Patents by Inventor Heather A. Boux
Heather A. Boux has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7326574Abstract: Compositions and methods for detection of the stress-inducible Hsp70B? protein are disclosed. These include antibodies directed against particular amino acid regions of Hsp70B? and various peptides corresponding, or antigenically equivalent, to the regions. The ability to generate anti-Hsp70B? antibodies to defined epitopes permits a variety of in vitro and in vivo uses.Type: GrantFiled: October 3, 2006Date of Patent: February 5, 2008Assignee: Stressgen Biotechnologies CorporationInventors: Heather A. Boux, Geraldine S. Wong, Henry Rodriguez
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Publication number: 20070020695Abstract: Compositions and methods for detection of the stress-inducible Hsp70B? protein are disclosed. These include antibodies directed against particular amino acid regions of Hsp70B? and various peptides corresponding, or antigenically equivalent, to the regions. The ability to generate anti-Hsp70B? antibodies to defined epitopes permits a variety of in vitro and in vivo uses.Type: ApplicationFiled: October 3, 2006Publication date: January 25, 2007Inventors: Heather Boux, Geraldine Wong, Henry Rodriguez
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Patent number: 7138247Abstract: Compositions and methods for detection of the stress-inducible Hsp70B? protein are disclosed. These include antibodies directed against particular amino acid regions of Hsp70B? and various peptides corresponding, or antigenically equivalent, to the regions. The ability to generate anti-Hsp70B? antibodies to defined epitopes permits a variety of in vitro and in vivo uses.Type: GrantFiled: March 25, 2005Date of Patent: November 21, 2006Assignee: Stressgen Biotechnologies CorporationInventors: Heather A. Boux, Geraldine S. Wong, Henry Rodriguez
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Patent number: 7105161Abstract: A modulated immune response to an antigen is achieved by coadministering the antigen and a genetically-detoxified pertussis holotoxin, particularly one retaining its immunogenicity, to a host. The modulated immune response enables immunogenic compositions, including multivalent pediatric vaccines such as DTP, to be provided which produce a modulated immune response in the absence of extrinsic adjuvants such as alum. The adjuvanting effect achieved by the genetically-detoxified pertussis holotoxin enables at least the same level of adjuvanting effect to be achieved as previously attained by alum, without the undesirable side effects thereof.Type: GrantFiled: June 8, 1995Date of Patent: September 12, 2006Assignee: Sanofi Pasteur Inc.Inventors: Diane M. Gajewczyk, Heather A. Boux, Anton Novak, Michel H. Klein
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Patent number: 6964851Abstract: Compositions and methods for detection of the stress-inducible Hsp70B? protein are disclosed. These include antibodies directed against particular amino acid regions of Hsp70B? and various peptides corresponding, or antigenically equivalent, to the regions. The ability to generate anti-Hsp70B? antibodies to defined epitopes permits a variety of in vitro and in vivo uses.Type: GrantFiled: December 7, 2000Date of Patent: November 15, 2005Assignee: Stressgen Biotechnologies Corp.Inventors: Heather A. Boux, Geraldine S. Wong, Henry Rodriguez
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Publication number: 20050186199Abstract: Compositions and methods for detection of the stress-inducible Hsp70B? protein are disclosed. These include antibodies directed against particular amino acid regions of Hsp70B? and various peptides corresponding, or antigenically equivalent, to the regions. The ability to generate anti-Hsp70B? antibodies to defined epitopes permits a variety of in vitro and in vivo uses.Type: ApplicationFiled: March 25, 2005Publication date: August 25, 2005Inventors: Heather Boux, Geraldine Wong, Henry Rodriguez
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Publication number: 20030073160Abstract: Compositions and methods for detection of the stress-inducible Hsp70B′ protein are disclosed. These include antibodies directed against particular amino acid regions of Hsp70B′ and various peptides corresponding, or antigenically equivalent, to the regions. The ability to generate anti-Hsp70B′ antibodies to defined epitopes permits a variety of in vitro and in vivo uses.Type: ApplicationFiled: December 7, 2000Publication date: April 17, 2003Inventors: Heather A. Boux, Geraldine S. Wong, Henry Rodriguez
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Publication number: 20030072774Abstract: A modulated immune response to an antigen is achieved by coadministering the antigen and a genetically-detoxified pertussis holotoxin, particularly one retaining its immunogenicity, to a host. The modulated immune response enables immunogenic compositions, including multivalent pediatric vaccines, such as DTP, to be provided which produce a modulated immune response in the absence of extrinsic adjuvants, such as alum. The adjuvanting effect achieved by the genetically-detoxified pertussis holotoxin enables at least the same level of adjuvanting effect to be achieved as previously attained by alum, without the undesirable side effects thereof.Type: ApplicationFiled: June 7, 1995Publication date: April 17, 2003Inventors: DIANE M. GAJEWCZYK, HEATHER A. BOUX, ANTON NOVAK, MICHEL H. KLEIN
