Patents by Inventor Heather Michelle Grandin

Heather Michelle Grandin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230366117
    Abstract: Embodiments of methods and apparatuses for forming the metal oxide nanostructure on surfaces are disclosed. In certain embodiments, the nanostructures can be formed on a substrate made of a nickel titanium alloy, resulting in a nanostructure that can include both titanium oxide and nickel oxide. The nanostructure can be formed on the surface(s) of an implantable medical device, such as a stent.
    Type: Application
    Filed: March 7, 2023
    Publication date: November 16, 2023
    Inventors: David Alvin TYVOLL, Nan CHEN, Bharat Kumar MENON, Heather Michelle GRANDIN, Jenna Brynne LUBET
  • Patent number: 11643743
    Abstract: Embodiments of methods and apparatuses for forming the metal oxide nanostructure on surfaces are disclosed. In certain embodiments, the nanostructures can be formed on a substrate made of a nickel titanium alloy, resulting in a nanostructure that can include both titanium oxide and nickel oxide. The nanostructure can be formed on the surface(s) of an implantable medical device, such as a stent.
    Type: Grant
    Filed: September 13, 2019
    Date of Patent: May 9, 2023
    Assignee: ALFRED E. MANN INSTITUTE FOR BIOMEDICAL ENGINEERING AT THE UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: David Alvin Tyvoll, Bharat Kumar Menon, Nan Chen, Heather Michelle Grandin, Harald Nuhn, Jenna Brynne Lubet
  • Patent number: 11608565
    Abstract: Embodiments of nanostructures comprising metal oxide and methods for forming the nanostructure on surfaces are disclosed. In certain embodiments, the nanostructures can be formed on a substrate made of a nickel titanium alloy, resulting in a nanostructure containing both titanium oxide and nickel oxide. The nanostructure can include a lattice layer disposed on top of a nanotube layer. The distal surface of the lattice layer can have a titanium oxide to nickel oxide ratio of greater than 10:1, or about 17:1, resulting in a nanostructure that promotes human endothelial cell migration and proliferation at the interface between the lattice layer and human cells or tissue. The nanostructure may be formed on the outer surface of an implantable medical device, such a stent or an orthopedic implant (e.g. knee implant, bone screw, or bone staple).
    Type: Grant
    Filed: December 14, 2021
    Date of Patent: March 21, 2023
    Assignee: Alfred E. Mann Institute for Biomedical Engineering at the University of Southern California
    Inventors: David Alvin Tyvoll, Nan Chen, Bharat Kumar Menon, Heather Michelle Grandin, Cesar Escobar Blanco
  • Publication number: 20220106697
    Abstract: Embodiments of nanostructures comprising metal oxide and methods for forming the nanostructure on surfaces are disclosed. In certain embodiments, the nanostructures can be formed on a substrate made of a nickel titanium alloy, resulting in a nanostructure containing both titanium oxide and nickel oxide. The nanostructure can include a lattice layer disposed on top of a nanotube layer. The distal surface of the lattice layer can have a titanium oxide to nickel oxide ratio of greater than 10:1, or about 17:1, resulting in a nanostructure that promotes human endothelial cell migration and proliferation at the interface between the lattice layer and human cells or tissue. The nanostructure may be formed on the outer surface of an implantable medical device, such a stent or an orthopedic implant (e.g. knee implant, bone screw, or bone staple).
    Type: Application
    Filed: December 14, 2021
    Publication date: April 7, 2022
    Inventors: David Alvin Tyvoll, Nan Chen, Bharat Kumar Menon, Heather Michelle Grandin, Cesar Escobar Blanco
  • Patent number: 11230787
    Abstract: Embodiments of nanostructures comprising metal oxide and methods for forming the nanostructure on surfaces are disclosed. In certain embodiments, the nanostructures can be formed on a substrate made of a nickel titanium alloy, resulting in a nanostructure containing both titanium oxide and nickel oxide. The nanostructure can include a lattice layer disposed on top of a nanotube layer. The distal surface of the lattice layer can have a titanium oxide to nickel oxide ratio of greater than 10:1, or about 17:1, resulting in a nanostructure that promotes human endothelial cell migration and proliferation at the interface between the lattice layer and human cells or tissue. The nanostructure may be formed on the outer surface of an implantable medical device, such a stent or an orthopedic implant (e.g. knee implant, bone screw, or bone staple).
    Type: Grant
    Filed: September 21, 2018
    Date of Patent: January 25, 2022
    Assignee: Alfred E. Mann Institute for Biomedical Engineering at the University of Southern California
    Inventors: David Alvin Tyvoll, Nan Chen, Bharat Kumar Menon, Heather Michelle Grandin, Cesar Escobar Blanco
  • Publication number: 20210238764
    Abstract: Embodiments of methods and apparatuses for forming the metal oxide nanostructure on surfaces are disclosed. In certain embodiments, the nanostructures can be formed on a substrate made of a nickel titanium alloy, resulting in a nanostructure that can include both titanium oxide and nickel oxide. The nanostructure can be formed on the surface(s) of an implantable medical device, such as a stent.
    Type: Application
    Filed: September 13, 2019
    Publication date: August 5, 2021
    Inventors: David Alvin TYVOLL, Bharat Kumar MENON, Nan CHEN, Heather Michelle GRANDIN, Harald NUHN, Jenna Brynne LUBET
  • Publication number: 20200240034
    Abstract: Embodiments of nanostructures comprising metal oxide and methods for forming the nanostructure on surfaces are disclosed. In certain embodiments, the nanostructures can be formed on a substrate made of a nickel titanium alloy, resulting in a nanostructure containing both titanium oxide and nickel oxide. The nanostructure can include a lattice layer disposed on top of a nanotube layer. The distal surface of the lattice layer can have a titanium oxide to nickel oxide ratio of greater than 10:1, or about 17:1, resulting in a nanostructure that promotes human endothelial cell migration and proliferation at the interface between the lattice layer and human cells or tissue. The nanostructure may be formed on the outer surface of an implantable medical device, such a stent or an orthopedic implant (e.g. knee implant, bone screw, or bone staple).
    Type: Application
    Filed: September 21, 2018
    Publication date: July 30, 2020
    Inventors: David Alvin Tyvoll, Nan Chen, Bharat Kumar Menon, Heather Michelle Grandin, Cesar Escobar Blanco