Abstract: Embodiments herein relate to intravascular imaging display systems and related methods. In an embodiment, an intravascular imaging display system is included having a control circuit and a video output circuit. The video output circuit can be configured to generate a display output including a user interface. The user interface can include graphical elements related to a vessel being imaged. The graphical elements can include a first detected feature portion at least partially defined by a first graphic indicator and a second detected feature portion at least partially defined by a second graphic indicator. The first graphic indicator can be visually distinct from the second graphic indicator. The first detected feature portion and the second detected feature portion can be assigned to represent one or more locations along a vessel wall by the control circuit based on a degree of attenuation of an ultrasound return signal crossing a threshold value.

Abstract: Systems and methods for automatic lesion assessment and/or processing imaging data are disclosed. An example intravascular imaging system may include a catheter including an imaging device. A processor may be coupled to the catheter. The processor may be configured to process imaging data received from the imaging device. The processor may be configured to generate a longitudinal section view of a blood vessel from the imaging data received from the imaging device. The processor may be configured to identify a minimum lumen area along the longitudinal section view of the blood vessel, a distal reference point, and a proximal reference. A display unit may be coupled to the processor. The display unit may be configured to show a display including the longitudinal section view of the blood vessel.

Abstract: Provided are a system and method of generating an aggregated stability map of one or more rotational sources associated with a heart rhythm disorder. In accordance therewith, a plurality of rotational area profile maps is accessed for a plurality of analysis intervals. Each of the profile maps includes rotation intensity values for a plurality of locations associated with rotation of the one or more rotational sources. An aggregated stability map is generated based on the profile maps, wherein the stability map includes a plurality of locations. Each location includes a rotation intensity value based at least on a filter number of highest rotation intensity values from corresponding locations of the profile maps, the filter number being automatically determined from a plurality of filter numbers such that the plurality of profile maps as filtered includes a predetermined number of rotation intensity values in excess of a threshold intensity value.

Abstract: Provided are a system and method of generating an aggregated stability map of one or more rotational sources associated with a heart rhythm disorder. In accordance therewith, a plurality of rotational area profile maps is accessed for a plurality of analysis intervals. Each of the profile maps includes rotation intensity values for a plurality of locations associated with rotation of the one or more rotational sources. An aggregated stability map is generated based on the profile maps, wherein the stability map includes a plurality of locations. Each location includes a rotation intensity value based at least on a filter number of highest rotation intensity values from corresponding locations of the profile maps, the filter number being automatically determined from a plurality of filter numbers such that the plurality of profile maps as filtered includes a predetermined number of rotation intensity values in excess of a threshold intensity value.

Abstract: Provided is a system and method of generating an aggregated stability map of one or more rotational sources associated with a heart rhythm disorder. In accordance therewith, a plurality of rotational area profile maps is accessed for a plurality of analysis intervals. Each of the rotational area profile maps includes rotation intensity values for a plurality of locations associated with rotation of the one or more rotational sources. Thereafter, an aggregated stability map is generated map based on the plurality of rotational area profile maps, wherein the aggregated stability map includes a plurality of locations. Each location includes a rotation intensity value based at least on a filter level of highest rotation intensity values for that location from corresponding locations of the plurality of rotational area profile maps.

Abstract: Provided is a system and method of generating an aggregated stability map of one or more rotational sources associated with a heart rhythm disorder. In accordance therewith, a plurality of rotational area profile maps is accessed for a plurality of analysis intervals. Each of the rotational area profile maps includes rotation intensity values for a plurality of locations associated with rotation of the one or more rotational sources. Thereafter, an aggregated stability map is generated map based on the plurality of rotational area profile maps, wherein the aggregated stability map includes a plurality of locations. Each location includes a rotation intensity value based at least on a filter level of highest rotation intensity values for that location from corresponding locations of the plurality of rotational area profile maps.

Abstract: A method of finding the location of an occluded portion of a blood vessel relative to a three-dimensional angiographic image of a subject's vasculature includes identifying the location of the occluded portion of the blood vessel on each of a series of displayed two dimensional images derived from the three dimensional image data in planes substantially transverse to direction of the occluded portion of the vessel. The identified locations in the occluded portion of the vessel can then be used to determine the path of the occluded portion of the vessel.

Abstract: A method of treating vessel occlusions including chronic total occlusions (CTO) of the coronary arteries is presented that relies on remote navigation of a remotely steered medical device to the occlusion and controlled application of ablative energy or mechanical push together with real-time local imaging of the vasculature or real-time vessel wall sensing. The combinative use of remote navigation methods and real-time imaging or real-time sensing enables crossing of elongated lesions and CTOs, calcified lesions and CTOs and lesions and CTOs located at vessel branches.

Abstract: A method of finding the location of an occluded portion of a blood vessel relative to a three-dimensional angiographic image of a subject's vasculature includes identifying the location of the occluded portion of the blood vessel on each of a series of displayed two dimensional images derived from the three dimensional image data in planes substantially transverse to direction of the occluded portion of the vessel. The identified locations in the occluded portion of the vessel can then be used to determine the path of the occluded portion of the vessel.

Abstract: A method for reconstructing surfaces and analyzing surface and volume representations of the shape of an object or structure corresponding to image data, in which the structure has been modeled as one or more physically distinct compartments. The characteristics of a compartmental model are specified in terms of the material types contained in each distinct compartment and in terms of the nature of compartmental boundaries as defined by the image data. An image model that includes scalar or vector image intensity functions for each material type and for each boundary type defined by the image data is specified. Gradient functions that characterize each boundary type and some compartmental regions are specified. A set of probabilistic volume representations of the location of different compartments and the location and orientation of compartmental boundaries is generated.