Patents by Inventor Heather D. Maynard
Heather D. Maynard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11951176Abstract: Trehalose-based nanogels for stabilizing and controlled releasing biomolecules such as glucagons are disclosed. Specifically, trehalose-based nanogels comprise (a) a copolymer comprising first methacrylate units and second methacrylate units, wherein (i) the first methacrylate units comprise trehalose side chains; and (ii) the second methacrylate units comprise disulfide side chains; (b) dithiol cross-linkers; wherein the dithiol cross-linkers cross link the copolymer through the disulfide side chains of the second methacrylate units.Type: GrantFiled: November 30, 2018Date of Patent: April 9, 2024Assignee: The Regents of the University of CaliforniaInventors: Heather D. Maynard, Natalie Boehnke
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Patent number: 11879019Abstract: An enzyme-responsive peptide and a method off using such enzyme-responsive peptide are disclosed. An enzyme-responsive peptide, the peptide comprising an amino acid having an ?-amino group, an ?-carboxylic acid group and a ?-amine group, wherein the ?-amine group is covalently bonded with a first group and the ?-carboxylic acid is covalently bonded with a second group.Type: GrantFiled: December 19, 2017Date of Patent: January 23, 2024Assignee: The Regents of the University of CaliforniaInventors: Heather D. Maynard, Natalie Boehnke
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Patent number: 11541125Abstract: Non-crushable pill formulations and methods of using the formulations are disclosed. A non-crushable pill formulation for preventing unintended use of a drug, comprising a polymer, the polymer forming a polymer backbone of the complex; cross-linkers, the cross-linkers connecting the polymer backbone through covalently bonding to form at least one inner cavity within the complex; and the drug, the drug being trapped either covalently or non-covalently in the at least one inner cavity within the complex, wherein the drug is protected from releasing outside of the complex.Type: GrantFiled: December 19, 2017Date of Patent: January 3, 2023Assignee: The Regents of The University of CaliforniaInventors: Heather D. Maynard, Natalie Boehnke, Samantha J. Paluck
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Patent number: 11479470Abstract: Novel three-dimensional molecular clusters and methods of their synthesis are provided. The three-dimensional molecular clusters may be perfunctionalized polyhedral boranes and carboranes. The three-dimensional clusters may be configured to manipulate the photophysical properties of other materials, including, for example, for use as photooxidants or as components in organic light-emitting diode materials. Methods are also provided for synthesizing and perfunctionalizing such three-dimensional clusters. The three-dimensional clusters may also be configured for use as organomimetic materials.Type: GrantFiled: February 21, 2017Date of Patent: October 25, 2022Assignee: The Regents of the University of CaliforniaInventors: Alexander Spokoyny, Heather D. Maynard, Elaine A. Qian, Marco S. Messina, Alex Wixtrom, Jonathan Axtell, Kent Kirlikovali, Alejandra Gonzalez
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Patent number: 10899879Abstract: Structures and methods of making biodegradable trehalose co-polymers are disclosed. Specifically, biodegradable trehalose co-polymers consist of the general structure R5—[R1R2C—CR3R4]n-[DG]m-R6, wherein R1-R4 are independently selected from hydrogen or a side chain comprising at least one carbon atom, and wherein at least one of R1-R4 is a side chain comprising -L-trehalose, wherein L is a linker molecule that links trehalose to the monomer through at least one of the trehalose hydroxyl groups (—OH), wherein DG is a biodegradable group, and wherein R5 and R6 are end groups.Type: GrantFiled: August 13, 2015Date of Patent: January 26, 2021Assignee: The Regents of the University of CaliforniaInventor: Heather D. Maynard
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Publication number: 20200297866Abstract: Trehalose-based nanogels for stabilizing and controlled releasing biomolecules such as glucagons are disclosed. Specifically, trehalose-based nanogels comprise (a) a copolymer comprising first methacrylate units and second methacrylate units, wherein (i) the first methacrylate units comprise trehalose side chains; and (ii) the second methacrylate units comprise disulfide side chains; (b) dithiol cross-linkers; wherein the dithiol cross-linkers cross link the copolymer through the disulfide side chains of the second methacrylate units.Type: ApplicationFiled: November 30, 2018Publication date: September 24, 2020Inventors: Heather D. Maynard, Natalie Boehnke
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Publication number: 20200199177Abstract: An enzyme-responsive peptide and a method off using such enzyme-responsive peptide are disclosed. An enzyme-responsive peptide, the peptide comprising an amino acid having an ?-amino group, an ?-carboxylic acid group and a ?-amine group, wherein the ?-amine group is covalently bonded with a first group and the ?-carboxylic acid is covalently bonded with a second group.Type: ApplicationFiled: December 19, 2017Publication date: June 25, 2020Inventors: Heather D. Maynard, Natalie Boehnke
