Patents by Inventor Heather Koehler

Heather Koehler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Oncolytic vaccinia virus mutants and using same for cancer treatment
    Patent number: 10842835
    Abstract: Methods utilizing vaccinia virus with mutations in E3L to infect and cause lysis of cancer cells with less than normal protein levels of RIP3 and/or DAI. Further, the disclosed vaccinia viruses with mutations in E3L cannot replicate well in cells with normal expression or upregulation of RIP3, DAI, and/or MLKL.
    Type: Grant
    Filed: May 25, 2017
    Date of Patent: November 24, 2020
    Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
    Inventors: Bertram Jacobs, Heather Koehler, William Arndt, Karen Kibler, Kelly Trainor, Chandra Mitnik, Jeffrey Langland
  • ONCOLYTIC VACCINIA VIRUS MUTANTS AND USING SAME FOR CANCER TREATMENT
    Publication number: 20190183947
    Abstract: Methods utilizing vaccinia virus with mutations in E3L to infect and cause lysis of cancer cells with less than normal protein levels of RIP3 and/or DAI. Further, the disclosed vaccinia viruses with mutations in E3L cannot replicate well in cells with normal expression or upregulation of RIP3, DAI, and/or MLKL.
    Type: Application
    Filed: May 25, 2017
    Publication date: June 20, 2019
    Inventors: Bertram Jacobs, Heather Koehler, William Arndt, Karen Kibler, Kelly Trainor, Chandra Mitnik, Jeffrey Langland