Patents by Inventor Hedieh BARKHORDARIAN

Hedieh BARKHORDARIAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MODULATING PRODUCT QUALITY OF ASYMMETRIC MULTISPECIFIC ANTIBODIES THROUGH THE USE OF TEMPERATURE
    Publication number: 20240174752
    Abstract: The present invention relates to the field of biopharmaceutical manufacturing. In particular, the invention relates to using temperature as a lever to modulate product quality during upstream operations.
    Type: Application
    Filed: April 26, 2022
    Publication date: May 30, 2024
    Applicant: AMGEN INC.
    Inventors: Li ZHANG, Hedieh BARKHORDARIAN, Ewelina ZASADZINSKA, Jonathan DIEP
  • VECTORS AND EXPRESSION SYSTEMS FOR PRODUCING RECOMBINANT PROTEINS
    Publication number: 20220243222
    Abstract: Inventions disclosed herein relates to vectors and expression systems for producing heteromeric recombinant proteins such as monoclonal antibodies. Vectors and expression systems disclosed herein are based on the finding that the selectable marker glutamine synthetase can be divided into two fragments at selected amino acid positions of the glutamine synthetase polypeptide, and the two fragments can internet and/or associate to form a monomer and then a functional multimeric glutamine synthetase protein.
    Type: Application
    Filed: May 4, 2020
    Publication date: August 4, 2022
    Inventors: Pavan Ghattyvenkatakrishna, Hedieh Barkhordarian, Kristine Marie Daris, Charilyn Tejamo
  • Increasing ornithine accumulation to increase high mannose glycoform content of recombinant proteins
    Patent number: 11254963
    Abstract: The present invention relates to a method for manipulating the high mannose glycoform content of recombinant glycoproteins by regulating ornithine metabolism during cell culture.
    Type: Grant
    Filed: November 6, 2019
    Date of Patent: February 22, 2022
    Assignee: Amgen Inc.
    Inventors: Sohye Kang, Chung Huang, Jr., Hedieh Barkhordarian, Pavel Bondarenko, Zhongqi Zhang
  • CONTINUOUS MANUFACTURING PROCESS FOR BISPECIFIC ANTIBODY PRODUCTS
    Publication number: 20210163592
    Abstract: The present invention provides a continuous upstream manufacturing process for the production of bispecific antibody products, which comprise at least two binding domains. The process comprises at least the steps of (i) providing in a perfusion bioreactor at least one mammalian cell culture, which is capable of expressing the bispecific antibody product, (ii) growing the mammalian cell culture at a first perfusion rate until a set point viable cell density is reached, and (iii) maintaining perfusion culture at a second perfusion rate, wherein the bispecific antibody product concentration in the bioreactor is kept below a threshold value. The bispecific antibody product is then subject to subsequent downstream processing. Moreover, the invention provides a bispecific antibody product produced by the continuous upstream manufacturing process.
    Type: Application
    Filed: December 11, 2018
    Publication date: June 3, 2021
    Inventors: Chetan Goudar, Rohini Deshpande, Natalia Gomez, Hedieh Barkhordarian, Yan Wang
  • DECREASING ORNITHINE METABOLISM TO DECREASE THE HIGH MANNOSE GLYCOFORM CONTENT OF RECOMBINANT PROTEINS
    Publication number: 20200071738
    Abstract: The present invention relates to a method for manipulating the high mannose glycoform content of recombinant glycoproteins by regulating ornithine metabolism during cell culture.
    Type: Application
    Filed: November 6, 2019
    Publication date: March 5, 2020
    Applicant: Amgen Inc.
    Inventors: Sohye KANG, Chung HUANG, JR., Hedieh BARKHORDARIAN, Pavel BONDARENKO, Zhongqi ZHANG
  • Decreasing ornithine production to decrease high mannose glycoform content of recombinant proteins
    Patent number: 10513723
    Abstract: The present invention relates to a method for manipulating the high mannose glycoform content of recombinant glycoproteins by regulating ornithine metabolism during cell culture.
    Type: Grant
    Filed: December 9, 2014
    Date of Patent: December 24, 2019
    Inventors: Sohye Kang, Chung Huang, Jr., Hedieh Barkhordarian, Pavel Bondarenko, Zhongqi Zhang
  • REGULATING ORINTHINE METABOLISM TO MANIPULATE THE HIGH MANNOSE GLYCOFORM CONTENT OF RECOMBINANT PROTEINS
    Publication number: 20160333385
    Abstract: The present invention relates to a method for manipulating the high mannose glycoform content of recombinant glycoproteins by regulating ornithine metabolism during cell culture.
    Type: Application
    Filed: December 9, 2014
    Publication date: November 17, 2016
    Applicant: AMGEN INC.
    Inventors: Sohye KANG, Chung HUANG, Jr., Hedieh BARKHORDARIAN, Pavel BONDARENKO, Zhongqi ZHANG