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Patent number: 10676534Abstract: The invention relates to compositions of vault complexes for use as delivery agents for hydrophobic and/or aqueous insoluble therapeutic compounds. In one aspect, provided herein is a vault complex comprising a modified major vault protein (MVP), wherein the modified major vault protein comprises a fusion peptide, wherein said fusion peptide is fused to the N-terminus of the major vault protein, and wherein said peptide provides enhanced sequestering of a hydrophobic and/or aqueous insoluble therapeutic compound within the vault complex.Type: GrantFiled: October 17, 2014Date of Patent: June 9, 2020Assignee: The Regents of the University of CaliforniaInventors: Leonard H. Rome, Daniel Buehler, Heather D. Maynard
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Patent number: 10662295Abstract: Trehalose-based hydrogels and methods of making such hydrogels are disclosed. Specifically, a method of creating a trehalose-based hydrogel, comprising the steps of: a) forming a trehalose homopolymer or co-polymer; b) preparing a cross-linker; and c) reacting the trehalose homopolymer or co-polymer with the cross-linker to form the trehalose-based hydrogel.Type: GrantFiled: August 12, 2015Date of Patent: May 26, 2020Assignee: The Regents of the University of CaliforniaInventor: Heather D. Maynard
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Publication number: 20200085964Abstract: Non-crushable pill formulations and methods of using the formulations are disclosed. A non-crushable pill formulation for preventing unintended use of a drug, comprising a polymer, the polymer forming a polymer backbone of the complex; cross-linkers, the cross-linkers connecting the polymer backbone through covalently bonding to form at least one inner cavity within the complex; and the drug, the drug being trapped either covalently or non-covalently in the at least one inner cavity within the complex, wherein the drug is protected from releasing outside of the complex.Type: ApplicationFiled: December 19, 2017Publication date: March 19, 2020Inventors: Heather D. Maynard, Natalie Boehnke, Samantha J. Paluck
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Patent number: 10543280Abstract: Compositions and methods for stabilizing biomolecules are disclosed. Specifically, the compositions include novel homopolymers or copolymers containing trehalose side chains conjugated to biomolecules. When such homopolymers or copolymers are placed in close proximity to biomolecules, such as proteins, the homopolymers or copolymers protect and/or stabilize the biomolecule. The compositions and methods may be suitable for use in various industries such as healthcare (pharmaceuticals), molecular biology, biofuels, paper, personal care, detergent, photographic, rubber, brewing, dairy and food processing industries.Type: GrantFiled: January 29, 2018Date of Patent: January 28, 2020Assignee: The Regents of the University of CaliforniaInventors: Heather D. Maynard, Rock J. Mancini, Juneyoung Lee, En-Wei Lin
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Publication number: 20190125885Abstract: Compositions and methods for stabilizing biomolecules are disclosed. Specifically, the compositions include novel homopolymers or copolymers containing trehalose side chains conjugated to biomolecules. When such homopolymers or copolymers are placed in close proximity to biomolecules, such as proteins, the homopolymers or copolymers protect and/or stabilize the biomolecule. The compositions and methods may be suitable for use in various industries such as healthcare (pharmaceuticals), molecular biology, biofuels, paper, personal care, detergent, photographic, rubber, brewing, dairy and food processing industries.Type: ApplicationFiled: January 29, 2018Publication date: May 2, 2019Inventors: Heather D. Maynard, Rock J. Mancini, Juneyoung Lee, En-Wei Lin
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Patent number: 10273333Abstract: Structures and methods of making biodegradable trehalose co-polymers are disclosed. Specifically, biodegradable trehalose co-polymers consist of the general structure R5—[R1R2C—CR3R4]n-[DG]m—R6, wherein R1-R4 are independently selected from hydrogen or a side chain comprising at least one carbon atom, and wherein at least one of R1-R4 is a side chain comprising -L-trehalose, wherein L is a linker molecule that links trehalose to the monomer through at least one of the trehalose hydroxyl groups (—OH), wherein DG is a biodegradable group, and wherein R5 and R6 are end groups.Type: GrantFiled: December 29, 2016Date of Patent: April 30, 2019Assignee: The Regents of the University of CaliforniaInventor: Heather D. Maynard
