Patents by Inventor Heath H. Herman
Heath H. Herman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20130264263Abstract: The present invention is directed to methods and compositions for separating and isolating target molecules. In particular, the present invention comprises devices, such as CCDs, that contain particles without the need for support structures. Chromatography separation techniques, including but not limited to, ion exchange, size separation, affinity chromatography, ion exclusion, ligand exchange, reversed phase and normal phase partitioning, are used in the CCD. Methods also include low, medium and high pressure liquid chromatography. Such methods can be used for analytical, semi-preparative processes, initial clarification, preparative filtration and process scale applications.Type: ApplicationFiled: March 26, 2013Publication date: October 10, 2013Inventor: Heath H. Herman
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Publication number: 20080264865Abstract: The present invention is directed to methods and compositions for separating and isolating target molecules. In particular, the present invention comprises devices, such as CCDs, that contain particles without the need for support structures. Chromatography separation techniques, including but not limited to, ion exchange, size separation, affinity chromatography, ion exclusion, ligand exchange, reversed phase and normal phase partitioning, are used in the CCD. Methods also include low, medium and high pressure liquid chromatography. Such methods can be used for analytical, semi-preparative processes, initial clarification, preparative filtration and process scale applications.Type: ApplicationFiled: March 25, 2008Publication date: October 30, 2008Inventor: Heath H. Herman
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Patent number: 7347943Abstract: The present invention is directed to methods and compositions for separating and isolating target molecules. In particular, the present invention comprises devices, such as CCDs, that contain particles without the need for support structures. Chromatography separation techniques, including but not limited to, ion exchange, size separation, affinity chromatography, ion exclusion, ligand exchange, reversed phase and normal phase partitioning, are used in the CCD. Methods also include low, medium and high pressure liquid chromatography. Such methods can be used for analytical, semi-preparative processes, initial clarification, preparative filtration and process scale applications.Type: GrantFiled: August 29, 2005Date of Patent: March 25, 2008Assignee: Kinetic Biosystems Inc.Inventor: Heath H. Herman
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Patent number: 6942804Abstract: The present invention is directed to methods and compositions for separating and isolating target molecules. In particular, the present invention comprises devices, such as CCDs, that contain particles without the need for support structures. Chromatography separation techniques, including but not limited to, ion exchange, size separation, affinity chromatography, ion exclusion, ligand exchange, reversed phase and normal phase partitioning, are used in the CCD. Methods also include low, medium and high pressure liquid chromatography. Such methods can be used for analytical, semi-preparative processes, initial clarification, preparative filtration and process scale applications.Type: GrantFiled: November 12, 2002Date of Patent: September 13, 2005Assignee: Kinetic Biosystems, Inc.Inventor: Heath H. Herman
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Patent number: 6916652Abstract: The invention comprises novel culture methods and devices in which biocatalysts are substantially immobilized contained, suspended and or incubated in a chamber. At least one injection element provides a fluid flow to a perimeter of the chamber and the fluid force of the fluids flowing into the chamber works with the centripetal force created by rotation of the device to suspend the cells within the chamber, promote cell growth and/or clean the fluid as it passes thru the suspended biocatalyst.Type: GrantFiled: May 22, 2002Date of Patent: July 12, 2005Assignee: Kinetic Biosystems, Inc.Inventors: Peter J. Petrecca, Heath H. Herman, Tod M. Herman, Robert A. Cuneo
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Patent number: 6703217Abstract: The present invention comprises novel culture methods and devices in which living cells or subcellular biocatalysts are immobilized in an open chamber defined by two rotating disks. The fluid force of nutrient fluids flowing into the chamber opposes the centripetal force created by rotation of the device to suspend the cells within the chamber and promote cell growth. Use of an open chamber increases the capacity of the device to produce the desired cellular products.Type: GrantFiled: January 31, 2001Date of Patent: March 9, 2004Assignee: Kinetic BioSystems, Inc.Inventors: Heath H. Herman, Tod M. Herman, Robert A. Cuneo, Gerard W. Osborne
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Patent number: 6660509Abstract: Abstract of the Invention The present invention comprises novel culture methods and devices in which living cells or subcellular biocatalysts are immobilized by the opposition of forces. The immobilized cells or biocatalysts may be attached to support complexes that add to the resultant vector forces. One embodiment of the apparatus comprises a cruciform design. Commercial applications of the apparatus include efficient isolation of metals from ores and removal of gases.Type: GrantFiled: May 21, 1999Date of Patent: December 9, 2003Assignee: Kinetic Biosystems, Inc.Inventors: Heath H. Herman, Tod M. Herman, Arlan K. Andrews, Sr.
