Patents by Inventor Heather O'NEILL

Heather O'NEILL has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Therapeutic oligonucleotides
    Patent number: 11725023
    Abstract: Methods and compositions are provided for oligonucleotides that bind targets of interest. The targets include cells and microvesicles, such as those derived from various diseases. The oligonucleotides can be used for diagnostic and therapeutic purposes. The target of the oligonucleotides can be a target such as PARP1, HIST1H1B, HIST1H1D, NCL, FBL, SFPQ, RPL12, ACTB, HIST1H4A, SSBP1, NONO, H2AFJ, and DDX21, or a complex, subunit or fragment thereof.
    Type: Grant
    Filed: February 3, 2021
    Date of Patent: August 15, 2023
    Assignee: Caris Science, Inc.
    Inventors: Heather O'Neill, Günter Mayer, Mark Miglarese, David Spetzler
  • THERAPEUTIC OLIGONUCLEOTIDES
    Publication number: 20220356203
    Abstract: Methods and compositions are provided for oligonucleotides that bind targets of interest. The targets include cells and microvesicles, such as those derived from various diseases. The oligonucleotides can be used for diagnostic and therapeutic purposes. The target of the oligonucleotides can be a target such as PARP1, HIST1H1B, HIST1H1D, NCL, FBL, SFPQ, RPL12, ACTB, HIST1H4A, SSBP1, NONO, H2AFJ, and DDX21, or a complex, subunit or fragment thereof.
    Type: Application
    Filed: February 3, 2021
    Publication date: November 10, 2022
    Inventors: Heather O`Neill, Günter Mayer, Mark Miglarese, David Spetzler
  • Oligonucleotide probes and uses thereof
    Patent number: 11332748
    Abstract: Methods and compositions are provided to identify oligonucleotides that bind targets of interest. The targets include tissues, cells, circulating biomarkers such as microvesicles, including those derived from various diseases. The oligonucleotides can be used in diagnostic and therapeutic applications.
    Type: Grant
    Filed: June 10, 2020
    Date of Patent: May 17, 2022
    Assignee: Caris Science, Inc.
    Inventors: Valeriy Domenyuk, Tassilo Hornung, Heather O'Neill, Mark Miglarese, David Spetzler
  • THERAPEUTIC OLIGONUCLEOTIDES
    Publication number: 20220073919
    Abstract: Methods and compositions are provided for oligonucleotides that bind targets of interest. The targets include cells and microvesicles, such as those derived from various diseases. The oligonucleotides can be used for diagnostic and therapeutic purposes. The target of the oligonucleotides can be a therapeutic target such as Complement Component 1, Q Subcomponent (C1q) or a subunit thereof.
    Type: Application
    Filed: July 15, 2021
    Publication date: March 10, 2022
    Inventors: Heather O'Neill, Mark Miglarese, David Spetzler
  • Therapeutic oligonucleotides
    Patent number: 11091765
    Abstract: Methods and compositions are provided for oligonucleotides that bind targets of interest. The targets include cells and microvesicles, such as those derived from various diseases. The oligonucleotides can be used for diagnostic and therapeutic purposes. The target of the oligonucleotides can be a therapeutic target such as Complement Component 1, Q Subcomponent (C1q) or a subunit thereof.
    Type: Grant
    Filed: February 6, 2020
    Date of Patent: August 17, 2021
    Assignee: Caris Science, Inc.
    Inventors: Heather O'Neill, Mark Miglarese, David Spetzler
  • Therapeutic oligonucleotides
    Patent number: 10941176
    Abstract: Methods and compositions are provided for oligonucleotides that bind targets of interest. The targets include cells and microvesicles, such as those derived from various diseases. The oligonucleotides can be used for diagnostic and therapeutic purposes. The target of the oligonucleotides can be a target such as PARP1, HIST1H1B, HIST1H1D, NCL, FBL, SFPQ, RPL12, ACTB, HIST1H4A, SSBP1, NONO, H2AFJ, and DDX21, or a complex, subunit or fragment thereof.
    Type: Grant
    Filed: July 28, 2016
    Date of Patent: March 9, 2021
    Assignee: Caris Science, Inc.
    Inventors: Heather O'Neill, Günter Mayer, Mark Miglarese, David Spetzler
  • OLIGONUCLEOTIDE PROBES AND USES THEREOF
    Publication number: 20210062191
    Abstract: Methods and compositions are provided to identify oligonucleotides that bind targets of interest. The targets include tissues, cells, circulating biomarkers such as microvesicles, including those derived from various diseases. The oligonucleotides can be used in diagnostic and therapeutic applications.
    Type: Application
    Filed: June 10, 2020
    Publication date: March 4, 2021
    Inventors: Valeriy Domenyuk, Tassilo Hornung, Heather O'Neill, Mark Miglarese, David Spetzler
  • Therapeutic Oligonucleotides
    Publication number: 20200277606
    Abstract: Methods and compositions are provided for oligonucleotides that bind targets of interest. The targets include cells and microvesicles, such as those derived from various diseases. The oligonucleotides can be used for diagnostic and therapeutic purposes. The target of the oligonucleotides can be a therapeutic target such as Complement Component 1, Q Subcomponent (C1q) or a subunit thereof.
