Patents by Inventor Heather E. Upton

Heather E. Upton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Reactions with non-retroviral reverse transcriptase
    Patent number: 12480106
    Abstract: Improved compositions and methods for using modified non-retroviral reverse transcriptase to perform 3? extension of a nucleic acid, employ non-templated deoxynucleotide addition to a single-stranded nucleic acid and/or synthesis of complementary DNA using non-complementary nucleic acids as primer and template (RNA- or DNA-templated DNA polymerase activity.
    Type: Grant
    Filed: April 4, 2023
    Date of Patent: November 25, 2025
    Assignee: The Regents of the University of California
    Inventors: Heather E. Upton, Lucas Ferguson, Sidney Pimentel, Kathleen Collins
  • Multicomponent systems for site-specific genome modifications
    Publication number: 20250049960
    Abstract: The invention includes systems, compositions, and methods for the making of modular gene editing through reverse transcriptase related processes. Systems and methods that use modified nucleotides and peptides are specifically provided.
    Type: Application
    Filed: October 26, 2024
    Publication date: February 13, 2025
    Applicant: The Regents of the University of California
    Inventors: Kathleen Collins, Xiaozhu Zhang, Briana Van Treeck, Heather E. Upton, Sarah Palm, Jeremy McIntyre
  • Compositions and methods for ordered and continuous complementary DNA (cDNA) synthesis across non-continuous templates
    Publication number: 20240344050
    Abstract: The invention provides compositions and methods for nucleic acid synthesis, including ordered and continuous complementary DNA (cDNA) synthesis across non-continuous templates using a modified eukaryotic non-long terminal repeat reverse transcriptase (non-LTR RT) protein.
    Type: Application
    Filed: June 25, 2024
    Publication date: October 17, 2024
    Applicant: The Regents of the University of California
    Inventors: Kathleen Collins, Heather E. Upton
  • Compositions and methods for ordered and continuous complementary DNA (cDNA) synthesis across non-continuous templates
    Publication number: 20240344051
    Abstract: The invention provides compositions and methods for nucleic acid synthesis, including ordered and continuous complementary DNA (cDNA) synthesis across non-continuous templates using a modified eukaryotic non-long terminal repeat reverse transcriptase (non-LTR RT) protein.
    Type: Application
    Filed: June 25, 2024
    Publication date: October 17, 2024
    Applicant: The Regents of the University of California
    Inventors: Kathleen Collins, Heather E. Upton
  • Compositions and methods for ordered and continuous complementary DNA (cDNA) synthesis across non-continuous templates
    Patent number: 12054705
    Abstract: The invention provides compositions and methods for nucleic acid synthesis, including ordered and continuous complementary DNA (cDNA) synthesis across non-continuous templates using a modified eukaryotic non-long terminal repeat reverse transcriptase (non-LTR RT) protein.
    Type: Grant
    Filed: February 4, 2021
    Date of Patent: August 6, 2024
    Assignee: The Regents of the University of California
    Inventors: Kathleen Collins, Heather E. Upton
  • Site-Specific Gene Modifications
    Publication number: 20230340523
    Abstract: Systems, compositions, and methods for target site-specific insertion of a transgene of interest to a subject genome are provided. Systems and methods that facilitate primed reverse transcription (TPRT) mediated by retroelement derived reverse transcriptase (RTs) site-specific transgene insertion are also provided.
    Type: Application
    Filed: May 9, 2023
    Publication date: October 26, 2023
    Applicant: The Regents of the University of California
    Inventors: Zhang Zhang, Heather E. Upton, Briana van Treeck, Kathleen Collins
  • Reactions with non-retroviral reverse transcriptase
    Publication number: 20230235302
    Abstract: Improved compositions and methods for using modified non-retroviral reverse transcriptase to perform 3? extension of a nucleic acid, employ non-templated deoxynucleotide addition to a single-stranded nucleic acid and/or synthesis of complementary DNA using non-complementary nucleic acids as primer and template (RNA- or DNA-templated DNA polymerase activity.
    Type: Application
    Filed: April 4, 2023
    Publication date: July 27, 2023
    Applicant: The Regents of the University of California
    Inventors: Heather E. Upton, Lucas Ferguson, Sidney Pimentel, Kathleen Collins
  • Compositions and methods for ordered and continuous complementary DNA (cDNA) synthesis across non-continuous templates
    Publication number: 20210261944
    Abstract: The invention provides compositions and methods for nucleic acid synthesis, including ordered and continuous complementary DNA (cDNA) synthesis across non-continuous templates using a modified eukaryotic non-long terminal repeat reverse transcriptase (non-LTR RT) protein.
    Type: Application
    Filed: February 4, 2021
    Publication date: August 26, 2021
    Applicant: The Regents of the University of California
    Inventors: Kathleen Collins, Heather E. Upton