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Publication number: 20030146161Abstract: The present invention is directed to methods and compositions for separating and isolating target molecules. In particular, the present invention comprises devices, such as CCDs, that contain particles without the need for support structures. Chromatography separation techniques, including but not limited to, ion exchange, size separation, affinity chromatography, ion exclusion, ligand exchange, reversed phase and normal phase partitioning, are used in the CCD. Methods also include low, medium and high pressure liquid chromatography. Such methods can be used for analytical, semi-preparative processes, initial clarification, preparative filtration and process scale applications.Type: ApplicationFiled: November 12, 2002Publication date: August 7, 2003Inventor: Heath H. Herman
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Publication number: 20030064428Abstract: The present invention is directed to novel culture methods and devices in which living cells or subcellular biocatalysts are immobilized in an open chamber defined by two rotating disks. The fluid force of nutrient fluids flowing into the chamber opposes the centripetal force created by rotation of the device to suspend the cells within the chamber and promote cell growth. Use of an open chamber increases the capacity of the device to produce the desired cellular products. Commercial applications of the apparatus include efficient isolation of metals from ores and removal of gases. Further, the present invention is directed to methods and apparatuses for degrading, removing or remediating contaminants, such as ether-based environmental contaminants, by removing the contaminants from a contaminated fluid using a biocatalyst to remediate the contaminant.Type: ApplicationFiled: February 20, 2001Publication date: April 3, 2003Inventors: Heath H. Herman, Gerard W. Osborne, Tod M. Herman, Robert A. Cuneo
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Publication number: 20030054546Abstract: The invention comprises novel culture methods and devices in which biocatalysts are substantially immobilized contained, suspended and or incubated in a chamber. At least one injection element provides a fluid flow to a perimeter of the chamber and the fluid force of the fluids flowing into the chamber works with the centripetal force created by rotation of the device to suspend the cells within the chamber, promote cell growth and/or clean the fluid as it passes thru the suspended biocatalyst.Type: ApplicationFiled: May 22, 2002Publication date: March 20, 2003Inventors: Peter J. Petrecca, Heath H. Herman, Tod M. Herman, Robert A. Cuneo
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Publication number: 20010044143Abstract: The present invention comprises novel culture methods and devices in which living cells or subcellular biocatalysts are immobilized in an open chamber defined by two rotating disks. The fluid force of nutrient fluids flowing into the chamber opposes the centripetal force created by rotation of the device to suspend the cells within the chamber and promote cell growth. Use of an open chamber increases the capacity of the device to produce the desired cellular products.Type: ApplicationFiled: January 31, 2001Publication date: November 22, 2001Inventors: Heath H. Herman, Tod M. Herman, Robert A. Cuneo, Gerard W. Osborne
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Patent number: 6214617Abstract: The present invention comprises a novel culture methods and devices in which living cells or subcellular biocatalysts are immobilized by the opposition of forces. The immobilized cells or biocatalysts may be attached to support complexes that add to the resultant vector forces.Type: GrantFiled: December 31, 1998Date of Patent: April 10, 2001Assignee: Kinetic Biosystems, Inc.Inventor: Heath H. Herman