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Publication number: 20190047871Abstract: Novel three-dimensional molecular clusters and methods of their synthesis are provided. The three-dimensional molecular clusters may be perfunctionalized polyhedral boranes and carboranes. The three-dimensional clusters may be configured to manipulate the photophysical properties of other materials, including, for example, for use as photooxidants or as components in organic light-emitting diode materials. Methods are also provided for synthesizing and perfunctionalizing such three-dimensional clusters. The three-dimensional clusters may also be configured for use as organomimetic materials.Type: ApplicationFiled: February 21, 2017Publication date: February 14, 2019Applicant: The Regents of the University of CaliforniaInventors: Alexander Spokoyny, Heather D. Maynard, Elaine A. Qian, Marco S. Messina, Alex Wixtrom, Jonathan Axtell, Kent Kirlikovali, Alejandra Gonzalez
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Patent number: 10201613Abstract: A method of creating a hydrogel, comprising the step of condensing first and second functional groups, wherein the first group comprises a molecule or macromolecule of interest containing two or more hydroxylamine or aminooxy groups and the second group comprises a molecule or macromolecule of interest containing two or more aldehyde/ketone/other reactive oxo groups, under conditions such that a hydrogel forms.Type: GrantFiled: August 20, 2013Date of Patent: February 12, 2019Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Heather D. Maynard, Tatiana Segura, Gregory Grover, Jonathan Lam
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Publication number: 20180312630Abstract: Structures and methods of making biodegradable trehalose co-polymers are disclosed. Specifically, biodegradable trehalose co-polymers consist of the general structure R5[R1R2C—CR3R4]n-[DG]m-R6, wherein R1-R4 are independently selected from hydrogen or a side chain comprising at least one carbon atom, and wherein at least one of R1-R4 is a side chain comprising -L-trehalose, wherein L is a linker molecule that links trehalose to the monomer through at least one of the trehalose hydroxyl groups (—OH), wherein DG is a biodegradable group, and wherein R5 and R6 are end groups.Type: ApplicationFiled: August 13, 2015Publication date: November 1, 2018Inventor: Heather D. Maynard
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Patent number: 10039807Abstract: A heparin mimicking polymer, its conjugate with bFGF, and method of making and using the same are disclosed. In particular, described herein are conjugates of biologic agents (e.g., bFGF) and heparin mimicking polymers having superior stability while retaining full native activity after a variety of stressors.Type: GrantFiled: February 8, 2017Date of Patent: August 7, 2018Assignee: The Regents of the University of CaliforniaInventors: Heather D. Maynard, Thi Nguyen
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Publication number: 20180112034Abstract: Structures and methods of making biodegradable trehalose co-polymers are disclosed. Specifically, biodegradable trehalose co-polymers consist of the general structure R5—[R1R2C—CR3R4]n-[DG]m—R6, wherein R1-R4 are independently selected from hydrogen or a side chain comprising at least one carbon atom, and wherein at least one of R1-R4 is a side chain comprising -L-trehalose, wherein L is a linker molecule that links trehalose to the monomer through at least one of the trehalose hydroxyl groups (—OH), wherein DG is a biodegradable group, and wherein R5 and R6 are end groups.Type: ApplicationFiled: December 29, 2016Publication date: April 26, 2018Inventor: Heather D. Maynard
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Patent number: 9925270Abstract: A heparin mimicking polymer, its conjugate with bFGF, and method of making and using the same are disclosed. In particular, described herein are conjugates of biologic agents (e.g., bFGF) and heparin mimicking polymers having superior stability while retaining full native activity after a variety of stressors.Type: GrantFiled: November 28, 2012Date of Patent: March 27, 2018Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Heather D. Maynard, Thi Nguyen
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Patent number: 9901648Abstract: Compositions and methods for stabilizing biomolecules are disclosed. Specifically, the compositions include novel homopolymers or copolymers containing trehalose side chains conjugated to biomolecules. When such homopolymers or copolymers are placed in close proximity to biomolecules, such as proteins, the homopolymers or copolymers protect and/or stabilize the biomolecule. The compositions and methods may be suitable for use in various industries such as healthcare (pharmaceuticals), molecular biology, biofuels, paper, personal care, detergent, photographic, rubber, brewing, dairy and food processing industries.Type: GrantFiled: January 25, 2013Date of Patent: February 27, 2018Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Heather D. Maynard, Rock J. Mancini, Juneyoung Lee, En-Wei Lin