    Type: Application
    Filed: February 6, 2020
    Publication date: September 3, 2020
    Inventors: Heather O`Neill, Mark Miglarese, David Spetzler
  • Oligonucleotide probes and uses thereof
    Patent number: 10731166
    Abstract: Methods and compositions are provided to identify oligonucleotides that bind targets of interest. The targets include tissues, cells, circulating biomarkers such as microvesicles, including those derived from various diseases. The oligonucleotides can be used in diagnostic and therapeutic applications.
    Type: Grant
    Filed: March 18, 2017
    Date of Patent: August 4, 2020
    Assignee: Caris Science, Inc.
    Inventors: Valeriy Domenyuk, Tassilo Hornung, Heather O'Neill, Mark Miglarese, David Spetzler
  • Therapeutic oligonucleotides
    Patent number: 10590425
    Abstract: Methods and compositions are provided for oligonucleotides that bind targets of interest. The targets include cells and microvesicles, such as those derived from various diseases. The oligonucleotides can be used for diagnostic and therapeutic purposes. The target of the oligonucleotides can be a therapeutic target such as Complement Component 1, Q Subcomponent (C1q) or a subunit thereof.
    Type: Grant
    Filed: June 29, 2016
    Date of Patent: March 17, 2020
    Assignee: Caris Science, Inc.
    Inventors: Heather O'Neill, Mark Miglarese, David Spetzler
  • Oligonucleotide Probes and Uses Thereof
    Publication number: 20200032265
    Abstract: Methods and compositions are provided for oligonucleotides and libraries of oligonucleotides that bind targets of interest. The targets include cellular biomarkers of viral infection. The viral infection may be that of human immunodeficiency virus-1.
    Type: Application
    Filed: September 27, 2017
    Publication date: January 30, 2020
    Inventors: Tassilo Hornung, Heather O'Neill, Mark Miglarese, David Spetzler
  • TARGETED OLIGONUCLEOTIDES
    Publication number: 20190359983
    Abstract: Methods and compositions are provided for oligonucleotides that bind targets of interest. The targets include cells and microvesicles, such as those derived from various diseases. The oligonucleotides can be used for diagnostic and therapeutic purposes. The target of the oligonucleotides can be a member of a ribonucleoprotein or spliceosomal complex such heterologous nuclear ribonucleoprotein U (hnRNP U).
    Type: Application
    Filed: February 2, 2018
    Publication date: November 28, 2019
    Inventors: Heather O'Neill, Günter Mayer, Sonal Tonapi, Vaishali Pannu, Mark Miglarese, David Spetzler
  • THERAPEUTIC OLIGONUCLEOTIDES
    Publication number: 20190256546
    Abstract: Methods and compositions are provided for oligonucleotides that bind targets of interest. The targets include cells and microvesicles, such as those derived from various diseases. The oligonucleotides can be used for diagnostic and therapeutic purposes. The target of the oligonucleotides can be a target such as PARP1, HIST1H1B, HIST1H1D, NCL, FBL, SFPQ, RPL12, ACTB, HIST1H4A, SSBP1, NONO, H2AFJ, and DDX21, or a complex, subunit or fragment thereof.
    Type: Application
    Filed: July 28, 2016
    Publication date: August 22, 2019
    Inventors: Heather O'Neill, Günter Mayer, Mark Miglarese, David Spetzler
  • OLIGONUCLEOTIDE PROBES AND USES THEREOF
    Publication number: 20190078093
    Abstract: Methods and compositions are provided to identify oligonucleotides that bind targets of interest. The targets include tissues, cells, circulating biomarkers such as microvesicles, including those derived from various diseases. The oligonucleotides can be used in diagnostic and therapeutic applications.
    Type: Application
    Filed: March 18, 2017
    Publication date: March 14, 2019
    Inventors: Valeriy DOMENYUK, Tassilo HORNUNG, Heather O'NEILL, Mark MIGLARESE, David SPETZLER
  • THERAPEUTIC OLIGONUCLEOTIDES
    Publication number: 20180171337
    Abstract: Methods and compositions are provided for oligonucleotides that bind targets of interest. The targets include cells and microvesicles, such as those derived from various diseases. The oligonucleotides can be used for diagnostic and therapeutic purposes. The target of the oligonucleotides can be a therapeutic target such as Complement Component 1, Q Subcomponent (C1q) or a subunit thereof.
    Type: Application
    Filed: June 29, 2016
    Publication date: June 21, 2018
    Inventors: Heather O'Neill, Mark Miglarese, David Spetzler
  • OLIGONUCLEOTIDE PROBES AND USES THEREOF
    Publication number: 20170356903
    Abstract: Methods and compositions are provided to identify oligonucleotide probes that can detect various targets of interest. The targets include microvesicles, microvesicle antigens, and nucleic acids. The target detection may be used to provide a diagnosis, prognosis or theranosis of a medical condition, a disease or a disorder.
    Type: Application
    Filed: November 23, 2015
    Publication date: December 14, 2017
    Inventors: Valeriy DOMENYUK, Andrew HUNTER, Heather O'NEILL, David SPETZLER