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Patent number: 6133019Abstract: The present invention comprises a novel culture method and device in which living cells or subcellular biocatalysts are immobilized by the opposition of a centrifugal force field and a liquid flow field. The immobilized cells or biocatalysts are ordered into a three-dimensional array of articles, the density of which is determined by the particle size, shape, intrinsic density and by the selection of combinations of parameters such as liquid flow rate and angular velocity of rotation.Type: GrantFiled: July 13, 1998Date of Patent: October 17, 2000Assignee: Kinetic Biosystems, Inc.Inventor: Heath H. Herman
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Patent number: 5821116Abstract: The present invention comprises a novel culture method and device in which living cells or subcellular biocatalysts are immobilized by the opposition of a centrifugal force field and a liquid flow field. The immobilized cells or biocatalysts are ordered into a three-dimensional array of articles, the density of which is determined by the particle size, shape, intrinsic density and by the selection of combinations of parameters such as liquid flow rate and angular velocity of rotation.Type: GrantFiled: January 16, 1997Date of Patent: October 13, 1998Assignee: Kinetic Biosystems, Inc.Inventor: Heath H. Herman
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Patent number: 5622819Abstract: The present invention comprises a novel culture method and device in which living cells or subcellular biocatalysts are immobilized by the opposition of a centrifugal force field and a liquid flow field. The immobilized cells or biocatalysts are ordered into a three-dimensional array of particles, the density of which is determined by the particle size, shape, intrinsic density and by the selection of combinations of parameters such as liquid flow rate and angular velocity of rotation.Type: GrantFiled: March 28, 1995Date of Patent: April 22, 1997Assignee: Kinetic Biosystems, Inc.Inventor: Heath H. Herman
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Patent number: 4906668Abstract: The preparation of aminoalkyl phenyl selenides and pharmaceutically acceptable salts thereof is disclosed which are useful for the treatment of hypertension and related vascular diseases and the treatment of nervous system dysfunctions.Type: GrantFiled: October 13, 1987Date of Patent: March 6, 1990Assignee: Georgia Tech Research CorporationInventors: Sheldon W. May, Heath H. Herman, Steven F. Roberts
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Patent number: 4722940Abstract: The preparation of aminoalkyl phenyl selenides and pharmaceutically acceptable salts thereof is disclosed which are useful for the treatment of hypertension and related vascular diseases and the treatment of nervous system dysfunctions.Type: GrantFiled: January 8, 1986Date of Patent: February 2, 1988Assignee: Georgia Tech Research CorporationInventors: Sheldon W. May, Heath H. Herman, Steven F. Roberts
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Patent number: 4579870Abstract: The preparation of aminoalkyl phenyl selenides and pharmaceutically acceptable salts thereof is disclosed which are useful for the treatment of hypertension and related vascular diseases and the treatment of nervous system dysfunctions.Type: GrantFiled: August 23, 1984Date of Patent: April 1, 1986Assignee: Georgia Tech Research CorporationInventors: Sheldon W. May, Heath H. Herman, Steven F. Roberts
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Patent number: 4415591Abstract: Hypertension in mammals can be treated by administering an effective amount of an aminoalkyl phenyl sulfide having the formula ##STR1## wherein (C.sub.n H.sub.2n)=a linear or branched alkyl chain of 10 carbons or less (n=1-10);R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5,=H, OH, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy, F, Cl, Br, or I;R.sub.6 R.sub.7 =H, C.sub.1 -C.sub.4 -alkyl;and the pharmaceutically acceptable salts thereof. The hypotensive potential of the compounds may be evaluated by oxygenation with dopamine-beta-hydroxylase.Type: GrantFiled: June 4, 1981Date of Patent: November 15, 1983Assignee: Georgia Tech Research InstituteInventors: Sheldon W. May, Robert S. Phillips, Heath H. Herman, Patricia W. Mueller