a compound of the disclosure and methods of using the compositions in the treatment of proliferative, inflammatory, cardiovascular, and neurodegenerative diseases or disorders.

Abstract: The present disclosure provides antibody drug conjugates comprising STING modulators. Also provided are compositions comprising the antibody drug conjugates. The compounds and compositions are useful for stimulating an immune response in a subject in need thereof.

Abstract: The present disclosure provides antibody drug conjugates comprising STING modulators. Also provided are compositions comprising the antibody drug conjugates. The compounds and compositions are useful for stimulating an immune response in a subject in need thereof.

Abstract: A method of low-frequency seismic data enhancement for improving the characterization precision of a deep carbonate reservoir includes: first performing inversions on an input seismic data set to obtain the corresponding reflection coefficients and average seismic wavelet; then constructing a seismic wavelet with rich low-frequency information; and finally, performing convolution on the seismic wavelet with rich low-frequency information and the reflection coefficients to obtain seismic data with rich low-frequency information and enhanced low-frequency energy. In the present invention, changes of the seismic data in a work area in transverse and longitudinal directions are taken into consideration, and processing parameters can be quickly determined according to actual conditions of the work area to obtain an optimal processing effect.

Abstract: A method of differentiating pluripotent stem cells into mesenchymal stem cells, a culture medium used in the method of differentiating pluripotent stem cells into mesenchymal stem cells and a method of performing tissue and organ regeneration by using the mesenchymal stem cells obtained by differentiation using the method of differentiating pluripotent stem cells into mesenchymal stem cells are provided. The method of differentiating pluripotent stem cells into mesenchymal stem cells comprises differentiating, completely under 3D suspension conditions, pluripotent stem cells into trophoblast-like cells using BMP4 and A8301, and then differentiating the trophoblast-like cells into mesenchymal stem cells. Neither of two differentiation processes needs passaging or replacement of a culture container.