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Patent number: 5433945Abstract: A new method is described for the preparation of a safe, immunogenic and efficacious vaccine for protection against the disease pertussis. In development of this vaccine, specific functional sites of pertussis toxin have been identified, and using this information, defined mutant holotoxins have been produced by site directed mutagenesis of the toxin gene. A number of these holotoxin analogues are detoxified, retain an immunodominant S1 epitope, are immunogenic and are protective in the standard pertussis vaccine potency test in mice.Type: GrantFiled: November 20, 1992Date of Patent: July 18, 1995Assignee: Connaught Laboratories LimitedInventors: Michel H. Klein, Heather A. Boux, Stephen A. Cockle, Sheena M. Loosmore, Gavin R. Zealey
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Patent number: 5358868Abstract: A new method is described for the preparation of a safe, immunogenic and efficacious vaccine for protection against the disease pertussis. In development of this vaccine, specific functional sites of pertussis toxin have been identified, and using this information, defined mutant holotoxins have been produced by site directed mutagenesis of the toxin gene. A number of these holotoxin analogues are detoxified, retain an immunodominant S1 epitope, are immunogenic and are protective in the standard pertussis vaccine potency test in mice.Type: GrantFiled: November 5, 1991Date of Patent: October 25, 1994Assignee: Connaught Laboratories LimitedInventors: Michel H. Klein, Heather A. Boux, Stephen A. Cockle, Sheena M. Loosmore, Gavin R. Zealey
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Patent number: 5332583Abstract: A new method is described for the preparation of a safe, immunogenic and efficacious vaccine for protection against the disease pertussis. In development of this vaccine, specific functional sites of pertussis toxin have been identified, and using this information, defined mutant holotoxins have been produced by site directed mutagenesis of the toxin gene. A number of these holotoxin analogues are detoxified, retain an immunodominant S1 epitope, are immunogenic and are protective in the standard pertussis vaccine potency test in mice.Type: GrantFiled: November 5, 1991Date of Patent: July 26, 1994Assignee: Connaught Laboratories LimitedInventors: Michel H. Klein, Heather A. Boux, Stephen A. Cockle, Sheena M. Loosmore, Gavin R. Zealey
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Patent number: 5244657Abstract: A new method is described for the preparation of a safe, immunogenic and efficacious vaccine for protection against the disease pertussis. In development of this vaccine, specific functional sites of pertussis toxin have been identified, and using this information, defined mutant holotoxins have been produced by site directed mutagenesis of the toxin gene. A number of these holotoxin analogs are detoxified, retain an immunodominant S1 epitope, are immunogenic and are protective in the standard pertussis vaccine potency test in mice.Type: GrantFiled: September 28, 1990Date of Patent: September 14, 1993Assignee: Connaught Laboratories LimitedInventors: Michel H. Klein, Heather A. Boux, Stephen A. Cockle, Sheena M. Loosmore, Gavin R. Zealey
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Patent number: 5221618Abstract: A new method is described for the preparation of a safe, immunogenic and efficacious vaccine for protection against the disease pertussis. In development of this vaccine, specific functional sites of pertussis toxin have been identified, and using this information, defined mutant holotoxins have been produced by site directed mutagenesis of the toxin gene. A number of these toxin analogues are detoxified, retain an immunodominant S1 epitope, are immunogenic and are protective in the standard pertussis vaccine potency test in mice.Type: GrantFiled: September 30, 1991Date of Patent: June 22, 1993Assignee: Connaught Laboratories LimitedInventors: Michel H. Klein, Heather A. Boux, Stephen A. Cockle, Sheena M. Loosmore, Gavin R. Zealey
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Patent number: 5085862Abstract: A new method is described for the preparation of a safe, immunogenic and efficacious vaccine for protection against the disease pertussis. In development of this vaccine, specific functional sites of pertussis toxin have been identified, and using this information, defined mutant holotoxins have been produced by site directed mutagenesis of the toxin gene. A number of these toxin analogues are detoxified, retain an immunodominant S1 epitope, are immunoganic and are protective in the standard pertussis vaccine potency test in mice.Type: GrantFiled: November 23, 1988Date of Patent: February 4, 1992Assignee: Connaught Laboratories LimitedInventors: Michel H. Klein, Heather A. Boux, Stephen A. Cockle, Sheena M. Loosmore, Gavin R. Zealey