Abstract: Provided is a method, whereby weights are assigned to edges in a signal propagation process starting from a node corresponding to a queried entity and directionality of signal propagation is assigned based on the weights so that a target node related to the queried entity can be searched for with high accuracy.

Abstract: A composition for preventing or treating a TNF-?-related disease is disclosed. The composition includes hydroflumethiazide or a pharmaceutically acceptable salt thereof as an active ingredient. The composition can effectively inhibit the expression or activity of TNF-? and exhibits an excellent treatment effect compared to methotrexate (MTX) or hydroxychloroquine (HCQ), which are rheumatoid arthritis treatment agents currently on the market, and, thus, can be effectively used for prevention or treatment of a TNF-?-related disease.

Abstract: The present invention relates to a method capable of recognizing disease-related factors included in document data and extracting relations between the disease-related factors.

Abstract: A composition for preventing or treating synucleinopathies, which includes efavirenz or a salt or solvate thereof and a pharmaceutically acceptable carrier, is provided. The composition is useful in preventing or treating synucleinopathies, such as Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy, because the composition serves to hinder cell-to-cell transmission of alpha-synuclein, prevent intracellular aggregation of ?-synuclein, and inhibit transmission of aggregated ?-synuclein.

Abstract: A composition for preventing or treating synucleinopathies, which includes nevirapine or a salt or solvate thereof and a pharmaceutically acceptable carrier, is provided. The composition is useful in preventing or treating synucleinopathies, such as Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy, because the composition serves to hinder cell-to-cell transmission of ?-synuclein, prevent intracellular aggregation of ?-synuclein, and inhibit transmission of aggregated ?-synuclein.

Abstract: The present invention relates to a pharmaceutical composition for preventing or treating non-alcoholic fatty liver disease, comprising trametinib. The composition of the present invention, which comprises trametinib, reduces steatosis, inflammation, or ballooning in liver tissue where non-alcoholic fatty liver has been induced; reduces the level of fibrosis of inflammation induced by non-alcoholic fatty liver; and reduces the weight of a liver that has increased due to non-alcoholic fatty liver disease. Accordingly, the composition of the present invention can be provided for use in preventing or treating metabolic liver disease, including non-alcoholic fatty liver disease.

Abstract: Provided is a method, whereby data is collected from a plurality of databases to build a graph database, and an artificial neural network is trained based on the data stored in the built graph database so that an entity, for example, a disease, a gene, or a protein related to a queried entity on the artificial neural network for which the training has been completed, may be predicted, and a system built by using the same.